Evidence for DNA Damage as a Biological Link Between Diabetes and Cancer
Open accessAbstract
OBJECTIVE: This review examines the evidence that: Diabetes is a state of DNA damage; pathophysiological factors in diabetes can cause DNA damage; DNA damage can cause mutations; and DNA mutation is linked to carcinogenesis. DATA SOURCES: We retrieved information from the PubMed database up to January, 2014, using various search terms and their combinations including DNA damage, diabetes, cancer, high glucose, hyperglycemia, free fatty acids, palmitic acid, advanced glycation end products, mutation and carcinogenesis. STUDY SELECTION: We included data from peer-reviewed journals and a textbook printed in English on relationships between DNA damage and diabetes as well as pathophysiological factors in diabetes. Publications on relationships among DNA damage, mutagenesis, and carcinogenesis, were also reviewed. We organized this information into a conceptual framework to explain the possible causal relationship between DNA damage and carcinogenesis in diabetes. RESULTS: There are a large amount of data supporting the view that DNA mutation is a typical feature in carcinogenesis. Patients with type 2 diabetes have increased production of reactive oxygen species, reduced levels of antioxidant capacity, and increased levels of DNA damage. The pathophysiological factors and metabolic milieu in diabetes can cause DNA damage such as DNA strand break and base modification (i.e., oxidation). Emerging experimental data suggest that signal pathways (i.e., Akt/tuberin) link diabetes to DNA damage. This collective evidence indicates that diabetes is a pathophysiological state of oxidative stress and DNA damage which can lead to various types of mutation to cause aberration in cells and thereby increased cancer risk. CONCLUSIONS: This review highlights the interrelationships amongst diabetes, DNA damage, DNA mutation and carcinogenesis, which suggests that DNA damage can be a biological link between diabetes and cancer.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Reduced expression of DNA repair genes due to increased levels of oxidative stress has been implicated in several other human diseases, including diabetes, obesity, and glaucoma.
“In fact, reduced expression of DNA repair genes due to increased levels of oxidative stress has been implicated with several other human diseases, including diabetes [84], obesity [137], and glaucoma [109].”
From DNA repair deficiency and senescence in concussed professional athletes involved in contact sports (2019) · cites this paper as [84]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
1 retracted
Dan, H. C., Sun, M., Yang, L., Feldman, R. I., Sui, X.-M., Ou, C. C., Nellist, M. D., Yeung, R. S. W., Halley, D. J. J., Nicosia, S. V., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m205838200 · Cited by 370 · see citing works
RetractedOxidative DNA damage: mechanisms, mutation, and disease
Cooke, M. S., Evans, M. D., Dizdaroglu, M., & Lunec, J. (2003) · The FASEB Journal · doi:10.1096/fj.02-0752rev · Cited by 3,245 · see citing works
DeFronzo, R. A. (2009) · Diabetes · doi:10.2337/db09-9028 · Cited by 3,016 · see citing works
Giovannucci, E., Harlan, D. M., Archer, M. C., Bergenstal, R. M., Gapstur, S. M., Habel, L. A., Pollak, M., Regensteiner, J. G., & Yee, D. (2010) · Diabetes Care · doi:10.2337/dc10-0666 · Cited by 2,366 · see citing works
Diabetes in Asia: Epidemiology, Risk Factors, and Pathophysiology
Chan, J. C. N., Malik, V., Jia, W., Kadowaki, T., Yajnik, C. S., Yoon, K.-H., & Hu, F. B. (2009) · JAMA · doi:10.1001/jama.2009.726 · Cited by 1,997 · see citing works
Self-citationOxidative Stress and Oxidative Damage in Carcinogenesis
Klaunig, J. E., Kamendulis, L. M., & Hocevar, B. A. (2009) · Toxicologic Pathology · doi:10.1177/0192623309356453 · Cited by 960 · see citing works
Genomics, type 2 diabetes, and obesity
McCarthy, M. I. (2010) · New England Journal of Medicine · doi:10.1056/nejmra0906948 · Cited by 938 · see citing works
Oxidative damage to DNA in diabetes mellitus
Dandona, P., Thusu, K., Cook, S., Snyder, B., Makowski, J., Armstrong, D., & Nicotera, T. M. (1996) · The Lancet · doi:10.1016/s0140-6736(96)90013-6 · Cited by 788 · see citing works
Quagliaro, L., Piconi, L., Assaloni, R., Martinelli, L., Motz, E., & Ceriello, A. (2003) · Diabetes · doi:10.2337/diabetes.52.11.2795 · Cited by 771 · see citing works
In search of the tumour-suppressor functions of BRCA1 and BRCA2
Scully, R., & Livingston, D. M. (2000) · Nature · doi:10.1038/35044000 · Cited by 643 · see citing works
DNA damage by reactive species: Mechanisms, mutation and repair
Jena, N. R. (2012) · Journal of Biosciences · doi:10.1007/s12038-012-9218-2 · Cited by 344 · see citing works
Akt: A Double-Edged Sword in Cell Proliferation and Genome Stability
Xu, N., Lao, Y., Zhang, Y., & Gillespie, D. A. (2012) · Journal of Oncology · doi:10.1155/2012/951724 · Cited by 308 · see citing works
DNA damage and repair in type 2 diabetes mellitus
Błasiak, J., Arabski, M., Krupa, R., Woźniak, K., Zadrożny, M., Kasznicki, J., Żurawska-Kliś, M., & Drzewoski, J. (2004) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2004.05.011 · Cited by 258 · see citing works
High glucose induces DNA damage in cultured human endothelial cells.
