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Cited by 274Immune cells in cancerPhagocytosis and Immune RegulationParasites and Host Interactions

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Alternative Activation Is an Innate Response to Injury That Requires CD4+ T Cells to be Sustained during Chronic Infection

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Loke, P’ng, Gallagher, Iain, Nair, Meera G, Zang, Xingxing, Brombacher, Frank, Mohrs, Markus, Allison, James P, Allen, Judith E·2007·The Journal of Immunology
DOI 10.4049/jimmunol.179.6.3926
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Abstract

Alternatively activated macrophages (AAMPhi) are found in abundance during chronic Th2 inflammatory responses to metazoan parasites. Important roles for these macrophages are being defined, particularly in the context of Th2-mediated pathology and fibrosis. However, a full understanding of the requirements for alternative activation, particularly at the innate level, is lacking. We present evidence that alternative activation by the Th2 cytokines IL-4 and IL-13 is an innate and rapid response to tissue injury that takes place even in the absence of an infectious agent. This early response does not require CD4+ Th2 cells because it occurred in RAG-deficient mice. However, class II-restricted CD4+ T cell help is essential to maintain AAMPhi in response to infection, because AAMPhi were absent in RAG-deficient and MHC class II-deficient, but not B cell-deficient mice after chronic exposure to the nematode parasite, Brugia malayi. The absence of AAMPhi was associated with increased neutrophilia and reduced eosinophilia, suggesting that AAMPhi are involved in the clearance of neutrophils as well as the recruitment of eosinophils. Consistent with this hypothesis, AAMPhi show enhanced phagocytosis of apoptotic neutrophils, but not latex beads. Our data demonstrate that alternative activation by type 2 cytokines is an innate response to injury that can occur in the absence of an adaptive response. However, analogous to classical activation by microbial pathogens, Th2 cells are required for maintenance and full activation during the ongoing response to metazoan parasites.

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Research works printed but not linked: 71

  1. 2003, Nat. Rev. Immunol., 23
  2. 2000, Eur. J. Immunol., 2669
  3. 2005, Infect. Immun., 385
  4. 2005, J. Immunol., 6095
  5. 2002, Infect. Immun., 3656
  6. 2001, J. Leukocyte Biol., 597
  7. 2001, J. Immunol., 6533
  8. 2000, EMBO J., 4046
  9. 1999, J. Immunol., 6867
  10. 2003, J. Clin. Invest., 1863
  11. 2004, Immunity, 623
  12. 2006, J. Immunol., 1115
  13. 2003, J. Immunol., 3655
  14. 2003, J. Immunol., 5064
  15. 2005, Cancer Res., 11743
  16. 1986, N. Engl. J. Med., 1650
  17. 2004, Mol. Immunol., 1089
  18. 2004, Microbes Infect., 1382
  19. 2003, Annu. Rev. Immunol., 335
  20. 2002, Curr. Opin. Immunol., 111
  21. 2000, Nature, 793
  22. 2003, Med. Microbiol. Immunol., 33
  23. 2002, Biomed. Central, 7
  24. 1999, J. Immunol., 7302
  25. 1991, Nature, 423
  26. 2001, Immunity, 303
  27. 2005, J. Immunol., 1063
  28. 2003, Wound Repair Regen., 445
  29. 2001, J. Immunol., 5348
  30. 2003, Infect. Immun., 4361
  31. 1998, J. Immunol., 4124
  32. 2003, J. Clin. Invest., 1309
  33. 2004, Front. Biosci., 283
  34. 2005, Cellular and molecular regulation of wound healing, 17
  35. 2007, J. Invest. Dermatol., 514
  36. 2005, J. Immunol., 5306
  37. 1995, Annu. Rev. Immunol., 417
  38. 2004, J. Exp. Med., 559
  39. 1994, Curr. Opin. Immunol., 85
  40. 1995, Nature, 255
  41. 1998, Int. Immunol., 1583
  42. 1996, J. Exp. Med., 1871
  43. 2004, Infect. Immun., 398
  44. 2005, Infect. Immun., 166
  45. 2004, J. Immunol., 3425
  46. 2001, J. Immunol., 2173
  47. 2001, J. Biol. Chem., 41969
  48. 2002, J. Biol. Chem., 42821
  49. 2004, Immunity, 267
  50. 1999, Curr. Opin. Immunol., 53
  51. 1995, J. Exp. Med., 1373
  52. 2006, Infect. Immun., 4970
  53. 2007, Nature, 92
  54. 2001, J. Biol. Chem., 17497
  55. 2006, Proc. Natl. Acad. Sci. USA, 7777
  56. 2000, Eur. J. Immunol., 1127
  57. 1999, Immunity, 753
  58. 2006, J. Immunol., 6918
  59. 2007, J. Leukocyte Biol., 1434
  60. 2001, J. Biol. Chem., 5468
  61. 2004, Immunity, 215
  62. 2005, Blood, 2549
  63. 2005, Proc. Natl. Acad. Sci. USA, 9872
  64. 1997, Immunol. Today, 115
  65. 2003, Trends Immunol., 44
  66. 1986, Infect. Immun., 820
  67. 1998, Scand. J. Immunol., 159
  68. 2004, Nat. Rev. Immunol., 583
  69. 2005, Annu. Rev. Ecol. Evol. Syst., 373
  70. 2002, Parasite Immunol., 15
  71. 2007, Am. J. Pathol., 188

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Metadata

Authors
Loke, P., Gallagher, I., Nair, M. G., Zang, X., Brombacher, F., Mohrs, M., Allison, J. P., & Allen, J. E.
Affiliations
  • University of California, San Francisco (US)
  • University of Edinburgh (GB)
  • Memorial Sloan Kettering Cancer Center (US)
  • University of Cape Town (ZA)
  • Trudeau Institute (US)
ORCID
Venue
The Journal of Immunology
Publisher
Oxford University Press (OUP)
Published
2007-09
Volume
179
Issue
6
Pages
3926-3936
ISSN
  • 0022-1767 (ISSN-L)
  • 1550-6606
DOI
10.4049/jimmunol.179.6.3926
OpenAlex
W2152215671
Cited by
274
References
73
Citations by year
2026: 2 · 2025: 6 · 2024: 10 · 2023: 1 · 2022: 4 · 2021: 9 · 2020: 5 · 2019: 5 · 2018: 18 · 2017: 15 · 2016: 19 · 2015: 21 · 2014: 22 · 2013: 26 · 2012: 31
FWCI
6.56
Type
journal article
Language
en
Open access
Licence
Locations
  • The Journal of Immunology (publishedVersion)
  • PubMed (publishedVersion)
  • Research Explorer (The University of Manchester) (publishedVersion)
  • Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, other-oa)
Funders
  • Wellcome Trust
  • Medical Research Council
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
  • Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
  • Life Sciences › Immunology and Microbiology › Parasitology › Parasites and Host Interactions
Keywords
alternative activation, M2 macrophages, CD4+ T cells, Th2 cytokines, IL-4, IL-13, tissue damage, innate immunity, chronic infection, Brugia malayi, MHC class II, RAG-deficient mice, eosinophilia, neutrophilia, metazoan parasites
MeSH terms
Animals, Arginase, beta-N-Acetylhexosaminidases, Cell Movement, Chronic Disease, Female, Filariasis, Immunity, Active, Macrophage Activation, Male, Mice, Inbred C57BL, Neutrophils, Proteins, CD4-Positive T-Lymphocytes, Brugia malayi, Mice, Knockout, Nerve Growth Factor, Intercellular Signaling Peptides and Proteins, Lectins, Mice

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