The role of oxidative stress in the pathophysiology of hypertension
Open accessAbstract
Hypertension is considered to be the most important risk factor in the development of cardiovascular disease. An increasing body of evidence suggests that oxidative stress, which results in an excessive generation of reactive oxygen species (ROS), has a key role in the pathogenesis of hypertension. The modulation of the vasomotor system involves ROS as mediators of vasoconstriction induced by angiotensin II, endothelin-1 and urotensin-II, among others. The bioavailability of nitric oxide (NO), which is a major vasodilator, is highly dependent on the redox status. Under physiological conditions, low concentrations of intracellular ROS have an important role in the normal redox signaling maintaining vascular function and integrity. However, under pathophysiological conditions, increased levels of ROS contribute to vascular dysfunction and remodeling through oxidative damage. In human hypertension, an increase in the production of superoxide anions and hydrogen peroxide, a decrease in NO synthesis and a reduction in antioxidant bioavailability have been observed. In turn, antioxidants are reducing agents that can neutralize these oxidative and otherwise damaging biomolecules. The use of antioxidant vitamins, such as vitamins C and E, has gained considerable interest as protecting agents against vascular endothelial damage. Available data support the role of these vitamins as effective antioxidants that can counteract ROS effects. This review discusses the mechanisms involved in ROS generation, the role of oxidative stress in the pathogenesis of vascular damage in hypertension, and the possible therapeutic strategies that could prevent or treat this disorder.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Oxidative stress may play a role in the development of vascular complications that promote cardiovascular disease by contributing to the pathogenesis of hypertension and atherosclerosis.
“Oxidative stress may play a role in the development of vascular complications that promote cardiovascular disease by contributing to the pathogenesis of hypertension [143,144] and atherosclerosis [145].”
From Nrf2 and Oxidative Stress: A General Overview of Mechanisms and Implications in Human Disease (2022) · cites this paper as [144]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Yusuf, S., Hawken, S., Ôunpuu, S., Dans, T., Avezum, A., Lanas, F., McQueen, M., Budaj, A., Pais, P., Varigos, J., et al. (2004) · The Lancet · doi:10.1016/s0140-6736(04)17018-9 · Cited by 12,026 · see citing works
A Clinical Trial of the Effects of Dietary Patterns on Blood Pressure
Appel, L. J., Moore, T. J., Obarzanek, E., Vollmer, W. M., Svetkey, L. P., Sacks, F. M., Bray, G. A., Vogt, T. M., Cutler, J. A., Windhauser, M. M., et al. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704173361601 · Cited by 5,981 · see citing works
Meister, A., & Anderson, M. E. (1983) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.52.070183.003431 · Cited by 5,694 · see citing works
Vitamin C as an Antioxidant: Evaluation of Its Role in Disease Prevention
Padayatty, S. J., Katz, A., Wang, Y., Eck, P., Kwon, O., Lee, J.-H., Chen, S., Corpe, C., Dutta, A., Dutta, S. K., et al. (2003) · Journal of the American College of Nutrition · doi:10.1080/07315724.2003.10719272 · Cited by 1,949 · see citing works
The sympathetic control of blood pressure
Guyenet, P. G. (2006) · Nature reviews. Neuroscience · doi:10.1038/nrn1902 · Cited by 1,814 · see citing works
Landmesser, U., Dikalov, S., Price, S. R., McCann, L., Fukai, T., Holland, S. M., Mitch, W. E., & Harrison, D. G. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200314172 · Cited by 1,660 · see citing works
Landmesser, U., Dikalov, S., Price, S. R., McCann, L. A., Fukai, T., Holland, S. M., Mitch, W. E., & Harrison, D. G. (2003) · Journal of Clinical Investigation · doi:10.1172/jci14172 · Cited by 1,652 · see citing works
Elevated Uric Acid Increases Blood Pressure in the Rat by a Novel Crystal-Independent Mechanism
Mazzali, M., Hughes, J., Kim, Y.-G., Jefferson, J. A., Kang, D., GORDON, K. L., Lan, H. Y., Kivlighn, S. D., & Johnson, R. J. (2001) · Hypertension · doi:10.1161/hy1101.092839 · Cited by 1,298 · see citing works
Superoxide anions and hyperoxia inactivate endothelium-derived relaxing factor
Rubanyi, G. M., & Vanhoutte, P. M. (1986) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1986.250.5.h822 · Cited by 1,192 · see citing works
Lee, I.-M., Cook, N. R., Gaziano, J. M., Gordon, D., Ridker, P. M., Manson, J. E., Hennekens, C. H., & Buring, J. E. (2005) · JAMA · doi:10.1001/jama.294.1.56 · Cited by 1,137 · see citing works
Zoccali, C., Bode-Böger, S. M., Mallamaci, F., Benedetto, F. A., Tripepi, G., Malatino, L. S., Cataliotti, A., Bellanuova, I., Fermo, I., Frölich, J. C., et al. (2001) · The Lancet · doi:10.1016/s0140-6736(01)07217-8 · Cited by 1,087 · see citing works
Reactive Oxygen Species in the Vasculature
Taniyama, Y., & Griendling, K. K. (2003) · Hypertension · doi:10.1161/01.hyp.0000100443.09293.4f · Cited by 1,067 · see citing works
Vascular NAD(P)H oxidases: specific features, expression, and regulation
Lassegue, B. P., & Clempus, R. E. (2003) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00758.2002 · Cited by 1,016 · see citing works
Feig, D., Soletsky, B., & Johnson, R. J. (2008) · Journal of the American Medical Association (JAMA) · doi:10.1001/jama.300.8.924 · Cited by 936 · see citing works
Reactive Oxygen Species, Vascular Oxidative Stress, and Redox Signaling in Hypertension
Touyz, R. M. (2004) · Hypertension · doi:10.1161/01.hyp.0000138070.47616.9d · Cited by 866 · see citing works
Effect of Allopurinol in Chronic Kidney Disease Progression and Cardiovascular Risk
Goicoechea, M., de Vinuesa, S. G., Verdalles, Ú., Ruiz-Caro, C., Ampuero, J., Rincón, A., Arroyo, D., & Luño, J. (2010) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.01580210 · Cited by 834 · see citing works
Rubanyi, G. M., Galvas, P. E., Disalvo, J., & Paul, R. J. (1986) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1986.250.3.c406 · Cited by 799 · see citing works
Laursen, J. B., Somers, M., Kurz, S., McCann, L., Warnholtz, A., Freeman, B. A., Tarpey, M., Fukai, T., & Harrison, D. G. (2001) · Circulation · doi:10.1161/01.cir.103.9.1282 · Cited by 721 · see citing works
Han, D., Antunes, F., Canali, R., Rettori, D., & Cadenas, E. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210269200 · Cited by 711 · see citing works
Interactions of Peroxynitrite, Tetrahydrobiopterin, Ascorbic Acid, and Thiols
Kuzkaya, N., Weissmann, N., Harrison, D. G., & Dikalov, S. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m302227200 · Cited by 692 · see citing works
Blumenthal, J. A. (2010) · Archives of Internal Medicine · doi:10.1001/archinternmed.2009.470 · Cited by 592 · see citing works
Redox signaling in hypertension
Paravicini, T. M., & Touyz, R. M. (2006) · Cardiovascular Research · doi:10.1016/j.cardiores.2006.05.001 · Cited by 575 · see citing works
