The DOI matches its Crossref record.
Risperidone, but Not Olanzapine, Decreases Bone Mineral Density in Female Premenopausal Schizophrenia Patients
Abstract
BACKGROUND: The hyperprolactinemia induced by conventional antipsychotics often leads to osteoporosis. The commonly used atypical antipsychotics risperidone and olanzapine vary in their hyperprolactinemic properties. Therefore, we compared hormone profiles and bone properties in female premenopausal schizophrenia patients treated with either risperidone or olanzapine. METHOD: In a cross-sectional study, consecutive premenopausal, female, DSM-IV schizophrenia patients who were treated with either risperidone (N = 12) or olanzapine (N = 14) for at least 2 years were included. Dual energy X-ray absorptiometry evaluated bone mineral density, and multisite quantitative ultrasound measured bone speed of sound. In addition, profiles of urinary excretion of deoxypyridinoline and circulating levels of hormones and lipids were assessed. RESULTS: Serum prolactin levels were higher in the risperidone-treated group as compared with the olanzapine subjects (123 +/- 144 and 25.9 +/- 25.7, p <.05). Whereas bone mineral density was similar in the treatment groups, bone speed of sound was lower in the risperidone group as compared with the olanzapine-treated group. Expressed as age-adjusted Z score, bone speed of sound at the radius was -0.31 and 0.58, respectively, p <.05, and at the phalanx, -1.41 and 0.04, respectively, p <.05. The bone speed of sound in the risperidone-treated patients inversely correlated with urinary deoxypyridinoline excretion (r = 0.73, p <.05). CONCLUSION: Risperidone treatment, as opposed to olanzapine, for female premenopausal schizophrenia results in hyperprolactinemia and clinically relevant decrease in bone mineral density. The calculated relative risk for fragility fracture of women treated with risperidone as compared to those treated with olanzapine is 1.78 when bone speed of sound was measured at the phalanx and 1.23 when measured at the radius.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Some studies (490-493) found a relationship between the use of prolactin-raising medication and low BMD in patients with chronic schizophrenia, while others (474,489,494-498) failed to find a relationship between prolactin, AP and osteoporosis.”
From Physical illness in patients with severe mental disorders. I. Prevalence, impact of medications and disparities in health care (2011) · cites this paper as [495]
Citations
Cited by
Sorted by citations
DE HERT, M., CORRELL, C. U., BOBES, J., CETKOVICH‐BAKMAS, M., COHEN, D., ASAI, I., DETRAUX, J., GAUTAM, S., MÖLLER, H., NDETEI, D. M., et al. (2011) · World Psychiatry · doi:10.1002/j.2051-5545.2011.tb00014.x · Cited by 2,488
“Some studies (490493) found a relationship between the use of prolactin-raising medication and low BMD in patients with chronic schizophrenia, while others (474,489,494-498) failed to find a relationship between prolactin, AP and osteoporosis.”
BackgroundAntipsychotic Drugs: A New Risk Factor for Osteoporosis in Young Women With Schizophrenia?
O'Keane, V., & Meaney, A. M. (2005) · Journal of Clinical Psychopharmacology · doi:10.1097/01.jcp.0000150223.31007.e0 · Cited by 307
Medication-Induced Hyperprolactinemia
Molitch, M. E. (2005) · Mayo Clinic Proceedings · doi:10.4065/80.8.1050 · Cited by 251
Gender Differences in the Prescribing of Antipsychotic Drugs
Seeman, M. V. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.8.1324 · Cited by 237
“Women taking drugs that raise prolactin levels show decreased bone mineral density relative to women treated with drugs less prone to increase prolactin (105, 106).”
Molitch, M. E. (2008) · Pituitary · doi:10.1007/s11102-008-0106-6 · Cited by 160
“In children and adolescents, in one study the substantial PRL elevation seen with risperidone decreased to levels within the normal range but still significantly elevated compared to baseline [21], but in other studies PRL levels remained elevated for years [ 20 , 23].”
