The DOI matches its Crossref record; 132 of the 134 references it cites were found in a registry or an index.
The Role of Zinc in Alzheimer′s Disease
Open accessAbstract
Zinc, the most abundant trace metal in the brain, has numerous functions, both in health and in disease. Zinc is released into the synaptic cleft of glutamatergic neurons alongside glutamate from where it interacts and modulates NMDA and AMPA receptors. In addition, zinc has multifactorial functions in Alzheimer′s disease (AD). Zinc is critical in the enzymatic nonamyloidogenic processing of the amyloid precursor protein (APP) and in the enzymatic degradation of the amyloid‐ β (A β ) peptide. Zinc binds to A β promoting its aggregation into neurotoxic species, and disruption of zinc homeostasis in the brain results in synaptic and memory deficits. Thus, zinc dyshomeostasis may have a critical role to play in the pathogenesis of AD, and the chelation of zinc is a potential therapeutic approach.
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“Mechanistically, high concentrations of Zinc released into the synaptic cleft can induce neurotoxicity through NMDAR and AMPAR inhibition [548].”
From Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease (2020) · cites this paper as [548]
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“Zinc may aggravate AD pathogenesis, as zinc can bind Aβ and promote Aβ accumulation. In addition, the accumulation of zinc can cause synaptic and memory defects [548].”
From Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease (2020) · cites this paper as [548]
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2 retracted
RETRACTED ARTICLE: APP binds DR6 to trigger axon pruning and neuron death via distinct caspases
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Metadata
- Authors
- Watt, N. T., Whitehouse, I. J., & Hooper, N. M.
- Affiliations
- University of Leeds (GB)
- Corresponding author
- Hooper, Nigel M.
- Venue
- International Journal of Alzheimer’s Disease
- Publisher
- Wiley
- Published
- 2010-12-20
- Volume
- 2011
- Issue
- 1
- Pages
- 971021-971021
- ISSN
- 2090-0252 (ISSN-L)
- 2090-8024
- PMC
- PMC3010690
- OpenAlex
- W2012671084
- Cited by
- 148
- References
- 134
- Citations by year
- 2026: 7 · 2025: 13 · 2024: 12 · 2023: 10 · 2022: 10 · 2021: 12 · 2020: 19 · 2019: 5 · 2018: 8 · 2017: 10 · 2016: 7 · 2015: 8 · 2014: 6 · 2013: 4 · 2012: 11
- FWCI
- 4.55
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- International Journal of Alzheimer s Disease (publishedVersion, cc-by)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Research Explorer (The University of Manchester) (submittedVersion)
- Funders
- Medical Research Council
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- zinc, Alzheimer's disease, zinc homeostasis, zinc dyshomeostasis, amyloid precursor protein, amyloid-beta, amyloid-beta aggregation, NMDA receptor, AMPA receptors, glutamatergic synapses, synaptic dysfunction, memory impairment, zinc chelation
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