Risk of hip/femur fractures in patients using antipsychotics
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The objective of our study was to investigate whether use of antipsychotics is associated with hip/femur fractures and whether pharmacological differences between antipsychotics are related to the occurrence of fractures. A case-control study was conducted, in which cases were defined as patients with a hip/femur fracture. Each patient was matched to one control patient. The association between use of antipsychotics and the occurrence of hip/femur fractures was evaluated using conditional logistic regression. The study included 44,500 patients from 683 general practices from different geographical areas in the UK, registered within the General Practice Research Database (GPRD). Exposure to antipsychotics was categorized as "no use", "current use" and "prior use". Both current and prior use of antipsychotics were associated with an approximately two-fold increased risk of fractures. After adjustment for possible confounders, a small significant effect remained (Odds Ratios (OR) of 1.3). We did not find an association between dose of antipsychotics, or between the degree of blockade of the alpha-1 adrenoceptor or histamine-1 receptor and risk of fractures. The total number of days of antipsychotic use was significantly associated with an increased risk of hip/femur fractures. We conclude that there is a small increased risk of hip/femur fractures associated with the use of antipsychotics. This risk increases with long-term use.
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Other studies have found significant increases (OR=1.2-2.6) in the risk of fractures associated with antipsychotics.
“Other studies (506-510) have found significant increases (OR=1.2-2.6) in the risk of fractures associated with AP.”
From Physical illness in patients with severe mental disorders. I. Prevalence, impact of medications and disparities in health care (2011) · cites this paper as [507]
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- Authors
- Hugenholtz, G. W. K., Heerdink, E. R., van Staa, T. P., Nolen, W. A., & Egberts, A. C. G.
- Affiliations
- Utrecht University (NL)
- University Medical Center Groningen (NL)
- Corresponding author
- Heerdink, Eibert R.
- Venue
- Bone
- Publisher
- Elsevier BV
- Published
- 2005-12
- Volume
- 37
- Issue
- 6
- Pages
- 864-870
- ISSN
- 1873-2763 (ISSN-L)
- 8756-3282
- OpenAlex
- W2021192737
- Cited by
- 77
- References
- 38
- Citations by year
- 2026: 1 · 2024: 4 · 2023: 2 · 2022: 1 · 2021: 4 · 2020: 6 · 2019: 4 · 2018: 2 · 2017: 3 · 2016: 6 · 2015: 2 · 2014: 5 · 2013: 4 · 2012: 9
- FWCI
- 1.80
- Type
- journal article
- Language
- en
- Open access
- green
- dspace.library.uu.nl
- Licence
- Locations
- Bone (publishedVersion)
- PubMed (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion)
- Utrecht University Repository (Utrecht University) (submittedVersion, other-oa)
- ePrints Soton (University of Southampton) (submittedVersion)
- Research Explorer (The University of Manchester) (submittedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Health Sciences › Medicine › Geriatrics and Gerontology › Pharmaceutical Practices and Patient Outcomes
- Keywords
- antipsychotic drugs, hip fracture, femoral fracture, fracture risk, long-term antipsychotic use, alpha-1 adrenergic blockade, antipsychotic dosing, drug safety
- MeSH terms
- Adolescent, Adult, Aged, Dose-Response Relationship, Drug, Female, Femoral Fractures, United Kingdom, Hip Fractures, Humans, Male, Middle Aged, Receptors, Histamine H1, Risk, Antipsychotic Agents, Case-Control Studies, Receptors, Adrenergic, alpha-1
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