BackgroundResultInfluentialFracture Risk From Psychotropic Medications: A Population-Based Analysis
Bolton, J. M., Metge, C., Lix, L., Prior, H., Sareen, J., & Leslie, W. D. (2008) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e31817d5943 · Cited by 158
Byerly, M., Suppes, T., Tran, Q.-V., & Baker, R. A. (2007) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e31815ac4e5 · Cited by 153
Bartels, S. J. (2004) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2004.52601.x · Cited by 153
“An association between risperidone and reduced bone mineral density in women with schizophrenia has also been reported.(61) Although a direct relationship between prolactinelevating antipsychotic agents and osteoporosis remains controversial,(62,63) bone density screening in postmenopausal women and older men should b…”
BackgroundA review of the association between antipsychotic use and hyperprolactinaemia
Bushe, C., Shaw, M., & Peveler, R. (2008) · Journal of Psychopharmacology · doi:10.1177/0269881107088435 · Cited by 148
“In three studies that have found bone mineral density loss have mean cohort prolactin values of 908–3024 mIU/L (~43–142 ng/ml) with treatment with typical antipsychotics or risperidone for between 8–21 years (Meaney et al., 2004; O’Keane and Meaney 2005; Becker et al., 2003).”
Gender Differences in the Prescribing of Antipsychotic Drugs
Seeman, M. V. (2006) · FOCUS The Journal of Lifelong Learning in Psychiatry · doi:10.1176/foc.4.1.115 · Cited by 145
Prevalence of Hyperprolactinemia in Schizophrenia
Montgomery, J., Winterbottom, E., Jessani, M., Kohegyi, E., Fulmer, J., Seamonds, B., & Josiassen, R. C. (2004) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v65n1108 · Cited by 130
O'Keane, V. (2008) · Journal of Psychopharmacology · doi:10.1177/0269881107088439 · Cited by 126
“Becker et al. (2003) reported that subjects exposed for two years to risperidone had higher prolactin levels and reduced bone speed of sound at the radius and phalanx, compared with those exposed to olanzapine for a sim- ilar period.”
BackgroundOsteoporosis in Patients With Schizophrenia
Hummer, M., Malik, P., Gasser, R. W., Hofer, A., Kemmler, G., Moncayo Naveda, R. C., Rettenbacher, M. A., & Fleischhacker, W. W. (2005) · American Journal of Psychiatry · doi:10.1176/appi.ajp.162.1.162 · Cited by 125
Deberdt, W. G., Dysken, M. W., Rappaport, S. A., Feldman, P. D., Young, C. A., Hay, D. P., Lehman, D. L., Dossenbach, M. R. K., Degenhardt, E. K., & Breier, A. F. (2005) · American Journal of Geriatric Psychiatry · doi:10.1097/00019442-200508000-00012 · Cited by 129
Use of antipsychotics in children and adolescents.
Findling, R. L., Steiner, H., & Weller, E. B. (2005) · PubMed · Cited by 118
Osteoporosis and fracture risk in people with schizophrenia
Kishimoto, T., Binder, M. D., Carlson, H. E., Manu, P., & Correll, C. U. (2012) · Current Opinion in Psychiatry · doi:10.1097/yco.0b013e328355e1ac · Cited by 121
Antipsychotic Use and the Risk of Hip Fracture Among Older Adults Afflicted With Dementia
Jalbert, J. J., Eaton, C. B., Miller, S. C., & Lapane, K. L. (2010) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2009.10.001 · Cited by 105
Bone mass in schizophrenia and normal populations across different decades of life
Renn, J.-H., Yang, N., Chueh, C., Lin, C., Lan, T., & Chou, P. (2009) · BMC Musculoskeletal Disorders · doi:10.1186/1471-2474-10-1 · Cited by 102
“Classic neuroleptics were reported to cause hyperprolactinemia and an increased prevalence of osteoporosis than atypical neuroleptics [36,37,41,42].”
BackgroundSex-Specific Differences in Side Effects of Psychotropic Drugs: Genes or Gender?
