Vitamin D3: a helpful immuno-modulator: Vitamin D3 as immuno-modulator

Di Rosa, Michelino; Malaguarnera, Michele; Nicoletti, Ferdinando; Malaguarnera, Lucia

doi:10.1111/j.1365-2567.2011.03482.x

Cited by 448Vitamin D Research StudiesT-cell and B-cell ImmunologyPsoriasis: Treatment and Pathogenesis

Vitamin D3: a helpful immuno-modulator: Vitamin D3 as immuno-modulator

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Di Rosa, Michelino, Malaguarnera, Michele, Nicoletti, Ferdinando, Malaguarnera, Lucia·2011·Immunology

DOI 10.1111/j.1365-2567.2011.03482.xPMC PMC3194221

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Abstract

The active metabolite of vitamin D, 1α, 25-dihydroxyvitamin D3 [1,25(OH)(2) D3], is involved in calcium and phosphate metabolism and exerts a large number of biological effects. Vitamin D3 inhibits parathyroid hormone secretion, adaptive immunity and cell proliferation, and at the same time promotes insulin secretion, innate immunity and stimulates cellular differentiation. The role of vitamin D3 in immunoregulation has led to the concept of a dual function as both as an important secosteroid hormone for the regulation of body calcium homeostasis and as an essential organic compound that has been shown to have a crucial effect on the immune responses. Altered levels of vitamin D3 have been associated, by recent observational studies, with a higher susceptibility of immune-mediated disorders and inflammatory diseases. This review reports the new developments with specific reference to the metabolic and signalling mechanisms associated with the complex immune-regulatory effects of vitamin D3 on immune cells.

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Crossref · 10.1111/j.1365-2567.2011.03482.x

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UV can elicit the synthesis of vitamin D, an important molecule in calcium homeostasis of various types of skin cells contributing to DNA repair and immunomodulation.
“Furthermore, UV can elicit the synthesis of vitamin D, an important molecule in calcium homeostasis of various types of skin cells contributing to DNA repair and immunomodulation.”
From Molecular Mechanisms of UV-Induced Apoptosis and Its Effects on Skin Residential Cells: The Implication in UV-Based Phototherapy (2013) · cites this paper as [86]
The Vitamin D3 synthesis section says UV light initiates vitamin D3 production in skin, and the Introduction describes vitamin D3’s role in calcium homeostasis and immune regulation. However, the copy does not establish calcium homeostasis specifically in various skin-cell types or a contribution to DNA repair; the DNA-related passages concern gene regulation, not repair. No page number is available for these passages. (LLM, conf=0.88)
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Local 1,25(OH)2D3 synthesis activates innate immune responses but suppresses adaptive immune responses.
“Intriguingly, local 1,25(OH)2D3 synthesis activates innate immune responses, but suppresses adaptive immune responses [86].”
From Molecular Mechanisms of UV-Induced Apoptosis and Its Effects on Skin Residential Cells: The Implication in UV-Based Phototherapy (2013) · cites this paper as [86]

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Vitamin D3 as immuno-modulator 13652567, 2011, 2, Downloaded from https://onlinelibrary.wiley.com/doi/10.1111/j.1365-2567.2011.03482.x by Readcube (Labtiva Inc.), Wiley Online Library on [31/08/2023]. See the Terms and Conditions (https://onlinelibrary.wiley.com/terms-and-conditions) on Wiley Online Library for rules of use; OA articles are governed by the applicable Creative Commons License · DOI
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Polymeric nanocapsules as drug carriers for sustained anticancer activity of calcitriol in breast cancer cells
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Self-citation
The Effect of Nutritional Elements on the Immune System
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Authors: Di Rosa, M., Malaguarnera, M., Nicoletti, F., & Malaguarnera, L.
Affiliations: University of Catania (IT)
Corresponding author: Malaguarnera, Lucia
ORCID: Malaguarnera, Michele
Malaguarnera, Lucia
Venue: Immunology
Publisher: Wiley
Published: 2011-09-06
Volume: 134
Issue: 2
Pages: 123-139
ISSN: 0019-2805 (ISSN-L)
DOI: 10.1111/j.1365-2567.2011.03482.x
PMC: PMC3194221
OpenAlex: W1579451442
Cited by: 447
References: 160
Citations by year: 2026: 14 · 2025: 16 · 2024: 27 · 2023: 44 · 2022: 39 · 2021: 44 · 2020: 54 · 2019: 34 · 2018: 26 · 2017: 29 · 2016: 20 · 2015: 24 · 2014: 22 · 2013: 23 · 2012: 30
FWCI: 3.07
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: doi.wiley.com/10.1002/tdm_license_1.1 (tdm, 1456 d)
Locations: Immunology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Pathology and Forensic Medicine › Vitamin D Research Studies
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Keywords: vitamin D3, 1,25-dihydroxyvitamin D3, immunomodulation, immune regulation, innate immunity, adaptive immunity, calcium homeostasis, parathyroid hormone, vitamin D metabolism, inflammatory diseases, immune-mediated diseases, immune cell differentiation
MeSH terms: Animals, Bacterial Infections, Calcitriol, Humans, Immunity, Cellular, Virus Diseases, Mice, Immunomodulation

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Vitamin D3: a helpful immuno-modulator: Vitamin D3 as immuno-modulator

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