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Cutting Edge: Thymocyte-Independent and Thymocyte-Dependent Phases of Epithelial Patterning in the Fetal Thymus
Open accessAbstract
Thymic epithelial cells (TECs) in adult mice have been classified into distinct subsets based on keratin expression profiles. To explore the emergence of TEC subsets during ontogeny, we analyzed keratin 8 and keratin 5 expression at several stages of fetal development in normal C57BL/6J mice. In addition, thymic epithelial development and compartmentalization were explored in recombination-activating gene 2/common cytokine receptor γ-chain-deficient and Ikaros-null mice that sustain early and profound blocks in thymocyte differentiation. The results demonstrate that initial patterning of the thymic epithelial compartment as defined by differential keratin expression does not depend on inductive signals from hematopoietic cells. However, thymocyte-derived signals are required during late fetal stages for continued development and maintenance of TEC subsets in the neonate and adult.
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Citations
Cited by
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Senoo, M., Pinto, F., Crum, C. P., & McKeon, F. (2007) · Cell · doi:10.1016/j.cell.2007.02.045 · Cited by 881
Mechanisms of thymus organogenesis and morphogenesis
Gordon, J., & Manley, N. R. (2011) · Development · doi:10.1242/dev.059998 · Cited by 293
Reduction in the Developmental Potential of Intrathymic T Cell Progenitors with Age
Min, H., Montecino-Rodriguez, E., & Dorshkind, K. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.1.245 · Cited by 216
Effects of aging on early B‐ and T‐cell development
Min, H., Montecino‐Rodriguez, E., & Dorshkind, K. (2005) · Immunological Reviews · doi:10.1111/j.0105-2896.2005.00263.x · Cited by 96
Nabarra, B., Pontoux, C., Godard, C., Osborne‐Pellegrin, M., & Ezine, S. (2005) · International Journal of Experimental Pathology · doi:10.1111/j.0959-9673.2005.00451.x · Cited by 3
Metadata
- Authors
- Klug, D. B., Carter, C., Gimenez-Conti, I. B., & Richie, E. R.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2002-09
- Volume
- 169
- Issue
- 6
- Pages
- 2842-2845
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2100890363
- Cited by
- 191
- References
- 0
- FWCI
- 2.67
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Klug, D. B., Carter, C., Gimenez-Conti, I. B., & Richie, E. R. (2002). Cutting Edge: Thymocyte-Independent and Thymocyte-Dependent Phases of Epithelial Patterning in the Fetal Thymus. The Journal of Immunology. https://doi.org/10.4049/jimmunol.169.6.2842
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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