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Glutathione as an antioxidant in inorganic mercury-induced nephrotoxicity

Jan, AT, Ali, A, Haq, QMR·2011·Journal of Postgraduate Medicine
DOI 10.4103/0022-3859.74298
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Abstract

Heavy metal toxicity represents an uncommon but clinically significant medical condition, which if unrecognized or inappropriately treated results in significant morbidity and mortality. Among heavy metals, mercury is recognized as a potent and widely distributed toxicant having the ability to accumulate at various levels of food chain besides possessing ability to cross placental and blood-brain barrier. Symptom picture of mercury (Hg 2+ ) toxicity is characterized mainly by a series of renal disorders. Mechanism of inorganic mercury toxicity includes production of reactive oxygen species (ROS) capable of damaging lipids in membrane, proteins or enzymes in tissues, and DNA to induce oxidative stress as balance between generation, and elimination of ROS is essential for maintaining the functional integrity of a cell. Mitigation of endogenous mercury depends as a part on the presence of antioxidants such as glutathione - most abundant intracellular non-protein thiol that plays a central role in the maintenance of cellular redox status by quenching free radicals generated during oxidative stress. Ability of a cell to survive the threat posed by endogenous mercury represents a biological adaptation fundamental to survival. This review describes the current understanding and the mechanisms involved by different forms of mercury in eliciting their toxicity in kidney along with the knowledge of major intracellular reductant that plays important role in the mitigation of mercury toxicity for the maintenance of homeostasis within the body of living organisms.

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  • Excessive consumption of heavy metal-contaminated vegetables may cause carcinogenic, mutagenic, neurotoxic, and teratogenic effects and serious health risks.

    “Previous studies found that excessive consumption of heavy metalcontaminated vegetables may cause carcinogenic, mutagenic, neurotoxic, and teratogenic effects on human health, leading to serious health risks like Alzheimer's in adults, intellectual disability in children, DNS (deviated nasal septum), insomnia, kidney, and liver diseases, and more”

    From Assessment of heavy metals accumulation by vegetables irrigated with different stages of textile wastewater for evaluation of food and health risk (2024) · cites this paper as Jan et al., 2011

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Metadata

Authors
Jan, A., Ali, A., & Haq, Q.
Venue
Journal of Postgraduate Medicine
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2011
Volume
57
Issue
1
Pages
72-77
ISSN
0022-3859
DOI
10.4103/0022-3859.74298
Cited by
77
References
2
Language
en

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