Cited by 368T-cell and B-cell ImmunologyImmunotherapy and Immune ResponsesCancer Immunotherapy and Biomarkers

The DOI matches its Crossref record; 41 of the 42 references it cites were found in a registry or an index.

Murine B7-H3 Is a Negative Regulator of T Cells

Open access

Prasad, Durbaka V R, Nguyen, Thang, Li, Zhaoxia, Yang, Yang, Duong, Julie, Wang, Ying, Dong, Chen·2004·The Journal of Immunology

DOI 10.4049/jimmunol.173.4.2500

Open this paper in CoChat — free account Open PDF

Abstract

T cell activation is regulated by the innate immune system through positive and negative costimulatory molecules. B7-H3 is a novel B7-like molecule with a putative receptor on activated T cells. Human B7-H3 was first described as a positive costimulator, most potently inducing IFN-gamma production and cellular immunity. In this study we examined the expression and function of mouse B7-H3. B7-H3 is mostly expressed on professional APCs; its expression on dendritic cells appears to be up-regulated by LPS. In contrast to human B7-H3, we found that mouse B7-H3 protein inhibited T cell activation and effector cytokine production. An antagonistic mAb to B7-H3 enhanced T cell proliferation in vitro and led to exacerbated experimental autoimmune encephalomyelitis in vivo. Therefore, mouse B7-H3 serves as a negative regulator of T cell activation and function.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.4049/jimmunol.173.4.2500

Cites

41 of 41 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Innate immune recognition
Janeway, C. A., & Medzhitov, R. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.083001.084359 · Cited by 8,394
Engagement of the Pd-1 Immunoinhibitory Receptor by a Novel B7 Family Member Leads to Negative Regulation of Lymphocyte Activation
Freeman, G. J., Long, A. J., Iwai, Y., Bourque, K., Chernova, T., Nishimura, H., Fitz, L. J., Malenkovich, N., Okazaki, T., Byrne, M. C., et al. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.7.1027 · Cited by 5,294
Development of Lupus-like Autoimmune Diseases by Disruption of the PD-1 Gene Encoding an ITIM Motif-Carrying Immunoreceptor
Nishimura, H., Nose, M., Hiai, H., Minato, N., & Honjo, T. (1999) · Immunity · doi:10.1016/s1074-7613(00)80089-8 · Cited by 2,749
CD28/B7 SYSTEM OF T CELL COSTIMULATION
Lenschow, D. J., Walunas, T. L., & Bluestone, J. A. (1996) · Annual Review of Immunology · doi:10.1146/annurev.immunol.14.1.233 · Cited by 2,717
B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion
Dong, H., Zhu, G., Tamada, K., & Chen, L. (1999) · Nature Medicine · doi:10.1038/70932 · Cited by 2,496
Autoimmune Dilated Cardiomyopathy in PD-1 Receptor-Deficient Mice
Nishimura, H., Okazaki, T., Tanaka, Y., Nakatani, K., Hara, M., Matsumori, A., Sasayama, S., Mizoguchi, A., Hiai, H., Minato, N., et al. (2001) · Science · doi:10.1126/science.291.5502.319 · Cited by 1,868
The B7–CD28 superfamily
Sharpe, A. H., & Freeman, G. J. (2002) · Nature reviews. Immunology · doi:10.1038/nri727 · Cited by 1,759
ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28
Hutloff, A., Dittrich, A. M., Beier, K. C., Eljaschewitsch, B., Kraft, R., Anagnostopoulos, I., & Kroczek, R. A. (1999) · Nature · doi:10.1038/16717 · Cited by 1,482
Antigen Recognition By Class-I Restricted T Lymphocyte
Townsend, A., & Bodmer, H. C. (1989) · Annual Review of Immunology · doi:10.1146/annurev.iy.07.040189.003125 · Cited by 1,193
Binding of the B cell activation antigen B7 to CD28 costimulates T cell proliferation and interleukin 2 mRNA accumulation.
Linsley, P. S., Brady, W., Grosmaire, L. S., Aruffo, A. A., Damle, N. K., & Ledbetter, J. A. (1991) · The Journal of Experimental Medicine · doi:10.1084/jem.173.3.721 · Cited by 1,126

Flagged first, then by citations

Show all 42 references

1 of the 42 references couldn’t be matched to a known paper.

Research works printed but not linked: 41

1985, Annu. Rev. Immunol., 237
1989, Annu. Rev. Immunol., 601
2002, Annu. Rev. Immunol., 197
1997, Crit. Rev. Immunol., 89
1991, J. Exp. Med., 721
1996, Annu. Rev. Immunol., 233
1999, Curr. Opin. Cell Biol., 203
1997, Immunity, 445
1999, Nature, 263
1999, Nature, 827
1999, Immunity, 423
2003, J. Autoimmun., 255
2001, Nature, 97
2001, J. Immunol., 3659
2001, Nature, 102
2001, Nature, 105
2003, Immunity, 801
1999, Immunity, 141
2000, J. Exp. Med., 1027
2001, Science, 319
2003, Immunity, 863
2003, Immunity, 849
2003, Proc. Natl. Acad. Sci. USA, 10388
2003, Nat. Immunol., 670
2001, Nat. Immunol., 269
2002, J. Immunol., 6294
2002, J. Immunol., 3847
1995, Curr. Opin. Immunol., 333
1999, J. Exp. Med., 309
2000, Nature, 91
2002, J. Exp. Med., 97
2001, Proc. Natl. Acad. Sci. USA, 13866
1998, Science, 2263
2002, Annu. Rev. Immunol., 29
2003, Nat. Immunol., 899
2002, J. Immunol., 4524
2003, Genomics, 365
2003, Gene Ther., 1728
2002, J. Clin. Invest., 295
1999, Nat. Med., 1365
2002, Nat. Rev. Immunol., 116

