METHYLATION OF SEROTONIN RECEPTOR 3A IN ADHD, BORDERLINE PERSONALITY, AND BIPOLAR DISORDERS: LINK WITH SEVERITY OF THE DISORDERS AND CHILDHOOD MALTREATMENT: Research Article: Epigenetics of 5HT 3A R in Psychiatric Disorders
Open accessAbstract
BACKGROUND: Serotonin 3A receptor (5-HT3A R) is associated at the genetic and epigenetic levels with a variety of psychiatric disorders and interacts with early-life stress such as childhood maltreatment. We studied the impact of childhood maltreatment on the methylation status of the 5-HT3A R and its association with clinical severity outcomes in relation with a functional genetic polymorphism. METHODS: Clinical severity indexes of 346 bipolar, borderline personality, and adult attention deficit hyperactivity disorders patients were tested for association with the DNA methylation status of eight 5-HT3A R gene CpGs. Relationship between the functional variant rs1062613 (C > T) and methylation status on severity of the disorders were also assessed. RESULTS: Childhood maltreatment was associated with higher severity of the disease (higher number of mood episodes, history of suicide attempts, hospitalization, and younger age at onset) across disorders and within each individual disorder. This effect was mediated by two 5-HT3A R CpGs. Compared to T allele carriers, CC carriers had higher methylation status at one CpG located 1 bp upstream of this variant. CONCLUSIONS: This study shows that epigenetic modification of the 5-HT3A R is involved in the mechanism underlying the relationship between maltreatment in childhood and the severity of several psychiatric disorders in adulthood.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Hypermethylation in the 5-HT3A-R gene appeared to mediate the link between exposure to adversity and higher severity of disease parameters in a mixed sample of BD and Borderline PD.
“Moreover, hypermethylation in the 5-HT3A-R gene appeared to mediate the link between exposure to adversity and higher severity of disease parameters in a mixed sample of BD and Borderline PD (Perroud et al., 2016).”
From Can epigenetics shine a light on the biological pathways underlying major mental disorders? (2022) · cites this paper as Perroud et al., 2016
The Mediation Analysis reports that methylation at two 5-HT3A-R CpG sites mediated associations between childhood physical abuse and selected severity outcomes. But the sample included ADHD as well as bipolar disorder and borderline personality disorder, and the methylation–severity associations were not uniformly in the direction of hypermethylation (5HT3A-R Methylation Status According to Severity of Disorder). Page numbers are unavailable in our copy. (LLM, conf=0.88)
Experimental — accuracy not yet measuredSome studies in this review have found evidence that some genotypic variation in some risk alleles can influence DNA methylation.
“Although some studies presented in this review have found evidence that some genotypic variation in some risk alleles can influence DNAm (Klengel et al., 2013; Melas et al., 2013; Perroud et al., 2016)”
From Can epigenetics shine a light on the biological pathways underlying major mental disorders? (2022) · cites this paper as Perroud et al., 2016
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Jaenisch, R., & Bird, A. (2003) · Nature Genetics · doi:10.1038/ng1089 · Cited by 6,325 · see citing works
Kessler, R. C., Adler, L., Barkley, R., Biederman, J., Conners, C. K., Demler, O., Faraone, S. V., Greenhill, L. L., Howes, M. J., Secnik, K., et al. (2006) · American Journal of Psychiatry · doi:10.1176/ajp.2006.163.4.716 · Cited by 3,886 · see citing works
Merikangas, K. R., Akiskal, H. S., Angst, J., Greenberg, P. E., Hirschfeld, R. M. A., Petukhova, M., & Kessler, R. C. (2007) · Archives of General Psychiatry · doi:10.1001/archpsyc.64.5.543 · Cited by 2,399 · see citing works
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs
Cross-Disorder Group of the Psychiatric Genomics Consortium (2013) · Nature Genetics · doi:10.1038/ng.2711 · Cited by 2,263 · see citing works
Allele-specific FKBP5 DNA demethylation mediates gene–childhood trauma interactions
Klengel, T., Mehta, D., Anacker, C., Rex-Haffner, M., Pruessner, J. C., Pariante, C. M., Pace, T. W. W., Mercer, K. B., Mayberg, H. S., Bradley, B., et al. (2013) · Nature Neuroscience · doi:10.1038/nn.3275 · Cited by 1,447 · see citing works
(1993) · American Journal of Psychiatry · doi:10.1176/ajp.150.6.885 · Cited by 1,421 · see citing works
Borderline personality disorder
Leichsenring, F., Leibing, E., Kruse, J., New, A. S., & Leweke, F. (2011) · The Lancet · doi:10.1016/s0140-6736(10)61422-5 · Cited by 895 · see citing works
Hicks, R., & Tingley, D. H. (2011) · The Stata Journal Promoting communications on statistics and Stata · doi:10.1177/1536867x1201100407 · Cited by 810 · see citing works
Mehta, D., Klengel, T., Conneely, K. N., Smith, A. K., Altmann, A., Pace, T. W., Rex-Haffner, M., Loeschner, A., Gonik, M., Mercer, K. B., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1217750110 · Cited by 548 · see citing works
Perroud, N., Paoloni-Giacobino, A., Prada, P., Olié, E., Salzmann, A., Nicastro, R., Guillaume, S., Mouthon, D., Stouder, C., Dieben, K., et al. (2011) · Translational Psychiatry · doi:10.1038/tp.2011.60 · Cited by 516 · see citing works
Self-citationBroad Epigenetic Signature of Maternal Care in the Brain of Adult Rats
McGowan, P. O., Suderman, M., Sasaki, A., Huang, T. C. T., Hallett, M., Meaney, M. J., & Szyf, M. (2011) · PLoS ONE · doi:10.1371/journal.pone.0014739 · Cited by 452 · see citing works
Impact of childhood abuse on the clinical course of bipolar disorder
Garno, J. L., Goldberg, J. F., RAMIREZ, P. M., & Ritzler, B. A. (2005) · The British Journal of Psychiatry · doi:10.1192/bjp.186.2.121 · Cited by 413 · see citing works
McGough, J. J., Smalley, S. L., McCracken, J. T., YANG, M. H., Del’Homme, M., Lynn, D. E., & Loo, S. K. (2005) · American Journal of Psychiatry · doi:10.1176/appi.ajp.162.9.1621 · Cited by 398 · see citing works
Zanarini, M., Yong, L., Frankenburg, F., Hennen, J., Reich, D. B., Marino, M. F., & Vujanovic, A. A. (2002) · Journal of Nervous and Mental Disease · doi:10.1097/00005053-200206000-00006 · Cited by 357 · see citing works
Perroud, N., Rutembesa, E., Paoloni-Giacobino, A., Mutabaruka, J., Mutesa, L., Stenz, L., Malafosse, A., & Karege, F. (2014) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2013.866693 · Cited by 336 · see citing works
Self-citationSchaffer, A., Isometsä, E. T., Tondo, L., H Moreno, D., Turecki, G., Reis, C., Cassidy, F., Sinyor, M., Azorin, J., Kessing, L. V., et al. (2015) · Bipolar Disorders · doi:10.1111/bdi.12271 · Cited by 335 · see citing works
Response to psychotherapy in borderline personality disorder and methylation status of the BDNF gene
Perroud, N., Salzmann, A., Prada, P., Nicastro, R., Hoeppli, M.-E., Furrer, S., Ardu, S., Krejci, I., Karege, F., & Malafosse, A. (2013) · Translational Psychiatry · doi:10.1038/tp.2012.140 · Cited by 320 · see citing works
Self-citationPreisig, M., Fenton, B. T., Matthey, M., Berney, A., & Ferrero, F. (1999) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s004060050084 · Cited by 307 · see citing works
Early and late onset bipolar disorders: two different forms of manic-depressive illness?
