Pharmacotherapy for Adult ADHD
Abstract
The U.S. Food and Drug Administration has approved 3 medications, atomoxetine and the extended-release formulations of amphetamine salts and dexmethylphenidate, for the treatment of adult attention-deficit hyperactivity disorder (ADHD). Different formulations of the same drugs, as well as other agents and cognitive-behavioral therapy, have been tested to determine efficacy in ADHD alone and in ADHD with comorbid substance use disorders, mood disorders, and anxiety disorders. A deficit in research exists in regard to these comorbidities in adults with ADHD.
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Atomoxetine may be an alternative to stimulant treatment in substance abuse patients with ADHD, although studies showing superiority over stimulants in this population are still lacking.
“The non stimulant atomoxetine may be an alternative to treatment with stimulants in substance abuse patients with ADHD, although studies showing superiority over stimulants in this difficult patient population are still lacking [200,284-286].”
From European consensus statement on diagnosis and treatment of adult ADHD: The European Network Adult ADHD (2010) · cites this paper as [286]
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Kooij, S. J., Bejerot, S., Blackwell, A., Caci, H., Casas-Brugué, M., Carpentier, P. J., Edvinsson, D., Fayyad, J., Foeken, K., Fitzgerald, M., et al. (2010) · BMC Psychiatry · doi:10.1186/1471-244x-10-67 · Cited by 928 · see citing works
ADHD Treatments, Sleep, and Sleep Problems: Complex Associations
Stein, M. A., Weiss, M., & Hlavaty, L. (2012) · Neurotherapeutics · doi:10.1007/s13311-012-0130-0 · Cited by 165 · see citing works
- Authors
- Adler, L. A.
- Affiliations
- VA NY Harbor Healthcare System (US)
- Corresponding author
- Adler, Lenard A.
- ORCID
- Adler, Lenard A.
- Venue
- The Journal of Clinical Psychiatry
- Publisher
- Physicians Postgraduate Press, Inc
- Published
- 2009-05-15
- Volume
- 70
- Issue
- 5
- Pages
- e12
- ISSN
- 0160-6689 (ISSN-L)
- OpenAlex
- W1980082942
- Cited by
- 14
- References
- 0
- Citations by year
- 2025: 1 · 2024: 1 · 2020: 1 · 2019: 1 · 2018: 1 · 2012: 3
- FWCI
- 1.44
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- adult ADHD, pharmacotherapy, atomoxetine, amphetamine salts, sustained-release formulation, dexmethylphenidate, comorbid substance use disorders, comorbid mood disorders, comorbid anxiety disorders, cognitive behavioral therapy, drug efficacy
- MeSH terms
- Adult, Amphetamines, Central Nervous System Stimulants, Attention Deficit Disorder with Hyperactivity, Combined Modality Therapy, Humans, Comorbidity, Cognitive Behavioral Therapy, Adrenergic Uptake Inhibitors, Substance-Related Disorders
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