Sorted by citations

Items 201–300 of 368

Targeting novel immune checkpoints in the B7-H family: advancing cancer immunotherapy from bench to bedside
Luo, Y., Yuan, Y., Liu, D., Peng, H., Shen, L., & Chen, Y. (2025) · Trends in cancer · doi:10.1016/j.trecan.2025.02.007 · Cited by 22
Tissue Biomarkers for Prostate Cancer Radiation Therapy
Tran, P. T., Hales, R. K., Zeng, J., Aziz, K., Salih, T., Gajula, R., Chettiar, S. T., Gandhi, N. S., Wild, A. T., Kumar, R., et al. (2012) · Current Molecular Medicine · doi:10.2174/156652412800792589 · Cited by 22
“B7-H3 functions are likely context dependent and can involve inhibition or stimulation of the immune response [192-195], but overexpression of B7-H3 has been correlated to worse clinical outcomes in prostate cancer [196].”
Background
Treatment advances in high-grade gliomas
Chen, X., Cui, Y., & Zou, L. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1287725 · Cited by 22
Human muscle cells express the costimulatory molecule B7‐H3, which modulates muscle–immune interactions
Waschbisch, A., Wintterle, S., Lochmüller, H., Walter, M. C., Wischhusen, J., Kieseier, B. C., & Wiendl, H. (2008) · Arthritis & Rheumatism · doi:10.1002/art.23997 · Cited by 22
Adoptive transfer of FTY720-treated immature BMDCs significantly prolonged cardiac allograft survival
Yang, H., Ma, Y., Yin, H., Duan, L., Xiong, P., Xu, Y. X., Feng, W., Fang, M., Tan, Z., Chen, Y.-F., et al. (2010) · Transplant International · doi:10.1111/j.1432-2277.2010.01119.x · Cited by 21
“We also analyzed the expression of B7H3(CD276), B7H4 (V-set domain containing T-cell activation inhibitor 1) and B7-DC (programmed cell death 1 ligand 2), which have been reported as negative regulators of T-cell activation and function [36,37].”
Method
Costimulatory and coinhibitory immune checkpoint receptors in head and neck cancer: unleashing immune responses through therapeutic combinations
Davis, R. J., Ferris, R. L., & Schmitt, N. C. (2016) · Cancers of the Head & Neck · doi:10.1186/s41199-016-0013-x · Cited by 21
“Initially identified as a co-stimulatory receptor of T cell function [63], B7-H3 has since been described as a coinhibitory checkpoint expressed in a variety of tumor types [64, 65].”
Background
Activation of the TLR2-mediated downstream signaling pathways NF-κB and MAPK is responsible for B7-H3-augmented inflammatory response during S. pneumoniae infection
Chen, X., Meng, X., Foley, N. M., Shi, X., Liu, M., Chai, Y., Li, Y., Redmond, H. P., Wang, J., & Wang, J. H. (2017) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2017.07.002 · Cited by 21
“B7-H3, in addition to its regulating effects on Ag-specific T cellmediated adaptive immune responses (Chapoval et al., 2001; Luo et al., 2004; Prasad et al., 2004; Suh et al., 2003), has been shown to participate in the innate immune response by acting as a costimulator to amplify inflammatory…”
Frequent B7-H3 overexpression in craniopharyngioma
Chen, C., Wang, Y., Zhong, K., Jiang, C., Wang, L. Y., Yuan, Z., Nie, C., Xu, J., Guo, G. F., Zhou, L., et al. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.04.142 · Cited by 20
B7-H3-targeting Fc-optimized antibody for induction of NK cell reactivity against sarcoma
Hagelstein, I., Engel, M., Hinterleitner, C., Manz, T., Märklin, M., Jung, G., Salih, H. R., & Zekri, L. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1002898 · Cited by 20
The tumor microenvironment and immune targeting therapy in pediatric renal tumors
Hont, A. B., Dumont, B., Sutton, K. S., Anderson, J., Kentsis, A., Drost, J., Hong, A. L., & Verschuur, A. C. (2022) · Pediatric Blood & Cancer · doi:10.1002/pbc.30110 · Cited by 19
Expression and regulation of B7‐H3 immunoregulatory receptor, in human mesothelial and mesothelioma cells: Immunotherapeutic implications
Calabrò, L., Sigalotti, L., Fonsatti, E., Bertocci, E., Giacomo, A. M. D., Danielli, R., Cutaia, O., Colizzi, F., Covre, A., Mutti, L., et al. (2010) · Journal of Cellular Physiology · doi:10.1002/jcp.22600 · Cited by 20
“…because both stimulatory and inhibitory effects have been described (Chapoval et al., 2001; Suh et al., 2003; Castriconi et al., 2004; Prasad et al., 2004; Wang et al., 2005; Fukushima et al., 2007), possibly due to presence of two or more receptor isoforms (Hashiguchi et al., 2008;…”
Background
GPA33 is expressed on multiple human blood cell types and distinguishes CD4 + central memory T cells with and without effector function
Opstelten, R., Suwandi, J. S., Slot, M. C., Morgana, F., Scott, A. M., Laban, S., Nikolić, T., Turksma, A. W., Kroeze, A., Voermans, C., et al. (2021) · European Journal of Immunology · doi:10.1002/eji.202048744 · Cited by 19
Crosstalk between the B7/CD28 and EGFR pathways: Mechanisms and therapeutic opportunities
Ren, X., Li, Y., Nishimura, C., & Zang, X. (2021) · Genes & Diseases · doi:10.1016/j.gendis.2021.08.009 · Cited by 19
“In mice, B7-H3 inhibits T cell activation and effector cytokine production, so an anti-B7-H3 antagonistic mAb exacerbated experimental autoimmune encephalomyelitis (EAE) in vivo.(85) In the context of graft-versus-host disease (GVHD), absent B7-H3 expression on allogeneic donor T cells leads to accelerated GVHD lethal…”
Background
The Proliferative Role of Immune Checkpoints in Tumors: Double Regulation
Tang, X., Luo, Z.-L., Xiong, Y., Yang, J., Shi, A., Zheng, K., Liu, Y., Shu, C., Ma, N., Lü, Q., et al. (2022) · Cancers · doi:10.3390/cancers14215374 · Cited by 20
“CD276 can also inhibit Cancers 2022, 14, 5374 7 of 19 the proliferation and activation of CD4+ and CD8+ T cells by inhibiting the production of cytokines such as IL-2 and IFN-γ, which are associated with the inactivation of NK-κB, NFAT, and AP-1 [68].”
BackgroundInfluential
