The DOI matches its Crossref record.
Increased Mortality Among Patients Admitted With Major Psychiatric Disorders: A Register-Based Study Comparing Mortality in Unipolar Depressive Disorder, Bipolar Affective Disorder, Schizoaffective Disorder, and Schizophrenia
Abstract
CONTEXT: Persons suffering from severe mental disorder have an excess mortality compared to persons with no mental disorder. However, the magnitude of the excess mortality differs from one mental disorder to another, and the impact on mortality if a first-degree family member suffers from a mental disorder has never been examined in a population-based study. OBJECTIVE: Our objective was to examine and compare mortality rates after admission with schizophrenia, schizoaffective disorder, unipolar depressive disorder, or bipolar affective disorder and to examine the impact of family history of psychiatric admission on mortality. METHOD: We established a register-based cohort study of 5.5 million persons born in Denmark who were alive on or born after January 1, 1973 and alive on their 15th birthday. Mortality rate ratios were estimated by survival analysis, using Poisson regression. RESULTS: Unipolar depressive disorder, bipolar affective disorder, and schizoaffective disorder were associated with the same pattern of excess mortality. Schizophrenia had a lower mortality from unnatural causes of death and a higher mortality from natural causes compared to the 3 other disorders. Family history of psychiatric admission was associated with excess mortality. CONCLUSION: Patients suffering from the 4 disorders all had an excess mortality, but the pattern of excess mortality was not the same. There was an excess mortality associated with mental disorder in a first-degree family member, but this only explained a small part of the general excess mortality associated with the 4 mental disorders examined.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Notably, the SMR for cancer was only 1.37, which has also been observed in other studies (Laursen et al. 2007;Mortensen & Juel 1990, 1993).”
From Excess early mortality in schizophrenia. (2014) · cites this paper as Laursen et al. 2007
In the citing paper
“Patients with bipolar disorder or schizophrenia seem to be a particular vulnerable patient group [6].”
From Life expectancy and death by diseases of the circulatory system in patients with bipolar disorder or schizophrenia in the Nordic countries. (2013) · cites this paper as [6]
In the citing paper
“Today, respiratory diseases are still more prevalent in people with SMI (8,(410)(411)(412)(413)(414)(415)(416)(417).”
From Physical illness in patients with severe mental disorders. I. Prevalence, impact of medications and disparities in health care (2011) · cites this paper as [8]
In the citing paper
“In the population of bipolar spectrum disorders, deaths from cancer are not higher (8,288,416,417,454-456) or only slightly elevated (417,418,456) compared with the general population, despite the higher number of risk factors for cancer (such as obesity) in this population.”
From Physical illness in patients with severe mental disorders. I. Prevalence, impact of medications and disparities in health care (2011) · cites this paper as [8]
In the citing paper
“The excess mortality is not solely explained by increased risk of suicide and other external causes of death; it is also due to diseases and medical conditions.”
From Excess mortality, causes of death and life expectancy in 270,770 patients with recent onset of mental disorders in Denmark, Finland and Sweden (2013) · cites this paper as [6]
In the citing paper
“A recent Danish study confirms that mortality from cardiovascular disease, malignant neoplasms, respiratory diseases and endocrine and metabolic conditions was more than twofold higher for both men and women with schizophrenia and affective disorders compared to the general population. [6].”
From Excess mortality, causes of death and life expectancy in 270,770 patients with recent onset of mental disorders in Denmark, Finland and Sweden (2013) · cites this paper as [6]
Citations
Cited by
Sorted by citations
Items 101–200 of 380
Post-mortem toxicology in young sudden cardiac death victims: a nationwide cohort study
Bjune, T., Risgaard, B., Kruckow, L., Glinge, C., Hansen, O. I., Leth, P. M., Línnet, K., Banner, J., Winkel, B. G., & Tfelt‐Hansen, J. (2017) · EP Europace · doi:10.1093/europace/euw435 · Cited by 61
Abnormal glycemic homeostasis at the onset of serious mental illnesses: A common pathway
García‐Rizo, C., Kirkpatrick, B. W., Fernández-Egea, E., Oliveira, C., & Bernardo, M. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.02.001 · Cited by 60
“As we have previously stated, SMI is associated with increased morbidity and mortality, mainly due to cardiovascular related pathologies (Laursen et al., 2007).”
Hatzenbuehler, M. L., Bränström, R., & Pachankis, J. E. (2016) · Stigma and Health · doi:10.1037/sah0000066 · Cited by 63
Association Between Retinal Features From Multimodal Imaging and Schizophrenia
Wagner, S. K., Cortina‐Borja, M., Silverstein, S. M., Zhou, Y., Romero-Bascones, D., Struyven, R., Trucco, E., Mookiah, M. R. K., MacGillivray, T., Hogg, S., et al. (2023) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2023.0171 · Cited by 59
Robinson, E. J., & Henderson, C. (2018) · Psychological Medicine · doi:10.1017/s0033291718003677 · Cited by 60
“, 2011); reduced life expectancy (Laursen et al., 2007); exclusion from higher education and employment (Social Exclusion Unit, 2004); increased risk of contact with criminal justice systems; victimisation (Clement et al.”
