The DOI matches its Crossref record.
Current Comorbidity of Psychiatric Disorders Among DSM-IV Major Depressive Disorder Patients in Psychiatric Care in the Vantaa Depression Study
Abstract
BACKGROUND: While numerous studies have documented the high comorbidity of major depressive disorder (MDD) with individual mental disorders, no published study has reported overall current comorbidity with all Axis I and II disorders among psychiatric patients with MDD, nor systematically investigated variations in current comorbidity by sociodemographic factors, inpatient versus outpatient status, and number of lifetime depressive episodes. METHOD: Psychiatric outpatients and inpatients in Vantaa, Finland, were prospectively screened for an episode of DSM-IV MDD, and 269 patients with a new episode of MDD were enrolled in the Vantaa Depression MDD Cohort Study. Axis I and II comorbidity was assessed via semistructured Schedules for Clinical Assessment in Neuropsychiatry, version 2.0, and Structured Clinical Interview for DSM-II-R personality disorders interviews. RESULTS: The great majority (79%) of patients with MDD suffered from 1 or more current comorbid mental disorders, including anxiety disorder (57%), alcohol use disorder (25%), and personality disorder (44%). Several anxiety disorders were associated with specific Axis II clusters, and panic disorder with agoraphobia was associated with inpatient status. The prevalence of personality disorders varied with inpatient versus outpatient status, number of lifetime depressive episodes, and type of residential area, and the prevalence of substance use disorders varied with gender and inpatient versus outpatient status. CONCLUSION: Most psychiatric patients with MDD have at least 1 current comorbid disorder. Comorbid disorders are associated not only with other comorbid disorders, but also with sociodemographic factors, inpatient versus outpatient status, and lifetime number of depressive episodes. The influence of these variations on current comorbidity patterns among MDD patients needs to be taken account of in treatment facilities.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Large-scale cohort studies have documented that clinical populations have interindividual variability with substantial heterogeneity in types of comorbidity and aetiological risk (Lamers et al., 2010;Melartin et al., 2002;Sterling et al., 2008;Wessman et al., 2009).”
From Meta-analysis of the effects of intranasal oxytocin on interpretation and expression of emotions (2017) · cites this paper as Melartin et al., 2002
In the citing paper
“Another possible interpretation of the present findings is that there is substantial heterogeneity within and between clinical groups that could dilute the true effects of intranasal oxytocin on social threat processing among clinical populations (Lamers et al., 2010;Melartin et al., 2002;Wessman et al., 2009).”
From Meta-analytic review of the effects of a single dose of intranasal oxytocin on threat processing in humans (2018) · cites this paper as Melartin et al., 2002
Citations
Cites
Still being checked.
Cited by
Sorted by citations
Items 201–259 of 259
Movements of Moods: Interplay Between Science, Clinical Practice and Patient in Psychiatry
Hautamäki, L. (2016) · Työväentutkimus Vuosikirja · Cited by 3
Gelenberg, A. J., Kocsis, J. H., & McCullough, J. P. (2006) · The Primary Care Companion For CNS Disorders · doi:10.4088/pcc.v08n0201 · Cited by 2
백옥미 (2011) · Korean Journal of Gerontological Social Welfare · doi:10.21194/kjgsw..52.201106.7 · Cited by 2
Comparison of childhood trauma between depressive disorders and personality disorders
Jayakody, K., & Gunadasa, S. (2023) · Personality and Mental Health · doi:10.1002/pmh.1589 · Cited by 2
Epidemiología y comorbilidad de los trastornos de personalidad.
Díaz, M. J. M., & León, A. M. (2006) · Psiquiatria.com · Cited by 2
Depressive Disorders in Primary Health Care
Vuorilehto, M. S. (2008) · Työväentutkimus Vuosikirja · Cited by 2
Functional and Work Disability and Treatment Received by Patients with Major Depressive Disorder
Rytsälä, H. J. (2006) · Työväentutkimus Vuosikirja · Cited by 2
Chou, C.-T., & Lin, I. (2024) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2024.111913 · Cited by 1
Ištoňová, M., Dorko, E., Knap, V., Stehlíková, B., Murgová, A., Ondová, P., & Rimárová, K. (2024) · Central European Journal of Public Health · doi:10.21101/cejph.a7888 · Cited by 1
Training in iterativer Hypothesenbildung in der psychiatrischen Lehre
Lampen-Imkamp, S., Alte, C., Sipos, V., Kordon, A., Hohagen, F., Schweiger, U., & Kahl, K. G. (2011) · Der Nervenarzt · doi:10.1007/s00115-011-3252-4 · Cited by 1
Does depressed person perceive time as passing slowly?