Stimulation of B7-H3 (CD276) directs the differentiation of human marrow stromal cells to osteoblasts
Xu, L., Zhang, G., Zhou, Y., Chen, Y., Xu, W., Wu, S., & Zhang, X. (2011) · Immunobiology · doi:10.1016/j.imbio.2011.05.013 · Cited by 19
The interaction of MMP-2/B7-H3 in human osteoporosis
Feng, P., Zhang, H., Zhang, Z., Dai, X., Mao, T., Fan, Y., Xie, X., Wen, H., Yu, P., Hu, Y., et al. (2015) · Clinical Immunology · doi:10.1016/j.clim.2015.11.009 · Cited by 19
Modulation of Immune Response by B7 Family Molecules in Tumor Microenvironments
Flies, D. B., & Chen, L. (2006) · Immunological Investigations · doi:10.1080/08820130600755017 · Cited by 20
Immunobiology of Human Pregnancy
Hunt, J. A., McIntire, R. H., & Petroff, M. G. (2006) · Elsevier eBooks · doi:10.1016/b978-012515400-0/50056-7 · Cited by 21
Clinical progress of B7-H3 targeted antibody drug conjugate ifinatamab deruxtecan for small-cell lung cancer
Wespiser, M., Gille, R., & Pérol, M. (2025) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2025.2512566 · Cited by 18
Genome-scale CRISPR–Cas9 screen reveals novel regulators of B7-H3 in tumor cells
Zhao, S., Wang, Y., Yang, N., Mu, M., Wu, Z., Li, H., Tang, X., Zhong, K., Zhang, Z., Huang, C., et al. (2022) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2022-004875 · Cited by 18
Characterization of B7S3 as a Novel Negative Regulator of T Cells
Yang, Y., Liu, X. K., Nguyen, T. D., Bishop, C., Graf, D., & Dong, C. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.6.3661 · Cited by 18
“Recent studies indicated mouse B7-H3 as a negative regulator of T cell activation and autoimmune responses (11, 12).”
Background
Immune Checkpoints in Recurrent Pregnancy Loss: New Insights into a Detrimental and Elusive Disorder
Marozio, L., Nuzzo, A. M., Gullo, E., Moretti, L., Canuto, E. M., Tancredi, A., Goia, M., Cosma, S. D., Revelli, A., Rolfo, A., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241713071 · Cited by 17
“Initially identified as a co-stimulatory factor of the immune response, recent studies have shown that it is predominantly a T-cell co-inhibitory molecule [3,24].”
Background
Immune checkpoint pathways in glioblastoma: a diverse and evolving landscape
Inocencio, J. F., Mitrasinovic, S., Asad, M., Parney, I. F., Zang, X., & Himes, B. T. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1424396 · Cited by 18
The Regulatory Cross-Talk between microRNAs and Novel Members of the B7 Family in Human Diseases: A Scoping Review
Ahangar, N. K., Hemmat, N., Khalaj‐Kondori, M., Shadbad, M. A., Sabaie, H., Mokhtarzadeh, A., Alizadeh, N., Derakhshani, A., Baghbanzadeh, A., Dolatkhah, K., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22052652 · Cited by 16
Expression levels of B7-H3 and TLT-2 in human oral squamous cell carcinoma
Zhang, S., Tang, J. P., Yu, S., MA, L., WANG, F., Xie, S., Jin, L., & YANG, H.-Y. (2015) · Oncology Letters · doi:10.3892/ol.2015.3274 · Cited by 16
“However, a number of recent studies have demonstrated that B7-H3 exhibits an inhibitory effect during autoimmunity by coinhibiting T-cell function (6,33).”
Detection and Quantitation of Soluble B7-H3 in Expressed Prostatic Secretions: A Novel Marker in Patients With Chronic Prostatitis
Wei, X., Zhang, G., Yuan, H., Ding, X., Li, S., Zhang, X., & Hou, J. (2010) · The Journal of Urology · doi:10.1016/j.juro.2010.09.104 · Cited by 16
Dendritic cell-associated B7-H3 suppresses the production of autoantibodies and renal inflammation in a mouse model of systemic lupus erythematosus
Zheng, X., Xiao, Z. X., Hu, L., Fang, X., Luo, L., & Chen, L. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-1623-0 · Cited by 16
New battlefields for costimulation
Martín‐Orozco, N., & Dong, C. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20060219 · Cited by 16
Effects of B7-H3 on the Inflammatory Response and Expression of MMP-9 in Mice with Pneumococcal Meningitis
Chen, X., Bai, Y., Cui, W., Wang, Z., Zhang, G., Xu, Y., Zhu, X., Li, Y., & Wang, J. H. (2012) · Journal of Molecular Neuroscience · doi:10.1007/s12031-012-9885-3 · Cited by 15
Reduced B7-H3 expression by PAX3-FOXO1 knockdown inhibits cellular motility and promotes myogenic differentiation in alveolar rhabdomyosarcoma
Kanayama, T., Miyachi, M., Sugimoto, Y., Yagyu, S., Kikuchi, K., Tsuchiya, K., Iehara, T., & Hosoi, H. (2021) · Scientific Reports · doi:10.1038/s41598-021-98322-z · Cited by 15
Helicobacter pylori Elicits B7-H3 Expression on Gastric Epithelial Cells: Implications in Local T Cell Regulation and Subset Development During Infection
Lina, T. T., Gonzalez, J., Pinchuk, I. V., Beswick, E. J., & Reyes, V. E. (2019) · Clinical Oncology and Research · doi:10.31487/j.cor.2019.05.05 · Cited by 15
miR-4759 suppresses breast cancer through immune checkpoint blockade
Lin, Y.-Z., Liu, S., Wu, W., Shen, Y.-C., Wang, Y., Liao, C.-C., Lin, P., Chang, H., Liu, L., Cheng, W., et al. (2021) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2021.12.020 · Cited by 15
Cancer Cell B7-H3 Expression Is More Prevalent in the Pancreato-Biliary Subtype of Ampullary Cancer Than in Pancreatic Cancer
Geerdes, E. E., Sideras, K., Aziz, M. H., van Eijck, C. H. J., Bruno, M. J., Sprengers, D., Boor, P. P. C., & Kwekkeboom, J. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.615691 · Cited by 13
The DNA damage repair-related gene PKMYT1 is a potential biomarker in various malignancies
Shao, C., Wang, Y., Pan, M., Guo, K. X., Molnar, T. F., Kocher, F., Seeber, A., Barr, M. P., Navarro, A., Han, J., et al. (2021) · Translational Lung Cancer Research · doi:10.21037/tlcr-21-973 · Cited by 13
“…trials, the application of PKMYT1 (I) LAG3 was reported to be expressed on activated T cells and exert suppressive effect (43,44); (II) CD276 was recently reported to be involved in T cells inhibition (45); (III) in contrast, CD70 and TNFRSF18 could boost the immune response to cancer (46,47).”