Role of p47 phox in Vascular Oxidative Stress and Hypertension Caused by Angiotensin II
Landmesser, U., Cai, H. “., Dikalov, S., McCann, L. A., Hwang, J., Jo, H., Holland, S. M., & Harrison, D. G. (2002) · Hypertension · doi:10.1161/01.hyp.0000032100.23772.98 · Cited by 572 · see citing works
Rapola, J., Virtamo, J. R. K., Ripatti, S., Huttunen, J. K., Albanes, D., Taylor, P. R., & Heinonen, O. P. (1997) · The Lancet · doi:10.1016/s0140-6736(97)01234-8 · Cited by 569 · see citing works
Protection against reactive oxygen species by selenoproteins
Steinbrenner, H., & Sies, H. (2009) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2009.02.014 · Cited by 513 · see citing works
Oxidative Stress and Hypertension
Harrison, D. G., & Góngora, M. C. (2009) · Medical Clinics of North America · doi:10.1016/j.mcna.2009.02.015 · Cited by 451 · see citing works
Zimmerman, M. C., Lazartigues, E. D., Sharma, R. V., & Davisson, R. L. (2004) · Circulation Research · doi:10.1161/01.res.0000135483.12297.e4 · Cited by 440 · see citing works
Antioxidant Activities and Oxidative Stress Byproducts in Human Hypertension
Redón, J., Oliva, M. R., Tormos, C., Giner, V., Chaves, F. J., Iradi, A., & Sáez, G. T. (2003) · Hypertension · doi:10.1161/01.hyp.0000068370.21009.38 · Cited by 417 · see citing works
Chen, X., Touyz, R. M., Park, J. B., & Schiffrin, E. L. (2001) · Hypertension · doi:10.1161/hy09t1.094005 · Cited by 410 · see citing works
Jackson, T. S., Xu, A., Vita, J. A., & Keaney, J. F. (1998) · Circulation Research · doi:10.1161/01.res.83.9.916 · Cited by 400 · see citing works
Different Effect of Antihypertensive Drugs on Conduit Artery Endothelial Function
Ghiadoni, L., Magagna, A., Versari, D., Kardasz, I., Huang, Y., Taddei, S., & Salvetti, A. (2003) · Hypertension · doi:10.1161/01.hyp.0000070956.57418.22 · Cited by 366 · see citing works
Oxidative Stress and Hypertension: Current Concepts
Briones, A. M., & Touyz, R. M. (2010) · Current Hypertension Reports · doi:10.1007/s11906-010-0100-z · Cited by 344 · see citing works
Smith, P. J., Blumenthal, J. A., Babyak, M. A., Craighead, L. W., Welsh-Bohmer, K. A., Browndyke, J. N., Strauman, T. J., & Sherwood, A. (2010) · Hypertension · doi:10.1161/hypertensionaha.109.146795 · Cited by 343 · see citing works
Reactive oxygen species in hypertension*1An update
Lassegue, B. P. (2004) · American Journal of Hypertension · doi:10.1016/j.amjhyper.2004.02.004 · Cited by 341 · see citing works
Assessment of Sympathetic Cardiovascular Drive in Human Hypertension
Grassi, G. M. (2009) · Hypertension · doi:10.1161/hypertensionaha.108.119883 · Cited by 340 · see citing works
Treatment of hypertension with ascorbic acid
Duffy, S., Gokce, N., HOLBROOK, M. M., Huang, A., Frei, B. B., Keaney, J. F., & Vita, J. A. (1999) · The Lancet · doi:10.1016/s0140-6736(99)04410-4 · Cited by 333 · see citing works
Michel, J. B., Féron, O., Sase, K., Prabhakar, P., & Michel, T. M. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.41.25907 · Cited by 323 · see citing works
Decreased blood pressure in NOX1‐deficient mice
Gavazzi, G., Banfi, B., Deffert, C., Fiette, L., Schappi, M., Herrmann, F., & Krause, K.-H. (2006) · FEBS Letters · doi:10.1016/j.febslet.2005.12.049 · Cited by 321 · see citing works
Touyz, R. M. (2004) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x2004000800018 · Cited by 312 · see citing works
Kishi, T., Hirooka, Y., Kimura, Y., Ito, K., Shimokawa, H., & Takeshita, A. (2004) · Circulation · doi:10.1161/01.cir.0000128695.49900.12 · Cited by 306 · see citing works
Azadbakht, L., Fard, N. R. P., Karimi, M., Baghaei, M. H., Surkan, P. J., Rahimi, M., Esmaillzadeh, A., & Willett, W. C. (2011) · Diabetes Care · doi:10.2337/dc10-0676 · Cited by 304 · see citing works
Plasma Hydrogen Peroxide Production in Human Essential Hypertension
Lacy, F., Kailasam, M. T., O’Connor, D. T., Schmid‐Schönbein, G. W., & Parmer, R. J. (2000) · Hypertension · doi:10.1161/01.hyp.36.5.878 · Cited by 299 · see citing works
Systemic Uric Acid Administration Increases Serum Antioxidant Capacity in Healthy Volunteers
Waring, W. S., Webb, D. J., & Maxwell, S. R. J. (2001) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-200109000-00005 · Cited by 291 · see citing works
Angiotensin II–Induced Reactive Oxygen Species and the Kidney
Sachse, A., & Wolf, G. (2007) · Journal of the American Society of Nephrology · doi:10.1681/asn.2007020149 · Cited by 277 · see citing works
Peroxynitrite and Vascular Endothelial Dysfunction in Diabetes Mellitus
Zou, M., Cohen, R. A., & Ullrich, V. (2004) · Endothelium · doi:10.1080/10623320490482619 · Cited by 270 · see citing works
Xanthine oxidase activity associated with arterial blood pressure in spontaneously hypertensive rats
Suzuki, H., DeLano, F. A., Parks, D. A., Jamshidi, N., Granger, D. N., Ishii, H., Suematsu, M., Zweifach, B. W., & Schmid‐Schönbein, G. W. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.8.4754 · Cited by 262 · see citing works
Uric acid reduces exercise-induced oxidative stress in healthy adults
Waring, W. S., CONVERY, A., Mishra, V., Shenkin, A., Webb, D. J., & Maxwell, S. R. J. (2003) · Clinical Science · doi:10.1042/cs20030149 · Cited by 257 · see citing works
Touyz, R. M., & Schiffrin, E. L. (2001) · Journal of Hypertension · doi:10.1097/00004872-200107000-00009 · Cited by 257 · see citing works
S-Nitrosothiols: cellular formation and transport
Zhang, Y., & Hogg, N. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.12.016 · Cited by 257 · see citing works
Vitamins Reverse Endothelial Dysfunction Through Regulation of eNOS and NAD(P)H Oxidase Activities
Ülker, S., McKeown, P., & Bayraktutan, U. (2003) · Hypertension · doi:10.1161/01.hyp.0000057421.28533.37 · Cited by 255 · see citing works
Bilirubin Chemistry and Metabolism; Harmful and Protective Aspects
Vı́tek, L., & Ostrow, J. D. (2009) · Current Pharmaceutical Design · doi:10.2174/138161209789058237 · Cited by 252 · see citing works
Co-expression of urotensin II and its receptor (GPR14) in human cardiovascular and renal tissues
Matsushita, M., Shichiri, M., Imai, T., Iwashina, M., Tanaka, H., Takasu, N., & Hirata, Y. (2001) · Journal of Hypertension · doi:10.1097/00004872-200112000-00011 · Cited by 242 · see citing works
Relationship between Oxidative Stress and Essential Hypertension
Rodrigo, R., Hernán Prat, M., Walter Passalacqua, R., Julia Araya, A., Guichard, C., & Bächler, J. P. (2007) · Hypertension Research · doi:10.1291/hypres.30.1159 · Cited by 235 · see citing works
Mechanism of endothelial dysfunction in chronic kidney disease
Małyszko, J. (2010) · Clinica Chimica Acta · doi:10.1016/j.cca.2010.06.019 · Cited by 234 · see citing works
Plantinga, Y., Ghiadoni, L., Magagna, A., Giannarelli, C., Franzoni, F., Taddei, S., & Salvetti, A. (2007) · American Journal of Hypertension · doi:10.1016/j.amjhyper.2006.09.021 · Cited by 228 · see citing works
Are ACE Inhibitors a “Magic Bullet” Against Oxidative Stress?