Haack, S., Seeringer, A., Thürmann, P., Becker, T. M., & Kirchheiner, J. (2009) · Pharmacogenomics · doi:10.2217/pgs.09.102 · Cited by 103
Hyperprolactinaemia and antipsychotic therapy in schizophrenia
Hummer, M., & Huber, J. C. (2004) · Current Medical Research and Opinion · doi:10.1185/030079903125002865 · Cited by 94
Antipsychotics and hyperprolactinaemia: mechanisms, consequences and management
Holt, R. I. G., & Peveler, R. (2010) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2010.03814.x · Cited by 92
Bushe, C., & Shaw, M. (2007) · Journal of Psychopharmacology · doi:10.1177/0269881107078281 · Cited by 91
“Reduced bone mineral density has been found in schizophrenia patients taking prolactin-raising antipsychotics (risperidone, typicals) (Becker et al., 2003; Meaney and O’Keane, 2003; Meaney et al., 2004; Hummer et al., 2005; O’Keane and Meaney, 2005) and the plausible mechanism that has been…”
BackgroundKelly, D. L., Conley, R. R., & Carpenter, W. T. (2005) · Drugs · doi:10.2165/00003495-200565080-00006 · Cited by 86
Antipsychotic use and the risk of hip/femur fracture: a population-based case–control study
Pouwels, S., van Staa, T. P., Egberts, T. C. G., Leufkens, H. G. M., Cooper, C. C., & de Vries, F. (2009) · Osteoporosis International · doi:10.1007/s00198-008-0826-5 · Cited by 87
Binder, M. D., Detraux, J., & Stubbs, B. (2016) · Expert Opinion on Drug Safety · doi:10.1517/14740338.2016.1167873 · Cited by 82
“[105] 26 premenopausal female patients with schizophrenia (mean age: 38) Treatment with RIS (n = 12) or OLZ (n = 14) for at least 2 years.”
MethodRisk of hip/femur fractures in patients using antipsychotics
Hugenholtz, G. W. K., Heerdink, E. R., van Staa, T. P., Nolen, W. A., & Egberts, A. C. G. (2005) · Bone · doi:10.1016/j.bone.2005.07.005 · Cited by 77
“Which is probably caused by the effect of antipsychotics on decreasing bone mineralization, leading to weaker bones [3,5,12,21,25,39].”
BackgroundManagement of Schizophrenia with Obesity, Metabolic, and Endocrinological Disorders
Monteleone, P., Martiadis, V., & Maj, M. (2009) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2009.08.003 · Cited by 70
“may induce bone mineral density loss, which may predispose patients to osteoporosis.(93,94) This is a serious issue in persons with schizophrenia, because they tend to have other risk factors for osteoporosis, such as sedentary lifestyle, smoking, poor nutrition, and pathologic water drinking.”
BackgroundRisk of osteoporosis and fracture incidence in patients on antipsychotic medication
Graham, S. M., Howgate, D. J., Anderson, W. C., Howes, C., Heliotis, M., Mantalaris, A., Tsiridis, E. E., & Tsapakis, E.-M. (2011) · Expert Opinion on Drug Safety · doi:10.1517/14740338.2011.560112 · Cited by 57
“, 2003, investigated 26 premenopausal female patients with schizophrenia who had been treated with either risperidone (n = 12) or olanzapine (n = 14) for at least 2 years [41].”
BackgroundCrews, M., & Howes, O. D. (2012) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.1265 · Cited by 57
“The authors of the remaining study (Becker et al., 2003) also found no difference in BMD between the two groups when BMD was measured using DEXA, although they did report a statistically significant difference in BMD reduction between their risperidone (prolactin-raising) and olanzapine…”
BackgroundMethodResultInfluentialBone Mineral Density in Schizophrenia
Tseng, P., Chen, Y., Yeh, P., Tu, K.-Y., Cheng, Y., & Wu, C.-K. (2015) · Medicine · doi:10.1097/md.0000000000001967 · Cited by 55
The Management of Individuals with Bipolar Disorder
Malhi, G. S., Adams, D., Cahill, C. M., Dodd, S., & Berk, M. (2009) · Drugs · doi:10.2165/11318850-000000000-00000 · Cited by 54
Doknić, M., Marić, N. P., Britvić, D., Pekić, S., Damjanović, A., Miljić, D., Stojanović, M. D. M., Radojicic, Z. A., Gašić, M. J., & POPOVIC, V. M. (2011) · Neuroendocrinology · doi:10.1159/000329391 · Cited by 52
Skeletal Status in Psychotic Disorders: A Population-Based Study
Partti, K., Heliövaara, M., Impivaara, O., Perälä, J., Saarni, S. I., Lönnqvist, J. K., & Suvisaari, J. (2010) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3181f7abd3 · Cited by 52
Motyl, K. J., Dick-de-Paula, I., Maloney, A. E., Lotinun, S., Bornstein, S., de Paula, F. J. A., Baron, R., Houseknecht, K. L., & Rosen, C. J. (2011) · Bone · doi:10.1016/j.bone.2011.08.005 · Cited by 51
“At afirst glance, hyperprolactinemiawould be anothermechanismof bone loss secondary to risperidone, which is a dopamine receptor antagonist [11,12].”
