Inhibitory B7-family molecules in the tumour microenvironment
Abstract
The B7 family consists of activating and inhibitory co-stimulatory molecules that positively and negatively regulate immune responses. Recent studies have shown that human and rodent cancer cells, and stromal cells and immune cells in the cancer microenvironment upregulate expression of inhibitory B7 molecules and that these contribute to tumour immune evasion. In this Review, we focus on the roles of these B7 molecules in the dynamic interactions between tumours and the host immune system, including their expression, regulation and function in the tumour microenvironment. We also discuss novel therapeutic strategies that target these inhibitory B7 molecules and their signalling pathways to treat human cancer.
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Expression of inhibitory immune checkpoint molecules is often mis-regulated in human cancers in order to escape immune surveillance.
“their expression is often mis-regulated in human cancers in order to escape immune surveillance [3,4].”
From Characterizing the molecular regulation of inhibitory immune checkpoints with multimodal single-cell screens (2021) · cites this paper as [4]
In the tumor microenvironment, stimulatory and inhibitory B7 family members are imbalanced, with high inhibitory and low stimulatory expression.
“There is an active imbalance between stimulatory and inhibitory B7 family members in the tumor microenvironment [1,3,7,8].”
From T cell anergy, exhaustion, senescence, and stemness in the tumor microenvironment (2013) · cites this paper as [7]
Inhibitory B7 family members are widely expressed by malignant cells and APCs in the human tumor microenvironment.
“Given that members of the inhibitory B7 family are widely expressed by malignant cells and APCs within the human tumor microenvironment [7]”
From T cell anergy, exhaustion, senescence, and stemness in the tumor microenvironment (2013) · cites this paper as [7]
In animal models, introducing B7-1 into tumors or blocking inhibitory B7 family members reduces tumor growth or causes spontaneous tumor rejection.
“Animal model studies have shown that introduction of B7-1 into tumors by transfection or blockade of inhibitory B7 family members can reduce tumor growth or result in spontaneous tumor rejection in vivo [7–13].”
From T cell anergy, exhaustion, senescence, and stemness in the tumor microenvironment (2013) · cites this paper as [7]
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Self-citationInteraction between B7-H1 and PD-1 determines initiation and reversal of T-cell anergy
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B7-H4 Is Highly Expressed in Ductal and Lobular Breast Cancer
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B7-H1-Induced Apoptosis as a Mechanism of Immune Privilege of Corneal Allografts
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Dendritic cells: a journey from laboratory to clinic
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Generation and Characterization of B7-H4/B7S1/B7x-Deficient Mice
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Self-citationPD-L1 partially protects renal tubular epithelial cells from the attack of CD8+cytotoxic T cells
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The blockade of immune checkpoints in cancer immunotherapy
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“All patients All doses 49 5 10 (3-22) 6 12 (5-25) 31 (17-45)”
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Self-citationPDL1 Regulation by p53 via miR-34
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- Authors
- Zou, W., & Chen, L.
- Affiliations
- University of Michigan (US)
- Johns Hopkins University (US)
- Venue
- Nature Reviews Immunology
- Published
- 2008-06
- Volume
- 8
- Issue
- 6
- Pages
- 467-477
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- OpenAlex
- W2016732129
- Cited by
- 1,608
- References
- 135
- Citations by year
- 2026: 33 · 2025: 43 · 2024: 93 · 2023: 107 · 2022: 88 · 2021: 102 · 2020: 158 · 2019: 120 · 2018: 135 · 2017: 156 · 2016: 158 · 2015: 128 · 2014: 70 · 2013: 74 · 2012: 47
- FWCI
- 2.99
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- B7 family, PD-L1, B7-H4, tumor microenvironment, tumor immune evasion, T cell suppression, costimulatory molecules, hematopoietic cells, cancer immunotherapy
- MeSH terms
- Animals, Antigens, Neoplasm, Multigene Family, Humans, Neoplasms, Gene Expression Regulation, Neoplastic, B7-1 Antigen
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