The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Severe Depletion of Mucosal CD4+ T Cells in AIDS-Free Simian Immunodeficiency Virus-Infected Sooty Mangabeys
Open accessAbstract
HIV-infected humans and SIV-infected rhesus macaques experience a rapid and dramatic loss of mucosal CD4+ T cells that is considered to be a key determinant of AIDS pathogenesis. In this study, we show that nonpathogenic SIV infection of sooty mangabeys (SMs), a natural host species for SIV, is also associated with an early, severe, and persistent depletion of memory CD4+ T cells from the intestinal and respiratory mucosa. Importantly, the kinetics of the loss of mucosal CD4+ T cells in SMs is similar to that of SIVmac239-infected rhesus macaques. Although the nonpathogenic SIV infection of SMs induces the same pattern of mucosal target cell depletion observed during pathogenic HIV/SIV infections, the depletion in SMs occurs in the context of limited local and systemic immune activation and can be reverted if virus replication is suppressed by antiretroviral treatment. These results indicate that a profound depletion of mucosal CD4+ T cells is not sufficient per se to induce loss of mucosal immunity and disease progression during a primate lentiviral infection. We propose that, in the disease-resistant SIV-infected SMs, evolutionary adaptation to both preserve immune function with fewer mucosal CD4+ T cells and attenuate the immune activation that follows acute viral infection protect these animals from progressing to AIDS.
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Cites
Microbial translocation is a cause of systemic immune activation in chronic HIV infection
Brenchley, J. M., Price, D. A., Schacker, T. W., Asher, T. E., Silvestri, G., Rao, S., Kazzaz, Z., Bornstein, E., Lambotte, O., Altmann, D., et al. (2006) · Nature Medicine · doi:10.1038/nm1511 · Cited by 3,559
Self-citationBrenchley, J. M., Schacker, T. W., Ruff, L. E., Price, D. A., Taylor, J. H., Beilman, G. J., Nguyen, P. L., Khoruts, A., Larson, M., Haase, A. T., et al. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20040874 · Cited by 1,832
Self-citationMassive infection and loss of memory CD4+ T cells in multiple tissues during acute SIV infection
Mattapallil, J. J., Douek, D. C., Hill, B., Nishimura, Y., Martin, M., & Roederer, M. (2005) · Nature · doi:10.1038/nature03501 · Cited by 1,278
Self-citationAIDS as a Zoonosis: Scientific and Public Health Implications
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Peak SIV replication in resting memory CD4+ T cells depletes gut lamina propria CD4+ T cells
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Silvestri, G., Sodora, D. L., Koup, R. A., Paiardini, M., O'Neil, S. P., McClure, H. M., Staprans, S. I., & Feinberg, M. B. (2003) · Immunity · doi:10.1016/s1074-7613(03)00060-8 · Cited by 645
Self-citationThe dynamics of CD4+ T-cell depletion in HIV disease
McCune, J. M. (2001) · Nature · doi:10.1038/35073648 · Cited by 583
HIV disease: fallout from a mucosal catastrophe?
Brenchley, J. M., Price, D. A., & Douek, D. C. (2006) · Nature Immunology · doi:10.1038/ni1316 · Cited by 579
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Cited by
Differential Th17 CD4 T-cell depletion in pathogenic and nonpathogenic lentiviral infections
Brenchley, J. M., Paiardini, M., Knox, K. S., Asher, A. I., Cervasi, B., Asher, T. E., Scheinberg, P., Price, D. A., Hage, C. A., Kholi, L. M., et al. (2008) · Blood · doi:10.1182/blood-2008-05-159301 · Cited by 648
Self-citationJiang, W., Lederman, M. M., Hunt, P., Sieg, S. F., Haley, K., Rodriguez, B., Landay, A., Martin, J., Sinclair, E., Asher, A. I., et al. (2009) · The Journal of Infectious Diseases · doi:10.1086/597476 · Cited by 591
Self-citationJacquelin, B., Mayau, V., Targat, B., Liovat, A.-S., Kunkel, D., Petitjean, G., Dillies, M.-A., Roques, P., Butor, C., Silvestri, G., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci40093 · Cited by 481
Self-citationEstes, J. D., Harris, L. D., Klatt, N. R., Tabb, B., Pittaluga, S., Paiardini, M., Barclay, G. R., Smedley, J., Pung, R., Oliveira, K. M., et al. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1001052 · Cited by 477
Self-citationBosinger, S. E., Li, Q., Gordon, S. N., Klatt, N. R., Duan, L., Xu, L., Francella, N., Sidahmed, A., Smith, A. J., Cramer, E. M., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci40115 · Cited by 409
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Metadata
- Authors
- Gordon, S. N., Klatt, N. R., Bosinger, S. E., Brenchley, J. M., Milush, J. M., Engram, J. C., Dunham, R. M., Paiardini, M., Klucking, S., Danesh, A., Strobert, E. A., Apetrei, C., Pandrea, I. V., Kelvin, D., Douek, D. C., Staprans, S. I., Sodora, D. L., & Silvestri, G.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-09-01
- Volume
- 179
- Issue
- 5
- Pages
- 3026-3034
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2118790593
- Cited by
- 286
- References
- 29
- FWCI
- 13.25
- Type
- journal article
- Language
- en
- Open access
- green
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- Gordon, S. N., Klatt, N. R., Bosinger, S. E., Brenchley, J. M., Milush, J. M., Engram, J. C., Dunham, R. M., Paiardini, M., Klucking, S., Danesh, A., Strobert, E. A., Apetrei, C., Pandrea, I. V., Kelvin, D., Douek, D. C., Staprans, S. I., Sodora, D. L., & Silvestri, G. (2007). Severe Depletion of Mucosal CD4+ T Cells in AIDS-Free Simian Immunodeficiency Virus-Infected Sooty Mangabeys. The Journal of Immunology. https://doi.org/10.4049/jimmunol.179.5.3026
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
