The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
IL-17A Enhances Vitamin D3-Induced Expression of Cathelicidin Antimicrobial Peptide in Human Keratinocytes
Open accessAbstract
Cathelicidin is strongly expressed in lesional skin in psoriasis and may play an important role as both an antimicrobial peptide and as an autoinflammatory mediator in this chronic skin disease. The mechanism of increased cathelicidin in psoriatic keratinocytes is not known, but recent observations have found that psoriasis has abundant Th17 cells that produce IL-17A and IL-22. We found that human keratinocytes stimulated with supernatants from T cells isolated from lesional psoriatic skin increased expression of cathelicidin when stimulated in the presence of 1,25-dihydroxyvitamin D3 (1,25D3). This increase was signaled through the IL-17RA. In vitro, IL-17A, but not IL-22, enhanced cathelicidin mRNA and peptide expression in keratinocytes dependent on the presence of 1,25D3. At the same time, coincubation with 1,25D3 blocked induction of human β-defensin 2 (HBD2), IL-6, and IL-8, which are other target genes of IL-17A. Act1, an adaptor associated with IL-17RA and essential for IL-17A signaling, mediated cathelicidin induction, as its suppression by small interfering RNA inhibited HBD2 and cathelicidin. Both, 1,25D3 and IL-17A signaled cathelicidin induction through MEK-ERK. These results suggest that increased IL-17A in psoriatic skin increases cathelicidin through a vitamin D3-, Act1-, and MEK-ERK-dependent mechanism. Therapy targeting this cathelicidin-regulating system might be beneficial in patients suffering from psoriasis.
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Endogenous Antimicrobial Peptides and Skin Infections in Atopic Dermatitis
Ong, P. Y., Ohtake, T., Brandt, C., Strickland, I., Boguniewicz, M., Ganz, T., Gallo, R. L., & Leung, D. Y. M. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa021481 · Cited by 1,960
Self-citationPlasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide
Lande, R., Gregorio, J., Facchinetti, V., Chatterjee, B., Wang, Y.-H., Homey, B., Cao, W., Wang, Y.-H., Su, B., Nestle, F. O., et al. (2007) · Nature · doi:10.1038/nature06116 · Cited by 1,910
Qian, Y., Liu, C., Hartupee, J., Altuntas, C. Z., Gulen, M. F., Jane-wit, D., Xiao, J., Lu, Y., Giltiay, N., Liu, J., et al. (2007) · Nature Immunology · doi:10.1038/ni1439 · Cited by 614
Dorschner, R. A., Pestonjamasp, V. K., Tamakuwala, S., Ohtake, T., Rudisill, J., Nizet, V., Agerberth, B., Gudmundsson, G. H., & Gallo, R. L. (2001) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2001.01340.x · Cited by 567
Self-citationSchauber, J. (2003) · Gut · doi:10.1136/gut.52.5.735 · Cited by 383
Self-citationHistone-deacetylase inhibitors induce the cathelicidin LL-37 in gastrointestinal cells
Schauber, J., Iffland, K., Frisch, S., Kudlich, T., Schmausser, B., Eck, M., Menzel, T., Gostner, A., Lührs, H., & Scheppach, W. (2004) · Molecular Immunology · doi:10.1016/j.molimm.2004.05.005 · Cited by 109
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Cited by
Interleukin-17 and its target genes: mechanisms of interleukin-17 function in disease
Onishi, R. M., & Gaffen, S. L. (2010) · Immunology · doi:10.1111/j.1365-2567.2009.03240.x · Cited by 894
Mast Cells and Neutrophils Release IL-17 through Extracellular Trap Formation in Psoriasis
Lin, A. M., Rubin, C. J., Khandpur, R., Wang, J. Y., Riblett, M., Yalavarthi, S., Villanueva, E. C., Shah, P., Kaplan, M. J., & Bruce, A. T. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100123 · Cited by 906
Vitamin D3: a helpful immuno-modulator: Vitamin D3 as immuno-modulator
Di Rosa, M., Malaguarnera, M., Nicoletti, F., & Malaguarnera, L. (2011) · Immunology · doi:10.1111/j.1365-2567.2011.03482.x · Cited by 447
The Immunology of Psoriasis-Current Concepts in Pathogenesis
Sieminska, I., Pieniawska, M., & Grzywa, T. M. (2024) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-024-08991-7 · Cited by 346
Keratinocytes: innate immune cells in atopic dermatitis
Chieosilapatham, P., Kiatsurayanon, C., Umehara, Y., Trujillo-Paez, J. V., Peng, G., Yue, H., Nguyen, L. T. H., & Niyonsaba, F. (2021) · Clinical and Experimental Immunology · doi:10.1111/cei.13575 · Cited by 217
Metadata
- Authors
- Peric, M., Koglin, S., Kim, S.-M., Morizane, S., Besch, R., Prinz, J. C., Ruzicka, T., Gallo, R. L., & Schauber, J.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-12
- Volume
- 181
- Issue
- 12
- Pages
- 8504-8512
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2129946962
- Cited by
- 174
- References
- 7
- FWCI
- 4.84
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: IL-17A Enhances Vitamin D3-Induced Expression of Cathelicidin Antimicrobial Peptide in Human Keratinocytes. https://app.cochat.ai/papers/10.4049/jimmunol.181.12.8504
- The paper
- Peric, M., Koglin, S., Kim, S.-M., Morizane, S., Besch, R., Prinz, J. C., Ruzicka, T., Gallo, R. L., & Schauber, J. (2008). IL-17A Enhances Vitamin D3-Induced Expression of Cathelicidin Antimicrobial Peptide in Human Keratinocytes. The Journal of Immunology. https://doi.org/10.4049/jimmunol.181.12.8504
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