Schürhoff, F., Bellivier, F., Jouvent, R., Mouren-Siméoni, M.-C., Bouvard, M., Allilaire, J.-F., & Leboyer, M. (2000) · Journal of Affective Disorders · doi:10.1016/s0165-0327(99)00111-1 · Cited by 297 · see citing works
Nierenberg, A. A., Miyahara, S., Spencer, T., Wisniewski, S. R., Otto, M. W., Simon, N. M., Pollack, M. H., Ostacher, M. J., Yan, L. J., Siegel, R. S., et al. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.01.036 · Cited by 283 · see citing works
Bernardi, S., Faraone, S. V., Cortese, S., Kerridge, B. T., Pallanti, S., Wang, S., & Blanco, C. (2012) · Psychological Medicine · doi:10.1017/s003329171100153x · Cited by 251 · see citing works
Borderline Personality Disorder and Childhood Sexual Abuse: A Meta-Analytic Study
Fossati, A., Madeddu, F., & Maffei, C. (1999) · Journal of Personality Disorders · doi:10.1521/pedi.1999.13.3.268 · Cited by 233 · see citing works
The interface between borderline personality disorder and bipolar spectrum disorders
Paris, J., Gunderson, J. G., & Weinberg, I. (2007) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2006.10.001 · Cited by 232 · see citing works
Childhood Trauma Is Associated With Severe Clinical Characteristics of Bipolar Disorders
Etain, B., Aas, M., Andreassen, O. A., Lorentzen, S., Dieset, I., Gard, S., Kahn, J.-P., Bellivier, F., Leboyer, M., Melle, I., et al. (2013) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.13m08353 · Cited by 223 · see citing works
Philipsen, A., Limberger, M. F., Lieb, K., Feige, B., Kleindienst, N., Ebner-Priemer, U., Barth, J., Schmahl, C., & Bohus, M. (2008) · British Journal of Psychiatry · doi:10.1192/bjp.bp.107.035782 · Cited by 220 · see citing works
Fossati, A., Novella, L., Donati, D., Donini, M., & Maffei, C. (2002) · Comprehensive Psychiatry · doi:10.1053/comp.2002.34634 · Cited by 191 · see citing works
Human 5-HT1A receptor C(−1019)G polymorphism and psychopathology
Huang, Y., Battistuzzi, C., Oquendo, M. A., Harkavy‐Friedman, J., Greenhill, L. L., Zalsman, G., Brodsky, B. S., Arango, V., Brent, D. A., & Mann, J. J. (2004) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145704004663 · Cited by 182 · see citing works
Song, J., Bergen, S. E., Kuja‐Halkola, R., Larsson, H., Landén, M., & Lichtenstein, P. (2014) · Bipolar Disorders · doi:10.1111/bdi.12242 · Cited by 163 · see citing works
Wingo, A. P., & Ghaemi, S. N. (2007) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v68n1118 · Cited by 160 · see citing works
Philipsen, A. (2006) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-006-1006-2 · Cited by 146 · see citing works
Arloth, J., Bogdan, R., Weber, P., Frishman, G., Menke, A., Wagner, K. V., Balsevich, G., Schmidt, M. V., Karbalai, N., Czamara, D., et al. (2015) · Neuron · doi:10.1016/j.neuron.2015.05.034 · Cited by 142 · see citing works
Martín-Blanco, A., Ferrer, M., Soler, J., Salazar, J., Vega, D., Andión, O., Sanchez-Mora, C., Arranz, M. J., Ribases, M., Feliu-Soler, A., et al. (2014) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2014.06.011 · Cited by 138 · see citing works
Transcriptional regulation of the 5-HT 1A receptor: implications for mental illness
Albert, P. R. (2012) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2011.0376 · Cited by 137 · see citing works
Niesler, B., Flohr, T., Nöthen, M. M., Fischer, C., Rietschel, M., Franzek, E., Albus, M., Propping, P., & Rappold, G. (2001) · Pharmacogenetics · doi:10.1097/00008571-200108000-00002 · Cited by 131 · see citing works
Childhood trauma in bipolar disorder
Watson, S., Gallagher, P., Dougall, D., Porter, R., Moncrieff, J., Ferrier, I. N., & Young, A. H. (2014) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867413516681 · Cited by 122 · see citing works
Thaler, L., Gauvin, L., Joober, R., Groleau, P., de Guzman, R., Ambalavanan, A., Israel, M., Wilson, S., & Steiger, H. (2014) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2014.04.010 · Cited by 117 · cited 1× · see citing works
“[1–3] For instance, several studies found distinct epigenetic profiles in psychiatric patients according to the presence or absence of exposure to childhood abuse.[1, 3, 4] Considering the severity of psychiatric disorders and specifically of mood disorders, a recent report showed that stratification for disease sever…”
BackgroundChameau, P. J. P., Inta, D., Vitalis, T., Monyer, H., Wadman, W. J., & van Hooft, J. A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0810764106 · Cited by 114 · see citing works
Kondo, M., Nakamura, Y., Ishida, Y., & Shimada, S. (2014) · Molecular Psychiatry · doi:10.1038/mp.2014.153 · Cited by 111 · see citing works
Bhatnagar, S., Sun, L. M., Raber, J., Maren, S., Julius, D. J., & Dallman, M. F. (2004) · Physiology & Behavior · doi:10.1016/j.physbeh.2004.01.018 · Cited by 103 · see citing works