Lorenzi, M., Montisano, D. F., Toledo, S., & Barrieux, A. (1986) · Journal of Clinical Investigation · doi:10.1172/jci112295 · Cited by 251 · see citing works
Oxidative DNA damage in diabetes mellitus: its association with diabetic complications
Hinokio, Y., Suzuki, S., Hirai, M., Chiba, M., Hirai, A. M., & Toyota, T. (1999) · Diabetologia · doi:10.1007/s001250051258 · Cited by 209 · see citing works
Seghrouchni, I., Drai, J., Bannier, E., Rivière, J., Calmard, P., Garcia, I., Orgiazzi, J., & Revol, A. (2002) · Clinica Chimica Acta · doi:10.1016/s0009-8981(02)00099-2 · Cited by 205 · see citing works
DNA Damage in Diabetes: Correlation with a Clinical Marker
Collins, A. R., Rašlová, K., Somorovská, M., Petrovská, H., Ondrusova, A., Vohnout, B., Fábry, R., & Dušinská, M. (1998) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(98)00053-7 · Cited by 187 · see citing works
Oxidative DNA damage and obesity in type 2 diabetes mellitus
Al-Aubaidy, H. A., & Jelinek, H. F. (2011) · European Journal of Endocrinology · doi:10.1530/eje-11-0053 · Cited by 183 · see citing works
Yang, X., Ko, G. T. C., So, W. Y., Ronald, C. W., Yu, L. W. L., Kong, A. P. S., Zhao, H., Chow, C., Tong, P. C. Y., & Chan, J. C. N. (2010) · Diabetes · doi:10.2337/db09-1371 · Cited by 162 · see citing works
Self-citationMechanism of Oxidative DNA Damage in Diabetes
Simone, S., Gorin, Y. C., Velagapudi, C., Abboud, H. E., & Habib, S. L. (2008) · Diabetes · doi:10.2337/db07-1579 · Cited by 129 · see citing works
Insulin: A Novel Factor in Carcinogenesis
Gupta, K., Krishnaswamy, G. A., Karnad, A. B., & Peiris, A. N. (2002) · The American Journal of the Medical Sciences · doi:10.1097/00000441-200203000-00004 · Cited by 123 · see citing works
Nacerddine, K., Beaudry, J., Ginjala, V., Westerman, B. A., Mattiroli, F., Song, J., van der Poel, H. G., Balagué, O., Pritchard, C. E. J., Cornelissen‐Steijger, P., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci57477 · Cited by 113 · see citing works
Potential role of Akt signaling in chronic kidney disease
Lan, A., & Du, J. (2014) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfu196 · Cited by 109 · see citing works
Genotoxicity of advanced glycation end products in mammalian cells
Stopper, H., Schinzel, R., Šebeková, K., & Heidland, A. (2003) · Cancer Letters · doi:10.1016/s0304-3835(02)00626-2 · Cited by 108 · see citing works
Lee, A. T., Reis, D., & Eriksson, U. J. (1999) · Diabetes · doi:10.2337/diabetes.48.2.371 · Cited by 103 · see citing works
Yang, X. (2008) · Archives of Internal Medicine · doi:10.1001/archinte.168.5.451 · Cited by 98 · see citing works
Goodarzi, M. T., Navidi, A. A., Rezaei, M., & Babaahmadi‐Rezaei, H. (2010) · Journal of Clinical Laboratory Analysis · doi:10.1002/jcla.20328 · Cited by 96 · see citing works
Linoleic acid and antioxidants protect against DNA damage and apoptosis induced by palmitic acid
Beeharry, N., Lowe, J. E., Hernandez, A. L. R., Chambers, J. A., Fucassi, F., Cragg, P. J., Green, M. H. L., & Green, I. C. (2003) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s0027-5107(03)00134-9 · Cited by 92 · see citing works
Pu, J., Peng, G., Li, L., Na, H., Liu, Y., & Liu, P. (2011) · Journal of Lipid Research · doi:10.1194/jlr.m011254 · Cited by 86 · see citing works
Mutational specificity of oxidative DNA damage
Retèl, J., Hoebee, B., Braun, J. E. F., Lutgerink, J. T., van den Akker, E., Wanamarta, A. H., Joenje, H., & Lafleur, M. V. M. (1993) · Mutation Research/Genetic Toxicology · doi:10.1016/0165-1218(93)90094-t · Cited by 80 · see citing works