B7-H3 and CD47 co-expression in gastric cancer is a predictor of poor prognosis and potential targets for future dual-targeting immunotherapy
Chen, S., Zhan, S., Ding, S., Zhang, Q., Xuan, H., Zhang, X., & Cao, L. (2023) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-023-05408-4 · Cited by 13
“Initially thought to be a T cell-stimulating protein, recent studies suggested that B7-H3 functions as a co-inhibitory signal, inhibiting T cell activation and promoting tumor aggressiveness and proliferation (Suh et al. 2003; Prasad et al. 2004).”
Background
Mifepristone inhibited the expression of B7-H2, B7-H3, B7-H4 and PD-L2 in adenomyosis
Qin, X., Sun, W., Wang, C., Li, M., Ζhao, X., Li, C., & Zhang, H. (2021) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-021-00800-6 · Cited by 13
Inhibition of the B7-H3 immune checkpoint limits hepatocellular carcinoma progression by enhancing T lymphocyte-mediated immune cytotoxicity in vitro and in vivo
Zhou, Z., Yu, X., Chen, Y., Tan, X., Liu, W., Hua, W., Chen, L., & Zhang, W. (2022) · Clinical & Translational Oncology · doi:10.1007/s12094-022-03013-4 · Cited by 12
“reported that B7-H3 inhibits the activation, proliferation, and production of effector cytokines (IFNγ and IL-2) of CD4+ and CD8+ T cells [30].”
Background
Costimulation Blockade in Transplantation
Yeung, M. Y., Grimmig, T., & Sayegh, M. H. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-981-32-9717-3_10 · Cited by 13
Emerging strategies for treating autoimmune disease with genetically modified dendritic cells
Ma, Y., Shi, R., Li, F., & Chang, H. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-024-01641-7 · Cited by 14
“B7-H3 antibody results in earlier onset and worse disease in mouse encephalomyelitis model [111].”
Background
Novel antibody-drug conjugates based on DXd-ADC technology
Chen, R., Ren, Z., Bai, L., Hu, X., Chen, Y., Ye, Q., Hu, Y. J., & Shi, J. (2024) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2024.107697 · Cited by 13
Targeting CD276 for T cell-based immunotherapy of breast cancer
Hagelstein, I., Wessling, L., Rochwarger, A., Zekri, L., Klimovich, B., Tegeler, C. M., Jung, G., Schürch, C. M., Salih, H. R., & Lutz, M. S. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05689-4 · Cited by 12
“In turn, inhibiting CD276 was found to enhance T cell activation in murine models, indicating its potential as a therapeutic option [50].”
Background
Therapeutic effects of anti–B7-H3 antibody in an ovalbumin-induced mouse asthma model
Chen, Z., Zhang, G., Wang, Y., Yan, Y., Zhou, W., Zhu, C., Chen, Y., Wang, J., & Ji, W. (2013) · Annals of Allergy Asthma & Immunology · doi:10.1016/j.anai.2013.06.030 · Cited by 12
B7-H3 promoted proliferation of mouse spermatogonial stem cellsviathe PI3K signaling pathway
Wei, X., Li, K., Zhang, G., Huang, Y., Lv, J., Li, M., Zhao, L., Fan, C., Pu, J., Hou, J., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.23457 · Cited by 12
“In contrast, several subsequent studies found that B7H3 inhibited T cell function [9-12].”
Result
Immune Checkpoints of the B7 Family. Part 2. Representatives of the B7 Family B7-H3, B7-H4, B7-H5, B7-H6, B7-H7, and ILDR2 and Their Receptors
Chapoval, A. I., Chapoval, S. P., Shcherbakova, N. S., & Щербаков, Д. Н. (2019) · Russian Journal of Bioorganic Chemistry · doi:10.1134/s1068162019050091 · Cited by 12
Inhibitors of B7–CD28 Costimulation in Urologic Malignancies
Thompson, R. H., Kwon, E. D., & Allison, J. P. (2008) · Immunotherapy · doi:10.2217/1750743x.1.1.129 · Cited by 12
Potential role of soluble B7‐H3 in liver immunopathogenesis during chronic HBV infection
Luan, Y., Ju, J., Luo, L., Zhang, Z., Wang, J., Zhu, D., Cheng, L., Zhang, S. ‐., Chen, L., Wang, F., et al. (2011) · Journal of Viral Hepatitis · doi:10.1111/j.1365-2893.2010.01421.x · Cited by 12
Beyond PD(L)-1 Blockade in Microsatellite-Instable Cancers: Current Landscape of Immune Co-Inhibitory Receptor Targeting
Crimini, E., Bielo, L. B., Giachetti, P. P. M. B., Pellizzari, G., Antonarelli, G., Salimbeni, B. T., Repetto, M., Belli, C., & Curigliano, G. (2024) · Cancers · doi:10.3390/cancers16020281 · Cited by 11
“B7-H3 (B7 homolog 3 protein), also known as CD276, is a member of the B7 family of immune checkpoint proteins [46].”
Background
Comprehensive Analysis Reveals Distinct Immunological and Prognostic Characteristics of CD276/B7-H3 in Pan-Cancer
Ding, J., Sun, Y., Sulaiman, Z., Li, C., Cheng, Z., & Liu, S. (2023) · International Journal of General Medicine · doi:10.2147/ijgm.s395553 · Cited by 11
“CD276 suppressed the proliferation of CD4 and CD8 T cells and inhibited the activity of NK cells.(9,10) Recently, Wang et al reported that CD276 was hijacked by cancer stem cells (CSCs) to evade immune surveillance in head and neck squamous carcinoma (HNSC).”
Background
Reduced Serum B7-H3 Levels in Patients with Ankylosing Spondylitis
Yan, R., Hu, Y., Yu, P., Wen, H., Feng, P., & Yang, S. F. (2015) · Inflammation · doi:10.1007/s10753-014-0103-z · Cited by 11
“However, subsequent results indicated that B7-H3 downregulated Th1-mediated immune responses[10, 11].”
Overexpression of B7-H3 as an opportunity for targeted therapy in head and neck cancers.
Hu, J., Jiang, C., Zheng, M., Guo, Y.-X., Tang, X., Ren, J. L., Lu, D., Yu, L., Gan, W., Liu, S., et al. (2019) · Europe PMC (PubMed Central) · Cited by 12
Inhibitory axes impacting on the activity and fate of Innate Lymphoid Cells
Bottino, C., Dondero, A., & Castriconi, R. (2021) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2021.100985 · Cited by 11
Expression of Immune Checkpoints in Malignant Tumors: Therapy Targets and Biomarkers for the Gastric Cancer Prognosis