BackgroundMenstrual Cycle Dysfunction Associated with Neurologic and Psychiatric Disorders
Joffe, H., & Hayes, F. J. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1429.030 · Cited by 50
Bushe, C., Bradley, A., & Pendlebury, J. (2010) · Annals of Clinical Biochemistry International Journal of Laboratory Medicine · doi:10.1258/acb.2010.010025 · Cited by 48
Motyl, K. J., Beauchemin, M., Barlow, D. J., Le, P. T., Nagano, K., Treyball, A., Contractor, A., Baron, R., Rosen, C. J., & Houseknecht, K. L. (2017) · Bone · doi:10.1016/j.bone.2017.07.008 · Cited by 47
Osteoporosis, Schizophrenia and Antipsychotics
Halbreich, U. M. (2007) · CNS Drugs · doi:10.2165/00023210-200721080-00003 · Cited by 45
Kelly, D. L., Wehring, H. J., Earl, A. K., Sullivan, K. M., Dickerson, F., Feldman, S. M., McMahon, R. P., Buchanan, R. W., Warfel, D. T., Keller, W. R., et al. (2013) · BMC Psychiatry · doi:10.1186/1471-244x-13-214 · Cited by 45
“Other recent evidence suggests that having amenorrhea or using prolactin elevating antipsychotic drugs are associated with a higher risk for osteoporosis and fracture [79-82].”
BackgroundBushe, C., Yeomans, D., Floyd, T., & Smith, S. M. (2008) · Journal of Psychopharmacology · doi:10.1177/0269881107088436 · Cited by 45
“The relationship between prolactin and bone mineral density (BMD) loss and osteoporosis has been recognised as a putative link for some time, but has been a difficult area in which to arrive at definitive conclusions (Becker et al., 2003; Hummer et al., 2005; Halbreich et al., 2003).”
BackgroundPropranolol Attenuates Risperidone-Induced Trabecular Bone Loss in Female Mice
Motyl, K. J., DeMambro, V., Barlow, D. J., Olshan, D. S., Nagano, K., Baron, R., Rosen, C. J., & Houseknecht, K. L. (2015) · Endocrinology · doi:10.1210/en.2015-1099 · Cited by 39
“The dopamine receptor antagonist activity of RIS can induce clinical hyperprolactinemia, which leads to hypothalamic hypogonadism and could explain bone loss (9, 10, 13, 27).”
BackgroundPossible mechanisms for the skeletal effects of antipsychotics in children and adolescents
Calarge, C. A., Ivins, S. D., Motyl, K. J., Shibli-Rahhal, A. A., Bliziotes, M. M., & Schlechte, J. (2013) · Therapeutic Advances in Psychopharmacology · doi:10.1177/2045125313487548 · Cited by 39
“This is of significance in light of accumulating evidence in adults implicating APs in suboptimal bone mineral density (BMD) [Bilici et al. 2002; Abraham et al. 2003; Becker et al. 2003; Meaney et al. 2004; Howes et al. 2005; Jung et al. 2006; Meaney and O’Keane, 2007; Kishimoto et al. 2008].”
BackgroundHigh bone turnover but normal bone mineral density in women suffering from schizophrenia
Bergemann, N., Parzer, P., Mundt, C., & Auler, B. (2008) · Psychological Medicine · doi:10.1017/s003329170800319x · Cited by 37
“Several clinical trials have addressed this issue since that time (Keely et al. 1997 ; Abraham et al. 2002, 2003 ; Bilici et al. 2002 ; Becker et al. 2003 ; Meaney & O’Keane, 2003, 2007 ; Meaney et al. 2004 ; Maric et al. 2005 ; O’Keane & Meaney, 2005).”
