The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Experimental Models to Study Development and Function of the Human Immune System In Vivo
Abstract
The study of development and function of the immune system in vivo has made intensive use of animal models, but performing such work in humans is difficult for experimental, practical, and ethical reasons. Confronted with this scientific challenge, several pioneering groups have developed in the late 1980s mouse models of human immune system development. Although these experimental approaches were proven successful and useful, they were suffering from limitations due to xenograft transplantation barriers. By reviewing the characteristics of the successive models over the last 20 years, it becomes apparent that screening of potentially interesting mouse strains and usage of combinations of genetic deficiencies has led to major advances. This is particularly true for human T cell development in the murine thymus. This review will focus on these advances and the potential future improvements that remain to be accomplished.
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Citations
Cites
The Nature of the Principal Type 1 Interferon-Producing Cells in Human Blood
Siegal, F. P., Kadowaki, N., Shodell, M., Fitzgerald-Bocarsly, P. A., Shah, K., Ho, S., Antonenko, S., & Liu, Y.-J. (1999) · Science · doi:10.1126/science.284.5421.1835 · Cited by 2,293
Cited by
Wang, R. M., Johnson, T. D., He, J., Rong, Z., Wong, M., Nigam, V., Behfar, A., Xu, Y., & Christman, K. L. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.03.016 · Cited by 90
Legrand, N., Cupedo, T., van Lent, A. U., Ebeli, M. J., Weijer, K., Hanke, T., & Spits, H. (2006) · Blood · doi:10.1182/blood-2006-01-0190 · Cited by 82
Self-citationHTLV-1 Propels Thymic Human T Cell Development in “Human Immune System” Rag2-/- gamma c-/- Mice
Villaudy, J., Wencker, M., Gadot, N., Gillet, N. A., Scoazec, J.-Y., Gazzolo, L., Manz, M. G., Bangham, C. R. M., & Dodon, M. D. (2011) · PLoS Pathogens · doi:10.1371/journal.ppat.1002231 · Cited by 66
Human allograft rejection in humanized mice: a historical perspective
Brehm, M. A., & Shultz, L. D. (2012) · Cellular & Molecular Immunology · doi:10.1038/cmi.2011.64 · Cited by 30
Centlivre, M., Zhou, X., Pouw, S. M., Weijer, K., Kleibeuker, W., Das, A. T., Blom, B., Seppen, J., Berkhout, B., & Legrand, N. (2010) · Gene Therapy · doi:10.1038/gt.2009.109 · Cited by 30
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Metadata
- Authors
- Legrand, N., Weijer, K., & Spits, H.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-02
- Volume
- 176
- Issue
- 4
- Pages
- 2053-2058
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1536420296
- Cited by
- 177
- References
- 1
- FWCI
- 5.76
- Type
- journal article
- Language
- en
- Open access
- closed
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- Legrand, N., Weijer, K., & Spits, H. (2006). Experimental Models to Study Development and Function of the Human Immune System In Vivo. The Journal of Immunology. https://doi.org/10.4049/jimmunol.176.4.2053
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