Mansorunov, D., Апанович, Н. В., Апанович, П. В., Кипкеева, Ф. М., Музаффарова, Т. А., Kuzevanova, A. Y., Nikulin, M. P., Malikhova, O. A., & Karpukhin, A. V. (2021) · Diagnostics · doi:10.3390/diagnostics11122370 · Cited by 12
“Blocking CD276 binding with antagonistic antibodies significantly increased T-cell proliferation and IL-2 levels [30,31].”
Background
Research progress of B7-H3 in malignant tumors
Zhao, S., Zhang, H., & Shang, G. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1586759 · Cited by 11
A Phase I, Open-Label, Dose Escalation Study of Enoblituzumab in Children and Young Adults with B7-H3–Expressing Relapsed or Refractory Solid Tumors
DeSantes, K. B., McDowell, K. A., Sondel, P. M., Hutson, P. R., Kaplan, R. N., Park, J. R., Hegde, M. G., Mackall, C. L., & Maris, J. M. (2025) · Cancer Research Communications · doi:10.1158/2767-9764.crc-25-0293 · Cited by 13
Upregulation of the B7/CD28 family member B7-H3 in bladder cancer
Wu, D., Zhang, Z., PAN, H., FAN, Y., Qü, P., & Zhou, J. (2014) · Oncology Letters · doi:10.3892/ol.2014.2828 · Cited by 10
“In the majority of studies conducted thus far, human and mouse B7-H3 inhibit CD4 T-cell activation, and reduce the production of effector cytokines, such as IFN-γ and interleukin-4 (19,30,31).”
Multiomics2Targets identifies targets from cancer cohorts profiled with transcriptomics, proteomics, and phosphoproteomics
Deng, E. Z., Marino, G. B., Clarke, D. J. B., Diamant, I., Resnick, A. C., Ma, W., Wang, P., & Ma’ayan, A. (2024) · Cell Reports Methods · doi:10.1016/j.crmeth.2024.100839 · Cited by 11
The expanding repertoire of targets for immune checkpoint inhibition in bladder cancer: What lies beneath the tip of the iceberg, PD-L1
Sankin, A. I., Narasimhulu, D. M., John, P., Gartrell, B. A., Schoenberg, M., & Zang, X. (2017) · Urologic Oncology Seminars and Original Investigations · doi:10.1016/j.urolonc.2017.04.007 · Cited by 10
“[42] Prasad DV, Nguyen T, Li Z, Yang Y, Duong J, Wang Y, et al.”
Perspectives of Immune Suppression in the Tumor Microenvironment Promoting Oral Malignancy
Kondoh, N., Mizuno‐Kamiya, M., Takayama, E., Kawati, H., Umemura, N., Yamazaki, Y., Mitsudo, K., & Tohnai, I. (2018) · The Open Dentistry Journal · doi:10.2174/1874210601812010455 · Cited by 11
Expression of B7‐H3 and TIM ‐3 in gastric‐type endocervical adenocarcinoma: prevalence, association with PD‐L1 expression, and prognostic significance
Sun, Y., Zhou, X., Lucas, E., Chen, L., Zhang, H., Chen, H., & Zhou, F. (2023) · The Journal of Pathology Clinical Research · doi:10.1002/cjp2.345 · Cited by 9
“B7-H3 is a member of the B7 family of cell surface molecules, which can inhibit the activation and function of T-cells [37], and serves as a negative regulator in T-cell-mediated immune responses to convey protection of tumor cells from immune attack [38].”
Background
Spatial proteomic profiling of tumor and stromal compartments in non‐small‐cell lung cancer identifies signatures associated with overall survival
Naei, V. Y., Monkman, J. H., Sadeghirad, H., Mehdi, A. M., Blick, T., Mullally, W. J., O'Byrne, K. J., Warkiani, M. E., & Kulasinghe, A. (2024) · Clinical & Translational Immunology · doi:10.1002/cti2.1522 · Cited by 9
“59 – 61 Our ﬁnding replicates the negative impact of increased B7-H3 on patient survival.”
Background
DNA Methylation and mRNA Expression of B7-H3 Gene in Ankylosing Spondylitis: A Case-Control Study
Chen, Y., Wu, Y., Yang, H., Wang, J., Kong, J., Yu, L., Ni, M., Deng, Y., Xu, S., Yu, H., et al. (2022) · Immunological Investigations · doi:10.1080/08820139.2022.2095285 · Cited by 9
“Notably, the coinhibitory ability of B7-H3 on T cell proliferation, activation and cytokine secretion was also recently demonstrated (Prasad et al. 2004; Souweidane et al. 2018).”
Background
Genome-wide identification and evolutionary analysis of B7-H3
Duan, H., & Huang, M. (2012) · International Journal of Data Mining and Bioinformatics · doi:10.1504/ijdmb.2012.049247 · Cited by 9
Myeloid cell-like transcript 2 is related to liver inflammation and the pathogenesis of hepatitis B via the involvement of CD8+T cell activation
Xu, J., Gao, F., Liu, Y.-A., Zhang, X., Chen, H., Zhu, X., Song, H., Qian, F., Li, M., Yang, C. G., et al. (2018) · Clinical and Experimental Medicine · doi:10.1007/s10238-018-0534-1 · Cited by 9
CD276 Promotes an Inhibitory Tumor Microenvironment in Hepatocellular Carcinoma and is Associated with Poor Prognosis
Liu, W., Jiang, Q.-Y., Qi, Z., Zhang, F., Tang, W., Wang, H., & Dong, L. (2024) · Journal of Hepatocellular Carcinoma · doi:10.2147/jhc.s469529 · Cited by 8
“46 Additionally, CD276 promotes tumor progression and invasiveness by facilitating IL10 secretion and inducing immune tolerance in human breast cancer tissue.”
Background
PARP inhibitors accumulate B7-H3 on fibroblasts via blocking autophagic flux to potentiate immune evasion in ovarian cancer
Fang, T., Xia, Y., Li, Y., Xu, S., Li, H., Wang, S., Huang, P., Qian, Y., Jin, P., Jin, N. Y., et al. (2025) · OncoImmunology · doi:10.1080/2162402x.2025.2516294 · Cited by 8
“45–47 For example, inhibition of B7-H3 suppresses tumor growth in several mouse hematopoietic malignancy models relying on CD8 + T cells and natural killer cells.”
Olive flounder CD276 (B7-H3) a coinhibitory molecule for T cells: Responses during viral hemorrhagic septicemia virus (VHSV) stimulation
Hwang, J. Y., Jeong, J.-M., Kwon, M., Seo, J. S., Hwang, S. D., Son, M.-H., Bae, J.-S., Choi, K.-M., Cho, D., Jeswin, J., et al. (2017) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2017.12.021 · Cited by 7
Challenges and Prospects for Designer T and NK Cells in Glioblastoma Immunotherapy
