Pretreatment with Lycopene Attenuates Oxidative Stress-Induced Apoptosis in Human Mesenchymal Stem Cells
Open accessAbstract
Human mesenchymal stem cells (MSCs) have been used in cell-based therapy to promote revascularization after peripheral or myocardial ischemia. High levels of reactive oxygen species (ROS) are involved in the senescence and apoptosis of MSCs, causing defective neovascularization. Here, we examined the effect of the natural antioxidant lycopene on oxidative stress-induced apoptosis in MSCs. Although H2O2 (200 μM) increased intracellular ROS levels in human MSCs, lycopene (10 μM) pretreatment suppressed H2O2-induced ROS generation and increased survival. H2O2-induced ROS increased the levels of phosphorylated p38 mitogen activated protein kinase (MAPK), Jun-N-terminal kinase (JNK), ataxia telangiectasia mutated (ATM), and p53, which were inhibited by lycopene pretreatment. Furthermore, lycopene pretreatment decreased the expression of cleaved poly (ADP ribose) polymerase-1 (PARP-1) and caspase-3 and increased the expression of B-cell lymphoma 2 (Bcl-2) and Bcl-2-associated X protein (Bax), which were induced by H2O2 treatment. Moreover, lycopene significantly increased manganese superoxide dismutase (MnSOD) expression and decreased cellular ROS levels via the PI3K-Akt pathway. Our findings show that lycopene pretreatment prevents ischemic injury by suppressing apoptosis-associated signal pathway and enhancing anti-oxidant protein, suggesting that lycopene could be developed as a beneficial broad-spectrum agent for the successful MSC transplantation in ischemic diseases.
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Cellular pretreatment with lycopene protects MSCs against H2O2-induced senescence, enhances antioxidant defences (improved MnSOD activity and reduced ROS production) and prevents apoptosis through the modulation of Bax and Bak proteins.
“Similarly, studies conducted on MSCs demonstrated that cellular pretreatment with lycopene protects against H2O2-induced senescence, enhances antioxidant defences (i.e., improved MnSOD activity and reduced ROS production) and prevents apoptosis through the modulation of Bax and Bak proteins [172].”
From The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence (2022) · cites this paper as [172]
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- Authors
- Kim, J. Y., Lee, J.-S., Han, Y.-S., Lee, J. H., Bae, I., Yoon, Y. M., Kwon, S. M., & Lee, S. H.
- Affiliations
- Pusan National University (KR)
- Sunchon National University (KR)
- Soonchunhyang University (KR)
- Department of Animal Science and Technology, Sunchon National University, Suncheon 57922, Republic of Korea
- Corresponding author
- Kwon, Sang Mo
- Lee, Sang Hun
- Venue
- Biomolecules & Therapeutics
- Published
- 2015-11-01
- Volume
- 23
- Issue
- 6
- Pages
- 517-524
- ISSN
- 1976-9148 (ISSN-L)
- 2005-4483
- PMC
- PMC4624067
- OpenAlex
- W2107281979
- Cited by
- 59
- References
- 34
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 4 · 2023: 6 · 2022: 13 · 2021: 2 · 2020: 10 · 2019: 2 · 2018: 4 · 2017: 8 · 2016: 4
- FWCI
- 2.99
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Biomolecules & Therapeutics (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Funders
- Ministry of Education, Science and Technology(Korean Ministry of Education, Science and Technology) (2011-0009610)
- Ministry of Health and Welfare(Ministry of Health, Welfare and Family Affairs) (HI14C2253)
- Topics
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Keywords
- lycopene, mesenchymal stem cells, oxidative stress, apoptosis, reactive oxygen species, hydrogen peroxide, p38 MAPK, JNK, ATM, p53, Bcl-2/Bax, caspase-3, PARP1, manganese superoxide dismutase, PI3K/Akt signaling, antioxidants, cell therapy
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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