The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
The Role of ICOS in the CXCR5+ Follicular B Helper T Cell Maintenance In Vivo
Abstract
ICOS is a new member of the CD28 family of costimulatory molecules that is expressed on activated T cells. Its ligand B7RP-1 is constitutively expressed on B cells. Although the blockade of ICOS/B7RP-1 interaction inhibits T cell-dependent Ab production and germinal center formation, the mechanism remains unclear. We examined the contribution of ICOS/B7RP-1 to the generation of CXCR5+ follicular B helper T (TFH) cells in vivo, which preferentially migrate to the B cell zone where they provide cognate help to B cells. In the spleen, anti-B7RP-1 mAb-treated or ICOS-deficient mice showed substantially impaired development of CXCR5+ TFH cells and peanut agglutinin+ germinal center B cells in response to primary or secondary immunization with SRBC. Expression of CXCR5 on CD4+ T cells was associated with ICOS expression. Adoptive transfer experiments showed that the development of CXCR5+ TFH cells was enhanced by interaction with B cells, which was abrogated by anti-B7RP-1 mAb treatment. The development of CXCR5+ TFH cells in the lymph nodes was also inhibited by the anti-B7RP-1 mAb treatment. These results indicated that the ICOS/B7RP-1 interaction plays an essential role in the development of CXCR5+ TFH cells in vivo.
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Cites
CD28/B7 SYSTEM OF T CELL COSTIMULATION
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CD40 AND CD154 IN CELL-MEDIATED IMMUNITY
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ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28
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A chemokine-driven positive feedback loop organizes lymphoid follicles
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Cxc Chemokine Receptor 5 Expression Defines Follicular Homing T Cells with B Cell Helper Function
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ICOS co-stimulatory receptor is essential for T-cell activation and function
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Cited by
Follicular Helper CD4 T Cells (T FH )
Crotty, S. (2011) · Annual Review of Immunology · doi:10.1146/annurev-immunol-031210-101400 · Cited by 2,738
Johnston, R. J., Poholek, A. C., DiToro, D., Yusuf, I., Eto, D., Barnett, B., Dent, A. L., Craft, J., & Crotty, S. (2009) · Science · doi:10.1126/science.1175870 · Cited by 1,626
CD4 + T Cells: Differentiation and Functions
Luckheeram, R. V., Zhou, R., Verma, A. D., & Xia, B. (2012) · Clinical and Developmental Immunology · doi:10.1155/2012/925135 · Cited by 1,381
Nurieva, R. I., Chung, Y., Hwang, D., Yang, X. O., Kang, H. S., Ma, L., Wang, Y.-H., Watowich, S. S., Jetten, A. M., Tian, Q., et al. (2008) · Immunity · doi:10.1016/j.immuni.2008.05.009 · Cited by 1,205
Choi, Y. S., Kageyama, R., Eto, D., Escobar, T. C., Johnston, R. J., Monticelli, L., Lao, C., & Crotty, S. (2011) · Immunity · doi:10.1016/j.immuni.2011.03.023 · Cited by 958
Metadata
- Authors
- Akiba, H., Takeda, K., Kojima, Y., Usui, Y., Harada, N., Yamazaki, T., Ma, J., Tezuka, K., Yagita, H., & Okumura, K.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2005-08
- Volume
- 175
- Issue
- 4
- Pages
- 2340-2348
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1609716101
- Cited by
- 374
- References
- 45
- FWCI
- 3.65
- Type
- journal article
- Language
- en
- Open access
- closed
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- Akiba, H., Takeda, K., Kojima, Y., Usui, Y., Harada, N., Yamazaki, T., Ma, J., Tezuka, K., Yagita, H., & Okumura, K. (2005). The Role of ICOS in the CXCR5+ Follicular B Helper T Cell Maintenance In Vivo. The Journal of Immunology. https://doi.org/10.4049/jimmunol.175.4.2340
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