Arnesen, V. S., Navarro, A. G., & Chekenya, M. (2021) · Cancers · doi:10.3390/cancers13194986 · Cited by 8
CD40-activated Apoptotic Tumor Cell-pulsed Dendritic Cell Could Potentially Elicit Antitumor Immune Response
Chen, C., Zhu, Y., Qu, Q., Ge, Y., Huang, J., Wang, Y., & Zhang, X. (2008) · Journal of Immunotherapy · doi:10.1097/cji.0b013e31818c8816 · Cited by 8
The characteristic expression of B7‐H3 and B7‐H4 in liver biopsies from patients with HBV‐related acute‐on‐chronic liver failure
Guo, G., Cao, D., Xu, H., Ruan, Z., Fei, L., Xie, Z., Wu, Y., & Chen, Y. (2012) · Pathology International · doi:10.1111/j.1440-1827.2012.02856.x · Cited by 8
B7‐H3: A Useful Emerging Diagnostic Marker for Colon Cancer
Bostancı, Ö., Sayın, P., Kızıltan, R., Algül, Ş., Aydın, M. A., & Kemik, Ö. (2022) · BioMed Research International · doi:10.1155/2022/1523338 · Cited by 7
Interplay between B7–H3 and HLA class I in the clinical course of pancreatic ductal adenocarcinoma
Cattaneo, G., Ventin, M., Arya, S., Kontos, F., Michelakos, T. P., Sekigami, Y., Cai, L., Villani, V., Sabbatino, F., Chen, F., et al. (2024) · Cancer Letters · doi:10.1016/j.canlet.2024.216713 · Cited by 7
Contribution of long-chain fatty acid to induction of myeloid-derived suppressor cell (MDSC)-like cells – induction of MDSC by lipid vesicles (liposome)
Yoshida, Y., Nagamori, T., Ishibazawa, E., Kobayashi, H., Kure, T., Sakai, H., Takahashi, D., Fujihara, M., & Azuma, H. (2020) · Immunopharmacology and Immunotoxicology · doi:10.1080/08923973.2020.1837866 · Cited by 7
Cloning and Characterization of Porcine 4Ig-B7-H3: A Potent Inhibitor of Porcine T-Cell Activation
Chen, W., Hou, Z., Li, C., Xiong, S., & Liu, H. (2011) · PLoS ONE · doi:10.1371/journal.pone.0021341 · Cited by 7
“Other studies showed that human and murine B7-H3 had inhibitory functions [12,14,16].”
Background
Langerhans Cells Suppress CD8+ T Cells In Situ during Mucocutaneous Acute Graft-Versus-Host Disease
Kubota, N., Saito, A., Tanaka, R., Nakamura, Y., Watanabe, R., Fujisawa, Y., Ishitsuka, Y., Clausen, B. E., Fujimoto, M., & Okiyama, N. (2020) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2020.09.018 · Cited by 7
Induction of regulatory dendritic cells by topical application of NF-κB decoy oligodeoxynucleotides
Isomura, I., Shintani, Y., Yasuda, Y., Tsujimura, K., & Morita, A. (2008) · Immunology Letters · doi:10.1016/j.imlet.2008.04.002 · Cited by 7
The Many Sounds of T Lymphocyte Silence
Melero, I., Arina, A., & Chen, L. (2005) · Immunologic Research · doi:10.1385/ir:33:2:135 · Cited by 7
“shown to stimulate T cell proliferation and moderately exacerbate experimental autoimmune encephalomyelitis ( 100 ).”
Background
Development of a Human B7-H3-Specific Antibody with Activity against Colorectal Cancer Cells through a Synthetic Nanobody Library
Li, J., Zhou, B., Wang, S., Ouyang, J., Jiang, X., Wang, C., Zhou, T., Zheng, K., Wang, J., & Wang, J. (2024) · Bioengineering · doi:10.3390/bioengineering11040381 · Cited by 6
“In nonmalignant tissues, B7-H3 primarily assumes an inhibitory role in adaptive immunity by suppressing T-cell activation and proliferation [13,14].”
Background
Prognostic value of B7-H3 expression in metastatic renal cell carcinoma and its impact on immunotherapy response
Özalp, F. R., Yörükoğlu, K., Yıldırım, E. Ç., Uzun, M., & Semiz, H. S. (2024) · BMC Cancer · doi:10.1186/s12885-024-13238-x · Cited by 6
Variable Intrinsic Expression of Immunoregulatory Biomarkers in Breast Cancer Cell Lines, Mammospheres, and Co-Cultures
Montoyo-Pujol, Y. G., García-Escolano, M., Ponce, J., Delgado-García, S., Martín, T., Ballester, H., Castellón-Molla, E., Martínez-Peinado, P., Pascual-García, S., Sempere-Ortells, J. M., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24054478 · Cited by 6
“Although initially identified as a co-stimulatory molecule [38], it was later described as a co-inhibitory molecule in different neoplasias [39].”
Background
Immunotherapy and Cancer Therapeutics: Why Partner?
Emens, L. A., & Jaffee, E. M. (2007) · Elsevier eBooks · doi:10.1016/b978-012372551-6/50076-6 · Cited by 6
The expressions and significance of B7-H3 and CTLA-4 in the clinical stages of non-small-cell lung cancer.
Liu, Z., Pei, M., Liu, J., Shi, F., Zhang, Y., Zhao, D., Li, J., Guo, F.-R., Yan, J.-J., Liu, J., et al. (2019) · Europe PMC (PubMed Central) · Cited by 5
B7-H3 Associates with IMPDH2 and Regulates Cancer Cell Survival
Alhamad, S., Elmasry, Y., Uwagboe, I., Chekmeneva, E., Sands, C. J., Cooper, B. W., Camuzeaux, S., Salam, A., & Parsons, M. (2023) · Cancers · doi:10.3390/cancers15133530 · Cited by 5
“B7-H3 inhibits the proliferation of both CD4+ and CD8+ T-cells and decreases IL-2 and IFN-γ production [45]; however, the ligand(s) for B7-H3 that mediate these biological effects remain unknown.”
Global research trends on B7-H3 for cancer immunotherapy: A bibliometric analysis (2012-2022)
Huang, X., Guo, J., Wang, S., Lin, Z., Zhao, S., Li, W., Wang, Y., Zhu, C., Lv, J., & Qiu, W. (2023) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2023.2246498 · Cited by 5
“Accumulating evidence has demonstrated that B7-H3 weakens T-cell activation and increases regulatory T-cell infiltration, decreasing the efficacy of immunotherapy.(18,19) Moreover, B7-H3-mediated tumor glycolysis increases resistance to CI.”
Background
Preclinical Evaluation of a B7-H3 Targeting Antibody Enhancing NK Cell-Mediated Cytotoxicity for Ovarian Cancer Treatment
Hagelstein, I., Mattern, S., Wang, K., Haueisen, Y. E., Greiner, S. M., Englisch, A., Staebler, A., Singer, S., & Lutz, M. S. (2025) · ImmunoTargets and Therapy · doi:10.2147/itt.s521008 · Cited by 5
“35,36 Mechanistically, B7-H3 has been shown to suppress T cell proliferation and cytokine production, 37,38 as well as to inhibit NK cell-mediated cytotoxicity.”