Münzel, T. F., & Keaney, J. F. (2001) · Circulation · doi:10.1161/hc3801.095585 · Cited by 226 · see citing works
Klahr, S. (2001) · Seminars in Nephrology · doi:10.1053/snep.2001.20942 · Cited by 222 · see citing works
The Effect of Nutrition on Blood Pressure
Savica, V., Bellinghieri, G., & Kopple, J. D. (2010) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-010510-103954 · Cited by 221 · see citing works
Ascorbic Acid Reduces Blood Pressure and Arterial Stiffness in Type 2 Diabetes
Mullan, B. A., Young, I. S., Fee, H. J. P., & McCance, D. R. (2002) · Hypertension · doi:10.1161/01.hyp.0000039961.13718.00 · Cited by 212 · see citing works
Mitochondria-Derived Reactive Oxygen Species and Vascular MAP Kinases
Kimura, S., Zhang, G., Nishiyama, A., Shokoji, T., Yao, L., Fan, Y.-Y., Rahman, M., & Abe, Y. (2005) · Hypertension · doi:10.1161/01.hyp.0000157169.27818.ae · Cited by 207 · see citing works
Reduced Selenium Concentrations and Glutathione Peroxidase Activity in Preeclamptic Pregnancies
Mistry, H. D., Wilson, V., Ramsay, M., Symonds, M. E., & Pipkin, F. B. (2008) · Hypertension · doi:10.1161/hypertensionaha.108.116103 · Cited by 198 · see citing works
Combination Oral Antioxidant Supplementation Reduces Blood Pressure
Galley, H. F., Thornton, J., Howdle, P. D., WALKER, B. E., & Webster, N. R. (1997) · Clinical Science · doi:10.1042/cs0920361 · Cited by 184 · see citing works
Enhanced Oxidative Stress and Impaired Thioredoxin Expression in Spontaneously Hypertensive Rats
Tanito, M., Nakamura, H., Kwon, Y.-W., Teratani, A., Masutani, H., Shioji, K., Kishimoto, C., Ohira, A., Horie, R., & Yodoi, J. (2004) · Antioxidants and Redox Signaling · doi:10.1089/152308604771978381 · Cited by 180 · see citing works
Nitric oxide dynamics and endothelial dysfunction in type II model of genetic diabetes
Bitar, M. S., Wahid, S., Mustafa, S., Al‐Saleh, E., Dhaunsi, G. S., & Al‐Mulla, F. (2005) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2005.01.014 · Cited by 174 · see citing works
Hyperuricemia as a Predictor of Hypertension in a Screened Cohort in Okinawa, Japan
Nagahama, K., Inoue, T., Iseki, K., Touma, T., Kinjo, K., Ohya, Y., & Takishita, S. (2004) · Hypertension Research · doi:10.1291/hypres.27.835 · Cited by 167 · see citing works
Djordjevic, T., BelAiba, R. S., Bonello, S., Pfeilschifter, J. M., Hess, J., & Görlach, A. (2004) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000154279.98244.eb · Cited by 164 · see citing works
Rodrigo, R., & Bosco, C. (2005) · Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology · doi:10.1016/j.cbpc.2005.11.002 · Cited by 162 · see citing works
Role of inflammation in túbulo-interstitial damage associated to obstructive nephropathy
Grande, M. T., Pérez‐Barriocanal, F., & López-Novoa, J. M. (2010) · Journal of Inflammation · doi:10.1186/1476-9255-7-19 · Cited by 160 · see citing works
Stirrat, A., Gallagher, M. E., Douglas, S. A., Ohlstein, E. H., Berry, C., Kirk, A., Richardson, M., & MacLean, M. R. (2001) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.2001.280.2.h925 · Cited by 159 · see citing works
Angiotensin II and oxidative stress
Hitomi, H., Kiyomoto, H., & Nishiyama, A. (2007) · Current Opinion in Cardiology · doi:10.1097/hco.0b013e3281532b53 · Cited by 157 · see citing works
Renal damage mediated by oxidative stress: a hypothesis of protective effects of red wine
Rodrigo, R., & Rivera, G. M. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00908-5 · Cited by 156 · see citing works
Redox Control of Calcium Channels: From Mechanisms to Therapeutic Opportunities
Hool, L. C., & Corry, B. (2007) · Antioxidants and Redox Signaling · doi:10.1089/ars.2006.1446 · Cited by 155 · see citing works
Kim, I. Y., & Stadtman, T. C. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.24.12904 · Cited by 154 · see citing works
Alonso, Á., de la Fuente, C., Martin-Arnau, A., de Irala, J., Martínez, J. A., & Martínez‐González, M. Á. (2004) · British Journal Of Nutrition · doi:10.1079/bjn20041196 · Cited by 152 · see citing works
Oliveira‐Sales, E. B., Nishi, E. E., Carillo, B. A., Boim, M. A., Dolnikoff, M. S., Bergamaschi, C. T., & Campos, R. R. (2009) · American Journal of Hypertension · doi:10.1038/ajh.2009.17 · Cited by 146 · see citing works
Selenium-Dependent Enzymes in Endothelial Cell Function
Brigelius‐Flohé, R., Banning, A., & Schnurr, K. (2003) · Antioxidants and Redox Signaling · doi:10.1089/152308603764816569 · Cited by 145 · see citing works
Uric Acid and Hypertension: Cause or Effect?
Mazzali, M., Kanbay, M., Segal, M. S., Shafiu, M., Jalal, D. I., Feig, D. I., & Johnson, R. J. (2010) · Current Rheumatology Reports · doi:10.1007/s11926-010-0094-1 · Cited by 142 · see citing works
Ward, N. C., Wu, J. H. Y., Clarke, M. W., Puddey, I. B., Burke, V., Croft, K. D., & Hodgson, J. M. (2006) · Journal of Hypertension · doi:10.1097/01.hjh.0000254373.96111.43 · Cited by 141 · see citing works
Effect of vitamin C on ambulatory blood pressure and plasma lipids in older persons
Fotherby, M. D., Williams, J. C., Forster, L. A., Craner, P., & Ferns, G. A. (2000) · Journal of Hypertension · doi:10.1097/00004872-200018040-00009 · Cited by 139 · see citing works
Vita, J. A., Frei, B. B., HOLBROOK, M. M., Gokce, N., Leaf, C. D., & Keaney, J. F. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1155 · Cited by 139 · see citing works
Rodrigo, R., Hernán Prat, M., Walter Passalacqua, R., Julia Araya, A., & Bächler, J. P. (2008) · Clinical Science · doi:10.1042/cs20070343 · Cited by 139 · see citing works
Blood pressure and blood selenium: a cross-sectional and longitudinal population study
Nawrot, T. S., Staessen, J. A., Roels, H. A., Hond, E. D., Thijs, L., Fagard, R. H., Dominiczak, A. F., & Struijker-Boudier, H. A. J. (2006) · European Heart Journal · doi:10.1093/eurheartj/ehl479 · Cited by 137 · see citing works
Widder, J. D., Fraccarollo, D., Galuppo, P., Hansen, J. M., Jones, D. P., Ertl, G., & Bauersachs, J. K. (2009) · Hypertension · doi:10.1161/hypertensionaha.108.127928 · Cited by 136 · see citing works
Novel isoforms of NADPH oxidase in vascular physiology and pathophysiology
BENGTSSON, S. H. M., Gulluyan, L. M., Dusting, G. J., & Drummond, G. R. (2003) · Clinical and Experimental Pharmacology and Physiology · doi:10.1046/j.1440-1681.2003.03929.x · Cited by 135 · see citing works
Brainstem mechanisms of hypertension: Role of the rostral ventrolateral medulla
Sved, A. F., Ito, S., & Sved, J. C. (2003) · Current Hypertension Reports · doi:10.1007/s11906-003-0030-0 · Cited by 128 · see citing works
Selenite protects human endothelial cells from oxidative damage and induces thioredoxin reductase
MILLER, S., Walker, S. W., Arthur, J. R., Nicol, F., Pickard, K. M., Lewin, M., Howie, A. F., & Beckett, G. J. (2001) · Clinical Science · doi:10.1042/cs1000543 · Cited by 126 · see citing works
Emerging potential of thioredoxin and thioredoxin interacting proteins in various disease conditions
Maulik, N., & Das, D. K. (2008) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2007.12.008 · Cited by 124 · see citing works
Ward, N. C., Hodgson, J. M., Croft, K. D., Burke, V., Beilin, L. J., & Puddey, I. B. (2005) · Journal of Hypertension · doi:10.1097/00004872-200502000-00026 · Cited by 124 · see citing works
Clinical pharmacology and therapeutic use of antioxidant vitamins
Rodrigo, R., Guichard, C., & Charles, R. (2007) · Fundamental & Clinical Pharmacology · doi:10.1111/j.1472-8206.2006.00466.x · Cited by 124 · see citing works
Self-citationLack of Long-Term Effect of Vitamin C Supplementation on Blood Pressure
Kim, M. K., Sasaki, S., Sasazuki, S., Okubo, S., Hayashi, M., & Tsugane, S. (2002) · Hypertension · doi:10.1161/01.hyp.0000038339.67450.60 · Cited by 123 · see citing works
Yoshida, J., Yamamoto, K., Mano, T., Sakata, Y., Nishikawa, N., Nishio, M., Ohtani, T., Miwa, T., Hori, M., & Masuyama, T. (2004) · Hypertension · doi:10.1161/01.hyp.0000118017.02160.fa · Cited by 122 · see citing works
Levitan, E. B., Wolk, A., & Mittleman, M. A. (2009) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2009.06.061 · Cited by 119 · see citing works
Role of Thioredoxin in Cell Growth Through Interactions with Signaling Molecules
Yoshioka, J., Schreiter, E. R., & Lee, R. T. (2006) · Antioxidants and Redox Signaling · doi:10.1089/ars.2006.8.2143 · Cited by 119 · see citing works
Relationship between rate and extent of catechin absorption and plasma antioxidant status
Pietta, P., Simonetti, P., Gardana, C., Brusamolino, A., Morazzoni, P., & Bombardelli, E. (1998) · IUBMB Life · doi:10.1080/15216549800204442 · Cited by 119 · see citing works
Duffy, S. J., Gokce, N., HOLBROOK, M. M., Hunter, L. M., Biegelsen, E. S., Huang, A., Keaney, J. F., & Vita, J. A. (2001) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.2001.280.2.h528 · Cited by 118 · see citing works
Viel, E. C., Benkirane, K., Javeshghani, D., Touyz, R. M., & Schiffrin, E. L. (2008) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00304.2008 · Cited by 116 · see citing works
Reactive oxygen molecules, oxidant injury and renal disease
Andreoli, S. P. (1991) · Pediatric Nephrology · doi:10.1007/bf00857888 · Cited by 115 · see citing works
Penugonda, S., Mare, S., Goldstein, G. A., Banks, W. A., & Nuran Ercal, A. (2005) · Brain Research · doi:10.1016/j.brainres.2005.07.032 · Cited by 113 · see citing works
Nanayakkara, P. W. B., Teerlink, T., Stehouwer, C. D. A., Allajar, D., Spijkerman, A. M. W., Schalkwijk, C. G., ter Wee, P. M., & van Guldener, C. (2005) · Kidney International · doi:10.1111/j.1523-1755.2005.00680.x · Cited by 112 · see citing works
Hirooka, Y., Sagara, Y., Kishi, T., & Sunagawa, K. (2010) · Circulation Journal · doi:10.1253/circj.cj-10-0153 · Cited by 110 · see citing works
Nowson, C. A., Wattanapenpaiboon, N., & Pachett, A. (2009) · Nutrition Research · doi:10.1016/j.nutres.2008.12.002 · Cited by 107 · see citing works
The Effect of Dietary Patterns on Estimated Coronary Heart Disease Risk
Chen, S. T., Maruthur, N. M., & Appel, L. J. (2010) · Circulation Cardiovascular Quality and Outcomes · doi:10.1161/circoutcomes.109.930685 · Cited by 103 · see citing works
Ascorbic Acid Status and Subsequent Diastolic and Systolic Blood Pressure
Block, G., Mangels, A. R., Norkus, E. P., Patterson, B. H., Levander, O. A., & Taylor, P. R. (2001) · Hypertension · doi:10.1161/01.hyp.37.2.261 · Cited by 99 · see citing works
Zhan, C.-D., Sindhu, R. K., Pang, J., Ehdaie, A., & Vaziri, N. D. (2004) · Journal of Hypertension · doi:10.1097/00004872-200410000-00027 · Cited by 98 · see citing works
Red wine polyphenols induce vasorelaxation by increased nitric oxide bioactivity.