Kishi, T., Yoshimura, R., Fukuo, Y., Okochi, T., Matsunaga, S., Umene‐Nakano, W., Nakamura, J., Serretti, A., Correll, C. U., Kane, J. M., et al. (2012) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-012-0337-4 · Cited by 101 · see citing works
Attention deficit hyperactivity disorder and borderline personality disorder
Davids, E., & Gastpar, M. (2005) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2005.04.033 · Cited by 98 · see citing works
Johnson, B. A., Seneviratne, C., Wang, X.-Q., Ait‐Daoud, N., & Li, M. D. (2013) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2013.12091163 · Cited by 97 · see citing works
Array‐Based Profiling of DNA Methylation Changes Associated with Alcohol Dependence
Zhang, H., Herman, A. I., Kranzler, H. R., Anton, R. F., Zhao, H., Zheng, W., & Gelernter, J. E. (2012) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2012.01928.x · Cited by 89 · see citing works
Gatt, J. M., Nemeroff, C. B., Schofield, P. R., Paul, R. H., Clark, C. R., Gordon, E., & Williams, L. M. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.06.025 · Cited by 88 · see citing works
Lotan, A., Fencková, M., Bralten, J., O’Leary, A., Dixson, L., Williams, R. W., & van der Voet, M. (2014) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00331 · Cited by 87 · see citing works
Bipolar and ADHD comorbidity: Both artifact and outgrowth of shared mechanisms.
Youngstrom, E. A., Arnold, L. E., & Frazier, T. W. (2010) · Clinical Psychology Science and Practice · doi:10.1111/j.1468-2850.2010.01226.x · Cited by 85 · see citing works
The relationship between early adversities and attention-deficit/hyperactivity disorder
Fuller-Thomson, E., & Lewis, D. A. (2015) · Child Abuse & Neglect · doi:10.1016/j.chiabu.2015.03.005 · Cited by 84 · see citing works
Carlberg, L., Scheibelreiter, J., Hassler, M. R., Schloegelhofer, M., Schmoeger, M., Ludwig, B., Kasper, S. F., Aschauer, H. N., Egger, G., & Schosser, A. (2014) · Journal of Affective Disorders · doi:10.1016/j.jad.2014.07.022 · Cited by 84 · see citing works
Serotonin receptor 3A controls interneuron migration into the neocortex
Murthy, S. S., Niquille, M., Hurni, N., Limoni, G., Frazer, S. L., Chameau, P. J. P., van Hooft, J. A., Vitalis, T., & Dayer, A. G. (2014) · Nature Communications · doi:10.1038/ncomms6524 · Cited by 81 · see citing works
Self-citationImpact of the HTR3A gene with early life trauma on emotional brain networks and depressed mood
Gatt, J. M., Williams, L. M., Schofield, P. R., Dobson‐Stone, C., Paul, R. H., Grieve, S. M., Clark, C. R., Gordon, E., & Nemeroff, C. B. (2010) · Depression and Anxiety · doi:10.1002/da.20726 · Cited by 76 · see citing works
Bipolar Disorder and Comorbid Personality Psychopathology
Fan, A. H., & Hassell, J. (2008) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v69n1115 · Cited by 75 · see citing works
ADHD in adolescents with borderline personality disorder
Speranza, M., Révah‐Levy, A., Cortese, S., Falissard, B., Pham‐Scottez, A., & Corcos, M. (2011) · BMC Psychiatry · doi:10.1186/1471-244x-11-158 · Cited by 75 · see citing works
Sanctis, V. A. D., Nomura, Y., Newcorn, J. H., & Halperin, J. M. (2012) · Child Abuse & Neglect · doi:10.1016/j.chiabu.2012.08.003 · Cited by 71 · see citing works
Prada, P., Hasler, R., Baud, P., Bednarz, G., Ardu, S., Krejci, I., Nicastro, R., Aubry, J., & Perroud, N. A. (2014) · Psychiatry Research · doi:10.1016/j.psychres.2014.03.006 · Cited by 67 · see citing works
Self-citationDNA Modification Study of Major Depressive Disorder: Beyond Locus-by-Locus Comparisons
Oh, G., Wang, S.-C., Pal, M., Chen, Z. F., Khare, T., Tochigi, M., Ng, C., Yang, Y. A., Kwan, A., Kaminsky, Z. A., et al. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.06.016 · Cited by 66 · see citing works
Bipolar Symptoms in Adult Attention-Deficit/Hyperactivity Disorder
Halmøy, A., Halleland, H. B., Dramsdahl, M., Bergsholm, P., Fasmer, O. B., & Haavik, J. (2010) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.08m04722ora · Cited by 63 · see citing works
New developments in the neurobiology of borderline personality disorder
Bohus, M., Schmahl, C. G., & Lieb, K. (2004) · Current Psychiatry Reports · doi:10.1007/s11920-004-0038-4 · Cited by 62 · see citing works
The 5-HT3A receptor is essential for fear extinctionPreprint
Kondo, M., Nakamura, Y., Ishida, Y., Yamada, T., & Shimada, S. (2013) · Learning & Memory · doi:10.1101/lm.032193.113 · Cited by 47 · see citing works
Hammer, C., Cichon, S., Mühleisen, T. W., Haenisch, B., Degenhardt, F., Mattheisen, M., Breuer, R., Witt, S. H., Strohmaier, J., Oruč, L., et al. (2012) · Translational Psychiatry · doi:10.1038/tp.2012.30 · Cited by 47 · see citing works
Perugi, G., Ceraudo, G., Vannucchi, G., Rizzato, S., Toni, C., & Dell'Osso, L. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2012.12.010 · Cited by 46 · see citing works