An EBNA1-YAP signaling axis drives immune escape through CD276 in EBV-associated gastric cancer
Huang, B., Liu, M., Duan, Y., Guo, J., Wang, Z., Dou, Y., Wang, M., Abuhaidar, O., Sun, H., Kee, L. S., et al. (2025) · Cell Death and Disease · doi:10.1038/s41419-025-08251-2 · Cited by 4
“Inhibiting CD276 has shown promise in enhancing T cell activation and signi ﬁ cantly increasing CD8+ T cell in ﬁ ltration [24, 25].”
B7-H3 Promoted Sperm Motility in Humans
Wei, X., Li, Z., Zhang, G., Yuan, H., Lv, J., Jiang, Y., Zhang, W., Huang, Y., & Hou, J. (2013) · Urology · doi:10.1016/j.urology.2013.07.078 · Cited by 4
Spatial proteomics identifies a spectrum of immune dysregulation in acquired bone marrow failure syndromes
Koldej, R. M., Prabahran, A. A., Tan, C. W., Ludford‐Menting, M., Morgan, H., Holzwart, N., Davis, M. J., & Ritchie, D. S. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1213560 · Cited by 4
“Frontiers in Immunology 09 wide range of cells, including activated T cells, NK cells, dendritic cells, and macrophages (35–37), along with non-hematopoietic cells, including fibroblasts, synoviocytes, osteoblasts, and epithelial cells (38–40), with both immunostimulatory (41, 42) and inhibitory (43, 44) roles describ…”
Background
B7 homolog 3 in pancreatic cancer
Perović, D., Pjević, M. D., Perović, V., Grk, M., Rasic, M., Miličković, M., Mijović, T., & Rašić, P. (2024) · World Journal of Gastroenterology · doi:10.3748/wjg.v30.i31.3654 · Cited by 4
“Suh et al [61] were the first to show a contrasting role of B7-H3 as a negative regulator that preferentially affects Th1-mediated immune responses, which was enhanced by the findings of other studies[62,63].”
A Novel Monoclonal Antibody Against Mouse B7-H3 Developed in Rats
Yan, R., Yang, S. F., Sun, J., Chen, X., Zhang, G., Feng, P., & Zhang, X. (2012) · Hybridoma · doi:10.1089/hyb.2012.0008 · Cited by 4
“But subsequent results indicated that B7-H3 down-regulated Th1-mediated immune responses.((7,8)) Luo and colleagues demonstrated that B7-H3 had antitumor activity in mice.”
Result
Alteration of early dendritic cell activation by cancer cell lines predispose immunosuppression, which cannot be reversed by TLR4 stimulation
Kong, Y., Fuchsberger, M., Plebanski, M., & Apostolopoulos, V. (2016) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmw102 · Cited by 4
“It has been demonstrated in many studies that DCs can express inhibitory markers to regulate T-cell function [25-28].”
Abatacept (Cytotoxic T Lymphocyte Antigen 4-Fragment Crystallizable) Reduces Allergic Inflammation of Ovalbumin-Sensitized Mice.
Chung, J., Choi, M., Kim, M. G., Park, S. K., & Kim, Y. M. (2022) · American Journal of Rhinology and Allergy · doi:10.1177/19458924211072364 · Cited by 4
Strategies for Potentiating NK-Mediated Neuroblastoma Surveillance in Autologous or HLA-Haploidentical Hematopoietic Stem Cell Transplants
Bottino, C., Chiesa, M. D., Sorrentino, S., Morini, M., Vitale, C., Dondero, A., Tondo, A., Conte, M., Garaventa, A., & Castriconi, R. (2022) · Cancers · doi:10.3390/cancers14194548 · Cited by 4
“Functional data show that a receptor(s) with inhibitory function can be expressed by NK and T cells; however, it has not been identified yet, thus making not practicable a selection of haplo-donors based on its expression [91,92].”
Background
Treatment of Melanoma Metastasis: Surgical, Chemotherapy, and Innovation.
Rosen, C., Mayes, T., Overholt, C., & Lucke-Wold, B. P. (2023) · PubMed · Cited by 4
Expression patterns and action analysis of genes associated with inflammatory responses during rat liver regeneration
Shao, H. (2007) · World Journal of Gastroenterology · doi:10.3748/wjg.v13.i3.369 · Cited by 4
“. Three proteins including cluster of differentiation 276 (CD276) induced by LPS inhibit T cell proliferation [ 51 ]”
Background
B7-H3 ameliorates GVHD
Steinberger, P. (2015) · Blood · doi:10.1182/blood-2015-04-638304 · Cited by 4
Integrated analysis of cervical squamous cell carcinoma cohorts from three continents reveals conserved subtypes of prognostic significancePreprint
Chakravarthy, A., Reddin, I. G., Henderson, S. R., Dong, C., Kirkwood, N. K., Jeyakumar, M., Rothschild-Rodriguez, D., Gonzalez-Martinez, N., McDermott, J. R., Su, X., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.04.02.019711 · Cited by 4
Phenethyl isothiocyanate modulates macrophage migration inhibitory factor and suppresses malignant phenotypes of glioblastoma cells
Lin, J.-R., Liao, W., Chu, Y.-H., Chou, Y., & Liu, C.-H. (2025) · Food & Function · doi:10.1039/d5fo00415b · Cited by 3
Targeting Histone 3 Variants Epigenetic Landscape and Inhibitory Immune Checkpoints: An Option for Paediatric Brain Tumours Therapy
Meenakshi, S., Maharana, K. C., Nama, L., Vadla, U. K., Dhingra, S., Ravichandiran, V., Murti, K., & Kumar, N. (2023) · Current Neuropharmacology · doi:10.2174/1570159x21666230809110444 · Cited by 3
“Its wide expression on APCs inhibits T-cell function by diminishing the activity of NFAT, NF-kB, and AP-1 transcription factors [102].”
High CTLA-4 gene expression is an independent good prognosis factor in breast cancer patients, especially in the HER2-enriched subtype
Montoyo-Pujol, Y. G., Ponce, J., Delgado-García, S., Martín, T., Ballester, H., Castellón-Molla, E., Ramos-Montoya, A., Lozano, I., Sempere-Ortells, J. M., & Peiró, G. (2024) · Cancer Cell International · doi:10.1186/s12935-024-03554-4 · Cited by 4
Tumor vascular normalization by B7-H3 blockade augments T lymphocyte-mediated antitumor immunity
Dai, X., Cao, B., Liu, X., Meng, W., Qiu, Y., Sun, Y., Zhang, L., Li, D., Liu, Z., Li, D., et al. (2025) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2025.177334 · Cited by 3

