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The Value of Neuropsychological Assessment in the Differentiation Between Behavioral Variant Frontotemporal Dementia and Late-Onset Psychiatric Disorders
Open accessAbstract
Objective To investigate which neuropsychological tests can discriminate between behavioral variant frontotemporal dementia (bvFTD) and psychiatric disorders presenting with similar late-onset frontal behavioral changes, such as apathy, disinhibition, reduced empathy, or compulsive behavior. Methods Patients presenting with frontal behavioral changes in middle or late adulthood received extensive baseline examinations, including neuropsychological assessment and brain imaging. After 2 years, examinations were repeated and patients were diagnosed according to DSM-IV or international bvFTD consensus criteria. The study period was April 2011-June 2015. Two groups were selected: 32 patients with bvFTD and 53 patients with a psychiatric or psychological diagnosis. Associations between neuropsychological test scores and diagnostic group were investigated with logistic regression analyses, and diagnostic accuracy was investigated with a receiver operating characteristic curve. Results BvFTD patients scored lower on tests for confrontational naming, gestalt completion, and verbal abstraction compared to psychiatric patients (P Conclusions Although one of the criteria of bvFTD is low performance on executive tests, these tests are not useful in differentiating bvFTD from psychiatric disorders. We recommend administering language tests, especially an extensive confrontational naming test, to aid differentiation between bvFTD and a psychiatric disorder in patients presenting with late-o…
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In a study comparing 33 patients with bvFTD with 55 patients with miscellaneous psychiatric disorders, language tests, in particular picture naming, were more discriminative than executive tests.
“Although not specific to action naming, in a study comparing the neuropsychological profile of 33 patients with bvFTD with 55 patients with miscellaneous psychiatric disorders, language tests, in particular picture naming, were more discriminative than executive tests (Overbeek et al. , 2020).”
From Recommendations to distinguish behavioural variant frontotemporal dementia from psychiatric disorders (2020) · cites this paper as Overbeek et al. , 2020
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Metadata
- Authors
- Overbeek, J. M., Korten, N., Gossink, F., Fieldhouse, J., van de Beek, M., Reus, L., Dols, A., Pijnenburg, Y., & Schouws, S.
- Affiliations
- Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
- GGZ inGeest (NL)
- Amsterdam Neuroscience (NL)
- Corresponding author
- Overbeek, Jozefien M.
- ORCID
- Venue
- The Journal of Clinical Psychiatry
- Publisher
- Physicians Postgraduate Press, Inc
- Published
- 2020-02-04
- Volume
- 81
- Issue
- 1
- ISSN
- 0160-6689 (ISSN-L)
- 1555-2101
- OpenAlex
- W3004713873
- Cited by
- 19
- References
- 0
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 1 · 2023: 3 · 2022: 2 · 2021: 1 · 2020: 2
- FWCI
- 1.47
- Type
- journal article
- Language
- en
- Open access
- green
- pure.amsterdamumc.nl
- Licence
- other-oa
- Locations
- The Journal of Clinical Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- Pure Amsterdam UMC (submittedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Funders
- Massachusetts General Hospital
- Teva Pharmaceutical Industries
- Sunovion
- National Institute of Mental Health
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Social Sciences › Psychology › Clinical Psychology › Historical and Modern Theater Studies
- Social Sciences › Psychology › Applied Psychology › Psychological Testing and Assessment
- Keywords
- behavioral variant frontotemporal dementia, differential diagnosis, neuropsychological assessment, Boston Naming Test, confrontation naming, apathy, disinhibition, diagnostic accuracy
- MeSH terms
- Late Onset Disorders, Aged, Mental Disorders, Diagnosis, Differential, Female, Humans, Longitudinal Studies, Male, Middle Aged, Neuropsychological Tests, Prospective Studies, ROC Curve, Frontotemporal Dementia
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