Prenatal stress-induced programming of genome-wide promoter DNA methylation in 5-HTT-deficient mice
Schraut, K., Jakob, S., Weidner, M. T., Schmitt, A. G., Scholz, C. J., Strekalova, T. V., Hajj, N. E., Eijssen, L., Domschke, K., Reif, A., et al. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.107 · Cited by 45 · see citing works
Matthies, S., van Elst, L. T., Feige, B., Fischer, D., Scheel, C. N., Krogmann, E., Perlov, E., Ebert, D., & Philipsen, A. (2011) · Journal of Personality Disorders · doi:10.1521/pedi.2011.25.1.101 · Cited by 43 · see citing works
Romo, L., Legauffre, C., Mille, S., Cheze, N., Fougères, A.-L., Marquez, S., Excoffier, A., Dubertret, C., & Adės, J. (2010) · L'Encephale · doi:10.1016/j.encep.2009.12.005 · Cited by 36 · see citing works
Yang, J., & Li, M. D. (2014) · Human Genetics · doi:10.1007/s00439-014-1431-7 · Cited by 33 · see citing works
Seneviratne, C., Franklin, J. F., Beckett, K., Ma, J. Z., Ait‐Daoud, N., Payne, T. J., Johnson, B. A., & Li, M. D. (2013) · Human Genetics · doi:10.1007/s00439-013-1319-y · Cited by 33 · see citing works
Impaired Social Behavior in 5-HT3A Receptor Knockout Mice
Smit‐Rigter, L. A., Wadman, W. J., & van Hooft, J. A. (2010) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2010.00169 · Cited by 31 · see citing works
Ethanol‐Induced Htr3a Promoter Methylation Changes in Mouse Blood and Brain
Barker, J. M., Zhang, Y., Wang, F., Taylor, J. R., & Zhang, H. (2012) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2012.01906.x · Cited by 29 · see citing works
Falkenberg, V. R., & Rajeevan, M. S. (2010) · Journal of Molecular Neuroscience · doi:10.1007/s12031-009-9320-6 · Cited by 22 · see citing works
Post, R. M., Altshuler, L. L., Leverich, G. S., Frye, M. A., Suppes, T. M., McElroy, S. L., Keck, P. E., Nolen, W. A., Kupka, R., Grunze, H., et al. (2014) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2014.08.050 · Cited by 13 · see citing works
Flagged first, then by citations
2 of the 71 references couldn’t be matched to a known paper.
Research works printed but not linked: 4
- Smit-Rigter LA, Wadman WJ, vanHooft JA. Impaired social be- havior in 5-HT(3A) receptor knockout mice. Front Behav Neu- rosci 2010;4:169.
- McIntyre RS, Kennedy SH, Soczynska JK, et al. Attention- deficit/hyperactivity disorder in adults with bipolar disorder or major depressive disorder: results from the international mood disorders collaborative project. Prim Care Companion J Clin Psy- chiatry 2010;12(3):e1-e7.
- Ward MF, Wender PH, Reimherr FW. The Wender Utah Rating Scale: an aid in the retrospective diagnosis of childhood attention deficit hyperactivity disorder. Am J Psychiatry 1993;150(6):885- 890.
- First MB, Spitzer RL, Gibbon M, Williams JBW. Structured Clin- ical Interview for DSM-IV Axis I Disorders, Clinician Version (SCID-CV). Washington, DC: American Psychiatric Press, Inc; 1996.
Cited by
Sorted by citations
The effects of childhood maltreatment on brain structure, function and connectivity
Teicher, M. H., Samson, J. A., Anderson, C. M., & Ohashi, K. (2016) · Nature Reviews Neuroscience · doi:10.1038/nrn.2016.111 · Cited by 1,856 · see citing works
Lippard, E. T. C., & Nemeroff, C. B. (2020) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2019.19010020 · Cited by 527 · see citing works
Childhood adversity and borderline personality disorder: a meta‐analysis
Porter, C., Palmier‐Claus, J., Branitsky, A., Mansell, W., Warwick, H., & Varese, F. (2020) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.13118 · Cited by 450 · see citing works
Brummelte, S., Mc Glanaghy, E., Bonnin, A., & Oberlander, T. F. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2016.02.037 · Cited by 306 · see citing works
Biomarkers of Suicide Attempt Behavior: Towards a Biological Model of Risk
Sudol, K., & Mann, J. J. (2017) · Current Psychiatry Reports · doi:10.1007/s11920-017-0781-y · Cited by 225 · see citing works
Borderline personality disorder and substance use disorders: an updated review
Trull, T. J., Freeman, L. K., Vebares, T. J., Choate, A. M., Helle, A. C., & Wycoff, A. M. (2018) · Borderline Personality Disorder and Emotion Dysregulation · doi:10.1186/s40479-018-0093-9 · Cited by 196 · see citing works
Parade, S. H., Huffhines, L. P., Daniels, T. E., Stroud, L. R., Nugent, N. R., & Tyrka, A. R. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01207-y · Cited by 177 · see citing works
Cattane, N., Rossi, R., Lanfredi, M., & Cattaneo, A. (2017) · BMC Psychiatry · doi:10.1186/s12888-017-1383-2 · Cited by 177 · see citing works
Childhood maltreatment and DNA methylation: A systematic review
Cecil, C. A. M., Zhang, Y., & Nolte, T. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.02.019 · Cited by 171 · see citing works
A review of DNA methylation in depression
Chen, D., Meng, L., Pei, F., Zheng, Y., & Leng, J. (2017) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2017.05.022 · Cited by 154 · see citing works