BackgroundResultTakahashi, T., Uchida, H., John, M., Hirano, J., Watanabe, K., Mimura, M., Correll, C. U., & Kishimoto, T. (2013) · Schizophrenia Research · doi:10.1016/j.schres.2013.04.015 · Cited by 34
“However since then, a growing number of reports have focused on this topic (Abraham et al., 2003a; Becker et al., 2003; Howes et al., 2005; Lehman and Meyer, 2005), and a majority of them reported lower BMD in this population compared to healthy controls (Kishimoto et al., 2005; Renn et al., 2009;…”
Bone Mineral Density in Male Schizophrenia Patients: A Review
Meyer, J. M., & Lehman, D. (2006) · Annals of Clinical Psychiatry · doi:10.1080/10401230500464687 · Cited by 29
Javaid, M. K., & Holt, R. I. (2008) · Journal of Psychopharmacology · doi:10.1177/0269881107087955 · Cited by 28
“In cross sectional studies comparing those prescribed olanzapine with those receiving typical prolactin-raising medication, those prescribed olanzipine had lower prolactin concentrations, had higher BMD and were less likely to have menstrual abnormalities (O’Keane and Meaney, 2005; Becker et al., 2003).”
ResultSecond-generation antipsychotics and bone turnover in schizophrenia
Okita, K., Kanahara, N., Nishimura, M., Yoshida, T., Yasui‐Furukori, N., Niitsu, T., Yoshida, T., Ishikawa, M., Kimura, H., Nomura, F., et al. (2014) · Schizophrenia Research · doi:10.1016/j.schres.2014.05.009 · Cited by 27
“Several studies examining the relationship between given antipsychotics and the loss of BMD in patients with schizophrenia reported controversial results: some groups observed a meaningful relationship (O'Keane and Meaney, 2005; Meaney and O'Keane, 2007), but others reported the lack of such a relationship (Abraham et…”
ResultConforti, A., Chiamulera, C., Moretti, U., Colcera, S., Fumagalli, G. F., & Leone, R. (2007) · Current Drug Safety · doi:10.2174/157488607779315516 · Cited by 26
“This effect is most likely due to persistent risperidone-induced hyperprolactinemia [161].”
BackgroundAntipsychotic-induced bone loss: the role of dopamine, serotonin and adrenergic receptor signalling
Weerasinghe, D. K., Hodge, J. M., Pasco, J. A., Samarasinghe, R. M., Manavi, B. A., & Williams, L. J. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1184550 · Cited by 28
Serum Prolactin and Bone Mineral Density in Schizophrenia: A Systematic Review
Lally, J., Sahl, A. B., Murphy, K. C., Gaughran, F., & Stubbs, B. (2019) · Clinical Psychopharmacology and Neuroscience · doi:10.9758/cpn.2019.17.3.333 · Cited by 24
Management of Hyperprolactinemia in Patients Receiving Antipsychotics
Miller, K. K. (2004) · CNS Spectrums · doi:10.1017/s1092852900002340 · Cited by 24
Clozapine protects bone mineral density in female patients with schizophrenia
Lin, C., Huang, K.-H., Chang, Y., Huang, Y., Hsu, W.-C., Lin, C.-Y., Chou, F. H., Tsai, G. E., & Lane, H. (2011) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145711001507 · Cited by 22
“inconclusive (Abraham et al. 2003; Becker et al. 2003; Meaney & O’Keane, 2007 ; O’Keane & Meaney, 2005 ; Wyszogrodzka-Kucharska & Rabe-Jablonska, 2005b).”