BackgroundThe Efficacy of EMDR in the Treatment of Depression
Gauhar, Y. W. M. (2016) · Journal of EMDR Practice and Research · doi:10.1891/1933-3196.10.2.59 · Cited by 58
RetractedEvidence for accelerated vascular aging in bipolar disorder
Sodhi, S. K., Linder, J., Chenard, C. A., Miller, D. D., Haynes, W. G., & Fiedorowicz, J. G. (2012) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2012.06.004 · Cited by 57
“Although it is clear that bipolar disorder is associated with greater risk of cardiovascular morbidity and mortality [22–24], our prior analysis of a young sample found no evidence of vasculopathy relative to age, gender, and smoking matched controls [6], leading to the hypothesis that the negative results were due to…”
ResultGissler, M., Laursen, T. M., Ösby, U., Nordentoft, M., & Wahlbeck, K. (2013) · BMC Public Health · doi:10.1186/1471-2458-13-834 · Cited by 52
“The excess mortality among people with severe mental disorders is not only caused by an increased risk for suicides and unintentional injuries, but also from an increased risk for mortality from diseases and medical conditions, such as diseases of the circulatory system, cancer and diabetes [4-6].”
BackgroundSelf-citationAjetunmobi, O., Taylor, M., Stockton, D., & Wood, R. (2013) · BMJ Open · doi:10.1136/bmjopen-2013-002768 · Cited by 56
Increased DNA and RNA damage by oxidation in patients with bipolar I disorder
Jacoby, A. S., Vinberg, M., Poulsen, H. E., Kessing, L. V., & Munkholm, K. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.141 · Cited by 56
Schizophrenia and Cancer: In 2010 Do We Understand the Connection?
Bushe, C., & Hodgson, R. E. (2010) · The Canadian Journal of Psychiatry · doi:10.1177/070674371005501203 · Cited by 55
Altamura, A. C., Serati, M., Albano, A., Paoli, R. A., Glick, I. D., & Dell’Osso, B. M. (2011) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-011-0196-4 · Cited by 56
“Laursen and co-workers [32] compared mortality rates among severe mental disorders, finding that patients with SK had higher mortality from natural causes compared with both unipolar and bipolar depressed subjects.”
García‐Rizo, C., & Bitanihirwe, B. K. Y. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.109910 · Cited by 58
Mortality and causes of death in older patients with schizophrenia
Talaslahti, T., Alanen, H., Hakko, H., Isohanni, M., Häkkinen, U., & Leinonen, E. (2012) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.2833 · Cited by 54
“For cancer, the mortality has varied across studies and has been reported to be even lower in patients with schizophrenia than in general population (Laursen et al., 2007; Saha et al., 2007; Bushe et al., 2009).”
BackgroundMortality of 403 patients with mood disorders 48 to 52 years after their psychiatric hospitalisation
Angst, J., Hengartner, M. P., Gamma, A., Zerssen, D. V., & Angst, F. (2012) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-012-0380-1 · Cited by 53
“The most recent studies suggest that the mortality rate among patients with bipolar disorder is strongly elevated [17, 18] and is higher among patients with bipolar-I (BP-I) disorder than among those with bipolar-II (BP-II) disorder [16].”
Backgroundthe INDIGO READ study group, Deb, T., Lempp, H. K., Bakolis, I., Vince, T., Waugh, W. L., & Henderson, C. (2019) · BMC Medical Education · doi:10.1186/s12909-019-1472-7 · Cited by 54
Karabatsiakis, A., & Schönfeldt‐Lecuona, C. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-00901-7 · Cited by 53
Monteith, S., Glenn, T., Geddes, J. R., Whybrow, P. C., & Bauer, M. (2016) · International Journal of Bipolar Disorders · doi:10.1186/s40345-016-0051-7 · Cited by 51
“Uses for data from providers and payers The analysis of very large databases has provided fundamental information about bipolar disorder including the incidence, prevalence, decreased life expectancy (Munk-Jørgensen et al. 2014; Allebeck 2009; Laursen et al. 2007; Chang et al. 2011; Kessing et al. 2015c; Kessing et al…”
BackgroundCrump, C., Ioannidis, J. P. A., Sundquist, K., Winkleby, M. A., & Sundquist, J. (2013) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2013.05.034 · Cited by 48
“Most large, highly cited studies have ascertained mental disorders using hospital discharge data, which are more commonly available than outpatient data (Hamer et al., 2008; Hiroeh et al., 2001; Hiroeh et al., 2008; Hoang et al., 2011; Laursen et al., 2007; Politi et al., 2002; Qin et al., 2003; Wahlbeck et al., 2011).”
