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Empfehlungen für Diagnostik und Therapie der Depression im Alter: Therapy Recommendations for Diagnosis and Treatment of Depression in Old Age
Abstract
Zusammenfassung. Diese Empfehlungen sollen dazu dienen, Fachpersonen das Wissen über die aktuelle Evidenz von Diagnostik und Therapie der Depression im Alter zur Verfügung zu stellen und damit zur frühzeitigen Erkennung und evidenzbasierten Behandlung beizutragen. Da für einige Behandlungsansätze nur rudimentär kontrollierte Studien vorliegen, wird auch das klinische Expertenwissen in die Beurteilung einbezogen. Im diagnostischen Vorgehen wird die besondere Symptomatik der Depression im Alter beleuchtet, auf die Suizidalität eingegangen und werden die häufig vorkommenden somatischen Komorbiditäten hervorgehoben. Auch Hypothesen zur Pathogenese, wie Neuroendokrinologie, Neurodegeneration und vaskuläre Faktoren, werden erläutert. In der Behandlung gilt heute ein integrierter biopsychosozialer Ansatz mit gezielten psychosozialen Interventionen, spezifischer Psychotherapie und einer antidepressiven Pharmakotherapie bei schweren Depressionen als sinnvoll. Daneben kommen auch chronobiologische oder Neurostimulationsverfahren zum Einsatz.
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TCAs are generally not recommended as first-line treatments in older adults owing to their anticholinergic effects and the potential for adverse reactions such as falls and fractures.
“TCAs are generally not recommended as first-line treatments in this age group owing to their anticholinergic effects and the potential for adverse reactions such as falls and fractures [42].”
From Long-Term Antidepressant Use and Dementia Risk: A Propensity Score-Matched Study of Swiss Older Adults, with an Anticholinergic-Specific Analysis (2026) · cites this paper as [42]
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Cited by
Sorted by citations
Amrein, M. A., Hengartner, M. P., Näpflin, M., Farcher, R., & Huber, C. A. (2026) · Drugs - Real World Outcomes · doi:10.1007/s40801-026-00560-y
Metadata
- Authors
- Hatzinger, M., Hemmeter, U., Hirsbrunner, T., Holsboer-Trachsler, E., Leyhe, T., Mall, J.-F., Mosimann, U., Rach, N., Trächsel, N., & Savaskan, E.
- Affiliations
- Schweizerische Gesellschaft für Alterspsychiatrie und Alterspsychotherapie (SGAP)
- Schweizerischer Berufsverband der Pflegefachfrauen und Pflegefachmänner (SBK)
- Schweizerische Gesellschaft für Angst und Depression (SGAD)
- Schweizerische Gesellschaft für Biologische Psychiatrie (SGBP)
- Schweizerische Fachgesellschaft für Gerontopsychologie (SFGP)
- Venue
- Praxis
- Publisher
- Hogrefe Publishing Group
- Published
- 2018-01
- Volume
- 107
- Issue
- 3
- Pages
- 127-144
- ISSN
- 0369-8394 (ISSN-L)
- 1661-8157
- 1661-8165
- OpenAlex
- W2785501053
- Cited by
- 11
- References
- 25
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 3 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 1
- FWCI
- 0.05
- Type
- journal article
- Language
- de
- Open access
- closed
- Locations
- Praxis (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Health Sciences › Medicine › Psychiatry and Mental health › Mental Health Treatment and Access
- Keywords
- geriatric depression, depression diagnosis, antidepressant treatment, psychotherapy, suicide risk, somatic comorbidity, depression pathogenesis, neuroendocrinology, neurodegeneration, vascular factors, biopsychosocial model, psychosocial interventions, chronobiology, neurostimulation
- MeSH terms
- Suicide Prevention, Aged, Antidepressive Agents, Combined Modality Therapy, Depressive Disorder, Diagnosis, Differential, Humans, Psychotherapy, Risk Factors, Suicide, Evidence-Based Medicine, Guideline Adherence, International Classification of Diseases, Cognitive Dysfunction
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