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IL-17 Plays an Important Role in the Development of Experimental Autoimmune Encephalomyelitis
Open accessAbstract
IL-17 is a proinflammatory cytokine that activates T cells and other immune cells to produce a variety of cytokines, chemokines, and cell adhesion molecules. This cytokine is augmented in the sera and/or tissues of patients with contact dermatitis, asthma, and rheumatoid arthritis. We previously demonstrated that IL-17 is involved in the development of autoimmune arthritis and contact, delayed, and airway hypersensitivity in mice. As the expression of IL-17 is also augmented in multiple sclerosis, we examined the involvement of this cytokine in these diseases using IL-17−/− murine disease models. We found that the development of experimental autoimmune encephalomyelitis (EAE), the rodent model of multiple sclerosis, was significantly suppressed in IL-17−/− mice; these animals exhibited delayed onset, reduced maximum severity scores, ameliorated histological changes, and early recovery. T cell sensitization against myelin oligodendrocyte glycoprotein was reduced in IL-17−/− mice upon sensitization. The major producer of IL-17 upon treatment with myelin digodendrocyte glycopritein was CD4+ T cells rather than CD8+ T cells, and adoptive transfer of IL-17−/− CD4+ T cells inefficiently induced EAE in recipient mice. Notably, IL-17-producing T cells were increased in IFN-γ−/− cells, while IFN-γ-producing cells were increased in IL-17−/− cells, suggesting that IL-17 and IFN-γ mutually regulate IFN-γ and IL-17 production. These observations indicate that IL-17 rather than IFN-γ plays a crucial role in the development of EAE.
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“a subset of CD4+ T cells that is a major contributor to the pathogenicity of several inflammatory and autoimmune conditions (9–11)”
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“inflammatory subtypes of T cells, particularly Th17 cells, are clearly deleterious in diseases such as multiple sclerosis (9–11, 24)”
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“Th17 cells are deleterious to the CNS”
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“IL-6, which drives the production of T helper 17 (Th17) cells”
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Cites
Harrington, L. E., Hatton, R. D., Mangan, P. R., Turner, H., Murphy, T. L., Murphy, K. M., & Weaver, C. T. (2005) · Nature Immunology · doi:10.1038/ni1254 · Cited by 4,742
A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
Park, H., Li, Z., Yang, X. O., Chang, S. H., Nurieva, R., Wang, Y.-H., Wang, Y., Hood, L., Zhu, Z., Tian, Q., et al. (2005) · Nature Immunology · doi:10.1038/ni1261 · Cited by 4,265
IL-23 drives a pathogenic T cell population that induces autoimmune inflammation
Langrish, C. L., Chen, Y., Blumenschein, W. M., Mattson, J., Basham, B., Sedgwick, J. D., McClanahan, T., Kastelein, R. A., & Cua, D. J. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20041257 · Cited by 4,099
Aggarwal, S., Ghilardi, N., Xie, M.-H., de Sauvage, F. J., & Gurney, A. L. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m207577200 · Cited by 1,848
Lock, C., Hermans, G., Pedotti, R., Brendolan, A., Schadt, E. E., Garren, H., Langer-Gould, A. M., Strober, S., Cannella, B., Allard, J. D., et al. (2002) · Nature Medicine · doi:10.1038/nm0502-500 · Cited by 1,659
