Cited by 239Pneumonia and Respiratory InfectionsPhagocytosis and Immune RegulationImmune Response and Inflammation

The DOI matches its Crossref record; 68 of the 68 references it cites were found in a registry or an index.

Alveolar Macrophage Apoptosis Contributes to Pneumococcal Clearance in a Resolving Model of Pulmonary Infection

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Abstract

The role of alveolar macrophages (AM) in host defense against pulmonary infection has been difficult to establish using in vivo models. This may reflect a reliance on models of fulminant infection. To establish a unique model of resolving infection, with which to address the function of AM, C57BL/6 mice received low-dose intratracheal administration of pneumococci. Administration of low doses of pneumococci produced a resolving model of pulmonary infection characterized by clearance of bacteria without features of pneumonia. AM depletion in this model significantly increased bacterial outgrowth in the lung. Interestingly, a significant increase in the number of apoptotic AM was noted with the low-dose infection as compared with mock infection. Caspase inhibition in this model decreased AM apoptosis and increased the number of bacteremic mice, indicating a novel role for caspase activation in pulmonary innate defense against pneumococci. These results suggest that AM play a key role in clearance of bacteria from the lung during subclinical infection and that induction of AM apoptosis contributes to the microbiologic host defense against pneumococci.

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Metadata

Authors
Dockrell, D. H., Marriott, H. M., Prince, L. R., Ridger, V. C., Ince, P. G., Hellewell, P. G., & Whyte, M. K. B.
Affiliations
University of Sheffield (GB)
Venue
The Journal of Immunology
Published
2003-11
Volume
171
Issue
10
Pages
5380-5388
ISSN
  • 0022-1767 (ISSN-L)
  • 1550-6606
OpenAlex
W1781589933
Cited by
239
References
68
Citations by year
2026: 5 · 2025: 6 · 2024: 4 · 2023: 11 · 2022: 9 · 2021: 11 · 2020: 15 · 2019: 13 · 2018: 9 · 2017: 12 · 2016: 12 · 2015: 18 · 2014: 18 · 2013: 12 · 2012: 10
FWCI
5.55
Type
journal article
Language
en
Open access
Locations
  • The Journal of Immunology (publishedVersion)
  • PubMed (publishedVersion)
  • White Rose Research Online (University of Leeds, The University of Sheffield, University of York) (submittedVersion)
Funders
Wellcome Trust
Topics
  • Health Sciences › Medicine › Epidemiology › Pneumonia and Respiratory Infections
  • Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords
alveolar macrophages, macrophage apoptosis, Streptococcus pneumoniae, asymptomatic infection, caspase activation, bacteremia, pulmonary innate immunity, host defense
MeSH terms
Amino Acid Chloromethyl Ketones, Animals, Cell Count, Disease Models, Animal, Dose-Response Relationship, Immunologic, Female, Immunity, Innate, Injections, Intraperitoneal, Intubation, Intratracheal, Mice, Inbred C57BL, Pneumonia, Pneumococcal, Streptococcus pneumoniae, Cysteine Proteinase Inhibitors, Up-Regulation, Bacteremia, Macrophages, Alveolar, Apoptosis, Mice, Caspase Inhibitors

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