The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Cutting Edge: Influenza A Virus Activates TLR3-Dependent Inflammatory and RIG-I-Dependent Antiviral Responses in Human Lung Epithelial Cells
Open accessAbstract
Influenza A virus (IAV) triggers a contagious acute respiratory disease that causes considerable mortality annually. Recently, we established a role for the pattern-recognition TLR3 in the response of lung epithelial cells to IAV-derived dsRNA. However, additional nucleic acid-recognition proteins have lately been implicated as key viral sensors, including the RNA helicases retinoic acid-inducible gene-I (RIG-I) and melanoma differentiation-associated gene (MDA)-5. In this study, we investigated the respective role of TLR3 vs RIG-I/MDA-5 signaling in human respiratory epithelial cells infected by IAV using BEAS-2B cells transfected with vectors encoding either a dominant-negative form of TLR3 or of mitochondrial antiviral signaling protein (MAVS; a signaling intermediate of RIG-I and MDA-5), or with plasmids overexpressing functional RIG-I or MDA-5. We demonstrate that the sensing of IAV by TLR3 primarily regulates a proinflammatory response, whereas RIG-I (but not MDA-5) mediates both a type I IFN-dependent antiviral signaling and a proinflammatory response.
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Cites
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NF-κB regulation in the immune system
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“This finding also differs from other works that suggest a selective role for MDA-5 in the antiviral response to picornaviruses (29, 30).”
Result5'-Triphosphate RNA Is the Ligand for RIG-I
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Cited by
Innate immunity to influenza virus infection
Iwasaki, A., & Pillai, P. S. (2014) · Nature Reviews Immunology · doi:10.1038/nri3665 · Cited by 1,068
Respiratory epithelial cells orchestrate pulmonary innate immunity
Whitsett, J. A., & Alenghat, T. (2015) · Nature Immunology · doi:10.1038/ni.3045 · Cited by 801
Respiratory Viral Infections in Infants: Causes, Clinical Symptoms, Virology, and Immunology
Tregoning, J. S., & Schwarze, J. (2010) · Clinical Microbiology Reviews · doi:10.1128/cmr.00032-09 · Cited by 747
The airway epithelium: soldier in the fight against respiratory viruses
Vareille, M., Kieninger, E., Edwards, M. R., & Regamey, N. (2011) · Clinical Microbiology Reviews · doi:10.1128/cmr.00014-10 · Cited by 655
Zheng, M., & Kanneganti, T. (2020) · Immunological Reviews · doi:10.1111/imr.12909 · Cited by 586
Metadata
- Authors
- Le Goffic, R., Pothlichet, J., Vitour, D., Fujita, T., Meurs, E., Chignard, M., & Si-Tahar, M.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-03
- Volume
- 178
- Issue
- 6
- Pages
- 3368-3372
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1932202918
- Cited by
- 436
- References
- 36
- FWCI
- 9.32
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Cutting Edge: Influenza A Virus Activates TLR3-Dependent Inflammatory and RIG-I-Dependent Antiviral Responses in Human Lung Epithelial Cells. https://app.cochat.ai/papers/10.4049/jimmunol.178.6.3368
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- Le Goffic, R., Pothlichet, J., Vitour, D., Fujita, T., Meurs, E., Chignard, M., & Si-Tahar, M. (2007). Cutting Edge: Influenza A Virus Activates TLR3-Dependent Inflammatory and RIG-I-Dependent Antiviral Responses in Human Lung Epithelial Cells. The Journal of Immunology. https://doi.org/10.4049/jimmunol.178.6.3368
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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