Cited by 150Treatment of Major DepressionAnxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesMental Health Treatment and Access

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Bupropion Sustained Release Versus Paroxetine for the Treatment of Depression in the Elderly

Weihs, Karen L., Settle, Edmund C., Batey, Sharyn R., Houser, Trisha L., Donahue, Rafe M. J., Ascher, John A.·2000·The Journal of Clinical Psychiatry

DOI 10.4088/jcp.v61n0309

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Abstract

BACKGROUND: Depression is a serious and widespread emotional disorder among the elderly. This study compared the efficacy and safety of bupropion sustained release (SR) with the selective serotonin reuptake inhibitor paroxetine in the treatment of major depression in elderly outpatients. METHOD: Elderly (> or = 60 years) outpatients with major depressive disorder (DSM-IV criteria) were evaluated in this 6-week multicenter, randomized, double-blind study comparing bupropion SR, 100-300 mg/day, and paroxetine, 10-40 mg/day. Efficacy was assessed by changes in scores on the Hamilton Rating Scales for Depression (HAM-D) and Anxiety (HAM-A) and the Clinical Global Impressions-Severity of Illness and -Improvement scales. Safety was assessed by monitoring adverse events, vital signs, and body weight. RESULTS: A total of 100 patients ranging in age from 60 to 88 years were randomly assigned to treatment with bupropion SR (N = 48) or paroxetine (N = 52). Measurements of efficacy were similar between the 2 treatment groups, with both groups showing improved scores on all depression rating scales. Headache, insomnia, dry mouth, agitation, dizziness, and nausea occurred in > 10% of patients in both groups; somnolence, diarrhea, constipation, and anorexia occurred in > 10% of patients in the paroxetine group. No statistically significant differences between groups in vital signs or weight were found. CONCLUSION: Both bupropion SR and paroxetine were safe and effective for the treatment of depression in the elderly. Because of its favorable side effect profile, bupropion SR may provide a safe and effective nonserotonergic treatment alternative that is well suited as an antidepressant for the elderly.

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Authors: Weihs, K. L., Settle, E. C., Batey, S. R., Houser, T. L., Donahue, R. M. J., & Ascher, J. A.
Affiliations: George Washington University (US)
GlaxoSmithKline (United Kingdom) (GB)
ORCID: Weihs, Karen L.
Venue: The Journal of Clinical Psychiatry
Publisher: Physicians Postgraduate Press, Inc
Published: 2000-03-15
Volume: 61
Issue: 3
Pages: 196-202
ISSN: 0160-6689 (ISSN-L)
DOI: 10.4088/jcp.v61n0309
OpenAlex: W2018434620
Cited by: 150
References: 0
Citations by year: 2025: 1 · 2024: 3 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 3 · 2019: 2 · 2018: 3 · 2017: 2 · 2016: 3 · 2015: 1 · 2014: 6 · 2013: 6 · 2012: 6
FWCI: 7.33
Type: journal article
Language: en
Open access: closed
Locations: The Journal of Clinical Psychiatry (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Health Sciences › Medicine › Psychiatry and Mental health › Mental Health Treatment and Access
Keywords: bupropion sustained release, paroxetine, major depressive disorder, geriatric depression, antidepressant efficacy, antidepressant safety, adverse drug reactions, selective serotonin reuptake inhibitors, outpatients
MeSH terms: Aged, Ambulatory Care, Delayed-Action Preparations, Depressive Disorder, Double-Blind Method, Female, Humans, Male, Middle Aged, Psychiatric Status Rating Scales, Risk Factors, Seizures, Comorbidity, Bupropion, Treatment Outcome, Selective Serotonin Reuptake Inhibitors, Paroxetine, Antidepressive Agents, Second-Generation

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Bupropion Sustained Release Versus Paroxetine for the Treatment of Depression in the Elderly

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