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Cited by 156Personality Disorders and PsychopathologyBipolar Disorder and TreatmentPsychotherapy Techniques and Applications

Combined dialectical behavior therapy and fluoxetine in the treatment of borderline personality disorder

Simpson, Elizabeth B., Yen, Shirley, Costello, Ellen, Rosen, Karen, Begin, Ann, Pistorello, Jacqueline, Pearlstein, Teri·2004·The Journal of Clinical Psychiatry
DOI 10.4088/jcp.v65n0314
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Abstract

BACKGROUND: This study examines the therapeutic effect of fluoxetine, a selective serotonin reuptake inhibitor, added to dialectical behavior therapy (DBT), an empirically supported psychosocial therapy, for the treatment of borderline personality disorder. METHOD: This is a 12-week, randomized, double-blind, placebo-controlled study of patients with borderline personality disorder (identified using the Structured Clinical Interview for DSM-IV Axis II Disorders). All subjects received individual and group DBT. Of the 20 subjects that completed treatment, 9 were randomly assigned to receive up to 40 mg/day of fluoxetine and 11 were randomly assigned to the placebo condition. Subjects were evaluated at baseline and at week 10 or 11 on self-report measures of depression, anxiety, anger expression, dissociation, and global functioning. The study was conducted between January 1998 and February 2000. RESULTS: Time-by-group interaction effects revealed no significant group differences in scores from pre-treatment to posttreatment on any measure. However, within the DBT/placebo group, there were significant pretreatment/posttreatment differences in the direction of improvement on all measures. No significant pre-treatment/posttreatment differences were found within the DBT/fluoxetine condition. CONCLUSION: The data suggest that adding fluoxetine to an efficacious psychosocial treatment does not provide any additional benefits. Further studies with larger sample sizes are warranted.

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  • The pharmacotherapy review (Stoffers 2010) included three trials testing psychotherapy plus drug against psychotherapy plus placebo.

    “the pharmacotherapy review (Stoffers 2010) included three trials testing psychotherapy plus drug against psychotherapy plus placebo (Simpson 2004;Soler 2005;Linehan 2008).”

    From Psychological therapies for people with borderline personality disorder. (2012) · cites this paper as Simpson 2004

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Authors
Simpson, E. B., Yen, S., Costello, E., Rosen, K., Begin, A., Pistorello, J., & Pearlstein, T.
Affiliations
  • Harvard University (US)
  • Brown University (US)
  • University of Nevada, Reno (US)
ORCID
Venue
The Journal of Clinical Psychiatry
Publisher
Physicians Postgraduate Press, Inc
Published
2004-03-15
Volume
65
Issue
3
Pages
379-385
ISSN
0160-6689 (ISSN-L)
DOI
10.4088/jcp.v65n0314
OpenAlex
W2025624676
Cited by
156
References
0
Citations by year
2026: 5 · 2024: 7 · 2023: 1 · 2022: 3 · 2021: 4 · 2020: 4 · 2019: 6 · 2018: 4 · 2017: 9 · 2016: 3 · 2015: 3 · 2014: 11 · 2013: 12 · 2012: 10
FWCI
11.99
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Personality Disorders and Psychopathology
  • Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
  • Social Sciences › Psychology › Clinical Psychology › Psychotherapy Techniques and Applications
Keywords
borderline personality disorder, dialectical behavior therapy, fluoxetine, selective serotonin reuptake inhibitors, psychosocial interventions, depression, anxiety, anger expression, dissociation, global functioning
MeSH terms
Adult, Behavior Therapy, Borderline Personality Disorder, Combined Modality Therapy, Double-Blind Method, Female, Fluoxetine, Humans, Surveys and Questionnaires, Selective Serotonin Reuptake Inhibitors, Diagnostic and Statistical Manual of Mental Disorders

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