Peripheral Blood Fibrocytes: Differentiation Pathway and Migration to Wound Sites
Abstract
Fibrocytes are a distinct population of blood-borne cells that display a unique cell surface phenotype (collagen I+/CD11b+/CD13+/CD34+/CD45RO+/MHC class II+/CD86+) and exhibit potent immunostimulatory activities. Circulating fibrocytes rapidly enter sites of tissue injury, suggesting an important role for these cells in wound repair. However, the regulatory processes that govern the differentiation of blood-borne fibrocytes and the mechanisms that underlie the migration of these cells to wound sites are currently not known. We report herein that ex vivo cultured fibrocytes can differentiate from a CD14+-enriched mononuclear cell population and that this process requires contact with T cells. Furthermore, we demonstrate that TGF-β1 (1–10 ng/ml), an important fibrogenic and growth-regulating cytokine involved in wound healing, increases the differentiation and functional activity of cultured fibrocytes. Because fibrocytes home to sites of tissue injury, we examined the role of chemokine/chemokine receptor interactions in fibrocyte trafficking. We show that secondary lymphoid chemokine, a ligand of the CCR7 chemokine receptor, acts as a potent stimulus for fibrocyte chemotaxis in vitro and for the homing of injected fibrocytes to sites of cutaneous tissue injury in vivo. Finally, we demonstrate that differentiated, cultured fibrocytes express α smooth muscle actin and contract collagen gels in vitro, two characteristic features of wound-healing myofibroblasts. These data provide important insight into the control of fibrocyte differentiation and trafficking during tissue repair and significantly expand their potential role during wound healing.
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Fibrocyte migration to wounds is guided by DAMPs and chemokines such as CCL21.
“Their migration to wounds is guided by damage associated molecular patterns (DAMPs) and chemokines such as Chemokine (C-C motif) ligand 21 (CCL21) (86), and after arrival, these cells start differentiating into a myofibroblast-like phenotype under the influence of factors such as TGFβ (86).”
From Unraveling SSc Pathophysiology; The Myofibroblast (2018) · cites this paper as [86]
After arrival, fibrocytes start differentiating into a myofibroblast-like phenotype under the influence of factors such as TGFβ.
“Their migration to wounds is guided by damage associated molecular patterns (DAMPs) and chemokines such as Chemokine (C-C motif) ligand 21 (CCL21) (86), and after arrival, these cells start differentiating into a myofibroblast-like phenotype under the influence of factors such as TGFβ (86).”
From Unraveling SSc Pathophysiology; The Myofibroblast (2018) · cites this paper as [86]
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- Authors
- Abe, R., Donnelly, S. C., Peng, T., Bucala, R., & Metz, C. N.
- Affiliations
- Laboratory of Vascular Biology, The Picower Institute for Medical Research , Manhasset, NY 11030
- Laboratory of Medical Biochemistry, The Picower Institute for Medical Research , Manhasset, NY 11030
- Corresponding author
- Abe, Riichiro
- Peng, Tina
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2001-06
- Volume
- 166
- Issue
- 12
- Pages
- 7556-7562
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W4248565951
- Cited by
- 967
- References
- 40
- Citations by year
- 2026: 13 · 2025: 15 · 2024: 22 · 2023: 25 · 2022: 28 · 2021: 23 · 2020: 37 · 2019: 30 · 2018: 34 · 2017: 31 · 2016: 43 · 2015: 47 · 2014: 58 · 2013: 59 · 2012: 68
- FWCI
- 27.32
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Immunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Life Sciences › Immunology and Microbiology › Immunology › Macrophage Migration Inhibitory Factor
- Keywords
- fibrocytes, fibrocyte differentiation, wound healing, TGF-β1, CCR7, tissue damage, myofibroblasts, alpha-smooth muscle actin, collagen gel contraction
- MeSH terms
- Animals, Blood Cells, Cell Differentiation, Cell Movement, Cells, Cultured, Collagen, Female, Fibroblasts, Fibrosis, Gels, Humans, Injections, Intravenous, Mice, Inbred BALB C, Stem Cells, Wound Healing, Transforming Growth Factor beta, Lipopolysaccharide Receptors, Receptors, Chemokine, Stem Cell Transplantation, Mice, Transforming Growth Factor beta1
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