Childhood trauma in mood disorders: Neurobiological mechanisms and implications for treatment
Jaworska-Andryszewska, P., & RYBAKOWSKI, J. K. (2018) · Pharmacological Reports · doi:10.1016/j.pharep.2018.10.004 · Cited by 128 · see citing works
Lang, J., McKie, J., Smith, H. E., McLaughlin, A. L., Gillberg, C., Shiels, P. G., & Minnis, H. (2019) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-019-01329-1 · Cited by 125 · see citing works
Palladino, V. S., McNeill, R. V., Reif, A., & Kittel‐Schneider, S. (2019) · Psychiatric Genetics · doi:10.1097/ypg.0000000000000220 · Cited by 115 · see citing works
The Role of Trauma in Early Onset Borderline Personality Disorder: A Biopsychosocial Perspective
Bozzatello, P., Rocca, P., Baldassarri, L., Bosia, M., & Bellino, S. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.721361 · Cited by 111 · see citing works
Bipolar disorder: Trimodal age‐at‐onset distribution
Bolton, S., Warner, J., Harriss, E., Geddes, J. R., & Saunders, K. E. A. (2020) · Bipolar Disorders · doi:10.1111/bdi.13016 · Cited by 115 · see citing works
Epigenetics in Personality Disorders: Today's Insights
Gescher, D. M., Kahl, K. G., Hillemacher, T., Frieling, H., Kuhn, J., & Frodl, T. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00579 · Cited by 109 · see citing works
Intergenerational transmission of DNA methylation signatures associated with early life stress
Stenz, L., Schechter, D. S., Serpa, S. R., & Paoloni-Giacobino, A. (2018) · Current Genomics · doi:10.2174/1389202919666171229145656 · Cited by 101 · see citing works
Self-citationFakhfouri, G., Rahimian, R., Dyhrfjeld‐Johnsen, J., Zirak, M. R., & Beaulieu, J. (2019) · Pharmacological Reviews · doi:10.1124/pr.118.015487 · Cited by 103 · see citing works
Epigenetics in depression and gut-brain axis: A molecular crosstalk
Begum, N., Mandhare, A., Tryphena, K. P., Srivastava, S., Shaikh, M. F., Singh, S. B., & Khatri, D. K. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.1048333 · Cited by 99 · see citing works
Bartlett, A. A., Singh, R., & Hunter, R. G. (2017) · Advances in Experimental Medicine and Biology · doi:10.1007/978-3-319-53889-1_8 · Cited by 91 · see citing works
Dissecting bipolar disorder complexity through epigenomic approach
Ludwig, B., & Dwivedi, Y. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.123 · Cited by 85 · see citing works
Rasmi, Y., Shokati, A., Hassan, A., Aziz, S. G., Bastani, S., Jalali, L., Moradi, F., & Alipour, S. (2022) · IBRO Neuroscience Reports · doi:10.1016/j.ibneur.2022.12.002 · Cited by 87 · see citing works
The role of DNA methylation in the pathophysiology and treatment of bipolar disorder
Fries, G. R., Li, Q., McAlpin, B. R., Rein, T., Walss‐Bass, C., Soares, J. C., & Quevedo, J. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.06.010 · Cited by 82 · see citing works
Weiner, L., Perroud, N. A., & Weibel, S. (2019) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s192871 · Cited by 76 · see citing works
Self-citationThe Neurobiology of Borderline Personality Disorder
Pérez-Rodríguez, M. M., Bulbena‐Cabré, A., Nia, A. B., Zipursky, G., Goodman, M. S., & New, A. S. (2018) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2018.07.012 · Cited by 79 · see citing works
Ditrich, I., Philipsen, A., & Matthies, S. (2021) · Borderline Personality Disorder and Emotion Dysregulation · doi:10.1186/s40479-021-00162-w · Cited by 82 · see citing works
Prenatal risk factors and genetic causes of ADHD in children
Kian, N., Samieefar, N., & Rezaei, N. (2022) · World Journal of Pediatrics · doi:10.1007/s12519-022-00524-6 · Cited by 75 · see citing works
Psychometric properties of the French borderline symptom list, short form (BSL-23)
Nicastro, R., Prada, P., Küng, A., Salamin, V., Dayer, A. G., Aubry, J., Guenot, F., & Perroud, N. A. (2016) · Borderline Personality Disorder and Emotion Dysregulation · doi:10.1186/s40479-016-0038-0 · Cited by 65 · see citing works
Self-citationEpigenetics and ADHD: Toward an Integrative Approach of the Disorder Pathogenesis
Hamza, M., Halayem, S., Bourgou, S., Daoud, M., Charfi, F., & Belhadj, A. (2017) · Journal of Attention Disorders · doi:10.1177/1087054717696769 · Cited by 67 · see citing works
Lippard, E., & Nemeroff, C. B. (2023) · American Journal of Psychiatry · doi:10.1176/appi.ajp.19010020 · Cited by 63 · see citing works
Similarities between emotional dysregulation in adults suffering from ADHD and bipolar patients
Richard-Lepouriel, H., Étain, B., Hasler, R., Bellivier, F., Gard, S., Kahn, J., Prada, P., Nicastro, R., Ardu, S., Dayer, A. G., et al. (2016) · Journal of Affective Disorders · doi:10.1016/j.jad.2016.03.047 · Cited by 60 · see citing works
Self-citationCan epigenetics shine a light on the biological pathways underlying major mental disorders?
