Effects of aging on early B‐ and T‐cell development
Abstract
Summary: Lymphocyte production in the bone marrow and the thymus is reduced during aging, but why this decline occurs has not been fully elucidated. The ability to isolate hematopoietic stem and progenitor cells using sophisticated flow cytometric strategies and to manipulate them in vitro and in vivo has provided insights into the effects of aging on primary lymphopoiesis. These analyses have showed that intrinsic changes in hematopoietic precursors that affect their proliferative potential are one factor that contributes to the age‐related decline in B‐ and T‐cell production. This and other age‐related defects may be exacerbated by changes in the lymphopoietic support potential of the bone marrow and thymic microenvironments as well as by age‐induced fluctuations in the production of various endocrine hormones. Particular attention with regard to the latter point has focused on changes in the production of sex steroids, growth hormone, and insulin‐like growth factor‐I. The present review summarizes recent studies of how age‐related perturbations affect primary lymphopoiesis and highlights how the data necessitate the reevaluation of a number of existing paradigms.
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Common lymphoid progenitors, pre-pro-B cells, and pro-B cells from old mice proliferate less and undergo apoptosis more than young cells.
“For example, common lymphoid progenitors, pre-pro-B cells, and pro-B cells from old mice do not proliferate as extensively as do young cells, and they exhibit significantly higher rates of apoptosis.”
From Causes, consequences, and reversal of immune system aging (2013) · cites this paper as [34]
The poor quality of lymphoid progenitors produced in aged animals worsens the decline in lymphopoiesis.
“In addition, the poor quality of the lymphoid progenitors that are generated in the aged further exacerbates the decline in lymphopoiesis (29,32,34).”
From Causes, consequences, and reversal of immune system aging (2013) · cites this paper as [34]
Thymic involution reduces naive T-cell production and is thought to contribute to impaired immunity in the elderly.
“Involution of the thymus results in reduced production of naive T cells, and this in turn is thought to contribute to impaired immunity in the elderly.”
From Fibroblast growth factor-7 partially reverses murine thymocyte progenitor aging by repression of Ink4a (2012) · cites this paper as [5]
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- Authors
- Min, H., Montecino‐Rodriguez, E., & Dorshkind, K.
- Affiliations
- University of California, Los Angeles (US)
- Venue
- Immunological Reviews
- Publisher
- Wiley
- Published
- 2005-05-09
- Volume
- 205
- Issue
- 1
- Pages
- 7-17
- ISSN
- 0105-2896 (ISSN-L)
- 1600-065X
- OpenAlex
- W2129270330
- Cited by
- 96
- References
- 90
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 2 · 2023: 1 · 2022: 5 · 2021: 1 · 2020: 4 · 2019: 7 · 2018: 4 · 2017: 6 · 2016: 5 · 2015: 4 · 2014: 2 · 2013: 3 · 2012: 4
- FWCI
- 1.34
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Immunological Reviews (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (AG-21450, R01AG021450)
- Topics
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Blood disorders and treatments
- Keywords
- aging, B cell development, T cell development, hematopoietic stem and progenitor cells, bone marrow microenvironment, thymus, sex steroids, growth hormone, insulin-like growth factor I, endocrine hormones
- MeSH terms
- Aging, Animals, B-Lymphocytes, Cell Differentiation, Humans, T-Lymphocytes, Thymus Gland, Models, Immunological
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