InfluentialChoong, E., Bondolfi, G., Etter, M., Jermann, F., Aubry, J., Bartolomei, J., Gholam‐Rezaee, M., & Eap, C. B. (2012) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2012.01.014 · Cited by 46
“5e2-fold as compared to the general population was reported for depressed, bipolar and schizophrenic patients (Angst et al., 2002; Laursen et al., 2007), which appears to be mainly due to a two-fold excess of cardiovascular risk factors (Birkenaes et al.”
BackgroundPrevalence of the metabolic syndrome in Danish psychiatric outpatients treated with antipsychotics
Krane‐Gartiser, K., Breum, L., Glümer, C., Linneberg, A. R., Madsen, M., Køster, A., Jepsen, P. W., & Fink‐Jensen, A. (2011) · Nordic Journal of Psychiatry · doi:10.3109/08039488.2011.565799 · Cited by 45
Kessing, L. V. (2024) · International Journal of Bipolar Disorders · doi:10.1186/s40345-023-00322-7 · Cited by 55
“…among patients with bipolar disorder has consistently been found to be increased 2–3 times compared to the general population (Osby et al. 2001; Laursen et al. 2007; Crump et al. 2013) and life expectancy to be decreased by 8 to 12 years compared to the general population (Kessing et al.…”
BackgroundHildersley, R., Potts, L. C., Anderson, C., & Henderson, C. (2020) · Epidemiology and Psychiatric Sciences · doi:10.1017/s204579602000089x · Cited by 43
“…and discrimination (Thornicroft et al., 2007), towards people with mental illness contributes to inequality (Phelan et al., 2014), excess mortality (Laursen et al., 2007; Gissler et al., 2013; Starace et al., 2018) and affects help-seeking behaviour (Thornicroft, 2008; Henderson et al., 2013;…”
BackgroundRisk factors for suicidal ideations in patients with bipolar disorder
Vanamoorthy, U., Avasthi, A., & Grover, S. (2014) · Bipolar Disorders · doi:10.1111/bdi.12179 · Cited by 46
El complejo estigma-discriminación asociado a trastorno mental como factor de riesgo de suicidio
Campo‐Arias, A., & Herazo, E. (2015) · Revista Colombiana de Psiquiatría · doi:10.1016/j.rcp.2015.04.003 · Cited by 59
Comorbidity of depression and anxiety disorders in patients with hypertension
Graham, N., & Smıth, D. J. (2016) · Journal of Hypertension · doi:10.1097/hjh.0000000000000850 · Cited by 46
Psychiatric disorder as a first manifestation of cancer: A 10‐year population‐based study
Benros, M. E., Laursen, T. M., Dalton, S. O., & Mortensen, P. B. (2009) · International Journal of Cancer · doi:10.1002/ijc.24274 · Cited by 42
Self-citationMortality and tardive dyskinesia: long-term study using the US National Death Index
Dean, C. E., & THURAS, P. D. (2009) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.108.049395 · Cited by 42
Potts, L. C., Bakolis, I., Deb, T., Lempp, H. K., Vince, T., Benbow, Y., Waugh, W. L., Kim, S., Raza, S. A., Henderson, C., et al. (2022) · Social Psychiatry and Psychiatric Epidemiology · doi:10.1007/s00127-022-02284-0 · Cited by 46
“Stigma and discrimination related to mental illness constitute a significant public health problem, leading to reduced help seeking and access to healthcare [1, 2], fewer opportunities for education and work [3, 4], increased co-morbidity [5], and mortality [6, 7].”
BackgroundLemogne, C., Nabi, H., Melchior, M., Goldberg, M., Limosin, F., Consoli, S., & Zins, M. (2013) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2013.03.015 · Cited by 37
“, Journal of Psychiatric Researc natural mortality across five age categories, found higher risks associated with other SMD than depressive disorders, regardless of age and gender (Laursen et al., 2007).”
BackgroundResultInfluentialCarstensen, K., Lou, S., Jensen, L. G., Nissen, N. K., Ørtenblad, L., Pfau, M., & Ankersen, P. V. (2017) · Nordic Journal of Psychiatry · doi:10.1080/08039488.2017.1288759 · Cited by 40
Effects of psychopharmacological treatment with antipsychotic drugs on the vascular system
Kahl, K. G., Westhoff‐Bleck, M., & Krüger, T. H. C. (2017) · Vascular Pharmacology · doi:10.1016/j.vph.2017.09.001 · Cited by 40
Cardiovascular risk in individuals with depression
Bivanco-Lima, D., Santos, I. S., Vannucchi, A. M. C., & Ribeiro, M. C. S. D. A. (2013) · Revista da Associação Médica Brasileira · doi:10.1016/j.ramb.2012.12.006 · Cited by 41
Lin, J., McGlynn, K. A., Carter, C. A., Nations, J. A., Anderson, W. F., Shriver, C. D., & Zhu, K. (2016) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-16-0316 · Cited by 40
“3 Introduction There is mounting evidence of a higher all-cause mortality in people with mental illness than general population (1-9).”
