Cited by 208T-cell and B-cell ImmunologyCorneal surgery and disordersTransplantation: Methods and Outcomes

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B7-H1-Induced Apoptosis as a Mechanism of Immune Privilege of Corneal Allografts

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Hori, Junko, Wang, Mingcong, Miyashita, Megumi, Tanemoto, Keiko, Takahashi, Hiroshi, Takemori, Toshitada, Okumura, Ko, Yagita, Hideo, Azuma, Miyuki·2006·The Journal of Immunology

DOI 10.4049/jimmunol.177.9.5928

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Abstract

The programmed death-1 (PD-1) costimulatory pathway has been demonstrated to play a role in the regulation of immune responses and peripheral tolerance. We investigated the role of this pathway in establishing an immune privilege status of corneal allografts in mice. B7-H1, but not B7-DC or PD-1, was expressed constitutively in the eye, i.e., cornea, iris-ciliary body, and retina. After corneal allografting, PD-1+CD4+ T cells infiltrated and adhered with B7-H1+ corneal endothelium. Blockade of PD-1 or B7-H1, but not B7-DC, led to accelerated corneal allograft rejection. In B7-H1-expressing corneal allografts, apoptosis of the infiltrating PD-1+CD4+ or CD8+ T cells was observed, after which there was allograft acceptance. In contrast, B7-H1 blockade suppressed apoptosis of infiltrating PD-1+ T cells, which led to allograft rejection. In vitro, destruction of corneal endothelial cells by alloreactive T cells was enhanced when the cornea was pretreated with anti-B7-H1 Ab. This is the first demonstration that the constitutive expression of B7-H1 plays a critical role in corneal allograft survival. B7-H1 expressed on corneal endothelial cells maintains long-term acceptance of the corneal allografts by inducing apoptosis of effector T cells within the cornea.

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See all 208

Authors: Hori, J., Wang, M., Miyashita, M., Tanemoto, K., Takahashi, H., Takemori, T., Okumura, K., Yagita, H., & Azuma, M.
Affiliations: Nippon Medical School (JP)
National Institute of Infectious Diseases (JP)
Juntendo University (JP)
Department of Immunology, Juntendo University School of Medicine , Tokyo ,
Tokyo Medical and Dental University (JP)
ORCID: Hori, Junko
Takahashi, Hiroshi
Okumura, Ko
Azuma, Miyuki
Venue: The Journal of Immunology
Publisher: Oxford University Press (OUP)
Published: 2006-11-01
Volume: 177
Issue: 9
Pages: 5928-5935
ISSN: 0022-1767 (ISSN-L)
1550-6606
DOI: 10.4049/jimmunol.177.9.5928
OpenAlex: W2150372796
Cited by: 208
References: 58
Citations by year: 2026: 1 · 2025: 5 · 2024: 4 · 2023: 3 · 2022: 7 · 2021: 11 · 2020: 16 · 2019: 8 · 2018: 10 · 2017: 8 · 2016: 12 · 2015: 10 · 2014: 7 · 2013: 18 · 2012: 7
FWCI: 5.76
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations: The Journal of Immunology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Health Sciences › Medicine › Ophthalmology › Corneal surgery and disorders
Health Sciences › Medicine › Surgery › Transplantation: Methods and Outcomes
Keywords: PD-L1, PD-1, immune privilege, corneal allograft, corneal endothelium, T cell apoptosis, allograft rejection, costimulatory molecules, PD-L2, CD4+ T cells, CD8+ T cells
MeSH terms: Animals, Antibodies, Monoclonal, Antigens, Surface, Cornea, Graft Rejection, Graft Survival, Male, Membrane Glycoproteins, Mice, Inbred Strains, Peptides, Transplantation, Homologous, CD4-Positive T-Lymphocytes, Corneal Transplantation, Apoptosis, B7-1 Antigen, CD8-Positive T-Lymphocytes, Endothelial Cells, Apoptosis Regulatory Proteins, Mice, B7-H1 Antigen, Programmed Cell Death 1 Receptor, Programmed Cell Death 1 Ligand 2 Protein

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B7-H1-Induced Apoptosis as a Mechanism of Immune Privilege of Corneal Allografts

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