Alameda, L., Trotta, G., Quigley, H., Rodriguez, V., Gadelrab, R., Dwir, D., Dempster, E., Wong, C. C. Y., & Forti, M. D. (2022) · Psychological Medicine · doi:10.1017/s0033291721005559 · Cited by 60 · see citing works
Differential Diagnosis of Bipolar II Disorder and Borderline Personality Disorder
Bayes, A. J., Parker, G. B., & Paris, J. (2019) · Current Psychiatry Reports · doi:10.1007/s11920-019-1120-2 · Cited by 55 · see citing works
Sargin, D., Jeoung, H.-S., Goodfellow, N. M., & Lambe, E. K. (2019) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.9b00073 · Cited by 54 · see citing works
Nöthling, J., Malan-Müller, S., Abrahams, N., Hemmings, S. M. J., & Seedat, S. (2020) · The World Journal of Biological Psychiatry · doi:10.1080/15622975.2019.1583369 · Cited by 74 · see citing works
Ding, K.-J., Yang, J.-Z., Reynolds, G., Chen, B., Shao, J., Liu, R.-X., Qian, Q., Liu, H., Yang, R.-X., Wen, J.-F., et al. (2017) · World Journal of Biological Psychiatry · doi:10.1080/15622975.2016.1224928 · Cited by 55 · see citing works
Epigenetics in bipolar disorder: a critical review of the literature
Legrand, A., Iftimovici, A., Khayachi, A., & Chaumette, B. (2021) · Psychiatric Genetics · doi:10.1097/ypg.0000000000000267 · Cited by 48 · see citing works
Biological correlates of early life stressful events in major depressive disorder
Silva, R. C., Maffioletti, E., Gennarelli, M., Baune, B. T., & Minelli, A. (2020) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2020.105103 · Cited by 53 · see citing works
Schechter, D. S., Moser, D. A., Perizzolo, V. C., Aue, T., Stenz, L., Paoloni‐Giacobino, A., Adouan, W., Manini, A., Suardi, F., Vital, M., et al. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.10.009 · Cited by 52 · see citing works
Self-citationQuidé, Y., Tozzi, L., Corcoran, M., Cannon, D. M., & Dauvermann, M. R. (2020) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s285540 · Cited by 51 · see citing works
Cimino, S., Cerniglia, L., Ballarotto, G., Marzilli, E., Pascale, E., D’Addario, C., Adriani, W., & Tambelli, R. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2017.00303 · Cited by 48 · see citing works
Dualibe, A. L., & Osório, F. D. L. (2017) · Harvard Review of Psychiatry · doi:10.1097/hrp.0000000000000154 · Cited by 50 · see citing works
Childhood trauma, the stress response and metabolic syndrome: A focus on DNA methylation
Womersley, J. S., Nöthling, J., Toikumo, S., Malan‐Müller, S., van den Heuvel, L. L., McGregor, N. W., Seedat, S., & Hemmings, S. M. J. (2021) · European Journal of Neuroscience · doi:10.1111/ejn.15370 · Cited by 51 · see citing works
Soga, T., Teo, C. H., & Parhar, I. S. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2020.601868 · Cited by 47 · see citing works
Cimino, S., Cerniglia, L., Ballarotto, G., Marzilli, E., Pascale, E., D'Addario, C., Adriani, W., Maremmani, A., & Tambelli, R. (2019) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph16142567 · Cited by 44 · see citing works
Petruso, F., Giff, A., Milano, B. A., Rossi, M. M. D., & Saccaro, L. F. (2023) · Neuronal Signaling · doi:10.1042/ns20220077 · Cited by 51 · see citing works
Early life exposures, neurodevelopmental disorders, and transposable elements
Lapp, H. E., & Hunter, R. G. (2019) · Neurobiology of Stress · doi:10.1016/j.ynstr.2019.100174 · Cited by 44 · see citing works
Epigenetic mechanisms of stress and depression
Chmielewska, N., Szyndler, J., Maciejak, P., & Płaźnik, A. (2019) · Psychiatria Polska · doi:10.12740/pp/94375 · Cited by 46 · see citing works
Knoblich, N., Gundel, F., Brückmann, C., Becker-Sadzio, J., Frischholz, C., & Nieratschker, V. (2018) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2017.12.010 · Cited by 41 · see citing works
Wang, Y., Sun, Y., Missmer, S. A., Rexrode, K. M., Roberts, A. L., Chavarro, J. E., & Rich-Edwards, J. W. (2023) · BMJ · doi:10.1136/bmj-2022-073613 · Cited by 40 · see citing works
Epigenetic Mechanism of Early Life Stress-Induced Depression: Focus on the Neurotransmitter Systems
Cheng, Z., Su, J., Zhang, K. N., Jiang, H., & Li, B. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.929732 · Cited by 41 · see citing works
Lindsay, C., Seikaly, H. R., & Biron, V. L. (2017) · Journal of Otolaryngology - Head and Neck Surgery · doi:10.1186/s40463-017-0185-3 · Cited by 40 · see citing works
The Epigenetics of Early Life Adversity: Current Limitations and Possible Solutions
Barnett-Burns, S., Almeida, D. M., & Turecki, G. (2018) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2018.01.008 · Cited by 34 · see citing works
Zimmerman, M. A., Balling, C. E., Chelminski, I., & Dalrymple, K. L. (2020) · Psychological Medicine · doi:10.1017/s0033291720000215 · Cited by 31 · see citing works
Husain, S. F., Tang, T. B., Tam, W., Tran, B. X., Ho, C. S. H., & Ho, R. (2021) · BMC Psychiatry · doi:10.1186/s12888-021-03195-1 · Cited by 30 · see citing works
Tapping into 5-HT3 Receptors to Modify Metabolic and Immune Responses
Irving, H. R., Turek, I., Kettle, C., & Yaakob, N. S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222111910 · Cited by 30 · see citing works
Wilson, N., Robb, E., Gajwani, R., & Minnis, H. (2020) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2020.12.025 · Cited by 29 · see citing works
