The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Cutting Edge: A Common Polymorphism Impairs Cell Surface Trafficking and Functional Responses of TLR1 but Protects against Leprosy
Abstract
TLRs constitute an essential family of pattern recognition molecules that, through direct recognition of conserved microbial components, initiate inflammatory responses following infection. In this role, TLR1 enables host responses to a variety of bacteria, including pathogenic species of mycobacteria. In this study, we report that I602S, a common single nucleotide polymorphism within TLR1, is associated with aberrant trafficking of the receptor to the cell surface and diminished responses of blood monocytes to bacterial agonists. When expressed in heterologous systems, the TLR1 602S variant, but not the TLR1 602I variant, exhibits the expected deficiencies in trafficking and responsiveness. Among white Europeans, the 602S allele represents the most common single nucleotide polymorphism affecting TLR function identified to date. Surprisingly, the 602S allele is associated with a decreased incidence of leprosy, suggesting that Mycobacterium leprae subverts the TLR system as a mechanism of immune evasion.
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Pathogen Recognition and Innate Immunity
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Cutting Edge: Role of Toll-Like Receptor 1 in Mediating Immune Response to Microbial Lipoproteins
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Cited by
Innate Immune Recognition of Mycobacterium tuberculosis
Kleinnijenhuis, J., Oosting, M., Joosten, L. A. B., Netea, M. G., & Van Crevel, R. (2011) · Clinical and Developmental Immunology · doi:10.1155/2011/405310 · Cited by 414
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Toll-like receptor polymorphisms and susceptibility to human disease
Misch, E. A., & Hawn, T. R. (2008) · Clinical Science · doi:10.1042/cs20070214 · Cited by 263
Toll-like Receptor 1 Polymorphisms Affect Innate Immune Responses and Outcomes in Sepsis
Wurfel, M. M., Gordon, A. C., Holden, T. D., Radella, F., Strout, J., Kajikawa, O., Ruzinski, J. T., Rona, G., Black, A. R., Stratton, S., et al. (2008) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200803-462oc · Cited by 244
Metadata
- Authors
- Johnson, C. M., Lyle, E. A., Omueti, K. O., Stepensky, V. A., Yegin, O., Alpsoy, E., Hamann, L., Schumann, R. R., & Tapping, R. I.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-06
- Volume
- 178
- Issue
- 12
- Pages
- 7520-7524
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2107762058
- Cited by
- 264
- References
- 26
- FWCI
- 6.80
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Cutting Edge: A Common Polymorphism Impairs Cell Surface Trafficking and Functional Responses of TLR1 but Protects against Leprosy. https://app.cochat.ai/papers/10.4049/jimmunol.178.12.7520
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- Johnson, C. M., Lyle, E. A., Omueti, K. O., Stepensky, V. A., Yegin, O., Alpsoy, E., Hamann, L., Schumann, R. R., & Tapping, R. I. (2007). Cutting Edge: A Common Polymorphism Impairs Cell Surface Trafficking and Functional Responses of TLR1 but Protects against Leprosy. The Journal of Immunology. https://doi.org/10.4049/jimmunol.178.12.7520
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