Zenebe, W. J., Pecháňová, O., & Andriantsitohaina, R. (2003) · PubMed · Cited by 98 · see citing works
Thioredoxin in the cardiovascular system
World, C., Yamawaki, H., & Berk, B. C. (2006) · Journal of Molecular Medicine · doi:10.1007/s00109-006-0109-6 · Cited by 96 · see citing works
Homocysteine and Essential Hypertension
Rodrigo, R., Walter Passalacqua, R., Julia Araya, A., Myriam Orellana, B., & Rivera, G. M. (2003) · The Journal of Clinical Pharmacology · doi:10.1177/0091270003258190 · Cited by 94 · see citing works
Different antioxidants status, total antioxidant power and free radicals in essential hypertension
Kashyap, M. K., Yadav, V., Sehrawat, B. S., Jain, S., Kumari, S., Khullar, M., Sharma, P. C., & Nath, R. (2005) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-005-5424-7 · Cited by 94 · see citing works
Stojiljković, M. P., Lopes, H. F., Zhang, D., Morrow, J. D., Goodfriend, T. L., & Egan, B. M. (2002) · Journal of Hypertension · doi:10.1097/00004872-200206000-00036 · Cited by 94 · see citing works
Faure, P. (2003) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.2003.152 · Cited by 90 · see citing works
Reckelhoff, J. F., Kanji, V. K., Racusen, L. C., Schmidt, A. M., Yan, S. D., Morrow, J. D., Roberts, L. J., & Salahudeen, A. K. (1998) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1998.274.3.r767 · Cited by 88 · see citing works
Kędziora–Kornatowska, K., Czuczejko, J., Pawluk, H., Kornatowski, T., Motyl, J., Szadujkis‐Szadurski, L., Szewczyk‐Golec, K., & Kędziora, J. (2004) · PubMed · Cited by 87 · see citing works
Implications of Oxidative Stress and Homocysteine in the Pathophysiology of Essential Hypertension
Rodrigo, R., Walter Passalacqua, R., Julia Araya, A., Myriam Orellana, B., & Rivera, G. M. (2003) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-200310000-00001 · Cited by 85 · see citing works
Duarte, J., Andriambeloson, E., Diebolt, M., & Andriantsitohaina, R. (2006) · Physiological Research · doi:10.33549/physiolres.930000.53.595 · Cited by 82 · see citing works
Faure, P., Ramon, O., Favier, A. E., & Halimi, S. (2004) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2004.01362.x · Cited by 81 · see citing works
Zembowicz, A., Hatchett, R. J., Radziszewski, W., & Gryglewski, R. J. (1993) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)39382-1 · Cited by 79 · see citing works
Ghosh, S., Ekpo, E. B., Shah, I. U., Girling, A. J., Jenkins, C., & Sinclair, A. J. (2009) · Gerontology · doi:10.1159/000213595 · Cited by 73 · see citing works
Red wine polyphenols induce vasorelaxation via increased nitric oxide bioactivity
Zenebe, W. J., Pecháňová, O., & Andriantsitohaina, R. (2003) · Physiological Research · doi:10.33549/physiolres.930333 · Cited by 71 · see citing works
Localization of the urotensin II receptor in the rat central nervous system
Jégou, S., Cartier, D., Dubessy, C., Gonzalez, B. J., Chatenet, D., Tostivint, H., Scalbert, E., Leprince, J., Vaudry, H., & Lihrmann, I. (2006) · The Journal of Comparative Neurology · doi:10.1002/cne.20845 · Cited by 69 · see citing works
Modulation of endogenous glutathione availability
Wernerman, J., & Hammarqvist, F. (1999) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/00075197-199911000-00010 · Cited by 68 · see citing works
Zhou, L., Wei, X., Potts, J. L., Floyd, M. D., Sharan, C., Yang, H., Ross, J., Nyanda, A. M., & Guo, Z. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.07.019 · Cited by 67 · see citing works
Laakso, J. T., Teräväinen, T., Martelin, E., Vaskonen, T., & Lapatto, R. (2004) · Journal of Hypertension · doi:10.1097/01.hjh.0000125441.28861.9f · Cited by 66 · see citing works
Current Concepts in the Use of Antioxidants for the Treatment of Preeclampsia
Bilodeau, J., & Hubel, C. A. (2003) · Journal of Obstetrics and Gynaecology Canada · doi:10.1016/s1701-2163(16)31003-9 · Cited by 65 · see citing works
Effect of chronic N-acetylcysteine treatment on the development of spontaneous hypertension
Pecháňová, O., Zicha, J., Vranková, S., Dobešová, Z., Jendeková, L., & Kuneš, J. (2006) · Clinical Science · doi:10.1042/cs20050227 · Cited by 64 · see citing works
Update on gout and hyperuricemia
Baker, J. F., & Schumacher, H. R. (2009) · International Journal of Clinical Practice · doi:10.1111/j.1742-1241.2009.02188.x · Cited by 62 · see citing works
Redox signaling via lipid raft clustering in homocysteine-induced injury of podocytes
Zhang, C., Hu, J., Xia, M., Boini, K. M., Brimson, C. A., & Li, P. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2009.12.006 · Cited by 62 · see citing works
Chin, H. J., Song, Y. R., Kim, H. S., Park, M., Yoon, H. J., Na, K. Y., Kim, Y., Chae, D., & Kim, S. (2009) · Journal of Korean Medical Science · doi:10.3346/jkms.2009.24.s1.s50 · Cited by 59 · see citing works
la Fuente, M. D., & Víctor, V. M. (2001) · Free Radical Research · doi:10.1080/10715760100300611 · Cited by 58 · see citing works
Campbell, L., Howie, F. A., Arthur, J. R., Nicol, F., & Beckett, G. J. (2006) · Nutrition · doi:10.1016/j.nut.2006.10.006 · Cited by 58 · see citing works
Chung, S., Park, C. W., Shin, S. J., Lim, J. H., Chung, H. W., Youn, D., Kim, H., Kim, B. S., Lee, J. H., Kim, G., et al. (2009) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfp472 · Cited by 58 · see citing works
The role of oxidative stress in renovascular hypertension
Campos, R. R., Oliveira‐Sales, E. B., Nishi, E. E., Boim, M. A., Dolnikoff, M. S., & Bergamaschi, C. T. (2010) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2010.05437.x · Cited by 57 · see citing works
Thioredoxin in Vascular Biology: Role in Hypertension
Ebrahimian, T., & Touyz, R. M. (2008) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.1985 · Cited by 57 · see citing works
Takizawa, M., Komori, K., Tampo, Y., & Yonaha, M. (2006) · Toxicology in Vitro · doi:10.1016/j.tiv.2006.09.003 · Cited by 55 · see citing works
Use of vitamins C and E as a prophylactic therapy to prevent postoperative atrial fibrillation
Rodrigo, R., Vinay, J. I., Castillo, R. L., Cereceda, M., René Asenjo, G., Zamorano, J., Julia Araya, A., Castillo-Koch, R., Espinoza, J., & Larraín, E. (2009) · International Journal of Cardiology · doi:10.1016/j.ijcard.2009.04.043 · Cited by 54 · see citing works
Tian, N., Rose, R. A., Jordan, S., Dwyer, T. M., Hughson, M. D., & Manning, R. D. (2006) · Journal of Hypertension · doi:10.1097/01.hjh.0000249705.42230.73 · Cited by 54 · see citing works
Microvascular Display of Xanthine Oxidase and NADPH Oxidase in the Spontaneously Hypertensive Rat
DeLano, F. A., Parks, D. A., Ruedi, J. M., BABIOR, B. M., & Schmid‐Schönbein, G. W. (2006) · Microcirculation · doi:10.1080/10739680600885152 · Cited by 51 · see citing works
Beneficial effects of Provinols TM: cardiovascular system and kidney
Pecháňová, O., Rezzani, R., Babál, P., Bernátová, I., & Andriantsitohaina, R. (2006) · Physiological Research · doi:10.33549/physiolres.930000.55.s1.17 · Cited by 51 · see citing works
Exercise Training, NADPH Oxidase p22phox Gene Polymorphisms, and Hypertension
Feairheller, D. L., Brown, M. D., Park, J., Brinkley, T. E., Basu, S., Hagberg, J. M., Ferrell, R. E., & Fenty-Stewart, N. (2009) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e318199cee8 · Cited by 50 · see citing works
