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Cited by 417Psoriasis: Treatment and PathogenesisT-cell and B-cell ImmunologyCytokine Signaling Pathways and Interactions

IL-23 Promotes Maintenance but Not Commitment to the Th17 Lineage

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Stritesky, Gretta L., Yeh, Norman, Kaplan, Mark H.·2008·The Journal of Immunology
DOI 10.4049/jimmunol.181.9.5948PMC PMC2678905
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Abstract

IL-23 plays a critical role establishing inflammatory immunity and enhancing IL-17 production in vivo. However, an understanding of how it performs those functions has been elusive. In this report, using an IL-17-capture technique, we demonstrate that IL-23 maintains the IL-17-secreting phenotype of purified IL-17+ cells without affecting cell expansion or survival. IL-23 maintains the Th17 phenotype over multiple rounds of in vitro stimulation most efficiently in conjunction with IL-1β. However, in contrast to Th1 and Th2 cells, the Th17 phenotype is not stable and when long-term IL-23-stimulated Th17 cultures are exposed to Th1- or Th2-inducing cytokines, the Th17 genetic program is repressed and cells that previously secreted IL-17 assume the cytokine secreting profile of other Th subsets. Thus, while IL-23 can maintain the Th17 phenotype, it does not promote commitment to an IL-17-secreting lineage.

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  • Ongoing IL-6 signaling is indispensable and foundational, acting upstream of IL-23 via its unique function to sustain RORγt expression and thereby IL-23R expression.

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    From T <sub>H</sub> 17 cells require ongoing classic IL-6 receptor signaling to retain transcriptional and functional identity (2020) · cites this paper as [21]

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Research works printed but not linked: 27

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Authors
Stritesky, G. L., Yeh, N., & Kaplan, M. H.
Affiliations
Indiana University Indianapolis (US)
ORCID
Kaplan, Mark H.
Venue
The Journal of Immunology
Publisher
Oxford University Press (OUP)
Published
2008-11-01
Volume
181
Issue
9
Pages
5948-5955
ISSN
  • 0022-1767 (ISSN-L)
  • 1550-6606
DOI
10.4049/jimmunol.181.9.5948
PMC
PMC2678905
OpenAlex
W1697354033
Cited by
417
References
4
Citations by year
2026: 18 · 2025: 17 · 2024: 23 · 2023: 21 · 2022: 17 · 2021: 31 · 2020: 21 · 2019: 23 · 2018: 33 · 2017: 30 · 2016: 24 · 2015: 16 · 2014: 21 · 2013: 24 · 2012: 21
FWCI
10.75
Type
journal article
Language
en
Open access
Licence
academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations
  • The Journal of Immunology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • IUScholarWorks (Indiana University) (submittedVersion)
Funders
  • National Institutes of Health
  • U.S. Public Health Service
  • National Institute of Allergy and Infectious Diseases (R56AI045515, AI-45515, R01AI045515, T32AI060519)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
Keywords
IL-23, Th17 cells, IL-17, IL-1β, cytokine-induced differentiation, Th1 cells, Th2 cells
MeSH terms
Animals, Cell Differentiation, Cell Division, Cell Survival, Cells, Cultured, T-Lymphocytes, Helper-Inducer, Lymphocyte Activation, Mice, Inbred BALB C, Mice, Inbred C57BL, Immunophenotyping, Cell Lineage, Interleukin-17, Cell Proliferation, Mice, Interleukin-23

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