Ye, P., Rodriguez, F. H., Kanaly, S. T., Stocking, K. L., Schurr, J. R., Schwarzenberger, P. O., Oliver, P., Huang, W., Zhang, P., Zhang, J., et al. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.194.4.519 · Cited by 1,522
Suppression of Immune Induction of Collagen-Induced Arthritis in IL-17-Deficient Mice
Nakae, S., Nambu, A., Sudo, K., & Iwakura, Y. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.11.6173 · Cited by 1,272
Self-citationFerber, I., Brocke, S., Taylor-Edwards, C., Ridgway, W., Dinisco, C., Steinman, L., Dalton, D., & Fathman, C. (1996) · Journal of Immunology · doi:10.4049/jimmunol.156.1.5 · Cited by 1,088
Nakae, S., Komiyama, Y., Nambu, A., Sudo, K., Iwase, M., Homma, I., Sekikawa, K., Asano, M., & Iwakura, Y. (2002) · Immunity · doi:10.1016/s1074-7613(02)00391-6 · Cited by 1,053
Self-citationIL-17 is increased in asthmatic airways and induces human bronchial fibroblasts to produce cytokines
Molet, S., Hamid, Q. A., Davoineb, F., Nutku, E., Tahaa, R., Pagé, N., Olivenstein, R., Elias, J. A., & Chakir, J. (2001) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2001.117929 · Cited by 952
Research works printed but not linked: 50
- 2003, Cytokine Growth Factor Rev., 155
- 1999, Arthritis Rheum., 963
- 2000, Lupus, 589
- 2002, Scand. J. Rheumatol., 205
- 1999, J. Immunol., 577
- 2002, Nephron, 243
- 2001, Clin. Exp. Immunol., 177
- 2002, Nat. Med., 500
- 2002, Immunity, 375
- 2003, J. Immunol., 6173
- 2003, Proc. Natl. Acad. Sci. USA, 5986
- 2001, J. Exp. Med., 519
- 1999, J. Immunol., 1246
- 2000, J. Invest. Dermatol., 81
- 2000, J. Immunol., 6107
- 2001, J. Allergy Clin. Immunol., 430
- 2003, J. Immunol., 2106
- 2003, J. Immunol., 4432
- 1999, Mult. Scler., 101
- 2003, J. Immunol., 2153
- 2001, J. Neuroimmunol., 239
- 1996, J. Immunol., 5
- 1996, J. Immunol., 3223
- 2000, J. Exp. Med., 123
- 1996, Eur. J. Immunol., 1641
- 2005, J. Exp. Med., 233
- 1988, Ann. NY Acad. Sci., 309
- 2000, J. Neurosci., 5283
- 1998, Res. Immunol., 771
- 2002, J. Clin. Invest., 493
- 2002, J. Immunol., 7104
- 2005, Nat. Immunol., 1133
- 2005, Nat. Immunol., 1123
- 2003, J. Biol. Chem., 1910
- 2004, Int. Immunol., 1099
- 1991, J. Neuroimmunol., 91
- 1991, J. Immunol., 1490
- 1996, J. Immunol., 919
- 1996, J. Exp. Med., 2271
- 1998, J. Immunol., 4480
- 2000, J. Autoimmun., 311
- 1997, J. Neurol. Sci., 103
- 1996, J. Exp. Med., 2645
- 1999, Blood, 390
- 2005, Physiol. Genomics, 201
- 1997, J. Exp. Med., 989
- 1997, J. Exp. Med., 613
- 1996, Diabetes, 812
- 1997, Proc. Natl. Acad. Sci. USA, 13844
- 1998, J. Immunol., 631
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Items 601–700 of 1,003
Dai, H., Ciric, B., Zhang, G.-X., & Rostami, A. (2012) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2012.01.005 · Cited by 48
Sinha, S., Subramanian, S., Proctor, T. M., Kaler, L. J., Grafe, M. R., Dahan, R., Huan, J., Vandenbark, A. A., Burrows, G. G., & Offner, H. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.3599-07.2007 · Cited by 51
MicroRNAs as Novel Regulators of Neuroinflammation
Ksiazek-Winiarek, D. J., Kacperska, M. J., & Glabinski, A. R. (2013) · Mediators of Inflammation · doi:10.1155/2013/172351 · Cited by 51
Increased muscle expression of interleukin-17 in Duchenne muscular dystrophy
Pasquale, L. D., D’Amico, A., Verardo, M., Petrini, S., Bertini, E., & Benedetti, F. D. (2012) · Neurology · doi:10.1212/wnl.0b013e3182518302 · Cited by 51