Authors: Prasad, D. V. R., Nguyen, T., Li, Z., Yang, Y., Duong, J., Wang, Y., & Dong, C.
Affiliations: University of Washington (US)
ORCID: Prasad, Durbaka V R
Li, Zhaoxia
Duong, Julie
Wang, Ying
Dong, Chen
Venue: The Journal of Immunology
Publisher: Oxford University Press (OUP)
Published: 2004-08
Volume: 173
Issue: 4
Pages: 2500-2506
ISSN: 0022-1767 (ISSN-L)
1550-6606
DOI: 10.4049/jimmunol.173.4.2500
OpenAlex: W2110172571
Cited by: 368
References: 42
Citations by year: 2026: 9 · 2025: 18 · 2024: 30 · 2023: 22 · 2022: 27 · 2021: 34 · 2020: 27 · 2019: 18 · 2018: 10 · 2017: 16 · 2016: 11 · 2015: 11 · 2014: 6 · 2013: 14 · 2012: 17
FWCI: 5.54
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations: The Journal of Immunology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
Keywords: B7-H3, T cell activation, dendritic cells, professional antigen-presenting cells, IFN-gamma production, experimental autoimmune encephalomyelitis, T cell proliferation, mice
MeSH terms: Animals, Antigen-Presenting Cells, B-Lymphocytes, Cells, Cultured, Dendritic Cells, Encephalomyelitis, Autoimmune, Experimental, Female, Flow Cytometry, Lymphocyte Activation, Macrophages, T-Lymphocytes, Cytokines, B7-1 Antigen, Antibodies, Blocking, Mice, Rats, B7 Antigens

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Murine B7-H3 Is a Negative Regulator of T Cells

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks