Benztropine in the Treatment of Venlafaxine-Induced Sweating
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Article AbstractLetter to the Editor Sir: Sweating is a relatively common side effect seen with serotonin selective reuptake inhibitors (SSRIs) and has been reported in 7% to 11% of patients treated with SSRIs and 12% of patients treated with venlafaxine, an antidepressant with the ability to inhibit the reuptake of serotonin and norepinephrine. The following case indicates that this side effect can cause severe social disruption and limit effective treatment of depression. A possible management strategy is also suggested.
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Venlafaxine and TCAs also showed similar incidence rates of excessive sweating.
“Venlafaxine and TCAs also showed similar incidence rates.82”
From Addressing the Side Effects of Contemporary Antidepressant Drugs: A Comprehensive Review (2018) · cites this paper as [82]
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Cites
TEXTBOOK OF MEDICAL PHYSIOLOGY
Guyton, A. C. (1967) · The American Journal of the Medical Sciences · doi:10.1097/00000441-196701000-00031 · Cited by 2,861 · see citing works
The neostriatal mosaic: multiple levels of compartmental organization
Gerfen, C. R. (1992) · Trends in Neurosciences · doi:10.1016/0166-2236(92)90355-c · Cited by 1,471 · see citing works
Swedo, S. E., Leonard, H. L., Rapoport, J. L., Lenane, M. C., Goldberger, E. L., & Cheslow, D. L. (1989) · New England Journal of Medicine · doi:10.1056/nejm198908243210803 · Cited by 601 · see citing works
The Physicians' Desk Reference
Cohen, J. S. (1996) · Archives of Internal Medicine · doi:10.1001/archinte.1996.00440120021003 · Cited by 430 · see citing works
THE PHARMACOLOGICAL BASIS OF THERAPEUTICS
Goodman, L., & Gilman, A. G. (1941) · AJN American Journal of Nursing · doi:10.1097/00000446-194109000-00048 · Cited by 405 · see citing works
Blockade by newly-developed antidepressants of biogenic amine uptake into rat brain synaptosomes
Watson, C. B., & Richelson, E. (1993) · Life Sciences · doi:10.1016/0024-3205(93)90194-8 · Cited by 391 · see citing works
Muth, E. A., Haskins, J. T., Moyer, J. A., Husbands, G. E. M., Nielsen, S. T., & Sigg, E. B. (1986) · Biochemical Pharmacology · doi:10.1016/0006-2952(86)90769-0 · Cited by 374 · see citing works
Beyond the serotonin hypothesis: a role for dopamine in some forms of obsessive compulsive disorder?
Goodman, W. K., McDougle, C. J., Price, L. H., Riddle, M. A., Pauls, D. L., & Leckman, J. F. (1990) · PubMed · Cited by 283 · see citing works
Marin, R. S., Fogel, B. S., Hawkins, J. W., Duffy, J., & Krupp, B. H. (1995) · Journal of Neuropsychiatry · doi:10.1176/jnp.7.1.23 · Cited by 229 · see citing works
Leonard, H. L. (1991) · Archives of General Psychiatry · doi:10.1001/archpsyc.1991.01810330045007 · Cited by 146 · see citing works
A randomized double-blind study of fluoxetine versus placebo in the treatment of dysthymia
Hellerstein, D. J., Yanowitch, P., Rosenthal, J., Samstag, L. W., Maurer, M., Kasch, K. L., Burrows, L., Poster, M., Cantillon, M., & Winston, A. (1993) · American Journal of Psychiatry · doi:10.1176/ajp.150.8.1169 · Cited by 141 · see citing works
Venlafaxine in adults with attention-deficit/hyperactivity disorder: an open clinical trial.
Findling, R. L., SCHWARTZ, M. A., Flannery, D. J., & Manos, M. J. (1996) · PubMed · Cited by 128 · see citing works
Combined SSRI-moclobemide treatment of psychiatric illness.
Cj, M., Goodman, W. K., & Price, L. H. (1994) · PubMed · Cited by 124 · see citing works
A controlled trial of propoxyphene and naltrexone in patients with tourette's syndrome
Kurlan, R., Majumdar, L., Deeley, C., Mudholkar, G. S., Plumb, S., & Como, P. G. (1991) · Annals of Neurology · doi:10.1002/ana.410300105 · Cited by 87 · see citing works
A fixed-dose (300 mg) efficacy study of bupropion and placebo in depressed outpatients.
Lineberry, C. G., Ja, J., Rn, R., SAMARA, B., Feighner, J. P., Harto-Truax, N., Granacher, R. P., Weisler, R. H., Js, C., & Wf, B. (1990) · PubMed · Cited by 75 · see citing works
The role of venlafaxine in rational antidepressant therapy.
Feighner, J. P. (1994) · PubMed · Cited by 73 · see citing works
Castellanos, F. X., Ritchie, G. F., Marsh, W., & Rapoport, J. (1996) · PubMed · Cited by 72 · see citing works
The identification and treatment of adult brain dysfunction
Mann, H., & Greenspan, S. I. (1976) · American Journal of Psychiatry · doi:10.1176/ajp.133.9.1013 · Cited by 67 · see citing works
Compulsive Picking and Obsessive-Compulsive Disorder
Stein, D. J., Hutt, C., Spitz, J. L., & Hollander, E. (1993) · Psychosomatics · doi:10.1016/s0033-3182(93)71911-8 · Cited by 60 · see citing works
Bupropion treatment of fluoxetine-resistant chronic fatigue syndrome
Goodnick, P. J., Sandoval, R. A., Brickman, A. L., & Klimas, N. G. (1992) · Biological Psychiatry · doi:10.1016/0006-3223(92)90087-g · Cited by 53 · see citing works
Impact of a smoking ban on a locked psychiatric unit.
Haller, E., McNiel, D. E., & Binder, R. L. (1996) · PubMed · Cited by 48 · see citing works
Lhermitte's sign in a patient with herpes zoster
Vollmer, T. L., Brass, L. M., & Waxman, S. G. (1991) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(91)90252-3 · Cited by 23 · see citing works
Ratio of plasma fluoxetine to norfluoxetine concentrations and associated sedation.
Pe, K., & Sl, M. (1992) · PubMed · Cited by 19 · see citing works
The use of midazolam with pulse oximetry in the drug-assisted interview.
MARCUM, J. M. (1996) · PubMed · Cited by 10 · see citing works
Bupropion treatment of fluoxetine-resistant chronic fatigue syndrome
Goodnick, P. J. (1992) · Biological Psychiatry · doi:10.1016/0006-3223(92)90623-8 · Cited by 7 · see citing works
Flagged first, then by citations
1 of the 26 references couldn’t be matched to a known paper.
Research works printed but not linked: 17
- Sandyk R, Iacono RP, Crinnian C, et al. Effects of naltrexone in Tourette's syndrome [abstract]. Ann Neurol 1986;20:437
- Meuldijk R, Colon EJ. Methadone treatment of Tourette's disorder [let- ter]. Am J Psychiatry 1992;149:139-140
- McConville BJ, Norman AB, Fogelson MH, et al. Sequential use of opioid antagonists and agonists in Tourette's syndrome [letter]. Lancet 1994;343:601
- Lee CR, McTavish D, Sorkin EM. Tramadol: a preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in acute and chronic pain states. Drugs 1993;46:313-340
- Cohen DJ, Leckman JF, Shaywitz BA. The Tourette syndrome and other tics. In: Shaffer D, Ehrhardt AA, Greenhill LL, eds. The Clinical Guide to Child Psychiatry. New York, NY: The Free Press; 1985:3-28
- Gerfen CR, Engber TM, Mahan LC, et al. D 1 and D 2 dopamine recep- tor-regulated gene expression of striatonigral and striatopallidal neu- rons. Science 1990;250:1429-1432
- Hain JD, Smith BM, Stevenson I. Effectiveness and process of inter- viewing with drugs. J Psychiatr Res 1966;4:95-106
- McCall WV, Shelp FE, McDonald WM. Controlled investigation of the amobarbital interview for catatonic mutism. Am J Psychiatry 1992;149:202-206 REFERENCES
- Paroxetine hydrochloride. Physicians' Desk Reference. Montvale, NJ: Medical Economics; 1997:2681-2686
- Frost L, Lal S. Shock-like sensations after discontinuation of selective serotonin reuptake inhibitors [letter]. Am J Psychiatry 1995;152:810
- Gordon TR, Goldstein JM, Waxman SG. Sensory abnormalities of the limbs and trunk. In: Bradley WG, Daroff RB, Fenichel GM, et al, eds. Neurology in Clinical Practice: Principles of Diagnosis and Manage- ment. 2nd ed. Boston, Mass: Butterworth-Heinemann; 1996:401
- Feder R. Clonidine treatment of excessive sweating [letter]. J Clin Psychiatry 1995;56:35
- Butt MM. Managing antidepressant-induced sweating [letter]. J Clin Psychiatry 1989;50:146-147
- Stein DJ, Hollander E. Obsessive-compulsive spectrum disorders [let- ter]. J Clin Psychiatry 1995;56:265-266
- Martin LJ, Spicer DM, Lewis MH, et al. Social deprivation of infant monkeys alters the chemoarchitecture of the brain, I: subcortical re- gions. J Neurosci 1991;11:3344-3358
- American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition. Washington, DC: American Psy- chiatric Association; 1994:244
- Haller E, McNiel DE, Binder RL. Impact of a smoking ban and locked psychiatric unit. J Clin Psychiatry 1996;57:329-332
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Wang, S.-M., Han, C., Bahk, W.-M., Lee, S.-J., Patkar, A. A., Masand, P. S., & Pae, C.-U. (2018) · Chonnam Medical Journal · doi:10.4068/cmj.2018.54.2.101 · Cited by 299 · see citing works
Stolman, L. P. (1998) · Dermatologic Clinics · doi:10.1016/s0733-8635(05)70062-0 · Cited by 162 · see citing works
Antidepressant-Induced Sweating
Marcy, T. R., & Britton, M. L. (2005) · Annals of Pharmacotherapy · doi:10.1345/aph.1e564 · Cited by 59 · see citing works
Cyproheptadine for Drug-Induced Sweating
Ashton, A. K., & Weinstein, W. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.5.874-a · Cited by 35 · see citing works
Hyperhidrosis: medical and surgical treatment.