Zhou, J. Y., Álvarez‐González, C. A., & Cobb, B. A. (2021) · eLife · doi:10.7554/elife.57417 · Cited by 50
New concepts in the pathogenesis and treatment of psoriasis: key roles for IL-23, IL-17A and TGF-β1
Blauvelt, A. (2007) · Expert Review of Dermatology · doi:10.1586/17469872.2.1.69 · Cited by 51
Wang, Y., Feng, D., Liu, G., Luo, Q., Xu, Y., Lin, S., Fei, J., & Xu, L. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.12.8226 · Cited by 51
Uzawa, A., Mori, M., Taniguchi, J., Masuda, S., Muto, M., & Kuwabara, S. (2012) · Clinical & Experimental Immunology · doi:10.1111/cei.12036 · Cited by 52
Tsukimoto, M., Nakatsukasa, H., Sugawara, K., Yamashita, K., & Kojima, S. (2008) · Radiation Research · doi:10.1667/rr1352.1 · Cited by 52
Shi, P., Zhu, S., Lin, Y., Liu, Y., Liu, Y., Chen, Z. J., Shi, Y., & Qian, Y. (2011) · Science Signaling · doi:10.1126/scisignal.2001653 · Cited by 53
Mayuzumi, H., Inagaki‐Ohara, K., Uyttenhove, C., Okamoto, Y., & Matsuzaki, G. (2010) · Immunology · doi:10.1111/j.1365-2567.2010.03310.x · Cited by 51
Peron, J. P. S., de Oliveira, A. P. L., & Rizzo, L. V. (2009) · Autoimmunity Reviews · doi:10.1016/j.autrev.2009.02.024 · Cited by 52
Diversity of IL-17-producing T lymphocytes
Kim, J. S., & Jordan, M. S. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1163-6 · Cited by 51
Yang, K., Vega, J. L., Hadzipasic, M., Peron, J. P. S., Zhu, B., Carrier, Y., Masli, S., Rizzo, L. V., & Weiner, H. L. (2009) · Journal of Autoimmunity · doi:10.1016/j.jaut.2008.12.004 · Cited by 50
Kanakasabai, S., Walline, C. C., Chakraborty, S., & Bright, J. J. (2010) · Brain Research · doi:10.1016/j.brainres.2010.12.059 · Cited by 49
Junqueira, S. C., Coelho, I. D. S., Lieberknecht, V., Cunha, M. P., Calixto, J. Β., Rodrigues, A. L. S., Santos, A. R. S., & Dutra, R. C. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-9893-3 · Cited by 51
Zimmermann, J., Emrich, M., Krauthausen, M., Saxe, S., Nitsch, L., Heneka, M. T., Campbell, I. L., & Müller, M. (2017) · Molecular Neurobiology · doi:10.1007/s12035-016-0368-3 · Cited by 52
Anti-diabetic effects of natural products an overview of therapeutic strategies
Park, J., & Jang, H.-J. (2017) · Molecular & Cellular Toxicology · doi:10.1007/s13273-017-0001-1 · Cited by 49
Acharya, S., Timilshina, M., Jiang, L., Neupane, S., Choi, D., Park, S., Lee, S. Y., Jeong, B., Kim, J., Nam, T., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-26088-y · Cited by 47
Intracellular Galectin-9 Enhances Proximal TCR Signaling and Potentiates Autoimmune Diseases
Chen, H.-Y., Wu, Y.-F., Chou, F., Wu, Y.-H., Yeh, L., Lin, K., Liu, F., & Sytwu, H. (2020) · The Journal of Immunology · doi:10.4049/jimmunol.1901114 · Cited by 50
NF-κB1 p105 Regulates T Cell Homeostasis and Prevents Chronic Inflammation
Chang, M., Lee, A. J., Fitzpatrick, L. R., Zhang, M., & Sun, S. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803637 · Cited by 55
Chang, H., Hanawa, H., Yoshida, T., Hayashi, M., Liu, H., Ding, L., Otaki, K., Hao, K., Yoshida, K., Kato, K., et al. (2008) · Circulation Journal · doi:10.1253/circj.72.813 · Cited by 49
Ni, J., Shu, Y.-Y., Zhu, Y., Fu, Y., Tang, W., Zhong, X., Wang, H., Yang, Y., Ren, J., Wang, M., et al. (2007) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2007.03.012 · Cited by 49
FTY720 attenuates lesional interleukin‐17+ cell accumulation in rat experimental autoimmune neuritis