Omary, A. (2020) · Psychiatric Quarterly · doi:10.1007/s11126-020-09800-y · Cited by 42
Dopamine D2 receptor signaling modulates pancreatic beta cell circadian rhythms
Wei, H., Zapata, R. C., Valencia, M. L., Aslanoglou, D., Farino, Z. J., Benner, V., Osborn, O., Freyberg, Z., & McCarthy, M. J. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.104551 · Cited by 38
“These metabolic disturbances place patients at risk for cardiac disease and type 2 diabetes (T2D), causing excess morbidity and reducing life span (Goldstein et al., 2015; Khan et al., 2013; Laursen et al., 2007).”
BackgroundChoi, J. W., Park, S., Yi, K. K., & Hong, J. P. (2012) · Suicide and Life-Threatening Behavior · doi:10.1111/j.1943-278x.2012.00085.x · Cited by 40
Lawes, S., Demakakos, P., Steptoe, A., Lewis, G., & Carvalho, L. A. (2018) · Psychological Medicine · doi:10.1017/s003329171800209x · Cited by 40
“…studies have reported that people with depressive symptoms are at greater risk of mortality (Wulsin et al., 1999; Schulz et al., 2002; Wulsin et al., 2005; Lasserre et al., 2016), particularly from cardiovascular disease (CVD) (Laursen et al., 2007; Wu and Kling, 2016; Correll et al., 2017).”
BackgroundKessing, L. V., Ziersen, S. C., Andersen, P. K., & Vinberg, M. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.12.072 · Cited by 38
Increased cardiovascular events in young patients with mental disorders: a nationwide cohort study.
Park, C., Choi, E., Han, K., Ahn, H., Kwon, S., Lee, S.-R., Oh, S., & Lip, G. (2023) · European Journal of Preventive Cardiology · doi:10.1093/eurjpc/zwad102 · Cited by 32
Longitudinal Study of Low Serum LDL Cholesterol and Depressive Symptom Onset in Postmenopause
Persons, J. E., Robinson, J. G., Coryell, W. H., Payne, M. E., & Fiedorowicz, J. G. (2016) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.14m09505 · Cited by 34
Validation of the Mood Disorder Questionnaire in the general population in Hong Kong
Chung, K., Tso, K., & Chung, R. T.-Y. (2009) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2008.10.001 · Cited by 34
“Bipolar disorder is a serious illness causing substantial morbidity and mortality [1,2].”
BackgroundFond, G. B., Llorca, P., Boucékine, M., Zendjidjian, X. Y., Brunel, L., Lançon, C., Auquier, P., & Boyer, L. (2016) · Scientific Reports · doi:10.1038/srep20256 · Cited by 37
Bartoli, F., Crocamo, C., Caslini, M., Clerici, M., & Carrà, G. (2015) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2015.04.028 · Cited by 33
“…but also to SCZ/ONAP, of suffering from comorbid MetS, that represents an important risk factor (Galassi et al., 2006; Gami et al., 2007; Mottillo et al., 2010; Wu et al., 2010) at least partially explaining the excess mortality among SD patients (Capasso et al., 2008; Laursen et al., 2007).”
BackgroundGomes, F. A., de Almeida, K. M., Magalhães, P. V. D. S., Caetano, S. C., Kauer‐Sant’Anna, M., Lafer, B., & Kapczinski, F. P. (2013) · Brazilian Journal of Psychiatry · doi:10.1590/1516-4446-2011-0768 · Cited by 35
Gasse, C., Laursen, T. M., & Baune, B. T. (2012) · European Journal of Preventive Cardiology · doi:10.1177/2047487312467874 · Cited by 34
“The phenomenon of decreasing excess mortality with age has previously been observed in patients across different severe psychiatric disorders both with regard to natural and unnatural causes of death.(26) Second, the analysis of time since incident depression diagnosis prior to the cardiac events Table 3.”
BackgroundSelf-citationCan Exercise Increase Fitness and Reduce Weight in Patients with Schizophrenia and Depression?
Krogh, J., Speyer, H., Nørgaard, H. C. B., Moltke, A., & Nordentoft, M. (2014) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2014.00089 · Cited by 37
Self-citationPratt, L. A. (2012) · Psychiatric Services · doi:10.1176/appi.ps.201100442 · Cited by 34
“Also, there may be survival bias, given studies showing that persons with serious mental illness have higher mortality rates than the general population (6).”