Chronic Psychosocial Stress Impairs Bone Homeostasis: A Study in the Social Isolation Reared Rat
Schiavone, S., Morgese, M. G., Mhillaj, E., Bové, M., Giorgi, A. D., Cantatore, F. P., Camerino, C., Tucci, P., Maffulli, N., Cuomo, V., et al. (2016) · Frontiers in Pharmacology · doi:10.3389/fphar.2016.00152 · Cited by 19
Bulut, S. D., Bulut, S., Atalan, D. G., Tulacı, R. G., Türker, T., Gürçay, E., & Aydemir, Ç. (2016) · PubMed · Cited by 19
Metal exposure and bone remodeling during pregnancy: Results from the PROGRESS cohort study
Osorio-Yáñez, C., Sánchez-Guerra, M., Solano, M., Baccarelli, A., Wright, R. O., Sanders, A. P., Téllez‐Rojo, M. M., & Tamayo‐Ortiz, M. (2021) · Environmental Pollution · doi:10.1016/j.envpol.2021.116962 · Cited by 19
Treatment Considerations in Women with Schizophrenia
Kelly, D. L. (2006) · Journal of Women s Health · doi:10.1089/jwh.2006.15.1132 · Cited by 19
Besag, F., Vasey, M. J., & Salim, I. (2021) · CNS Drugs · doi:10.1007/s40263-021-00812-1 · Cited by 19
“Bone mineral density loss has been reported with long-term treatment (8–21 years) with risperidone and consequently raised prolactin levels of between 43 and 142 ng/mL [41, 44, 129].”
BackgroundRenn, J.-H., Yang, N.-P., & Chou, P. (2010) · BMC Musculoskeletal Disorders · doi:10.1186/1471-2474-11-35 · Cited by 17
“Nevertheless, the adjusted bone speed of sound was significantly lower in the hyperprolactinemia group at the radius and phalanx [33].”
BackgroundManavi, B. A., Stuart, A. L., Pasco, J. A., Hodge, J. M., Samarasinghe, R. M., Weerasinghe, D. K., & Williams, L. J. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.1004366 · Cited by 15
“Some have further investigated duration of use, finding chronic use to be related with reduced bone mineralization (3, 7, 8, 31).”
BackgroundLiang, M., Zhang, B., Deng, L., Xu, R. H., Wu, H., & Chen, J. (2019) · International Journal of Endocrinology · doi:10.1155/2019/1312804 · Cited by 15
“Such effect is presumably associated with the hyperprolactinemic effect of these atypical antipsychotics, which is high in risperidone and low in olanzapine [23].”
BackgroundBipolar depression: the role of atypical antipsychotics
Post, R. M., & Calabrese, J. R. (2004) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.4.6.s27 · Cited by 14
Zhang, S., He, W., Li, A., Zhao, C., Chen, Y., Xu, C., Zhang, Q., Zheng, D., Chen, M., Miao, H., et al. (2022) · Molecular Medicine · doi:10.1186/s10020-022-00466-9 · Cited by 13
“In addition, Risperidone is known to contribute to BMD reduction in female patients with premenopausal schizophrenia (Becker et al. 2003).”
BackgroundFactors associated with decreased bone mineral density in postmenopausal women with schizophrenia
Liang, Y., Huang, J. V., Tian, J., Cao, Y., Zhang, G., Wang, C., Cao, Y., & Li, J. (2016) · Clinical Interventions in Aging · doi:10.2147/cia.s100274 · Cited by 13
“6,7 However, other studies have obtained the opposite result, 8 which implies that there might be some other factors that affect the BMD of patients with schizophrenia.”
Gynecologic and Reproductive Health Concerns of Adolescents Using Selected Psychotropic Medications
Talib, H. J., & Alderman, E. M. (2012) · Journal of Pediatric and Adolescent Gynecology · doi:10.1016/j.jpag.2012.05.011 · Cited by 12
Clinical effectiveness of atypical antipsychotics in elderly patients with psychosis
Masand, P. S. (2004) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2004.08.005 · Cited by 10
Kunst, R. F., Langlais, A. L., Barlow, D. J., Houseknecht, K. L., & Motyl, K. J. (2021) · JBMR Plus · doi:10.1002/jbm4.10541 · Cited by 10
Kelly, D. L., Myers, C. S., Abrams, M. T., Feldman, S. M., Park, J., McMahon, R. P., & Shim, J.-C. (2010) · Osteoporosis International · doi:10.1007/s00198-010-1294-2 · Cited by 9
“However, because we did not observe a significant risk of osteoporosis in the non-SUD psychotic disorders group, this may suggest that comorbid substance use plays a significant role and may partially explain the higher rates of bone loss seen in other studies where substance use was not reported [12, 16, 33].”