Zhang, Z., Zhang, Z., & Schluesener, H. J. (2009) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2009.01016.x · Cited by 49
Wang, X., Ma, C., Wu, J., & Zhu, J. (2013) · Journal of Neuroscience Research · doi:10.1002/jnr.23233 · Cited by 49
Cutting Edge: An IL-17F-CreEYFP Reporter Mouse Allows Fate Mapping of Th17 Cells
Croxford, A. L., Kurschus, F. C., & Waisman, A. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.182.3.1237 · Cited by 48
Dendritic Cell-Induced Th1 and Th17 Cell Differentiation for Cancer Therapy
Terhune, J. H., Berk, E., & Czerniecki, B. J. (2013) · Vaccines · doi:10.3390/vaccines1040527 · Cited by 51
Seno, A., Maruhashi, T., Kaifu, T., Yabe, R., Fujikado, N., Ma, G., Ikarashi, T., Kakuta, S., & Iwakura, Y. (2014) · EXPERIMENTAL ANIMALS · doi:10.1538/expanim.14-0079 · Cited by 51
Self-citationWang, Y., Mei, Y., Feng, D., & Xu, L. (2008) · Journal of Neuroscience Research · doi:10.1002/jnr.21683 · Cited by 48
Estrada‐Capetillo, L., Hernández-Castro, B., Monsiváis-Urenda, A. E., Álvarez-Quiroga, C., Layseca‐Espinosa, E., Abud‐Mendoza, C., Baranda, L., Urzainqui, A., Sánchez‐Madrid, F., & González‐Amaro, R. (2013) · Clinical and Developmental Immunology · doi:10.1155/2013/584303 · Cited by 49
Waddell, A., Zhao, J., & Cantorna, M. T. (2015) · International Immunology · doi:10.1093/intimm/dxu147 · Cited by 48
Zornetzer, G. A., Frieman, M. B., Rosenzweig, E., Korth, M. J., Page, C., Baric, R. S., & Katze, M. G. (2010) · Journal of Virology · doi:10.1128/jvi.01130-10 · Cited by 48
Zhao, M., Sun, D., Guan, Y., Wang, Z., Sang, D., Liu, M., Pu, Y., Fang, X., Wang, D., Huang, A., et al. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.4587-15.2016 · Cited by 48
Zhang, H., Qi, Y., Yuan, Y., Cai, L., Xu, H., Zhang, L., Su, B., & Nie, H. (2017) · Scientific Reports · doi:10.1038/srep41887 · Cited by 48
NDR1 protein kinase promotes IL‐17‐ and TNF‐α‐mediated inflammation by competitively binding TRAF3
Ma, C., Lin, W., Liu, Z., Tang, W., Gautam, R., Li, H., Qian, Y., Huang, H., & Wang, X. (2017) · EMBO Reports · doi:10.15252/embr.201642140 · Cited by 49
Chen, D., Tang, P., Liu, L., Wang, F., Xing, H., Sun, L., & Jiang, Z. (2018) · Cell Cycle · doi:10.1080/15384101.2018.1442624 · Cited by 48
Altered frequency of Th17 and Treg cells in new‐onset systemic lupus erythematosus patients
Chen, M., Chen, X., & Wan, Q. (2018) · European Journal of Clinical Investigation · doi:10.1111/eci.13012 · Cited by 48
Zhao, Y., Cooper, D. K. C., Wang, H., Chen, P., He, C., Cai, Z., Mou, L., Luan, S., & Gao, H. (2019) · Xenotransplantation · doi:10.1111/xen.12502 · Cited by 50
Kim, Y. H., Choi, B. K., Shin, S. M., Kim, C. H., Oh, H. S., Park, S. H., Lee, D. G., Lee, M. J., Kim, K. H., Vinay, D. S., et al. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1002681 · Cited by 48
Role of interleukin 17 in TGF-β signaling-mediated renal interstitial fibrosis
Sun, B., Wang, H., Zhang, L., Yang, X., Zhang, M., Zhu, X., Ji, X., & Wang, H. (2018) · Cytokine · doi:10.1016/j.cyto.2017.10.015 · Cited by 47
Stoye, D., Schubert, C., Goihl, A., Guttek, K., Reinhold, A., Brocke, S., Grüngreiff, K., & Reinhold, D. (2012) · BioMetals · doi:10.1007/s10534-012-9532-z · Cited by 47
Kaminski, S., Hermann‐Kleiter, N., Meisel, M., Thuille, N., Cronin, S. J. F., Hara, H., Fresser, F., Penninger, J. M., & Baier, G. (2011) · Journal of Autoimmunity · doi:10.1016/j.jaut.2011.05.018 · Cited by 47