Seongyu, K. O., 강준, & Ko, Y.-G. (2012) · 한국심리학회지 사회및성격 · doi:10.21193/kjspp.2012.26.1.001 · Cited by 1
Medical Management of Obesity Associated with Mood Disorders
McElroy, S. L., Kotwal, R., & Keck, P. E. (2006) · CRC Press eBooks · doi:10.3109/9780849374517.016 · Cited by 1
Seo, M.-S., Jeong, J., Seo, H., Lim, H. K., Kim, T., Park, M., Hong, S., & Han, J. (2014) · 대한정신약물학회지 · Cited by 1
Depresyon Tedavisinde Karşılanmamış İhtiyaçlar: Eştanılı Anksiyete ve Yaklaşım
Dılbaz, N., Darçın, A. E., & Çavuş, S. Y. (2011) · Klinik Psikofarmakoloji Bülteni-Bulletin of Clinical Psychopharmacology · doi:10.1080/10177833.2011.11790744 · Cited by 1
Abou-Gharbia, M. A., & Childers, W. E. (2010) · doi:10.1002/9783527630035.ch21 · Cited by 1
Depression, Anxiety, Psychiatric Comorbidity and Dimensions of Temperament and Personality
Jylhä, P. J. (2008) · Työväentutkimus Vuosikirja · Cited by 1
Epidemiology of Illicit Drug Use Disorders
Compton, W., Lopez, M. F., Conway, K., & Thomas, Y. (2011) · Wiley eBooks · doi:10.1002/9780470976739.ch22 · Cited by 4
Interpretation processes in anxiety and depression
Hähnel, A. (2008) · Radboud Repository (Radboud University) · Cited by 1
Establishment of an Animal Model of Depression: The Serotonin Transporter Knockout Rat
Kidwell, M. (2019) · Open Access Victoria University of Wellington | Te Herenga Waka (Figshare) · doi:10.26686/wgtn.17135999 · Cited by 4
Recognition, comorbidity, and outcome of DSM-IV bipolar I and II disorders in psychiatric care
Mantere, O. (2007) · Työväentutkimus Vuosikirja · Cited by 1
Einordnung, Entwicklungsmöglichkeiten und Herausforderungen
Belz, M., Caspar, F., & Schramm, E. (2013) · Elsevier eBooks · doi:10.1016/b978-3-437-22426-3.00016-4
DSM-IV vakavan masennustilan pitkäaikaisennuste psykiatrisessa hoidossa
Holma, M. (2010) · STM:n Hallinnonalan avoin julkaisuarkisto (Julkari)
Solving the problem of antidepressant selection in Lithuania.
Burba, B., Jankuviene, O., Grigaliunien, V., Stolygaitė, A., & Jaras, A. (2007) · PubMed
Ferber, S. (2012) · John Spoor Broome Library Institutional Repository (California State University)
Life events and social support among patients with major depressive disorder
Leskelä, U. S. (2008) · STM:n Hallinnonalan avoin julkaisuarkisto (Julkari)
Puuronen, R., & Tossavainen, S. (2013) · Jyväskylä University Digital Archive (University of Jyväskylä)
La asociación psiquiátrica de América Latina
Rojas, R. N. C. (2014) · Revista Colombiana de Psiquiatría · doi:10.1016/j.rcp.2014.06.001
Colvin, A. B. (2012) · D-Scholarship@Pitt (University of Pittsburgh)
Testing for empty sets when misclassifications may be present
Bradley, J. R., & Farnsworth, D. L. (2012) · Journal of Statistical Planning and Inference · doi:10.1016/j.jspi.2011.12.015
Coêlho, B. M., Andrade, L. H., Guarniero, F. B., & Wang, Y. (2010) · DOAJ (DOAJ: Directory of Open Access Journals) · doi:10.1590/s1516-44462010000400013
Depression-Avoidance Defences in Bipolar-Euthymia
Granger, S. (2015) · Victoria University Research Repository (Victoria University)
THE ROLE OF DENDRITIC BDNF TRANSCRIPTS ON ALTERED INHIBITORY CIRCUITRY IN AGING AND DEPRESSION
Oh, H. (2015) · D-Scholarship@Pitt (University of Pittsburgh)
Karlsson, H. (2005) · Nordic Journal of Psychiatry · doi:10.1080/08039480510027652
Risk factors that influence suicidal behavior in affective disorders
Stanojević, A., Nenadović, M., Milosevic, D., & Popovic, I. (2016) · Praxis medica · doi:10.5937/pramed1601023s
Pfeiffer, J. R. (2017) · Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)
Bustamante, A. C. (2017) · Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)
Lässt sich ein sinnvolles Ranking von Antidepressiva erstellen?