Antioxidants and endothelial nitric oxide synthesis
Heller, R., Werner‐Felmayer, G., & Werner, E. R. (2005) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-005-0009-7 · Cited by 48 · see citing works
de Cavanagh, E. M. V., Ferder, L., Ferder, M., Stella, I. Y., Toblli, J. E., & Inserra, F. (2010) · American Journal of Hypertension · doi:10.1038/ajh.2010.167 · Cited by 47 · see citing works
α‐Tocopherol and Endothelial Nitric Oxide Synthesis
Heller, R., Werner‐Felmayer, G., & Werner, E. R. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1331.007 · Cited by 45 · see citing works
Estresse oxidativo e disfunção endotelial na doença renal crônica
Costa‐Hong, V., Bortolotto, L. A., Jorgetti, V., Consolim-Colombo, F., Krieger, E. M., & de Lima, J. J. G. (2009) · Arquivos Brasileiros de Cardiologia · doi:10.1590/s0066-782x2009000500013 · Cited by 44 · see citing works
Vitamin E Ameliorates the Renal Injury of Dahl Salt-Sensitive Rats
Atarashi, K. (1997) · American Journal of Hypertension · doi:10.1016/s0895-7061(97)00088-5 · Cited by 44 · see citing works
Moderate hyperbilirubinemia improves renal hemodynamics in ANG II-dependent hypertension
Vera, T., & Stec, D. E. (2010) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00316.2010 · Cited by 44 · see citing works
Xu, S., He, Y., Vokurková, M., & Touyz, R. M. (2009) · Hypertension · doi:10.1161/hypertensionaha.109.133983 · Cited by 40 · see citing works
Metabolic Syndrome and Chronic Kidney Disease
Guarnieri, G., Zanetti, M., Vinci, P., Cattin, M. R., Pirulli, A., & Barazzoni, R. (2010) · Journal of Renal Nutrition · doi:10.1053/j.jrn.2010.05.006 · Cited by 39 · see citing works
Lymbury, R., Marino, M. J., & Perkins, A. V. (2010) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201000012 · Cited by 38 · see citing works
The role of urate and xanthine oxidase in vascular oxidative stress: future directions
Casella, G. (2009) · Therapeutics and Clinical Risk Management · doi:10.2147/tcrm.s5701 · Cited by 36 · see citing works
Contribution of captopril thiol group to the prevention of spontaneous hypertension
Pecháňová, O. (2007) · Physiological Research · doi:10.33549/physiolres.931396 · Cited by 36 · see citing works
Eto, Y., Kang, D., Hasegawa, E., Takeshige, K., & Minakami, S. (1992) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(92)90493-g · Cited by 34 · see citing works
Gómez-Alamillo, C., Juncos, L. A., Cases, A., Haas, J. A., & Romero, J. C. (2003) · Hypertension · doi:10.1161/01.hyp.0000088854.04562.da · Cited by 34 · see citing works
Effects of Vitamin C on High Blood Pressure Induced by Salt in Spontaneously Hypertensive Rats
NISHIKAWA, Y., Tatsumi, K., MATSUURA, T., Yamamoto, A., Nadamoto, T., & Urabe, K. (2003) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.49.301 · Cited by 33 · see citing works
Glutathione system in young spontaneously hypertensive rats
Lee, S.-K., Sundaram, A., Sirajudeen, K. N. S., & Singh, H. J. (2010) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-010-0038-2 · Cited by 31 · see citing works
l ‐Arginine fails to protect against myocardial remodelling in l ‐NAME‐induced hypertension
Šimko, F., Luptak, I., Matusková, J., Krajcirovicova, K., Sumbalová, Z., Kucharská, J., Gvozdjáková, A., Simko, J., Babál, P., Pecháňová, O., et al. (2005) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2005.01507.x · Cited by 27 · see citing works
Zhou, X., Ji, W., Zhu, Y., He, B., Li, H., Huang, T.-G., & Li, Y. (2006) · Medical Hypotheses · doi:10.1016/j.mehy.2006.09.058 · Cited by 23 · see citing works
Associação do eletrocardiograma com diabete melito e síndrome metabólica em nipo-brasileiros
Brollo, L., Bombig, M. T. N., Mazzaro, C. D. L., Francisco, Y. A., Fonseca, F. A. H., Carvalho, A. C. C., Harima, H., Hirai, A. T., & Póvoa, R. (2009) · Arquivos Brasileiros de Cardiologia · doi:10.1590/s0066-782x2009000500008 · Cited by 22 · see citing works
Sládková, M., Kojšová, S., Jendeková, L., & Pecháňová, O. (2007) · Physiological Research · doi:10.33549/physiolres.931402 · Cited by 19 · see citing works
Native LDL-induced oxidative stress in human proximal tubular cells: multiple players involved
Piccoli, C., Quarato, G., D’Aprile, A., Montemurno, E., Scrima, R., Ripoli, M. C., Gomaraschi, M., Cirillo, P., Boffoli, D., Calabresi, L., et al. (2009) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2009.00946.x · Cited by 17 · see citing works
Bilirubin Exerts Renoprotective Effects in Angiotensin II-Hypertension
LeBlanc, R. M., Navar, L. G., Botros, F. T., Navar, L. G., & Gooz, M. B. (2010) · The American Journal of the Medical Sciences · doi:10.1097/maj.0b013e3181e52de9 · Cited by 15 · see citing works
da Silva, A. P., Marinho, C., Gonçalves, M. C., Monteiro, C. P., Laires, M. J., Falcão, L. M., Nogueira, J. B., & Bich, M. (2010) · PubMed · Cited by 10 · see citing works
[Trace elements and blood pressure regulation].
Ito, Y., & Fujita, T. (1996) · PubMed · Cited by 7 · see citing works
Joles, J. A., Wesseling, S., & Braam, B. (2010) · Journal of Hypertension · doi:10.1097/hjh.0b013e328335fa99 · Cited by 4 · see citing works
Flagged first, then by citations
Research works printed but not linked: 9
- myocardial infarction in 52 countries (the INTERHEART Study): case control study. Lancet 2004; 364: 937-952.
- Paravicini TM, Touyz RM. Redox signalling in hypertension. Cardiovasc Res 2006; 71: 247-258.
- Costa-Hong V, Bortolotto LA, Jorgetti V, Consolim-Colombo F, Krieger EM, Lima JJ. Oxidative stress and endothelial dysfunction in chronic kidney disease. Arq Bras Cardiol 2009; 92: 381-386.
- Meister A, Anderson ME. Glutathione. Annu Rev Biochem 1983; 52: 711-760.
- Zhou L, Xiang W, Potts J, Floyd M, Sharan C, Yang H, Ross J, Nyanda AM, Guo Z. Reduction in extracellular superoxide dismutase activity in African-American patients with hypertension. Free Radic Biol Med 2006; 41: 1384-1391.
- Tanito M, Nakamura H, Kwon YW, Teratani A, Masutani H, Shioji K, Kishimoto C, Ohira A, Horie R, Yodoi J. Enhanced oxidative stress and impaired thioredoxin expression in spontaneously hypertensive rats. Antioxid Redox Signal 2004; 6: 89-97.
- Duffy SJ, Gokee N, Holbrook M, Huang A, Frei B, Keany JFJ. Treatment of hyperten- sion with ascorbic acid. Lancet 2004; 354: 2048-2049. 110
- Mullan B, Young IS, Fee H, McCance DR. Ascorbic acid reduces blood pressure and arterial stiffness in type 2 diabetes. Hypertension 2002; 40: 804-809. 124
- Galley HF, Thornton J, Howdle PD, Walker BE, Webster NR. Combination oral antioxidant supplementation reduces blood pressure. Clin Sci 1997; 92: 361-365. 125
Cited by
Sorted by citations
Nrf2 and Oxidative Stress: A General Overview of Mechanisms and Implications in Human Disease
Ngo, V., & Duennwald, M. L. (2022) · Antioxidants · doi:10.3390/antiox11122345 · Cited by 1,130 · see citing works
Medicinal prospects of antioxidants: A review
Neha, K., Haider, M. R., Pathak, A., & Yar, M. S. (2019) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2019.06.010 · Cited by 724 · see citing works
Oxidative stress and pathophysiology of ischemic stroke: novel therapeutic opportunities.