Xu, Z., Cheng, W., ZHANG, R., Yao, J., ZHANG, D., & Wang, L. (2015) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2015.2824 · Cited by 47
Ma, S., Zhong, D., Chen, H., Zheng, Y., Sun, Y., Luo, J., Li, H., Li, G., & Yin, Y. (2013) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2013.01.007 · Cited by 47
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Vojdani, A., Lambert, J., & Kellermann, G. H. (2009) · Evidence-based Complementary and Alternative Medicine · doi:10.1093/ecam/nep064 · Cited by 47
Ahmad, S. F., Zoheir, K. M. A., Abdel‐Hamied, H. E., Attia, S. M., Bakheet, S. A., Ashour, A. E., & Abd‐Allah, A. R. A. (2013) · Inflammation · doi:10.1007/s10753-013-9764-2 · Cited by 47
Tsiperson, V., Gruber, R. C., Goldberg, M. F., Jordan, A., Weinger, J. G., Macián, F., & Shafit‐Zagardo, B. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1201387 · Cited by 47
Carmona, E. M., Kottom, T. J., Hebrink, D. M., Moua, T., Singh, R.-D., Pagano, R. E., & LIMPER, A. H. (2012) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2011-0159oc · Cited by 48
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Romero-Adrián, T. B., Leal-Montiel, J. Y., Monsalve-Castillo, F., Mengual-Moreno, E., McGregor, E. G., Perini, L., & Antúnez, A. (2009) · Current Microbiology · doi:10.1007/s00284-009-9518-4 · Cited by 46
Chen, S., Wang, A. Y. L., Fan, H., Lo, W., Wang, C., & Sytwu, H. (2011) · Clinical and Developmental Immunology · doi:10.1155/2012/970789 · Cited by 46
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Teixeira, B., Bittencourt, V. C. B., Ferreira, T. B., Kasahara, T. M., Barros, P. O., Alvarenga, R. M. P., Hygino, J., de Andrade, R. M., Andrade, A. F. B., & Bento, C. A. M. (2013) · Clinical Immunology · doi:10.1016/j.clim.2013.05.012 · Cited by 46
Seki, T., Kumagai, T., Kwansa‐Bentum, B., Furushima‐Shimogawara, R., Anyan, W. K., Miyazawa, Y., Iwakura, Y., & Ohta, N. (2011) · Infection and Immunity · doi:10.1128/iai.05581-11 · Cited by 46
Self-citationAdvances in the role of helper T cells in autoimmune diseases
Zhang, X., Liu, C., & Shao, Z.-H. (2020) · Chinese Medical Journal · doi:10.1097/cm9.0000000000000748 · Cited by 46
Taylor, A. W., & Kitaichi, N. (2008) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2007.11.001 · Cited by 46
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Rampersad, R. R., Tarrant, T. K., Vallanat, C. T., Quintero-Matthews, T., Weeks, M. F., Esserman, D. A., Clark, J., Padova, F. D., Patel, D. D., Fong, A. M., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025833 · Cited by 45
Role of the Immunogenic and Tolerogenic Subsets of Dendritic Cells in Multiple Sclerosis
Xie, Z., Zhang, H., Wu, X., Zhu, J., Ma, D., & Jin, T. (2015) · Mediators of Inflammation · doi:10.1155/2015/513295 · Cited by 46
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Chao, K., Zhang, S., Yao, J., He, Y., Chen, B., Zeng, Z., Zhong, B., & Chen, M. (2014) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.12592 · Cited by 45
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O’Connor, R. A., Taams, L. S., & Anderton, S. M. (2009) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2009.04040.x · Cited by 46
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Muls, N., Nasr, Z., Dang, H. A., Sindic, C., & Pesch, V. V. (2017) · PLoS ONE · doi:10.1371/journal.pone.0173780 · Cited by 46
