The DOI matches its Crossref record; 74 of the 74 references it cites were found in a registry or an index.
The Loss of TET2 Promotes CD8+ T Cell Memory Differentiation
Abstract
T cell differentiation requires appropriate regulation of DNA methylation. In this article, we demonstrate that the methylcytosine dioxygenase ten-eleven translocation (TET)2 regulates CD8+ T cell differentiation. In a murine model of acute viral infection, TET2 loss promotes early acquisition of a memory CD8+ T cell fate in a cell-intrinsic manner without disrupting Ag-driven cell expansion or effector function. Upon secondary recall, TET2-deficient memory CD8+ T cells demonstrate superior pathogen control. Genome-wide methylation analysis identified a number of differentially methylated regions in TET2-deficient versus wild-type CD8+ T cells. These differentially methylated regions did not occur at the loci of differentially expressed memory markers; rather, several hypermethylated regions were identified in known transcriptional regulators of CD8+ T cell memory fate. Together, these data demonstrate that TET2 is an important regulator of CD8+ T cell fate decisions.
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“In this context, IL-17A production by T helper 17 (T H 17) cells, group 3 innate lymphoid cells (ILC3s) and inflammatory group 2 innate lymphoid cells (iILC2s) is significantly reduced in the setting of TET2 deficiency162,172.”
From Clonal haematopoiesis and dysregulation of the immune system (2023) · cites this paper as [162]
In the citing paper
“InmouseCD4+Tcellsand innate lymphoid cell (ILC) subsets, TET2 is recruited to the Il17a enhancer CNS2 via RORγt, leading to increased enhancer and promoter hydroxymethylation and increased Il17a expression162.”
From Clonal haematopoiesis and dysregulation of the immune system (2023) · cites this paper as [162]
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Cites
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Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
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Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1
Tahiliani, M., Koh, K. P., Shen, Y., Pastor, W. A., Bandukwala, H., Brudno, Y., Agarwal, S., Iyer, L. M., Liu, D. R., Aravind, L., et al. (2009) · Science · doi:10.1126/science.1170116 · Cited by 5,836
Age-related clonal hematopoiesis associated with adverse outcomes
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Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence
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Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine
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DNA methylation: roles in mammalian development
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Age-related mutations associated with clonal hematopoietic expansion and malignancies
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Cited by
TOX transcriptionally and epigenetically programs CD8+ T cell exhaustion
Khan, O., Giles, J. R., McDonald, S., Manne, S., Ngiow, S. F., Patel, K. P., Werner, M. T., Huang, A. C., Alexander, K. A., Wu, J. E., et al. (2019) · Nature · doi:10.1038/s41586-019-1325-x · Cited by 1,646
Self-citationDisruption of TET2 promotes the therapeutic efficacy of CD19-targeted T cells
Fraietta, J. A., Nobles, C. L., Sammons, M. A., Lundh, S., Carty, S. A., Reich, T. J., Cogdill, A. P., Morrissette, J. J. D., DeNizio, J. E., Reddy, S., et al. (2018) · Nature · doi:10.1038/s41586-018-0178-z · Cited by 862
Self-citationThe emerging role of epigenetic therapeutics in immuno-oncology
Topper, M. J., Vaz, M., Marrone, K. A., Brahmer, J. R., & Baylin, S. B. (2020) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-019-0266-5 · Cited by 433
Vitamin C and immune cell function in inflammation and cancer
Ang, A., Pullar, J. M., Currie, M. J., & Vissers, M. C. M. (2018) · Biochemical Society Transactions · doi:10.1042/bst20180169 · Cited by 191
Clonal hematopoiesis and non-hematologic disorders
Jaiswal, S. (2020) · Blood · doi:10.1182/blood.2019000989 · Cited by 182
Metadata
- Authors
- Carty, S. A., Gohil, M., Banks, L. B., Cotton, R. M., Johnson, M. E., Stelekati, E., Wells, A. D., Wherry, E. J., Koretzky, G. A., & Jordan, M. S.
- Affiliations
- Department of Medicine, Perelman School of Medicine, University of Pennsylvania , Philadelphia, PA 19104
- Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania , Philadelphia, PA 19104
- Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania , Philadelphia, PA 19104
- The Children’s Hospital of Philadelphia , Philadelphia, PA 19104
- Department of Microbiology, Perelman School of Medicine, University of Pennsylvania , Philadelphia, PA 19104
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2018-01-01
- Volume
- 200
- Issue
- 1
- Pages
- 82-91
- ISSN
- 0022-1767
- 1550-6606
- PMC
- PMC5736442
- Cited by
- 172
- References
- 74
- Language
- en
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- Carty, S. A., Gohil, M., Banks, L. B., Cotton, R. M., Johnson, M. E., Stelekati, E., Wells, A. D., Wherry, E. J., Koretzky, G. A., & Jordan, M. S. (2018). The Loss of TET2 Promotes CD8+ T Cell Memory Differentiation. The Journal of Immunology. https://doi.org/10.4049/jimmunol.1700559
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