Rodrigo, R., Fernández-Gajardo, R., Gutiérrez, R., Matamala, J. M., Carrasco, R., Miranda-Merchak, A., & Feuerhake, W. (2013) · CNS and Neurological Disorders - Drug Targets · doi:10.2174/1871527311312050015 · Cited by 621 · see citing works
Therapeutic Potential of Moringa oleifera Leaves in Chronic Hyperglycemia and Dyslipidemia: A Review
Mbikay, M. (2012) · Frontiers in Pharmacology · doi:10.3389/fphar.2012.00024 · Cited by 615 · see citing works
Eelen, G., de Zeeuw, P., Treps, L., Harjes, U., Wong, B. W., & Carmeliet, P. (2017) · Physiological Reviews · doi:10.1152/physrev.00001.2017 · Cited by 591 · see citing works
Herbal Medicine for Cardiovascular Diseases: Efficacy, Mechanisms, and Safety
Shaito, A. A., Thuan, D. T. B., Hoa, P. T., Nguyen, T. H. D., Hasan, H. A., Halabi, S., Abdelhady, S., Nasrallah, G. K., Eid, A. H., & Pintus, G. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00422 · Cited by 439 · see citing works
Oxidative Stress-Induced Endothelial Dysfunction in Cardiovascular Diseases
Shaito, A. A., Aramouni, K., Assaf, R., Parenti, A., Orekhov, A. N., EL‐Yazbi, A. F., Pintus, G., & Eid, A. H. (2022) · Frontiers in Bioscience-Landmark · doi:10.31083/j.fbl2703105 · Cited by 427 · see citing works
Thrombocytopathy and endotheliopathy: crucial contributors to COVID-19 thromboinflammation
Gu, S. X., Tyagi, T., Jain, K., Gu, V. W., Lee, S. H., Hwa, J. M., Kwan, J. M., Krause, D. S., Lee, A. I., Halene, S., et al. (2020) · Nature Reviews Cardiology · doi:10.1038/s41569-020-00469-1 · Cited by 414 · see citing works
Mechanisms of Coronary Artery Spasm
Lanza, G. A., Careri, G., & Crea, F. (2011) · Circulation · doi:10.1161/circulationaha.111.037283 · Cited by 403 · see citing works
Zhang, Z., Zhao, L. Q., Zhou, X., Meng, X., & Zhou, X. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1098725 · Cited by 387 · see citing works
Erejuwa, O. O., Sulaiman, S. A., & Wahab, M. S. A. (2012) · Molecules · doi:10.3390/molecules17044400 · Cited by 365 · see citing works
Frąk, W., Wojtasińska, A., Lisińska, W., Młynarska, E., Franczyk, B., & Rysz, J. (2022) · Biomedicines · doi:10.3390/biomedicines10081938 · Cited by 340 · see citing works
Oxidative stress and hypertension: Possibility of hypertension therapy with antioxidants.
Baradaran, A., Nasri, H., & Rafieian‐Kopaei, M. (2014) · Europe PMC (PubMed Central) · Cited by 296 · see citing works
Arterial stiffness and hypertension
Kim, H. (2023) · Clinical Hypertension · doi:10.1186/s40885-023-00258-1 · Cited by 249 · see citing works
Moreno‐Luna, R., Múñoz‐Hernández, R., Miranda, M. L., Costa, A. F., Jiménez-Jiménez, L., Vallejo‐Vaz, A. J., Muriana, F. J. G., Villar, J. R., & Stiefel, P. (2012) · American Journal of Hypertension · doi:10.1038/ajh.2012.128 · Cited by 243 · see citing works
Healthful aging mediated by inhibition of oxidative stress
Vatner, S. F., Zhang, J., Oydanich, M. K., Berkman, T., Naftalovich, R., & Vatner, D. E. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101194 · Cited by 239 · see citing works
Rodrigo, R., Libuy, M., Feliú, F., & Hasson, D. (2013) · Disease Markers · doi:10.1155/2013/974358 · Cited by 205 · see citing works
Coronary Artery Spasm: Review and Update
Hung, M., Hu, P., & Hung, M. (2014) · International Journal of Medical Sciences · doi:10.7150/ijms.9623 · Cited by 207 · see citing works
Phoswa, W. N., & Khaliq, O. P. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/5581570 · Cited by 208 · see citing works
Oxidative Stress in Hypertension: Role of the Kidney
Araújo, M., & Wilcox, C. S. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5259 · Cited by 187 · see citing works
Elimination of Vitamin D Receptor in Vascular Endothelial Cells Alters Vascular Function
Wei Min, N. I., Watts, S. W., Ng, M., Chen, S., Glenn, D. J., & Gardner, D. G. (2014) · Hypertension · doi:10.1161/hypertensionaha.114.03971 · Cited by 167 · see citing works
Targeting Ferroptosis against Ischemia/Reperfusion Cardiac Injury
Lillo‐Moya, J., Rojas-Solé, C., Muñoz-Salamanca, D., Panieri, E., Saso, L., & Rodrigo, R. (2021) · Antioxidants · doi:10.3390/antiox10050667 · Cited by 161 · see citing works
Role of Reactive Oxygen Species in Aging and Age-Related Diseases: A Review
Anik, M. I., Mahmud, N., Masud, A. A., Khan, M. I., Islam, M. N., Uddin, S., & Hossain, M. K. (2022) · ACS Applied Bio Materials · doi:10.1021/acsabm.2c00411 · Cited by 156 · see citing works
Lipid Peroxidation in Atherosclerotic Cardiovascular Diseases
Gianazza, E., Brioschi, M., Fernandez, A. M., Casalnuovo, F., Altomare, A., Aldini, G., & Banfi, C. (2020) · Antioxidants and Redox Signaling · doi:10.1089/ars.2019.7955 · Cited by 158 · see citing works
Oxidative Stress, Antioxidants and Hypertension
Amponsah-Offeh, M., Diaba‐Nuhoho, P., Speier, S., & Morawietz, H. (2023) · Antioxidants · doi:10.3390/antiox12020281 · Cited by 160 · see citing works
Extra Virgin Olive Oil and Cardiovascular Diseases: Benefits for Human Health
Nocella, C., Cammisotto, V., Fianchini, L., D’Amico, A., Novo, M., Castellani, V., Stefanini, L., Violi, F., & Carnevale, R. (2017) · Endocrine Metabolic & Immune Disorders - Drug Targets · doi:10.2174/1871530317666171114121533 · Cited by 138 · see citing works
Wong, S. K., Chin, K., Suhaimi, F. H., Ahmad, F., & Ima-Nirwana, S. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00444 · Cited by 132 · see citing works
Oxidative Stress, Atherogenic Dyslipidemia, and Cardiovascular Risk
Vekić, J., Stromsnes, K., Mazzalai, S., Zeljković, A., Rizzo, M., & Gambini, J. (2023) · Biomedicines · doi:10.3390/biomedicines11112897 · Cited by 129 · see citing works
Speisky, H., López‐Alarcón, C., Gómez, M., Fuentes, J., & Sandoval-Acuña, C. (2012) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf205167k · Cited by 128 · see citing works
Oxidative Stress and Cardiac Remodeling: An Updated Edge
Rababa’h, A. M., Guillory, A. N., Mustafa, R., & Hijjawi, T. B. (2018) · Current Cardiology Reviews · doi:10.2174/1573403x14666180111145207 · Cited by 125 · see citing works
Axelsen, L. N., Calløe, K., Holstein‐Rathlou, N., & Nielsen, M. S. (2013) · Frontiers in Pharmacology · doi:10.3389/fphar.2013.00130 · Cited by 121 · see citing works
Antioxidant therapy for management of oxidative stress induced hypertension
Ahmad, K. A., Yuan, D. Y., Nawaz, W., Hong, Z., Zhuo, C. X., Talal, B., Taleb, A., Mais, E., & Qi-long, D. (2017) · Free Radical Research · doi:10.1080/10715762.2017.1322205 · Cited by 118 · see citing works
The Antioxidant Therapy: New Insights in the Treatment of Hypertension
