Metabolic Syndrome in a French Cohort of Patients With Bipolar Disorder: Results From the FACE-BD Cohort
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OBJECTIVE: The aim of this study was to estimate the prevalence of metabolic syndrome (MetS) and its components in a cohort of French patients with bipolar disorder; determine correlations with sociodemographic, clinical, and treatment-related factors; and investigate the gap between optimal care and effective care of the treated patients. METHOD: 654 bipolar disorder patients from the FACE-BD cohort were included from 2009 to 2012. Sociodemographic and clinical characteristics, lifestyle information, and data on antipsychotic treatment and comorbidities were collected, and a blood sample was drawn. The Structured Clinical Interview for DSM-IV Axis I Disorders was used to confirm the diagnosis of bipolar disorder. Metabolic syndrome was defined according to the National Cholesterol Education Program Adult Treatment Panel III criteria. RESULTS: 18.5% of individuals with bipolar disorder met criteria for MetS. Two-thirds of bipolar disorder patients did not receive adequate treatment for MetS components. Multivariate analysis showed that risk of MetS in men was nearly twice that in women (OR = 1.9; 95% CI, 1.0-3.8), and older patients had a 3.5 times higher risk (95% CI, 1.5-7.8) of developing MetS than patients under the age of 35 years. Moreover, patients receiving antipsychotic treatment had a 2.3 times increased risk (95% CI, 1.2-3.5) of having MetS, independent of other potential confounders. CONCLUSIONS: The prevalence of MetS is high in bipolar disorder patients, and there was considerable undertreatment of the components of MetS in this population. The prevention and treatment of cardiovascular diseases in these patients should be assessed systematically. The findings highlight the need for integrated care, with more interaction and coordination between psychiatrists and primary care providers.
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Among 654 patients with bipolar disorder in the FACE-BD cohort, 18.5% met criteria for metabolic syndrome; only 11% and 28% of patients with hypercholesterolaemia and high fasting glycaemia, respectively, were treated for these conditions.
“Among 654 patients with bipolar disorder in the Fondamental Advanced Centers of Expertise in Bipolar Disorders (FACE-BD) cohort, 18.5% met the criteria for MetS; only 11% and 28% of the patients with hypercholesterolaemia and high fasting glycaemia, respectively, were treated for these conditions.441”
From 2016 ESC/EAS Guidelines for the Management of Dyslipidaemias (2016) · cites this paper as [441]
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Yoon, S. H., & Woo, Y. S. (2026) · Springer eBooks · doi:10.1007/978-981-92-1323-8_10
- Authors
- Godin, O., Collaborators, F. T. F. A. C. O. E. I. B. D. (.-B., Etain, B., Henry, C., Bougerol, T., Courtet, P., Mayliss, L., Passerieux, C., Azorin, J.-M., Kahn, J.-P., Gard, S., Costagliola, D., & Leboyer, M.
- Affiliations
- Inserm (FR)
- Corresponding author
- Godin, Ophélia
- ORCID
- Venue
- The Journal of Clinical Psychiatry
- Publisher
- Physicians Postgraduate Press, Inc
- Published
- 2014-10-28
- Volume
- 75
- Issue
- 10
- Pages
- 1078-1085
- ISSN
- 0160-6689 (ISSN-L)
- OpenAlex
- W1996388111
- Cited by
- 60
- References
- 23
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 11 · 2023: 4 · 2022: 4 · 2021: 2 · 2020: 7 · 2019: 3 · 2018: 4 · 2017: 5 · 2016: 7 · 2015: 2 · 2014: 1
- FWCI
- 3.82
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Clinical Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Funders
- Université de Lorraine
- Fondation FondaMental (ANR-11-IDEX-0004-02)
- Agence Nationale de la Recherche (ANR-11IDEX-0004-02, ANR-10-COHO-0010, ANR-11-IDEX, IDEX-0004-02, ANR-11-IDEX-0004)
- Institut National de la Santé et de la Recherche Médicale
- Université Paris-Est Créteil Val-de-Marne
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- metabolic syndrome, bipolar disorder, prevalence, antipsychotic drugs, undertreatment, cardiovascular risk, sex differences, age differences, comorbidities, integrated care
- MeSH terms
- Adult, Bipolar Disorder, Female, France, Humans, Male, Middle Aged, Antipsychotic Agents, Cohort Studies, Comorbidity, Prevalence, Metabolic Syndrome
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