Cited by 223Bipolar Disorder and TreatmentChild Abuse and TraumaPersonality Disorders and Psychopathology

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Childhood Trauma Is Associated With Severe Clinical Characteristics of Bipolar Disorders

Etain, Bruno, Aas, Monica, Andreassen, Ole A., Lorentzen, Steinar, Dieset, Ingrid, Gard, Sebastien, Kahn, Jean-Pierre, Bellivier, Frank, Leboyer, Marion, Melle, Ingrid, Henry, Chantal·2013·The Journal of Clinical Psychiatry

DOI 10.4088/jcp.13m08353

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Abstract

Objective Beyond genetic risk variants, the pathophysiology of bipolar disorders is likely to be partly determined by environmental susceptibility factors. Our study is one of the first to investigate, in a large sample of well-characterized bipolar patients, associations between clinical presentations and childhood trauma subtypes, including neglect and abuse items. Method 587 patients with DSM-IV-defined bipolar disorder were recruited from France and Norway between 1996-2008 and 2007-2012, respectively. History of childhood trauma was obtained using the Childhood Trauma Questionnaire. Clinical variables were assessed with the Structured Clinical Interview for DSM-IV Axis I Disorders (Norwegian sample) or the Diagnostic Interview for Genetic Studies (French sample). Results Earlier age at onset of bipolar illness, suicide attempts, rapid cycling, and an increased number of depressive episodes each had significant associations (P ≤ .001) with at least 1 subtype of childhood trauma (emotional abuse, sexual abuse, and emotional neglect). Multivariate analyses investigating trauma variables together showed that both emotional and sexual abuse were independent predictors of lower age at onset (P = .002 for each) and history of suicide attempts (OR = 1.60 [95% CI, 1.07 to 2.39], P = .023; OR = 1.80 [95% CI, 1.14 to 2.86], P = .012, respectively), while sexual abuse was the strongest predictor of rapid cycling (OR = 2.04 [95% CI, 1.21 to 3.42], P = .007). Females reported overall…

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Authors: Etain, B., Aas, M., Andreassen, O. A., Lorentzen, S., Dieset, I., Gard, S., Kahn, J.-P., Bellivier, F., Leboyer, M., Melle, I., & Henry, C.
Affiliations: Inserm (FR)
Corresponding author: Aas, Monica
ORCID: Aas, Monica
Andreassen, Ole A.
Lorentzen, Steinar
Dieset, Ingrid
Kahn, Jean-Pierre
Bellivier, Frank
Leboyer, Marion
Melle, Ingrid
Henry, Chantal
Venue: The Journal of Clinical Psychiatry
Publisher: Physicians Postgraduate Press, Inc
Published: 2013-10-15
Volume: 74
Issue: 10
Pages: 991-998
ISSN: 0160-6689 (ISSN-L)
DOI: 10.4088/jcp.13m08353
OpenAlex: W2005920624
Cited by: 223
References: 0
Citations by year: 2026: 10 · 2025: 13 · 2024: 15 · 2023: 27 · 2022: 14 · 2021: 14 · 2020: 21 · 2019: 15 · 2018: 13 · 2017: 17 · 2016: 24 · 2015: 20 · 2014: 17 · 2013: 2
FWCI: 14.88
Type: journal article
Language: en
Open access: closed
Locations: The Journal of Clinical Psychiatry (publishedVersion)
PubMed (publishedVersion)
Research Portal (King's College London) (submittedVersion)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
Social Sciences › Psychology › Clinical Psychology › Personality Disorders and Psychopathology
Keywords: childhood trauma, bipolar disorder, emotional abuse, sexual abuse, emotional neglect, age of onset, suicide attempts, rapid cycling, depressive episodes, sex differences, environmental risk factors, Childhood Trauma Questionnaire
MeSH terms: Adult, Bipolar Disorder, Child, Child Abuse, Female, France, Humans, Male, Middle Aged, Norway, Psychiatric Status Rating Scales, Surveys and Questionnaires, Statistics as Topic, Suicide, Attempted, Age of Onset, Diagnostic and Statistical Manual of Mental Disorders, Adult Survivors of Child Abuse

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Childhood Trauma Is Associated With Severe Clinical Characteristics of Bipolar Disorders

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