Sorriento, D., LUCA, N. D., Trimarco, B., & Iaccarino, G. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00258 · Cited by 119 · see citing works
Al-Magableh, M., Kemp‐Harper, B. K., & Hart, J. L. (2014) · Hypertension Research · doi:10.1038/hr.2014.125 · Cited by 118 · see citing works
Metformin in cardiovascular diabetology: a focused review of its impact on endothelial function
Ding, Y., Zhou, Y., Ling, P., Feng, X., Luo, S., Zheng, X., Little, P. J., Xu, S., & Weng, J. (2021) · Theranostics · doi:10.7150/thno.64706 · Cited by 121 · see citing works
Redox signaling in pathophysiology of hypertension
Majzúnová, M., Dovinová, I., Barančı́k, M., & Chan, J. Y. H. (2013) · Journal of Biomedical Science · doi:10.1186/1423-0127-20-69 · Cited by 116 · see citing works
Saura, M., Marquez, S. B., Reventún, P., Olea‐Herrero, N., Arenas, M. I., Moreno‐Gómez‐Toledano, R., Gómez‐Parrizas, M., Muñóz‐Moreno, C., Martínez, M. G.-S., Zaragoza, C., et al. (2014) · The FASEB Journal · doi:10.1096/fj.14-252460 · Cited by 113 · see citing works
Erejuwa, O. O., Sulaiman, S. A., Wahab, M. S. A., Sirajudeen, K. N. S., Salleh, M. S. M., & Gurtu, S. (2012) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2012/374037 · Cited by 101 · see citing works
Senaphan, K., Kukongviriyapan, U., Sangartit, W., Pakdeechote, P., Pannangpetch, P., Prachaney, P., Greenwald, S. E., & Kukongviriyapan, V. (2015) · Nutrients · doi:10.3390/nu7085283 · Cited by 99 · see citing works
Adherence to the DASH Diet and Risk of Hypertension: A Systematic Review and Meta-Analysis
Theodoridis, X., Chourdakis, M., Chrysoula, L., Chroni, V., Tirodimos, I., Δίπλα, Κ., Gkaliagkousi, Ε., & Triantafyllou, Α. (2023) · Nutrients · doi:10.3390/nu15143261 · Cited by 99 · see citing works
Tinkov, A. A., Bjørklund, G., Skalny, A. V., Holmgren, A., Геннадиевна, С. М., Chirumbolo, S., & Aaseth, J. (2018) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-018-2745-8 · Cited by 94 · see citing works
The Role of PPARγ in Cardiovascular Diseases
Kvandová, M., Majzúnová, M., & Dovinová, I. (2016) · Physiological Research · doi:10.33549/physiolres.933439 · Cited by 94 · see citing works
Quiñones, M., Guerrero, L., Suárez, M., Pons, Z., Aleixandre, A., Arola, L., & Muguerza, B. (2013) · Food Research International · doi:10.1016/j.foodres.2013.01.023 · Cited by 93 · see citing works
Vascular Extracellular Matrix Remodeling and Hypertension
Cai, Z., Gong, Z., Li, Z., Li, L., & Kong, W. (2020) · Antioxidants and Redox Signaling · doi:10.1089/ars.2020.8110 · Cited by 93 · see citing works
Pitter, G., Jeddi, M. Z., Barbieri, G., Gion, M., Fabricio, A. S. C., Daprà, F., Russo, F., Fletcher, T., & Canova, C. (2020) · Environmental Health · doi:10.1186/s12940-020-00656-0 · Cited by 83 · see citing works
Zhu, X., Cheang, I., Tang, Y., Shi, M., Zhu, Q., Gao, R., Liao, S., Yao, W., Zhou, Y., Zhang, H., et al. (2023) · Journal of the American Heart Association · doi:10.1161/jaha.122.027568 · Cited by 82 · see citing works
Redox-inflammatory synergy in the metabolic syndrome
Bryan, S., Baregzay, B., Spicer, D., Singal, P. K., & Khaper, N. (2013) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2012-0295 · Cited by 80 · see citing works
Antihypertensive Role of Polyphenols
Rodrigo, R., Gil, D., Miranda-Merchak, A., & Kalantzidis, G. (2012) · Advances in clinical chemistry · doi:10.1016/b978-0-12-394383-5.00014-x · Cited by 79 · see citing works
Isometric Exercise Training and Arterial Hypertension: An Updated Review
Edwards, J. J., Coleman, D. A., Ritti‐Dias, R. M., Farah, B. Q., Stensel, D. J., Lucas, S. J. E., Millar, P. J., Gordon, B. D., Cornelissen, V., Smart, N. A., et al. (2024) · Sports Medicine · doi:10.1007/s40279-024-02036-x · Cited by 76 · see citing works
Sun, X., Kumar, S., Sharma, S., Aggarwal, S., Lü, Q., Groß, C., Rafikova, O., Lee, S. G., Dasarathi, S., Hou, Y., et al. (2014) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2013-0187oc · Cited by 75 · see citing works
Li, M., Fan, W., & Xu, Y. (2021) · LWT · doi:10.1016/j.lwt.2021.112221 · Cited by 69 · see citing works
Novel Therapeutic Strategies for Traumatic Brain Injury: Acute Antioxidant Reinforcement
Fernández-Gajardo, R., Matamala, J. M., Carrasco, R. A., Gutiérrez, R., Melo, R., & Rodrigo, R. (2014) · CNS Drugs · doi:10.1007/s40263-013-0138-y · Cited by 68 · see citing works
Higashino, S., Sasaki, Y., Giddings, J. C., Hyodo, K., Sakata, S. F., Matsuda, K., Horikawa, Y., & Yamamoto, J. (2014) · Phytotherapy Research · doi:10.1002/ptr.5130 · Cited by 68 · see citing works
Wu, P.-T., Fitschen, P. J., Kistler, B. M., Jeong, J., Chung, H. R., Aviram, M., Phillips, S. A., Fernhall, B., & Wilund, K. R. (2015) · Journal of Medicinal Food · doi:10.1089/jmf.2014.0103 · Cited by 66 · see citing works
Deo, S. H., Fisher, J. P., Vianna, L. C., Kim, A., Chockalingam, A., Zimmerman, M. C., Zucker, I. H., & Fadel, P. J. (2012) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00289.2012 · Cited by 66 · see citing works
Serum bilirubin and the risk of hypertension
Wang, L., & Bautista, L. E. (2014) · International Journal of Epidemiology · doi:10.1093/ije/dyu242 · Cited by 63 · see citing works
Francisqueti‐Ferron, F. V., Ferron, A. J. T., Garcia, J. L., Silva, C. C. V. D. A., Costa, M. R., Gregolin, C. S., Moreto, F., Ferreira, A. L. A., Minatel, I. O., & Corrêa, C. R. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20133208 · Cited by 63 · see citing works
Kim, J. Y., Lee, J.-S., Han, Y.-S., Lee, J. H., Bae, I., Yoon, Y. M., Kwon, S. M., & Lee, S. H. (2015) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2015.085 · Cited by 59 · see citing works
Rao, K. N. S., Shen, X., Pardue, S., & Krzywanski, D. M. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101650 · Cited by 61 · see citing works
Antihypertensive effect of spent brewer yeast peptide
Amorim, M., Marques, C., Pereira, J. O., Guardão, L., Martins, M. J., Osório, H., Moura, D., Calhau, C., Pinheiro, H., & Pintado, M. (2018) · Process Biochemistry · doi:10.1016/j.procbio.2018.10.004 · Cited by 61 · see citing works
Deo, S. H., Jenkins, N. T., Padilla, J., Parrish, A. R., & Fadel, P. J. (2013) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00347.2013 · Cited by 60 · see citing works
Cellular Stress and General Pathological Processes
Gusev, E. Y., & Zotova, N. V. (2019) · Current Pharmaceutical Design · doi:10.2174/1381612825666190319114641 · Cited by 58 · see citing works
Role of oxidative stress on chronic kidney disease progression.
