Cited by 1,608Cancer Immunotherapy and BiomarkersImmunotherapy and Immune ResponsesT-cell and B-cell Immunology

Inhibitory B7-family molecules in the tumour microenvironment

Zou, Weiping, Chen, Lieping·2008·Nature Reviews Immunology

Abstract

The B7 family consists of activating and inhibitory co-stimulatory molecules that positively and negatively regulate immune responses. Recent studies have shown that human and rodent cancer cells, and stromal cells and immune cells in the cancer microenvironment upregulate expression of inhibitory B7 molecules and that these contribute to tumour immune evasion. In this Review, we focus on the roles of these B7 molecules in the dynamic interactions between tumours and the host immune system, including their expression, regulation and function in the tumour microenvironment. We also discuss novel therapeutic strategies that target these inhibitory B7 molecules and their signalling pathways to treat human cancer.

Integrity signals

Registry

Crossref · 10.1038/nri2326

Cites

135 of 135 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Zou, W., & Chen, L.
Affiliations
  • University of Michigan (US)
  • Johns Hopkins University (US)
Venue
Nature Reviews Immunology
Published
2008-06
Volume
8
Issue
6
Pages
467-477
ISSN
  • 1474-1733 (ISSN-L)
  • 1474-1741
OpenAlex
W2016732129
Cited by
1,608
References
135
Citations by year
2026: 33 · 2025: 43 · 2024: 93 · 2023: 107 · 2022: 88 · 2021: 102 · 2020: 158 · 2019: 120 · 2018: 135 · 2017: 156 · 2016: 158 · 2015: 128 · 2014: 70 · 2013: 74 · 2012: 47
FWCI
2.99
Type
journal article
Language
en
Open access
closed
Locations
  • Nature reviews. Immunology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Keywords
B7 family, PD-L1, B7-H4, tumor microenvironment, tumor immune evasion, T cell suppression, costimulatory molecules, hematopoietic cells, cancer immunotherapy
MeSH terms
Animals, Antigens, Neoplasm, Multigene Family, Humans, Neoplasms, Gene Expression Regulation, Neoplastic, B7-1 Antigen

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review