BackgroundPotts, L. C., & Henderson, C. (2020) · SSM - Population Health · doi:10.1016/j.ssmph.2020.100611 · Cited by 33
Vancampfort, D., Probst, M., Sweers, K., Maurissen, K., Knapen, J., Willems, J. B., Heip, T., & Hert, M. A. F. D. (2011) · European Psychiatry · doi:10.1016/j.eurpsy.2011.01.009 · Cited by 34
“In addition to the effects of antipsychotic treatment [12,29,30], the association of schizophrenia or schizoaffective disorder with increased cardio-metabolic risk factors is a complex interplay between unhealthy lifestyle (physical inactivity, unhealthy diet, smoking and substance use) [5,23,39], genetic risk [28,34]…”
Mental health related stigma in Romania: systematic review and narrative synthesis
Manescu, E. A., Henderson, C., Paroiu, C. R., & Mihai, A. (2023) · BMC Psychiatry · doi:10.1186/s12888-023-05147-3 · Cited by 36
“Researchers have reported several negative effects of stigma such as reluctance to seek help, engage in and maintain treatment [3], and an overall increase in co-morbidity and mortality [4, 5]; fewer opportunities for school, work or social interactions or trouble obtaining accommodation [6, 7].”
BackgroundRibe, A. R., Laurberg, T., Laursen, T. M., Charles, M., Vedsted, P., & Vestergaard, M. (2016) · PLoS ONE · doi:10.1371/journal.pone.0158013 · Cited by 35
“In addition, the registration of cause of death in women with SMI in our study could also be subject to differential misclassification caused by expected higher rates of death from external causes, cardiovascular disease, diabetes, or infections in persons with SMI [2, 23, 35].”
BackgroundSelf-citationTreatment following myocardial infarction in patients with schizophrenia
Attar, R., Johansen, M. B., Valentin, J. B., Aagaard, J., & Jensen, S. E. (2017) · PLoS ONE · doi:10.1371/journal.pone.0189289 · Cited by 33
Inhibition of mouse brown adipocyte differentiation by second-generation antipsychotics
Oh, J.-E., Cho, Y. M., Kwak, S.-N., Kim, J. H., Lee, K., Jung, H., Jeong, S., & Kwon, O.-J. (2012) · Experimental & Molecular Medicine · doi:10.3858/emm.2012.44.9.062 · Cited by 32
Ali, S., Santomauro, D. F., Ferrari, A. J., & Charlson, F. (2023) · Epidemiology and Psychiatric Sciences · doi:10.1017/s2045796023000045 · Cited by 33
Sugai, T., Suzuki, Y., Yamazaki, M., Shimoda, K., Mori, T., Ozeki, Y., Matsuda, H., Sugawara, N., Yasui‐Furukori, N., Minami, Y., et al. (2016) · Schizophrenia Research · doi:10.1016/j.schres.2016.01.016 · Cited by 30
“Patients with schizophrenia have a reduced life expectancy compared with the general population (Druss et al., 2011; Laursen et al., 2007).”
BackgroundRegional Differences in Five-Year Mortality After a First Episode of Schizophrenia in Finland
Kiviniemi, M., Suvisaari, J., Pirkola, S. P., Häkkinen, U., Isohanni, M. K., & Hakko, H. H. (2010) · Psychiatric Services · doi:10.1176/ps.2010.61.3.272 · Cited by 32
Treatment of bipolar disorder: New perspectives
Alda, M., Hájek, T., Calkin, C., & O’Donovan, C. (2008) · Annals of Medicine · doi:10.1080/07853890802409489 · Cited by 30
“Mood disorders are potentially lethal conditions, not only due to suicide, but also due to somatic causes, perhaps with the exception of malignancy (81).”
BackgroundRamsey, C. M., Spira, A. P., Mojtabai, R., Eaton, W. W., Roth, K. B., & Lee, H. B. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2013.06.019 · Cited by 28
“Most of these studies have concluded that bipolar disorder is associated with an increased risk of all-cause and cause-specific mortality (Osby et al., 2001; Hoyer et al., 2000; Sharma and Markar, 1994; Black et al., 1987a; Laursen et al., 2007; Hoang et al., 2011; Chang et al., 2011; Angst et al., 2002; Tsai et al.,…”
BackgroundMethodInfluentialFreyberg, Z., & McCarthy, M. J. (2017) · Schizophrenia · doi:10.1038/s41537-017-0018-4 · Cited by 28
Frailty and depressive symptoms in older adults: data from the FIBRA study - UNICAMP
do Nascimento, P. P. P., Batistoni, S. S. T., & Neri, A. L. (2016) · Psicologia Reflexão e Crítica · doi:10.1186/s41155-016-0033-9 · Cited by 25
“1999), pain, isolation (Tavares 2004), mortality (Laursen et al. 2007) and frailty.”