Putri, A. Y., & Thaha, M. (2014) · Acta medica Indonesiana · Cited by 58 · see citing works
Tain, Y., & Hsu, C. (2022) · Antioxidants · doi:10.3390/antiox11030511 · Cited by 57 · see citing works
Su, Q., Liu, J., Cui, W., Shi, X., Guo, J., Li, H., Huo, C.-J., Miao, Y.-W., Zhang, M., Yang, Q., et al. (2015) · Toxicology Letters · doi:10.1016/j.toxlet.2015.10.019 · Cited by 57 · see citing works
Maciejczyk, M., Taranta‐Janusz, K., Wasilewska, A. M., Kossakowska, A., & Zalewska, A. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9030837 · Cited by 53 · see citing works
Al-Waili, N., Salom, K., Al-Ghamdi, A., Ansari, M. J., Al-Waili, A. N., & Al-Waili, T. N. (2013) · Journal of Medicinal Food · doi:10.1089/jmf.2012.0285 · Cited by 54 · see citing works
Bornhoeft, J., Castaneda, D., Nemoseck, T., Wang, P., Henning, S. M., & Hong, M. Y. (2012) · Journal of Medicinal Food · doi:10.1089/jmf.2011.0258 · Cited by 52 · see citing works
Cao, Y., Zhang, Y., Wang, N., & He, L. (2014) · Journal of the American Society of Hypertension · doi:10.1016/j.jash.2014.04.006 · Cited by 53 · see citing works
Rodrigo, R., Retamal, C., Schupper, D., Vergara-Hernández, D., Saha, S., Profumo, E., Buttari, B., & Saso, L. (2022) · Molecules · doi:10.3390/molecules27082564 · Cited by 52 · see citing works
Barghchi, H., Dehnavi, Z., Nattagh‐Eshtivani, E., Alwaily, E. R., Almulla, A. F., Kareem, A. K., Barati, M., Ranjbar, G., Mohammadzadeh, A., Rahimi, P., et al. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114624 · Cited by 52 · see citing works
Potential Benefits of Antioxidant Phytochemicals in Type 2 Diabetes
Arabshomali, A., Bazzazzadehgan, S., Mahdi, F., & Shariat‐Madar, Z. (2023) · Molecules · doi:10.3390/molecules28207209 · Cited by 54 · see citing works
Astaxanthin inhibits thrombosis in cerebral vessels of stroke-prone spontaneously hypertensive rats
Sasaki, Y., Kobara, N., Higashino, S., Giddings, J. C., & Yamamoto, J. (2011) · Nutrition Research · doi:10.1016/j.nutres.2011.09.010 · Cited by 50 · see citing works
Nrf2 inhibition induces oxidative stress, renal inflammation and hypertension in mice
Farooqui, Z., Mohammad, R. S., Lokhandwala, M. F., & Banday, A. A. (2020) · Clinical and Experimental Hypertension · doi:10.1080/10641963.2020.1836191 · Cited by 49 · see citing works
Hypotension as a marker or mediator of perioperative organ injury: a narrative review
Ackland, G. L., & Abbott, T. E. F. (2022) · British Journal of Anaesthesia · doi:10.1016/j.bja.2022.01.012 · Cited by 50 · see citing works
BioAge: Toward a multi-determined, mechanistic account of cognitive aging
DeCarlo, C. A., Tuokko, H. A., Williams, D., Dixon, R. A., & MacDonald, S. W. S. (2014) · Ageing Research Reviews · doi:10.1016/j.arr.2014.09.003 · Cited by 46 · see citing works
Prdx6 Upregulation by Curcumin Attenuates Ischemic Oxidative Damage via SP1 in Rats after Stroke
Jia, G., Tan, B., Ma, J., Zhang, L., Jin, X., & Li, C. (2017) · BioMed Research International · doi:10.1155/2017/6597401 · Cited by 45 · see citing works
Isocitrate dehydrogenase 2 deficiency aggravates prolonged high-fat diet intake-induced hypertension
Noh, M. R., Kong, M. J., Han, S. J., Kim, J. I., & Park, K. M. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101548 · Cited by 45 · see citing works
Renal Dopamine Receptors and Oxidative Stress: Role in Hypertension
Yang, J., Villar, V. A. M., José, P. A., & Zeng, C. (2020) · Antioxidants and Redox Signaling · doi:10.1089/ars.2020.8106 · Cited by 45 · see citing works
Hypertension-related risk for dementia: A summary review with future directions.
Daugherty, A. M. (2021) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2021.03.002 · Cited by 39 · see citing works
Martineau-Côté, D., Achouri, A., Karboune, S., & L’Hocine, L. (2024) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.4c00829 · Cited by 44 · see citing works
Liang, D., Liu, L., Ye, C.-G., Zhao, L., Yu, F., Gao, D., Wang, Y., Yang, Z., & Wang, Y. (2013) · PLoS ONE · doi:10.1371/journal.pone.0064895 · Cited by 43 · see citing works
Mendes-Júnior, L. G., Monteiro, M. M. D. O., Carvalho, A. D. S., de Queiroz, T. M., & Braga, V. A. (2013) · Applied Physiology Nutrition and Metabolism · doi:10.1139/apnm-2013-0091 · Cited by 43 · see citing works
Li, J., Li, J., Li, Q., & Zhou, B. (2014) · Molecules · doi:10.3390/molecules190913587 · Cited by 42 · see citing works
Johnston, E. K., & Abbott, R. D. (2023) · Cells · doi:10.3390/cells12030407 · Cited by 41 · see citing works
Beňová, T. E., Bačová, B. S., Viczenczová, C., Diez, E. R., Barančı́k, M., & Tribulová, N. (2016) · Physiological Research · doi:10.33549/physiolres.933391 · Cited by 41 · see citing works
Lin, P. D., Cárdenas, A., Hauser, R. B., Gold, D. R., KLEINMAN, K. P., Hivert, M., Calafat, A. M., Webster, T. F., Horton, E. S., & Oken, E. (2020) · Environment International · doi:10.1016/j.envint.2020.105573 · Cited by 42 · see citing works
Rattanavipanon, W., Nithiphongwarakul, C., Sirisuwansith, P., Chaiyasothi, T., Thakkinstian, A., Nathisuwan, S., & Pathomwichaiwat, T. (2021) · Phytomedicine · doi:10.1016/j.phymed.2021.153512 · Cited by 41 · see citing works
Ramli, I., Posadino, A. M., Giordo, R., Fenu, G., Fardoun, M., Iratni, R., Eid, A. H., Zayed, H., & Pintus, G. (2023) · Antioxidants · doi:10.3390/antiox12020341 · Cited by 39 · see citing works
Ozone and hypertensive disorders of pregnancy in Florida: Identifying critical windows of exposure
Hu, H. Z., Ha, S., & Xu, X. (2016) · Environmental Research · doi:10.1016/j.envres.2016.12.002 · Cited by 40 · see citing works
Current insights and future perspectives of flavonoids: A promising antihypertensive approach
Harahap, U., Syahputra, R. A., Ahmed, A., Nasution, A., Wisely, W., Sirait, M. L., Dalimunthe, A., Zainalabidin, S., Taslim, N. A., Nurkolis, F., et al. (2024) · Phytotherapy Research · doi:10.1002/ptr.8199 · Cited by 38 · see citing works
Oxidative stress in patients with essential hypertension: A comparison of dippers and non-dippers
Gönenç, A., Hacışevki, A., Tavıl, Y., Çengel, A., & Torun, M. (2012) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2012.08.016 · Cited by 38 · see citing works
Aremu, O. O., Oyedeji, A. O., Oyedeji, O. O., Nkeh-Chungag, B. N., & Sewani-Rusike, C. R. (2019) · Antioxidants · doi:10.3390/antiox8080309 · Cited by 38 · see citing works
Andrés, C. M. C., de la Lastra, J. M. P., Andrés, C., Plou, F. J., & Pérez‐Lebeña, E. (2023) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.23455 · Cited by 40 · see citing works
Maideen, N. M. P., Balasubramanian, R., & Ramanathan, S. (2020) · Current Cardiology Reviews · doi:10.2174/1573403x16666201110125906 · Cited by 35 · see citing works
Kobi, J. B. B. S., Matias, A. M., Gasparini, P. V. F., Sales, S. T., Madureira, A. R., da Silva, D. S., Corrêa, C. R., Garcia, J. L., Haese, D., Nogueira, B. V., et al. (2023) · Physiological Reports · doi:10.14814/phy2.15635 · Cited by 35 · see citing works
Diosmin Protects Rat Retina from Ischemia/Reperfusion Injury
Tong, N., Zhang, Z., Gong, Y., Yin, L., & Wu, X. (2012) · Journal of Ocular Pharmacology and Therapeutics · doi:10.1089/jop.2011.0218 · Cited by 35 · see citing works
Emergency Management of Hypertension in Children
Singh, D., Akingbola, O., Yosypiv, I. V., & El-Dahr, S. S. (2012) · International Journal of Nephrology · doi:10.1155/2012/420247 · Cited by 35 · see citing works
Kunutsor, S. K., Kieneker, L. M., Burgess, S., Bakker, S. J. L., & Dullaart, R. P. F. (2017) · Journal of the American Heart Association · doi:10.1161/jaha.117.006503 · Cited by 37 · see citing works
Antihypertensive Indigenous Lebanese Plants: Ethnopharmacology and a Clinical Trial
Samaha, A., Fawaz, M. A., Salami, A., Baydoun, S. A., & Eid, A. H. (2019) · Biomolecules · doi:10.3390/biom9070292 · Cited by 34 · see citing works
- Authors
- Rodrigo, R., González, J., & Paoletto, F.
- Affiliations
- University of Chile (CL)
- Corresponding author
- Rodrigo, Ramón
- ORCID
- Rodrigo, Ramón
- Venue
- Hypertension Research
- Published
- 2011-01-13
- Volume
- 34
- Issue
- 4
- Pages
- 431-440
- ISSN
- 0916-9636 (ISSN-L)
- 1348-4214
- OpenAlex
- W2065634680
- Cited by
- 436
- References
- 164
- Citations by year
- 2026: 6 · 2025: 33 · 2024: 35 · 2023: 60 · 2022: 52 · 2021: 47 · 2020: 44 · 2019: 26 · 2018: 19 · 2017: 18 · 2016: 15 · 2015: 21 · 2014: 19 · 2013: 17 · 2012: 21
- FWCI
- 2.03
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Hypertension Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Keywords
- oxidative stress, hypertension, reactive oxygen species, nitric oxide bioavailability, vascular dysfunction, vascular remodeling, antioxidant vitamins, vitamin C, vitamin E, angiotensin II, endothelin-1, urotensin II, superoxide, hydrogen peroxide, antioxidant therapy
- MeSH terms
- Antioxidants, Blood Pressure, Cardiovascular System, Humans, Hypertension, Reactive Oxygen Species, Oxidative Stress
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
