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Cited by 59Pharmacovigilance and Adverse Drug ReactionsTreatment of Major DepressionSchizophrenia research and treatment

Antidepressant-Induced Sweating

Marcy, Todd R, Britton, Mark L·2005·Annals of Pharmacotherapy
DOI 10.1345/aph.1e564
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Abstract

OBJECTIVE: To report a case of excessive sweating probably caused by paroxetine, review the literature on antidepressant-induced sweating, and provide recommendations for the management of antidepressant-induced sweating. CASE SUMMARY: A 59-year-old white female presented to a pharmacist-staffed pharmacotherapy clinic with episodes of excessive sweating. The episodes occurred primarily on her head and back of the neck. Other etiologies were ruled out and paroxetine was discontinued. Paroxetine had been initiated at least 7 months prior to the reporting of symptoms. Sweating symptoms gradually improved until resolution 5 weeks following discontinuation of paroxetine. The Naranjo probability scale indicated a causal relationship is probable. DISCUSSION: Excessive sweating has been associated with antidepressants including tricyclic antidepressants, selective serotonin-reuptake inhibitors, and venlafaxine. In some patients, these symptoms require therapeutic intervention such as dose reduction, antidepressant substitution, antidepressant discontinuation, or addition of an agent to control sweating. Agents that have been reported successful in controlling the sweating include benztropine and cyproheptadine. CONCLUSIONS: We recommend a patient-specific approach for the management of antidepressant-induced sweating. First, consider dose reduction or a trial off antidepressant medication. In patients in whom this is inappropriate or ineffective, substitution of another antidepressant should be considered. If episodes of excessive sweating persist, consider treatment of sweating symptoms with benztropine or cyproheptadine in the absence of contraindications.

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Crossref · 10.1345/aph.1e564

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Authors
Marcy, T. R., & Britton, M. L.
Affiliations
University of Oklahoma Health Sciences Center (US)
Corresponding author
Marcy, Todd R
Venue
Annals of Pharmacotherapy
Publisher
SAGE Publications
Published
2005-04
Volume
39
Issue
4
Pages
748-752
ISSN
  • 0012-6578 (ISSN-L)
  • 1060-0280
  • 1542-6270
DOI
10.1345/aph.1e564
OpenAlex
W2171890021
Cited by
59
References
19
Citations by year
2026: 3 · 2025: 1 · 2024: 4 · 2023: 2 · 2022: 2 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 2 · 2017: 2 · 2016: 3 · 2015: 3 · 2014: 1 · 2013: 6 · 2012: 3
FWCI
7.05
Type
journal article
Language
en
Open access
closed
Licence
journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations
  • Annals of Pharmacotherapy (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Pharmacovigilance and Adverse Drug Reactions
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Keywords
paroxetine, selective serotonin reuptake inhibitors, adverse drug reactions, Naranjo probability scale, antidepressant discontinuation, dose reduction, benztropine, cyproheptadine, anticholinergic agents
MeSH terms
Antidepressive Agents, Depressive Disorder, Female, Humans, Middle Aged, Sweating

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