ResultLiang, Y., Su, Y.-A., Zhao, Z.-G., Gao, N., Huang, J.-Z., Tang, M.-Q., Li, K.-Q., Yang, F.-D., Yu, X., & Si, T.-M. (2015) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0000000000000379 · Cited by 6
Lambert, T. L., Farmer, K. C., & Brahm, N. C. (2012) · Intern J Endocrinol Metab · doi:10.5812/ijem.4366 · Cited by 6
Early onset schizophrenia: diagnostic dilemmas and treatment challenges
Shannon, J. C., & McClellan, J. (2004) · Therapy · doi:10.2217/14750708.1.1.131 · Cited by 8
Chen, Y., Zhang, Y., Fan, K., Xu, W., Teng, C., Wang, S., Tang, W., & Zhu, X. (2021) · PeerJ · doi:10.7717/peerj.11332 · Cited by 5
“Early studies of patients treated with risperidone found high PRL levels to be associated with low BMD values (Becker et al., 2003).”
BackgroundSpezielle Aspekte der pharmakotherapeutischen Behandlung forensisch untergebrachter Patientinnen
Singer, M., & Eckermann, G. (2023) · Forensische Psychiatrie Psychologie Kriminologie · doi:10.1007/s11757-023-00762-y · Cited by 7
“…(Oligomenorrhö, Amenorrhö) sowie Brustspannungsschmerzen und Milchfluss betroffen sein können, und langfristig wie auch bei Männern das Risiko für Osteoporose aufgrund reduzierter Knochenmineraldichte steigt (O’Keane und Meaney 2005; Becker et al. 2003; Aichhorn et al. 2007; Hummer et al. 2005).”
BackgroundAntipsychotika und Hyperprolaktinämie: Pathophysiologie, klinische Bedeutung, Abklärung und Therapie
Riecher‐Rössler, A., Schmid, C., Bleuer, S., & Birkhäuser, M. (2009) · Gynäkologische Endokrinologie · doi:10.1007/s10304-009-0316-7 · Cited by 5
Disha-Ibrahimi, S., Furlani, B., Drevenšek, G., Hudoklin, S., Marc, J., Žitnik, I. P., Sajovic, J., & Drevenšek, M. (2022) · Biomolecules and Biomedicine · doi:10.17305/bjbms.2022.7523 · Cited by 4
“The prolactin-sparing activity of olanzapine is favored due to the minimal loss of BMD [8,11].”
BackgroundInfluentialLanglais, A. L., Mountain, R. V., Kunst, R. F., Barlow, D. J., Houseknecht, K. L., & Motyl, K. J. (2023) · Biochimie · doi:10.1016/j.biochi.2023.05.002 · Cited by 4
Atypical antipsychotic drugs inhibit trabecular bone accrual in C57BL/6J mice.
Li, X., & Nagy, T. R. (2013) · PubMed · Cited by 3
Koçer, E., Yazıcı, S., & Canan, F. (2011) · Dusunen Adam The Journal of Psychiatry and Neurological Sciences · doi:10.5350/dajpn2011240407 · Cited by 3
Ulgar, Ş. B., & Ayaydın, H. (2018) · Psychiatry and Clinical Psychopharmacology · doi:10.1080/24750573.2018.1468617 · Cited by 3
“shown to cause a decrease in bone mineral density [3].”
BackgroundDisha-Ibrahimi, S., Drevenšek, G., Drevenšek, M., et al. (2024) · Acta Pharmaceutica · doi:10.2478/acph-2024-0029 · Cited by 2
“Some studies have associated olanzapine with induced bone resorption and bone loss (25–27), while others have reported its role in increasing bone density (28, 29).”
BackgroundHongyan, F., Yang, Z., Pang, L., et al. (2025) · Journal of Orthopaedic Surgery and Research · doi:10.1186/s13018-025-05520-w · Cited by 2
Osteoporosis secundaria a fármacos
Sallés, M., & Gelman, S. M. (2009) · Seminarios de la Fundación Española de Reumatología · doi:10.1016/j.semreu.2009.09.002 · Cited by 2
Tanino, Y., 米田, 浩., Takasaki, K., et al. (2011) · Journal of Physical Therapy Science · doi:10.1589/jpts.23.655 · Cited by 2
Medications for Mental Health Disorders and Impact on Bone
Leslie-Allen, N. L., Bolton, J. M., & Leslie, W. D. (2024) · Springer eBooks · doi:10.1007/978-3-031-32046-0_126-1 · Cited by 1
Clinical Characteristics and Management of Bipolar Disorder in Women across the Life Span
Dodd, S., Katsenos, S., Tiller, J. W. G., & Berk, M. (2005) · Women s Health · doi:10.2217/17455057.1.3.421 · Cited by 1
“There is also a suggestion that increased prolactin may lead to decreased bone mineral density and osteoporosis, impacting on another substantial women’s health issue [30].”