BackgroundForoughi, M., Medina‐Inojosa, J. R., Lopez-Jimenez, F., Saeidifard, F., Suarez, L., Stokin, G. B., Prieto, M. L., Rocca, W. A., Frye, M. A., & Morgan, R. J. (2021) · Psychosomatic Medicine · doi:10.1097/psy.0000000000001017 · Cited by 33
“Fourth, the patients in our cohort were not required to have seen a psychiatrist or to have been psychiatrically or medically hospitalized, potentially making these data more generalizable to community settings than prior studies that have used the inclusion criteria for hospitalization or presentation to psychiatric…”
ResultVancampfort, D., Sweers, K., Probst, M., Mitchell, A. J., Knapen, J., & Binder, M. D. (2011) · Community Mental Health Journal · doi:10.1007/s10597-011-9431-8 · Cited by 26
“The high prevalence of metabolic and CVD risk factors in people with schizophrenia is a complex interplay between environmental (physical inactivity, an unhealthy diet, substance abuse) (Hennekens et al. 2005; Bobes et al. 2010; Vancampfort et al. 2010, 2011), genetic (van Winkel et al. 2010) and illness related facto…”
BackgroundEuropean Psychiatric Association (EPA) guidance on quality assurance in mental healthcare
Gäebel, W., Großimlinghaus, I., Heun, R., Janssen, B., Johnson, B., Kurimay, T., Montellano, P., Muijen, M., Munk‐Jørgensen, P., Wulf Rössler, A., et al. (2015) · European Psychiatry · doi:10.1016/j.eurpsy.2015.01.011 · Cited by 31
“…care predicted better health outcomes Agreement of patients and carers on needs is one of the factors influencing patient outcomes Evidence level I Laursen et al., 2007 [56] Register-based cohort study 5.5 million persons in Denmark Excess mortality was found for patients with unipolar depressive…”
BackgroundInfluentialZhai, D., Cui, T., Xu, Y., Feng, Y., Wang, X., Yang, Y., Li, S., Zhou, D., Dong, G., Zhao, Y., et al. (2016) · Schizophrenia Research · doi:10.1016/j.schres.2016.09.001 · Cited by 25
“…is predominantly related to cardiovascular illness and obesityrelated diseases (McEvoy et al., 2005; Colton and Manderscheid, 2006; Hennekens, 2007; Laursen et al., 2007; Saha et al., 2007; Brown et al., iversity, School of Pharmacy, ork UpstateMedical University, 13210, USA. iversity, The Second…”
BackgroundOut-of-hospital cardiac arrest in patients with psychiatric disorders — Characteristics and outcomes
Barcella, C. A., Mohr, G. H., Kragholm, K. H., Blanche, P., Gerds, T. A., Wissenberg, M., Hansen, S. M., Ringgren, K. B., Lippert, F. K., Folke, F., et al. (2019) · Resuscitation · doi:10.1016/j.resuscitation.2019.07.008 · Cited by 24
“Accordingly, schizophrenia is associated more often than other psychiatric disorders with medical causes of death, including cardiovascular death.(8) Unwitnessed cardiac arrest and reduced probability of bystander intervention were seen in patients with schizophrenia and substance-abuse; possibly because of a stronger…”
BackgroundKuczynski, A. M., Kanter, J. W., & Robinaugh, D. J. (2019) · Quality of Life Research · doi:10.1007/s11136-019-02298-3 · Cited by 29
Ilgen, M. A., Czyz, E. K., Welsh, D. E., Zeber, J. E., Bauer, M. S., & Kilbourne, A. M. (2008) · Journal of Affective Disorders · doi:10.1016/j.jad.2008.07.019 · Cited by 27
Vascular Mortality in Participants of a Bipolar Genomics Study
Fiedorowicz, J. G., Jancic, D., Potash, J. B., Butcher, B. D., & Coryell, W. H. (2014) · Psychosomatics · doi:10.1016/j.psym.2014.02.001 · Cited by 26
Information systems for mental health
Amaddeo, F., & Tansella, M. (2009) · Epidemiologia e Psichiatria Sociale · doi:10.1017/s1121189x00001378 · Cited by 25
“Other examples are mortality studies, where MHISs are linked with “causes of death” databases (Amaddeo et al. , 1995; 2007; Laursen et al. , 2007); or ecological studies on the effect of deprivation or environmental factors on incidence, prevalence and services utilisation (Tello et al. , 2005;…”
BackgroundElectroconvulsive Therapy and All-Cause Mortality in Texas, 1998–2013
Dennis, N. M., Dennis, P. A., Shafer, A., Weiner, R. D., & Husain, M. M. (2016) · Journal of Ect · doi:10.1097/yct.0000000000000340 · Cited by 25
“However, it is unclear whether such a relationship might be a reflection of the higher overall death rate for patients with bipolar disorder or schizophrenia in comparison to patients with major depressive disorder, as has been demonstrated in population-level studies.(19) Although racial disparities in death rates we…”
Wang, D., Ma, J., Tan, L., Chen, Y., Li, X., Tian, X., Zhou, X., & Liu, X. (2017) · PLoS ONE · doi:10.1371/journal.pone.0188312 · Cited by 24
Schizophrenia — A predictor of suicide during the second half of life?