Rodriguez, A. M., Hogg, B., Gardoki-Souto, I., Valiente-Gómez, A., Trabsa, A., Mosquera, D., García-Estela, A., Colom, F., Pérez, V., Padberg, F., et al. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.681876 · Cited by 23 · see citing works
Jollant, F., Perreira, F., Fiori, L. M., Richard-Devantoy, S., Lutz, P.-E., Belzeaux, R., & Turecki, G. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.109909 · Cited by 25 · see citing works
Lippard, E., & Nemeroff, C. B. (2022) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2022.173361 · Cited by 26 · see citing works
Prenatal Alcohol Exposure in Rodents As a Promising Model for the Study of ADHD Molecular Basis
Rojas-Mayorquín, A. E., Padilla-Velarde, E., & Ortuño‐Sahagún, D. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00565 · Cited by 23 · see citing works
DNA-methylation dynamics across short-term, exposure-containing CBT in patients with panic disorder
Moser, S., Martins, J., Czamara, D., Lange, J. F., Müller‐Myhsok, B., & Erhardt, A. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-01802-7 · Cited by 23 · see citing works
DNA methylation associated with persistent ADHD suggests TARBP1 as novel candidate
Weiß, A. L., Meijer, M., Budeus, B., Pauper, M., Hakobjan, M., Groothuismink, J. M., Shi, Y., Neveling, K., Buitelaar, J. K., Hoogman, M., et al. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2020.108370 · Cited by 21 · see citing works
DNA Methylation in LIME1 and SPTBN2 Genes Is Associated with Attention Deficit in Children
Li, S., Kuo, H., Huang, L., Chou, W., Lee, S.-Y., Chan, W., & Wang, L. (2021) · Children · doi:10.3390/children8020092 · Cited by 19 · see citing works
Pisanu, C., Κάτσιλα, Θ., Patrinos, G. P., & Squassina, A. (2017) · Pharmacogenomics · doi:10.2217/pgs-2017-0111 · Cited by 19 · see citing works
Current Knowledge on Gene-Environment Interactions in Personality Disorders: an Update
Bulbena‐Cabré, A., Nia, A. B., & Pérez-Rodríguez, M. M. (2018) · Current Psychiatry Reports · doi:10.1007/s11920-018-0934-7 · Cited by 18 · see citing works
DNA methylation in adolescents with anxiety disorder: A longitudinal study
Bortoluzzi, A., Salum, G. A., da Rosa, E. D., Chagas, V. D. S., Castro, M. A. A., & Manfro, G. G. (2018) · Scientific Reports · doi:10.1038/s41598-018-32090-1 · Cited by 16 · see citing works
Serotonin system-associated genetic and epigenetic changes in pedophilia and child sexual offending
Jahn, K., Kurz, B., Sinke, C., Kneer, J., Riemer, O., Ponseti, J., Walter, M., Beier, K. M., Walter, H., Frieling, H., et al. (2021) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2021.11.042 · Cited by 15 · see citing works
Sculpting Cerebral Cortex with Serotonin in Rodent and Primate
Vitalis, T., & Verney, C. (2017) · InTech eBooks · doi:10.5772/intechopen.69000 · Cited by 14 · see citing works
Pfeiffer, J. R., Mutesa, L., & Uddin, M. (2018) · Current Behavioral Neuroscience Reports · doi:10.1007/s40473-018-0143-z · Cited by 14 · see citing works
The Impact of Emotional Lability Symptoms During Childhood in Adults With ADHD
Gisbert, L., Vanesa Richarte, B., Montse Corrales, F., Ibáñez, P., Bosch, R., Casas, M., & Ramos‐Quiroga, J. A. (2017) · Journal of Attention Disorders · doi:10.1177/1087054717719534 · Cited by 13 · see citing works
You, J. S., Lee, C. W., Park, J. Y., Jang, Y., Yu, H., Yoon, J., Kwon, S. S., Oh, S., Park, Y. S., Ryoo, H. A., et al. (2022) · Psychiatry Investigation · doi:10.30773/pi.2022.0114 · Cited by 11 · see citing works
Gescher, D. M., Schanze, D., Vavra, P., Wolff, P., Zimmer‐Bensch, G., Zenker, M., Frodl, T., & Schmahl, C. G. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02628-z · Cited by 10 · see citing works
Watamura, S. E., & Roth, T. L. (2018) · Developmental Psychobiology · doi:10.1002/dev.21796 · Cited by 11 · see citing works
A Neuroscience-Oriented Research Approach to Borderline Personality Disorder
Stanley, B., Pérez-Rodríguez, M. M., Labouliere, C. D., & Roose, S. P. (2018) · Journal of Personality Disorders · doi:10.1521/pedi_2018_32_326 · Cited by 18 · see citing works
Peedicayil, J. (2021) · Current Neuropharmacology · doi:10.2174/1570159x19666210920091036 · Cited by 9 · see citing works
Whitaker‐Azmitia, P. M. (2020) · Handbook of behavioral neuroscience · doi:10.1016/b978-0-444-64125-0.00023-2 · Cited by 9 · see citing works
Park, Y. (2020) · Brain Sciences · doi:10.3390/brainsci10060370 · Cited by 8 · see citing works
Tomasetti, C., Autullo, G., Ballerini, A. C., de Bartolomeis, A., Dell’Osso, B. M., Fiorentini, A., Tonioni, F., Villari, V., & Berardis, D. D. (2024) · Annals of General Psychiatry · doi:10.1186/s12991-024-00507-z · Cited by 8 · see citing works
Early life adversities, psychopathologies and novel pharmacological strategies
Cattaneo, A., Begni, V., Zonca, V., & Riva, M. A. (2024) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2024.108686 · Cited by 8 · see citing works
Childhood maltreatment and its impact on the mental health
Sivolap, Y. P., & Portnova, A. A. (2016) · S S Korsakov Journal of Neurology and Psychiatry · doi:10.17116/jnevro201611671108-112 · Cited by 6 · see citing works
Developmental Origins, Differential Susceptibility, and Resilience in Neurodevelopmental Disorders
White, M., Lafaille‐Magnan, M., Roche, C., Jolicoeur‐Martineau, A., Wazana, A. D., & Connor, K. L. (2023) · Springer eBooks · doi:10.1007/978-3-031-20792-1_45 · Cited by 4 · see citing works