Fontes, L. B. A., Dias, D. D. S., Aarestrup, B. J. V., Aarestrup, F. M., Filho, A. A. D. S., & Corrêa, J. O. D. A. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.04.092 · Cited by 45
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Hou, L., Rao, D. A., Yuki, K., Cooley, J., Henderson, L. A., Jonsson, A. H., Kaiserman, D., Gorman, M., Nigrovic, P. A., Bird, P. I., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1905762116 · Cited by 43
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Koenders, M. I., & van den Berg, W. B. (2009) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2009.04039.x · Cited by 42
Liu, X.-J., Zhang, J.-F., Sun, B., Peng, H.-S., Kong, Q.-F., Bai, S.-S., Liu, Y.-M., Wang, G. ‐., Wang, J.-H., & Li, H.-L. (2009) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2009.03995.x · Cited by 47
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Qiu, R., & Wang, Y. (2018) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.7b01314 · Cited by 45
Liu, Y., Xing, F., Han, X., Li, Q., Wu, H., Shi, H., Wang, Z., Huang, F., & Wu, X. (2018) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2018.10.024 · Cited by 44
Millward, J. M., Løbner, M., Wheeler, R. D., & Owens, T. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0902153 · Cited by 44
Yu, P., Bamford, R. N., & Waldmann, T. A. (2014) · European Journal of Immunology · doi:10.1002/eji.201444675 · Cited by 44
Immunosuppressive effect of silibinin in experimental autoimmune encephalomyelitis
Min, K., Yoon, W., Kim, S. K., & Kim, B.-H. (2007) · Archives of Pharmacal Research · doi:10.1007/bf02980267 · Cited by 44
Hiltensperger, M., & Korn, T. (2017) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a029637 · Cited by 45
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Induction of Th17 differentiation by corneal epithelial‐derived cytokines
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Zhou, J., Nagarkatti, P. S., Yin, Z., & Nagarkatti, M. (2010) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2010.04.002 · Cited by 44
Downregulation of Th17 cells and the related cytokines with treatment in Kawasaki disease
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Venken, K., Hellings, N., Hensen, K., Rummens, J., & Stinissen, P. (2010) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2010.05.025 · Cited by 43
Martín-Saavedra, F. M., Flores, N., Dorado, B., Eguiluz, C., Bravo, B., García‐Merino, A., & Ballester, S. (2007) · Molecular Immunology · doi:10.1016/j.molimm.2007.03.002 · Cited by 43
Wang, Y., Cao, L., Xu, L., Cao, F., Peng, B., Zhang, X., Shen, Y.-F., Uzan, G., & Zhang, D. (2015) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-015-9598-9 · Cited by 44
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Healy, L. M., Yaqubi, M., Ludwin, S. K., & Antel, J. P. (2019) · Glia · doi:10.1002/glia.23746 · Cited by 41
Bangsgaard, N., Engkilde, K., Thyssen, J. P., Linneberg, A. R., Nielsen, N. H., Menné, T., Skov, L., & Johansen, J. D. (2009) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2009.09314.x · Cited by 43
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Meisel, M., Hermann‐Kleiter, N., Hinterleitner, R., Gruber, T., Wachowicz, K., Pfeifhofer‐Obermair, C., Fresser, F., Leitges, M., Soldani, C., Viola, A., et al. (2013) · Immunity · doi:10.1016/j.immuni.2012.09.021 · Cited by 44
Uyttenhove, C., Sommereyns, C., Théate, I., Michiels, T., & Snick, J. V. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1423.035 · Cited by 43