Wiegand, H. F., Bschor, T., Schramm, E., Hegerl, U., & Härter, M. C. (2018) · InFo Neurologie + Psychiatrie · doi:10.1007/s15005-018-2593-y
Singh, D. B. P. (2018) · Journal of Medical Science And clinical Research · doi:10.18535/jmscr/v6i6.76
Clinical severity and familial risk in mood disorders
Doran, P. (2012) · doi:10.82308/42300
Investigations of the Activity of Phenobarbitone in Mice Models of Depression
Faruk, F., Magaji, M. G., Magaji, R. A., Yusha’u, Y., Buba, A. S., & Umar, M. (2022) · Jewel Journal of Medical Sciences · doi:10.56167/jjms.2022.0301.03
Grahovac, T., Crepulja, M. L., Stevanović, A., Ružić, K., Rončević-Gržeta, I., & Došen, A. (2019) · The European Journal of Psychiatry · doi:10.1016/j.ejpsy.2019.11.001
Chatterjee, D. (2019) · TSpace (University of Toronto)
Granlund, A. (2011) · Jyväskylä University Digital Archive (University of Jyväskylä)
Yoo, J.-M., Kim, S., Um, Y. H., Kim, T., Seo, H., Hong, S., & Jeong, J. (2021) · Mood and Emotion · doi:10.35986/me.2021.19.2.64
Wang, S., & Pae, C. (2017) · Oxford University Press eBooks · doi:10.1093/med/9780198746638.003.0019
Rivers, A. S., Ruan‐Iu, L., Winston‐Lindeboom, P., & Diamond, G. S. (2023) · Residential Treatment for Children & Youth · doi:10.1080/0886571x.2023.2298453
Elovainio, M. J., Hietapakka, L., Gutvilig, M., Niemi, R., Komulainen, K., Pulkki-Råbäck, L., Väisänen, V., Sinervo, T. S., & Hakulinen, C. A. (2024) · International Journal of Social Psychiatry · doi:10.1177/00207640241270827
Sleman, O., & Andersson, F. (2007) · KTH Publication Database DiVA (KTH Royal Institute of Technology)
Klein, J. P., & Klein, E. M. (2025) · Springer eBooks · doi:10.1007/978-3-662-71440-9_26
Ohi, K., Nishizawa, D., Fujikane, D., Hasegawa, J., Sato, N., Tanioka, F., Sugimura, H., Ikeda, K., & Shioiri, T. (2026) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyag014
Vaishnavi, V., Kumar, T. P., Valluru, R., Syamala, Y., Siva, C., & Bhavana, R. (2026) · SA pharmaceutical journal. · doi:10.36303/sapj.3549
Self-reported antidepressant side effects in psychiatric patients with depressive disorders
von Knorring, J., Baryshnikov, I., Jylhä, P., Talaslahti, T., & Isometsä, E. (2026) · Nordic Journal of Psychiatry · doi:10.1080/08039488.2026.2686197
Carter, D. B., Plunkett, S. W., Alpizar, D., Ainsworth, A. T., & Laganà, L. (2026) · Journal of Psychopathology and Behavioral Assessment · doi:10.1007/s10862-026-10305-4
Zimmerman, M. A., & Snyder, M. D. (2026) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2026.10.016
Nurse-led interpersonal counselling for depressive symptoms in patients with myocardial infarction
Oranta, O. (2011) · UTUPub (University of Turku)
Metadata
- Authors
- Melartin, T. K., Rytsala, H. J., Leskela, U. S., Lestela-Mielonen, P. S., Sokero, T. P., & Isometsa, E. T.
- Venue
- The Journal of Clinical Psychiatry
- Publisher
- Physicians Postgraduate Press, Inc
- Published
- 2002-02-15
- Volume
- 63
- Issue
- 2
- Pages
- 126-134
- ISSN
- 0160-6689 (ISSN-L)
- OpenAlex
- W1967325475
- Cited by
- 260
- References
- 0
- Citations by year
- 2026: 5 · 2025: 3 · 2024: 6 · 2023: 5 · 2022: 2 · 2021: 7 · 2020: 9 · 2019: 10 · 2018: 17 · 2017: 18 · 2016: 13 · 2015: 6 · 2014: 9 · 2013: 17 · 2012: 12
- FWCI
- 13.25
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- STM:n Hallinnonalan avoin julkaisuarkisto (Julkari) (submittedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Personality Disorders and Psychopathology
- Health Sciences › Medicine › Psychiatry and Mental health › Mental Health Treatment and Access
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Keywords
- major depressive disorder, psychiatric comorbidity, anxiety disorders, personality disorders, substance use disorders, alcoholism, panic disorder, agoraphobia, sociodemographic factors
- MeSH terms
- Adult, Age Factors, Ambulatory Care, Anxiety Disorders, Mental Disorders, Depressive Disorder, Female, Finland, Health Services Research, Hospitalization, Humans, Male, Personality Disorders, Psychiatric Status Rating Scales, Sex Factors, Comorbidity, Prevalence, Marital Status, Substance-Related Disorders
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review