Cutting Edge: Recent Immune Status Determines the Source of Antigens That Drive Homeostatic T Cell Expansion
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Homeostatic proliferation of naive T cells transferred to T cell-deficient syngeneic mice is driven by low-affinity self-MHC/peptide ligands and the cytokine IL-7. In addition to homeostatic proliferation, a subset of naive T cells undergoes massive proliferation in chronically immunodeficient hosts, but not in irradiated normal hosts. Such rapid T cell proliferation occurs largely independent of homeostatic factors, because it was apparent in the absence of IL-7 and in T cell-sufficient hosts devoid of functional T cell immunity. Strikingly, immunodeficient mice raised under germfree conditions supported only slow homeostatic proliferation, but not the marked T cell proliferation observed in conventionally raised immunodeficient mice. Thus, polyclonal naive T cell expansion in T cell-deficient hosts can be driven predominantly by either self-Ags or foreign Ags depending on the host's previous state of T cell immunocompetency.
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The microbiota orchestrates the local immune system in the intestine and shapes immune and non-immune cells located at distal sites and acting systemically.
“Notably, the microbiota orchestrates the local immune system in the intestine (67), and shapes immune and non-immune cells located in distal sites and acting systemically (68, 69).”
From The gut-brain axis: how microbiota and host inflammasome influence brain physiology and pathology (2020) · cites this paper as [68]
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- Authors
- Kieper, W. C., Troy, A., Burghardt, J. T., Ramsey, C., Lee, J. Y., Jiang, H.-Q., Dummer, W., Shen, H., Cebra, J. J., & Surh, C. D.
- Affiliations
- Scripps Research Institute (US)
- University of Pennsylvania (US)
- Corresponding author
- Ramsey, Chris
- Dummer, Wolfgang
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2005-03
- Volume
- 174
- Issue
- 6
- Pages
- 3158-3163
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1519531812
- Cited by
- 250
- References
- 23
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 8 · 2023: 9 · 2022: 7 · 2021: 11 · 2020: 6 · 2019: 9 · 2018: 8 · 2017: 17 · 2016: 13 · 2015: 15 · 2014: 11 · 2013: 13 · 2012: 17
- FWCI
- 6.03
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Crohn's and Colitis Foundation of America
- Crohn's and Colitis Foundation
- National Institutes of Health (5r01ai041079-04)
- U.S. Public Health Service
- National Institute on Aging (AG 20186, R01AG020186)
- National Institute of Allergy and Infectious Diseases (R01AI045809, AI37108, AI07244, AI45809, AI41079)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Keywords
- naive T cells, T cell-deficient mice, IL-7, immunodeficiency, germ-free mice, antigen source
- MeSH terms
- Animals, Antigens, B-Lymphocytes, Homeostasis, Immunologic Deficiency Syndromes, Lymphocyte Activation, Mice, Inbred C57BL, Mice, Transgenic, T-Lymphocytes, Interleukin-7, Mice, SCID, Genes, RAG-1, Mice, Knockout, Cell Proliferation, Mice
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