Erlangsen, A., Eaton, W. W., Mortensen, P. B., & Conwell, Y. (2011) · Schizophrenia Research · doi:10.1016/j.schres.2011.09.032 · Cited by 24
“…by Mortensen and Juel (1990), an effect similar to the healthy worker effect might explain this; older adults with schizophrenia might represent a select group that survived the high mortality due to both natural and other causes earlier in life (Harris and Barraclough, 1998; Laursen et al., 2007).”
BackgroundSelf-citationVascular function is not impaired early in the course of bipolar disorder
Murray, D. P., Metz, N. S., Haynes, W. G., & Fiedorowicz, J. G. (2012) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2011.12.006 · Cited by 25
“Perhaps as a consequence, individuals with bipolar disorder face nearly twice the adjusted risk for cardiovascular mortality [5–10].”
BackgroundEffects of psychopharmacological treatment with antidepressants on the vascular system
Kahl, K. G., Westhoff‐Bleck, M., & Krüger, T. H. C. (2017) · Vascular Pharmacology · doi:10.1016/j.vph.2017.07.004 · Cited by 25
Krogh, J., Lorentzen, A. K., Subhi, Y., & Nordentoft, M. (2014) · Mental health and physical activity · doi:10.1016/j.mhpa.2014.01.003 · Cited by 23
Self-citationSemız, M., Yücel, H., Kavakçı, Ö., Yıldırım, O., Zorlu, A., Yılmaz, M. B., Küçükdurmaz, Z., & Canan, F. (2013) · Europe PMC (PubMed Central) · Cited by 23
Is EMDR an Evidenced-Based Treatment for Depression? A Review of the Literature
Wood, E., & Ricketts, T. (2013) · Journal of EMDR Practice and Research · doi:10.1891/1933-3196.7.4.225 · Cited by 23
Chen, C.-C., Hsu, L., Huang, K., Goto, S., Chen, C., & Nakano, T. (2017) · Scientific Reports · doi:10.1038/s41598-017-11323-9 · Cited by 24
Lin, J., Liang, F., Li, C., & Lu, T. (2018) · Schizophrenia Research · doi:10.1016/j.schres.2018.01.011 · Cited by 23
Direct and indirect effects of psychopharmacological treatment on the cardiovascular system
Kahl, K. G. (2018) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2018-0054 · Cited by 23
Laursen, T. M., Trabjerg, B. B., Mors, O. N., Børglum, A. D., HOUGAARD, D. M., Mattheisen, M., Meier, S. M., Byrne, E. M., Mortensen, P. B., Munk‐Olsen, T., et al. (2016) · Schizophrenia Research · doi:10.1016/j.schres.2016.12.001 · Cited by 25
“Studies have shown that personswith schizophrenia have 2 to 3 fold higher mortality rates compared to the general population (Harris and Barraclough, 1998; Osby et al., 2000; Laursen et al., 2007; Saha et al., 2007), resulting in 15–20 years shorter life expectancy (Laursen, 2011).”
BackgroundSelf-citationTsai, S., Chang, W.-H., Cheng, C., Liang, C., Bai, Y., Hsu, J.-W., Huang, K., Su, T., Chen, T., & Chen, M. (2023) · Autism · doi:10.1177/13623613231167287 · Cited by 22
“…codes: F70, F71, F72, F73, F78, F79) (Hossain et al., 2020; Mutluer et al., 2022), which are also associated with an increased mortality rate (Laursen et al., 2007; Lomholt et al., 2019), these comorbidities also were investigated during the follow-up period for further evaluation of the…”
Prevention of Metabolic Syndrome in Serious Mental Illness
Ganguli, R., & Strassnig, M. (2011) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2010.11.004 · Cited by 22
Desai, R. A., Camacho, F., Tan, X., LeBaron, V. T., Blackhall, L. J., & Balkrishnan, R. (2019) · Journal of Oncology Practice · doi:10.1200/jop.18.00781 · Cited by 23
Schizophrenia and “unmet needs”: From diagnosis to care in Italy
Galderisi, S., Riva, M. A., Girardi, P., Amore, M., Carpiniello, B., Aguglia, E., Fagiolini, A. M., Mucci, A., & Vita, A. (2020) · European Psychiatry · doi:10.1192/j.eurpsy.2019.8 · Cited by 21
“Despite the increased mortality for cardiovascular disease [31,32], there is a very small number of studies on these factors.”
