The DOI matches its Crossref record.
A Double-Blind Comparison of Fluvoxamine and Paroxetine in the Treatment of Depressed Outpatients
Abstract
Background Fluvoxamine and paroxetine, both serotonin selective reuptake inhibitors (SSRIs), were compared at two centers in a 7-week double-blind study in outpatients with major depression, diagnosed by DSM-III-R criteria. Method Sixty patients were randomly assigned to receive dosage titrated upward to between 50-150 mg/day of fluvoxamine (N = 30) or 20-50 mg/day of paroxetine (N = 30). The mean +/- SD daily dose administered at the last assessment was 102 +/- 44 mg/day for fluvoxamine and 36 +/- 13 mg/day for paroxetine. Sixteen (53%) fluvoxamine-treated patients and 10 (33%) paroxetine-treated patients were titrated to the maximum permissible dosage of either drug. Sample size was calculated to provide at least 85% power at 5% level of significance to detect at least a 1.00-point difference in mean severity of adverse events, assuming a standard deviation of 1.0. Results Fluvoxamine and paroxetine were similarly effective in ameliorating depression as demonstrated by mean total scores of 10.9 +/- 7.3 (p Conclusion Observed differences in some side effects, although not statistically significant, indicate that when a patient has difficulty tolerating one SSRI, the clinician may choose to change to a different agent within the same class.
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In depressed outpatients comparing fluvoxamine (50-150 mg/day) and paroxetine (20-50 mg/day), somnolence was reported in 30% of the paroxetine group and 40% of the fluvoxamine group.
“Kiev and Feiger [1997] compared fluvoxamine (50-150 mg/day) and paroxetine (20-50 mg/day) in depressed outpatients.Somnolence was reported in 30% of the paroxetine group and 40% of the fluvoxamine group.”
From Depression, sleep physiology, and antidepressant drugs (2001) · cites this paper as Kiev and Feiger, 1997
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Metadata
- Authors
- Kiev, A., & Feiger, A.
- Venue
- The Journal of Clinical Psychiatry
- Publisher
- Physicians Postgraduate Press, Inc
- Published
- 1997-04-15
- Volume
- 58
- Issue
- 4
- Pages
- 146-152
- ISSN
- 0160-6689 (ISSN-L)
- OpenAlex
- W2057162218
- Cited by
- 89
- References
- 0
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 1 · 2020: 1 · 2019: 1 · 2017: 3 · 2016: 2 · 2015: 4 · 2014: 3 · 2013: 3 · 2012: 2
- FWCI
- 4.63
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Social Sciences › Psychology › Clinical Psychology › Psychological Treatments and Disorders
- Keywords
- fluvoxamine, paroxetine, major depressive disorder, outpatients, selective serotonin reuptake inhibitors, antidepressant efficacy, adverse events, drug tolerability, dose titration, sexual dysfunction, sleepiness, headache, nausea, xerostomia, sweating, insomnia, asthenia, dyspepsia, erectile dysfunction, Hamilton Depression Rating Scale
- MeSH terms
- Adolescent, Adult, Aged, Ambulatory Care, Depressive Disorder, Diarrhea, Double-Blind Method, Drug Administration Schedule, Female, Headache, Humans, Male, Middle Aged, Nausea, Psychiatric Status Rating Scales, Severity of Illness Index, Sleep, Sweating, Xerostomia, Fluvoxamine, Treatment Outcome, Paroxetine
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