The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Bone Marrow-Derived Progenitor Cells Are Important for Lung Repair after Lipopolysaccharide-Induced Lung Injury
Open accessAbstract
Tissue repair often occurs in organs damaged by an inflammatory response. Inflammatory stimuli induce a rapid and massive release of inflammatory cells including neutrophils from the bone marrow. Recently, many studies suggested that bone marrow cells have the potential to differentiate into a variety of cell types. However, whether inflammatory stimuli induce release of bone marrow-derived progenitor cells (BMPCs), or how much impact the suppression of BMPCs has on the injured organ is not clear. Here we show that LPS, a component of Gram-negative bacterial cell walls, in the lung airways, induces a rapid mobilization of BMPCs into the circulation in mice. BMPCs accumulate within the inflammatory site and differentiate to become endothelial and epithelial cells. Moreover, the suppression of BMPCs by sublethal irradiation before intrapulmonary LPS leads to disruption of tissue structure and emphysema-like changes. Reconstitution of the bone marrow prevents these changes. These data suggest that BMPCs are important and required for lung repair after LPS-induced lung injury.
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Cites
Isolation of Putative Progenitor Endothelial Cells for Angiogenesis
Asahara, T., Murohara, T., Sullivan, A., Silver, M., van der Zee, R., Li, T., Witzenbichler, B., Schatteman, G., & Isner, J. M. (1997) · Science · doi:10.1126/science.275.5302.964 · Cited by 8,725
Circulating endothelial progenitor cells, vascular function, and cardiovascular risk
Hill, J. M., Zalos, G., Halcox, J. P. J., Schenke, W. H., Waclawiw, M. A., Quyyumi, A. A., & Finkel, T. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa022287 · Cited by 3,423
Peripheral Blood Fibrocytes: Differentiation Pathway and Migration to Wound Sites
Abe, R., Donnelly, S. C., Peng, T., Bucala, R., & Metz, C. N. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.12.7556 · Cited by 967
Cited by
Reutershan, J., Basit, A., Galkina, E. V., & Ley, K. (2005) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00477.2004 · Cited by 309
Fang, X., Neyrinck, A. P., Matthay, M. A., & Lee, J. W. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.119917 · Cited by 258
Conese, M., Piro, D., Carbone, A., Castellani, S., & Di Gioia, S. (2014) · The Scientific World Journal · doi:10.1155/2014/859817 · Cited by 28
Huang, Z.-W., Liu, N., Li, D., Zhang, H.-Y., Wang, Y., Liu, Y., Zhang, L.-L., & Ju, X.-L. (2017) · Yonsei Medical Journal · doi:10.3349/ymj.2017.58.1.206 · Cited by 25
Metadata
- Authors
- Yamada, M., Kubo, H., Kobayashi, S., Ishizawa, K., Numasaki, M., Ueda, S., Suzuki, T., & Sasaki, H.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2004-01
- Volume
- 172
- Issue
- 2
- Pages
- 1266-1272
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2146906484
- Cited by
- 340
- References
- 3
- FWCI
- 15.26
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Bone Marrow-Derived Progenitor Cells Are Important for Lung Repair after Lipopolysaccharide-Induced Lung Injury. https://app.cochat.ai/papers/10.4049/jimmunol.172.2.1266
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- Yamada, M., Kubo, H., Kobayashi, S., Ishizawa, K., Numasaki, M., Ueda, S., Suzuki, T., & Sasaki, H. (2004). Bone Marrow-Derived Progenitor Cells Are Important for Lung Repair after Lipopolysaccharide-Induced Lung Injury. The Journal of Immunology. https://doi.org/10.4049/jimmunol.172.2.1266
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