BackgroundChang, J., Chen, H.-H., Yen, A. M., Chen, S. L., & Lee, C. (2012) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2012.07.014 · Cited by 20
Mental health and barriers to the achievement of the ‘right to health’
Henderson, J., & Battams, S. (2011) · Australian Journal of Primary Health · doi:10.1071/py10063 · Cited by 21
Thiol/disulphide homeostasis in bipolar disorder
Erzın, G., Kotan, V. O., Topçuoğlu, C., et al. (2018) · Psychiatry Research · doi:10.1016/j.psychres.2017.12.062 · Cited by 21
“Bipolar disorder (BD) is associated with increased mortality (Laursen et al., 2007) and one of the most debilitating psychiatric disorders characterized by disruptive episodes of mania/hypomania and depression (Anderson et al., 2012).”
BackgroundGervaix, J., Haour, G., Michel, M., & Chevreul, K. (2018) · Epidemiology and Psychiatric Sciences · doi:10.1017/s2045796018000203 · Cited by 21
Christensen, M. R., Poulsen, H. E., Henriksen, T., Weimann, A., Ellervik, C., Lynnerup, N., Rungby, J., & Banner, J. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.08.029 · Cited by 21
Salte, K., Titlestad, I. L., & Halling, A. (2015) · PubMed · Cited by 20
Ageing with schizophrenia: an update
Solomon, H. V., Sinopoli, M., & DeLisi, L. E. (2021) · Current Opinion in Psychiatry · doi:10.1097/yco.0000000000000694 · Cited by 20
Causes of mortality in a large population-based cohort of psychiatric patients in Southern Europe
Girardi, P., Schievano, E., Fedeli, U., Braggion, M., Nuti, M., & Amaddeo, F. (2021) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2021.01.050 · Cited by 20
Mental illness stigma among indigenous communities in Bangladesh: a cross-sectional study
Faruk, M. O., & Rosenbaum, S. (2023) · BMC Psychology · doi:10.1186/s40359-023-01257-5 · Cited by 24
“Subject to stigma lowers the quality of life [15] and can increase risk of poorer health outcomes including premature death [16, 17].”
BackgroundDefective Nitric Oxide–Cyclic Guanosine Monophosphate Signaling in Patients With Bipolar Disorder
Fontoura, P. C., Pinto, V. L. M., Matsuura, C., Resende, Â. C., de Bem, G. F., Ferraz, M. R., Cheniaux, E., Brunini, T. M. C., & Mendes‐Ribeiro, A. C. (2012) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3182689460 · Cited by 20
“L-Tyrosine 36 (1) 57 (3) 42 (4) 49 (7)”
BackgroundKiviniemi, M. (2014) · Cited by 20
Madan, A., Clapp, J. D., Osborne, P. J., Walker, C. R., Frueh, B. C., Allen, J. G., Oldham, J. M., & Fowler, J. C. (2016) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000298 · Cited by 20
Nugent, C., Rosato, M., Hughes, L., & Leavey, G. (2020) · Psychiatric quarterly · doi:10.1007/s11126-020-09827-1 · Cited by 19
Leinonen, T., Martikainen, P., Laaksonen, M., & Lahelma, E. (2014) · Social Psychiatry and Psychiatric Epidemiology · doi:10.1007/s00127-013-0747-2 · Cited by 21
“Those with depression and other mental disorders have a high risk of mortality from a wide range of natural and unnatural causes [11–15].”
BackgroundResultInfluential
Metadata
- Authors
- Laursen, T. M., Munk-Olsen, T., Nordentoft, M., & Mortensen, P. B.
- Affiliations
- Aarhus University (DK)
- Bispebjerg Hospital (DK)
- Venue
- The Journal of Clinical Psychiatry
- Publisher
- Physicians Postgraduate Press, Inc
- Published
- 2007-06-15
- Volume
- 68
- Issue
- 06
- Pages
- 899-907
- ISSN
- 0160-6689 (ISSN-L)
- OpenAlex
- W2006100396
- Cited by
- 380
- References
- 0
- Citations by year
- 2026: 9 · 2025: 10 · 2024: 9 · 2023: 17 · 2022: 15 · 2021: 17 · 2020: 19 · 2019: 14 · 2018: 26 · 2017: 17 · 2016: 35 · 2015: 25 · 2014: 24 · 2013: 33 · 2012: 31
- FWCI
- 26.09
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Lundbeckfonden (R5-2006-227)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Mental Health Treatment and Access
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
- Keywords
- excess mortality, severe mental illness, schizophrenia, schizoaffective disorder, major depressive disorder, bipolar disorder, first-degree relatives, causes of death, mortality rate ratio
- MeSH terms
- Adult, Aged, Aged, 80 and over, Bipolar Disorder, Cause of Death, Denmark, Depressive Disorder, Female, Humans, Male, Middle Aged, Mortality, Psychotic Disorders, Registries, Schizophrenia, Cohort Studies
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