BackgroundAging Bones: Osteoporosis and Injurious Falls in the Oldest Women
Heffernan, J. D., & Messinger‐Rapport, B. J. (2005) · Clinical Reviews in Bone and Mineral Metabolism · doi:10.1385/bmm:3:2:157 · Cited by 1
Vitamins, fatty acids, physical activity and peak bone mass
Högström, M. (2007) · DiVA at Umeå University (Umeå University) · Cited by 1
Wpływ flufenazyny i risperidonu na przebudowę kości u szczurów owariektomizowanych
Pytlik, M., & Fronczek-Sokół, J. (2012) · Annales Academiae Medicae Silesiensis
Schizofrenia a esordio precoce. Trattamento farmacologico
Paloscia, C., Rosa, C. G., Fagiolo, D., Pompili, E., Sciarretta, A., Curatolo, P., & Pasini, A. (2007) · Giornale italiano di psicopatologia/Journal of psychopathology/Italian journal of psychopathology
Carvajal, A., Arias, L. H. M., & Bulnes, N. J. (2007) · Side effects of drugs annual · doi:10.1016/s0378-6080(06)29006-8
Perte osseuse induite par les antidépresseurs et les neuroleptiques
Breuil, V., & Euller‐Ziegler, L. (2011) · Revue du Rhumatisme Monographies · doi:10.1016/j.monrhu.2011.01.008
OSTEOPORÓZA A SCHIZOFRENIE OSTEOPORÓZA A SCHIZOFRENIE
Králové, H. (2006)
Osteopenia by Risperidone-Induced Hyperprolactinemia: A Case Report
Milano, W., Rosa, M. D., Milano, L., Petrella, C., Ingenito, A., & Capasso, A. (2012) · Biomedical Research-tokyo
Maj, M., Ïðåçèäåíò, È., Tasman, A., & Herrman, H. (2011)
(2009) · CRC Press eBooks · doi:10.3109/9780203092835-3
(2015) · Elsevier eBooks · doi:10.1016/b978-0-444-53717-1.01410-4
Carvajal, A., Arias, L. H. M., & Bulnes, N. J. (2005) · Side effects of drugs annual · doi:10.1016/s0378-6080(05)80428-3
Current awareness in human psychopharmacology
(2004) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.563
(2009) · Elsevier eBooks · doi:10.1016/b978-0-444-53266-4.50005-7
Metadata
- Authors
- Becker, D., Liver, O., Mester, R., Rapoport, M., Weizman, A., & Weiss, M.
- Venue
- The Journal of Clinical Psychiatry
- Publisher
- Physicians Postgraduate Press, Inc
- Published
- 2003-07-15
- Volume
- 64
- Issue
- 7
- Pages
- 761-766
- ISSN
- 0160-6689 (ISSN-L)
- OpenAlex
- W2071226732
- Cited by
- 107
- References
- 0
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 4 · 2022: 6 · 2021: 7 · 2019: 2 · 2018: 1 · 2017: 1 · 2016: 4 · 2015: 4 · 2014: 1 · 2013: 4 · 2012: 6
- FWCI
- 4.69
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmacological Effects and Toxicity Studies
- Keywords
- risperidone, olanzapine, schizophrenia, bone mineral density, hyperprolactinemia, atypical antipsychotics, osteoporosis, bone speed of sound, deoxypyridinoline, fragility fracture risk, prolactin
- MeSH terms
- Olanzapine, Adolescent, Adult, Benzodiazepines, Female, Humans, Middle Aged, Osteoporosis, Pirenzepine, Prolactin, Schizophrenia, Serotonin Antagonists, Absorptiometry, Photon, Bone Density, Selective Serotonin Reuptake Inhibitors, Premenopause, Risperidone
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
