The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Desiccating Stress Induces T Cell-Mediated Sjögren’s Syndrome-Like Lacrimal Keratoconjunctivitis
Open accessAbstract
Chronic dry eye syndrome affects over 10 million people in the United States; it is associated with inflammation of the lacrimal gland (LG) and in some cases involves T cell infiltration of the conjunctiva. We demonstrate that environmental desiccating stress (DS) elicits T cell-mediated inflammation of the cornea, conjunctiva, and LG, but not other organs in mice. The lacrimal keratoconjunctivitis (LKC) was mediated by CD4+ T cells, which, when adoptively transferred to T cell-deficient nude mice, produced inflammation in the LG, cornea, and conjunctiva, but not in any other organ. Adoptively transferred CD4+ T cells produced LKC even though recipients were not exposed to DS. LKC was exacerbated in euthymic mice depleted of CD4+CD25+forkhead/winged helix transcription factor+ regulatory T cells. The results suggest that DS exposes shared epitopes in the cornea, conjunctiva, and LG that induce pathogenic CD4+ T cells that produce LKC, which under normal circumstances is restrained by CD4+CD25+forkhead/winged helix transcription factor+ regulatory T cells.
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Shimizu, J., Yamazaki, S., & Sakaguchi, S. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.10.5211 · Cited by 1,491
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Self-citationDry Eye Management: Targeting the Ocular Surface Microenvironment
Zhang, X., M, V. J., Qu, Y., He, X., Ou, S., Bu, J., Jia, C., Wang, J., Wu, H., Liu, Z., et al. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18071398 · Cited by 267
Lin, S., Ge, C., Wang, D., Xie, Q., Wu, B., Wang, J., Nan, K., Zheng, Q., & Chen, W. (2019) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.9b13851 · Cited by 88
Contreras-Ruiz, L., Ryan, D. S., Sia, R. K., Bower, K. S., Dartt, D. A., & Masli, S. (2014) · Ophthalmology · doi:10.1016/j.ophtha.2014.01.033 · Cited by 58
CAR-Treg cell therapies and their future potential in treating ocular autoimmune conditions
Abraham, A. R., Maghsoudlou, P., Copland, D. A., Nicholson, L. B., & Dick, A. D. (2023) · Frontiers in Ophthalmology · doi:10.3389/fopht.2023.1184937 · Cited by 20
“This effect of Tregs is also seen in ocular surface conditions, with exacerbation of a mouse model of ocular Sjögren’s following Treg depletion (53) and adoptive transfer of Tregs successfully suppressing ocular surface inflammation (54).”
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Metadata
- Authors
- Niederkorn, J. Y., Stern, M. E., Pflugfelder, S. C., De Paiva, C. S., Corrales, R. M., Gao, J., & Siemasko, K.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-04-01
- Volume
- 176
- Issue
- 7
- Pages
- 3950-3957
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1857016869
- Cited by
- 338
- References
- 1
- FWCI
- 15.54
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Desiccating Stress Induces T Cell-Mediated Sjögren’s Syndrome-Like Lacrimal Keratoconjunctivitis. https://app.cochat.ai/papers/10.4049/jimmunol.176.7.3950
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- Niederkorn, J. Y., Stern, M. E., Pflugfelder, S. C., De Paiva, C. S., Corrales, R. M., Gao, J., & Siemasko, K. (2006). Desiccating Stress Induces T Cell-Mediated Sjögren’s Syndrome-Like Lacrimal Keratoconjunctivitis. The Journal of Immunology. https://doi.org/10.4049/jimmunol.176.7.3950
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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