Absconding among admitted patients with bipolar affective disorder diagnosis in Uganda
Abaatyo, J., Favina, A., & Kaggwa, M. M. (2023) · BMC Psychiatry · doi:10.1186/s12888-023-04794-w · Cited by 4 · see citing works
Petruso, F., Giff, A. E., Milano, B. A., Rossi, M. M. D., & Saccaro, L. F. (2023) · doi:10.31234/osf.io/2rnk8 · Cited by 4 · see citing works
DNA Methylation and Bipolar Disorder
Yang, Z., Zhang, S., Ouyang, L., Liao, A., He, Y., Li, Z., & Chen, X. (2023) · Journal of Psychiatry and Brain Science · doi:10.20900/jpbs.20230012 · Cited by 3 · see citing works
Della, T. P., Peper‐Nascimento, J., Varela, R. B., Daminelli, T., Fries, G. R., Ceretta, L. B., Juruena, M. F., Quevedo, J., & Valvassori, S. S. (2024) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-024-01917-6 · Cited by 3 · see citing works
Pace, U., D’Urso, G., Buzzai, C., Passanisi, A., & Zappulla, C. (2022) · Current Psychology · doi:10.1007/s12144-022-03706-7 · Cited by 4 · see citing works
Hestbæk, E., Pedersen, J. K., Kjærstad, H. L., Grage, K. R., Kessing, L. V., Simonsen, S., & Miskowiak, K. W. (2025) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2025.06.010 · Cited by 2 · see citing works
The Epigenetic Landscape of Borderline Personality Disorder: Insights from a Systematic Review
Dawidowski, B., Franczak, Ł., Podwalski, P., Michalczyk, A., Łupkowska-Grygorcewicz, A., Piotrowska, O., & Samochowiec, J. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14228182 · Cited by 2 · see citing works
Bimodal modulation of L1 interneuron activity in anterior cingulate cortex during fear conditioning
Fossati, G., Kiss-Bodolay, D., Prados, J., Chéreau, R., Husi, E., Cadilhac, C., Gómez, L., Silva, B. A., Dayer, A. G., & Holtmaat, A. J. D. G. (2023) · Frontiers in Neural Circuits · doi:10.3389/fncir.2023.1138358 · Cited by 2 · see citing works
Self-citationACE and its implication over the lifespan
Rokach, A., & Clayton, S. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-85853-3.00008-2 · Cited by 2 · see citing works
Trauma and Gene Expression: Understanding the Connections
Pilkay, S. R., & Combs-Orme, T. D. (2020) · Social Work Research · doi:10.1093/swr/svz024 · Cited by 2 · see citing works
Biomarkers for Bipolar Disorder
O’Leary, E., Dodd, S., & Berk, M. (2023) · Springer eBooks · doi:10.1007/978-3-031-43356-6_14 · Cited by 2 · see citing works
Moore, J. T., Sunthimer, M. J., White, E., Mellott, J. G., & Rosen, M. J. (2026) · Neurobiology of Stress · doi:10.1016/j.ynstr.2026.100780 · Cited by 1 · see citing works
Logotheti, M., Chatziioannou, A. A., Venizelos, N., & Kolisis, F. N. (2019) · Örebro University (Örebro University) · Cited by 1 · see citing works
Epigenetics of bipolar disorder
Lima, C. N. D. C., Salarda, E. M., Pinjari, O. F., & Fries, G. R. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-823577-5.00025-8 · Cited by 1 · see citing works
Borderline Personality Disorder: Contemporary Approaches to Conceptualization and Etiology
Trull, T. J., & Hepp, J. (2023) · Oxford University Press eBooks · doi:10.1093/med-psych/9780197542521.003.0028 · Cited by 2 · see citing works
Epigenetics of attention-deficit hyperactivity disorder
Peedicayil, J. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-18516-8.00003-x · Cited by 1 · see citing works
Is Epigenetic Stress the Link Between Childhood Maltreatment and Borderline Personality Disorder?
Charoensook, J. (2017) · American Journal of Psychiatry Residents Journal · doi:10.1176/appi.ajp-rj.2017.120601 · Cited by 1 · see citing works
Epigenetics in mental and neurodegenerative disorders
Iatrou (2018) · doi:10.26481/dis.20180712ai · Cited by 1 · see citing works
- Authors
- Perroud, N., Zewdie, S., Stenz, L., Adouan, W., Bavamian, S., Prada, P., Nicastro, R., Hasler, R., Nallet, A., Piguet, C., Paoloni-Giacobino, A., Aubry, J.-M., & Dayer, A.
- Affiliations
- University of Geneva (CH)
- University Hospital of Geneva (CH)
- Department of Genetic Medicine and Development; University of Geneva Medical School; Geneva Switzerland
- Corresponding author
- Perroud, Nader
- ORCID
- Venue
- Depression and Anxiety
- Publisher
- Wiley
- Published
- 2015-09-09
- Volume
- 33
- Issue
- 1
- Pages
- 45-55
- ISSN
- 1091-4269 (ISSN-L)
- OpenAlex
- W2153328345
- Cited by
- 120
- References
- 71
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 6 · 2023: 15 · 2022: 10 · 2021: 13 · 2020: 13 · 2019: 14 · 2018: 15 · 2017: 13 · 2016: 11
- FWCI
- 5.65
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Depression and Anxiety (publishedVersion)
- PubMed (publishedVersion)
- Archive ouverte UNIGE (University of Geneva) (publishedVersion)
- Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
- Funders
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (155896, 31003A)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Keywords
- DNA methylation, epigenetics, child abuse, early life stress, attention deficit hyperactivity disorder, borderline personality disorder, bipolar disorder, disease severity, CpG sites
- MeSH terms
- Adult, Attention Deficit Disorder with Hyperactivity, Bipolar Disorder, Borderline Personality Disorder, Child, Child Abuse, Female, Humans, Male, Polymorphism, Genetic, Severity of Illness Index, DNA Methylation, Receptors, Serotonin, 5-HT3
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