Stolman, L. P. (2008) · PubMed Central · Cited by 31 · see citing works
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Pierre, J. M., & Guzé, B. H. (2000) · Journal of Clinical Psychopharmacology · doi:10.1097/00004714-200004000-00025 · Cited by 30 · see citing works
Emotionally induced hyperhidrosis.
Altman, R., & Schwartz, R. A. (2002) · PubMed · Cited by 29 · see citing works
Generalized Hyperhidrosis and Its Systemic Treatment
B�ni, R. (2002) · KARGER eBooks · doi:10.1159/000060676 · Cited by 24 · see citing works
Mirtazapine in drug-induced excessive sweating
Buecking, A., Vandeleur, C. L., Khazaal, Y., & ZULLINO, D. F. (2005) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-005-0956-z · Cited by 21 · see citing works
Disorders of sweat glands: hyperhidrosis: unapproved treatments
Cheung, J. S., & Solomon, B. A. (2002) · Clinics in Dermatology · doi:10.1016/s0738-081x(02)00284-5 · Cited by 14 · see citing works
Antidepressant-Induced Excessive Sweating: Clinical Features and Treatment with Terazosin
Mago, R., Thase, M. E., & Rovner, B. W. (2013) · Annals of Clinical Psychiatry · doi:10.1177/104012371302500304 · Cited by 13 · see citing works
Ghaleiha, A., Shahidi, K. M., Afzali, S., & Matinnia, N. (2012) · International Journal of Psychiatry in Clinical Practice · doi:10.3109/13651501.2012.687449 · Cited by 13 · see citing works
Glycopyrrolate for Antidepressant-Associated Excessive Sweating
Mago, R. (2013) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e31828567f2 · Cited by 11 · see citing works
To sweat or not to sweat? A hypothesis on the effects of venlafaxine and SSRIs
Demling, J. H., Beyer, S., & Kornhuber, J. (2009) · Medical Hypotheses · doi:10.1016/j.mehy.2009.07.011 · Cited by 11 · see citing works
Monoaminergic‐based Pharmacotherapy for Depression
Papakostas, G. I., & D, M. F. M. (2005) · Wiley eBooks · doi:10.1002/9783527619672.ch6 · Cited by 11 · see citing works
Venlafaxine-induced excessive yawning: A thermoregulatory connection
Gallup, A. C., & Gallup, G. G. (2009) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2009.03.009 · Cited by 9 · see citing works
Improvement of antidepressant-induced sweating with as-required benztropine.
Kolli, V. B., & Ramaswamy, S. (2013) · Europe PMC (PubMed Central) · Cited by 5 · see citing works
Managing psychotropic-induced hyperhidrosis
Burdette, E. L. (2023) · Current Psychiatry · doi:10.12788/cp.0399 · Cited by 1 · see citing works
Anticholinergic treatments for focal and generalized hyperhidrosis
Houdi, M., Kapur, S. K., Chamma, B., Sidhu, K., Wolinsky, E., Kancharla, P., & Burkhart, C. G. (2025) · JAAD reviews. · doi:10.1016/j.jdrv.2025.05.005 · Cited by 1 · see citing works
&NA; (1997) · Reactions Weekly · doi:10.2165/00128415-199706560-00033 · Cited by 1 · see citing works
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Options for Treating Antidepressant-Induced Sweating
Scarff, J. R. (2013) · Current psychiatry
Fisher, K. G., Leach, O. K., Greaney, J. L., Alexander, L. M., & Kenney, W. L. (2026) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00147.2026
- Authors
- Garber, A., & Gregory, R. J.
- ORCID
- Gregory, Robert J.
- Venue
- The Journal of Clinical Psychiatry
- Publisher
- Physicians Postgraduate Press, Inc
- Published
- 1997-04-15
- Volume
- 58
- Issue
- 4
- Pages
- 176-177
- ISSN
- 0160-6689 (ISSN-L)
- OpenAlex
- W2010209221
- Cited by
- 24
- References
- 26
- Citations by year
- 2026: 1 · 2025: 1 · 2023: 1 · 2018: 1 · 2014: 2 · 2013: 4 · 2012: 1
- FWCI
- 0.84
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Clinical Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Health Sciences › Medicine › Psychiatry and Mental health › Electroconvulsive Therapy Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- benztropine, venlafaxine, sweating, serotonin reuptake inhibitors, antidepressant side effects, anticholinergic agents, depression treatment, norepinephrine reuptake inhibition
- MeSH terms
- Venlafaxine Hydrochloride, Benztropine, Cyclohexanols, Depressive Disorder, Female, Humans, Hyperhidrosis, Middle Aged, Sweating, Selective Serotonin Reuptake Inhibitors
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