Haptoglobin deficiency facilitates the development of autoimmune inflammation
Galicia, G., Maes, W., Verbinnen, B., Kasran, A., Bullens, D. M. A., Arredouani, M. S., & Ceuppens, J. L. (2009) · European Journal of Immunology · doi:10.1002/eji.200939291 · Cited by 42
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Croxford, A. L., & Buch, T. (2010) · Immunology · doi:10.1111/j.1365-2567.2010.03372.x · Cited by 40
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Offner, H., Sinha, S., Burrows, G. G., Ferro, A. J., & Vandenbark, A. A. (2010) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2010.09.013 · Cited by 42
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Ferreira, T. B., Barros, P. O., Teixeira, B., Cassano, T., Centurião, N., Kasahara, T. M., Hygino, J., Vasconcelos, C. C. F., Filho, H. A., Alvarenga, R. M. P., et al. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.05.013 · Cited by 41
Wang, J. M., Shi, L., Cheng, J., Xiao, J., Ying, R. S., Wu, X. Y., Wang, K. S., Li, G., Moorman, J. P., & Yao, Z. Q. (2013) · Journal of Virology · doi:10.1128/jvi.03376-12 · Cited by 43
CD83 orchestrates immunity toward self and non-self in dendritic cells
Wild, A. B., Krzyzak, L., Peckert-Maier, K., Stich, L., Kuhnt, C., Butterhof, A., Seitz, C., Mattner, J., Grüner, N., Gänsbauer, M., et al. (2019) · JCI Insight · doi:10.1172/jci.insight.126246 · Cited by 42
Chiba, K. (2020) · The Journal of Antibiotics · doi:10.1038/s41429-020-0351-0 · Cited by 42
Wang, Y., Kai, H., Chang, F., Shibata, K., Tahara‐Hanaoka, S., Honda, S.-I., Shibuya, A., & Shibuya, K. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.12.104 · Cited by 42
Bettini, M., Rosenthal, K. M., & Evavold, B. D. (2009) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2009.05.017 · Cited by 41
Buzzard, K. A., Broadley, S., & Butzkueven, H. (2012) · International Journal of Molecular Sciences · doi:10.3390/ijms131012665 · Cited by 51
Metadata
- Authors
- Komiyama, Y., Nakae, S., Matsuki, T., Nambu, A., Ishigame, H., Kakuta, S., Sudo, K., & Iwakura, Y.
- Affiliations
- Institute of Medical Science, The University of Tokyo (JP)
- ORCID
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-07-01
- Volume
- 177
- Issue
- 1
- Pages
- 566-573
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1959664751
- Cited by
- 1,536
- References
- 54
- Citations by year
- 2026: 12 · 2025: 18 · 2024: 30 · 2023: 30 · 2022: 56 · 2021: 47 · 2020: 44 · 2019: 53 · 2018: 70 · 2017: 72 · 2016: 62 · 2015: 80 · 2014: 97 · 2013: 102 · 2012: 120
- FWCI
- 89.46
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- School of Medicine, Stanford University
- Topics
- Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- IL-17, experimental autoimmune encephalomyelitis, multiple sclerosis, interferon-gamma, myelin oligodendrocyte glycoprotein, CD4+ T cells, T cell sensitization, adoptive transfer, cytokine regulation, autoimmune disease
- MeSH terms
- Amino Acid Sequence, Animals, Autoantibodies, Cells, Cultured, Encephalomyelitis, Autoimmune, Experimental, Glycoproteins, Interferon-gamma, Lymph Nodes, Mice, Inbred C57BL, Molecular Sequence Data, Peptide Fragments, CD4-Positive T-Lymphocytes, Up-Regulation, Mice, Knockout, Epitopes, T-Lymphocyte, Adoptive Transfer, Interleukin-17, Mice, Myelin-Oligodendrocyte Glycoprotein
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