Mizutani, K., Ikeda, K., Nishikata, T., & Yamori, Y. (2000) · Journal of Hypertension · doi:10.1097/00004872-200018120-00018 · Cited by 78 · see citing works
PPARGC1A Variation Associated With DNA Damage, Diabetes, and Cardiovascular Diseases
Lai, C., Tucker, K. L., Parnell, L. D., Adiconis, X., García‐Bailo, B., Griffith, J. L., Meydani, M., & Ordovás, J. M. (2007) · Diabetes · doi:10.2337/db07-1238 · Cited by 75 · see citing works
Tatsch, E., Bochi, G. V., Piva, S. J., de Carvalho, J. A. M., Kober, H., Torbitz, V. D., Duarte, T., Signor, C., Coelho, A. C., Duarte, M. M. M. F., et al. (2012) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2012.01.004 · Cited by 71 · see citing works
Yang, S., Chintapalli, J., Sodagum, L., Baskin, S., Malhotra, A., Krzysztof Reiss, F., & Meggs, L. G. (2005) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00094.2005 · Cited by 71 · see citing works
Dinçer, Y., Akçay, T., ILKOVA, H. M., Alademir, Z., & Özbay, G. (2003) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s0027-5107(03)00073-3 · Cited by 70 · see citing works
Dönmez‐Altuntaş, H., Şahin, F., Bayram, F., Bıtgen, N., Mert, M., Güçlü, K., Hamurcu, Z., Aribaş, S., Gündoğan, K., & Diri, H. (2014) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2014.06.006 · Cited by 68 · see citing works
Śliwińska, A., Błasiak, J., Kasznicki, J., & Drzewoski, J. (2008) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2008.03.017 · Cited by 65 · see citing works
Effect of Metformin on Methylglyoxal Metabolism in Patients with Type 2 Diabetes
Κender, Ζ., Fleming, T. H., Kopf, S., Torzsa, P., Grolmusz, V. K., Herzig, S., Schleicher, E., Rácz, K., Reismann, P., & Nawroth, P.-P. (2014) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/s-0034-1371818 · Cited by 64 · see citing works
Na, H., Park, J., Pyo, J.-H., Lee, S., Jeon, H.-J., Kim, Y.-S., & Yoo, M. (2013) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2013.07.003 · Cited by 63 · see citing works
Self-citationReactive oxygen species in essential hypertension and non–insulin-dependent diabetes mellitus
Orie, N. N. (1999) · American Journal of Hypertension · doi:10.1016/s0895-7061(99)00129-6 · Cited by 61 · see citing works
Kushwaha, S., Vikram, A., Trivedi, P. P., & Jena, G. (2011) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2011.10.004 · Cited by 58 · see citing works
Schupp, N., Schinzel, R., Heidland, A., & Stopper, H. (2005) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1333.079 · Cited by 56 · see citing works
Gu, Y., Wang, C., Zheng, Y., Hou, X., Mo, Y., Yu, W., Zhang, L., Hu, C., Nan, H., Chen, L., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0053411 · Cited by 55 · see citing works
Insulin mediated DNA damage in mammalian colon cells and human lymphocytes in vitro
Othman, E. M., Leyh, A., & Stopper, H. (2013) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2013.03.006 · Cited by 51 · see citing works
Habib, S. L., & Liang, S. (2014) · Oncotarget · doi:10.18632/oncotarget.1833 · Cited by 46 · see citing works
Pazdro, R., & Burgess, J. R. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2012.01.003 · Cited by 45 · see citing works
Yang, X., So, W., Ronald, C. W., Kong, A. P. S., Xu, G., & Chan, J. C. N. (2012) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.2287 · Cited by 43 · see citing works
Self-citationBreak-Induced Replication and Genome Stability
Sakofsky, C. J., Ayyar, S., & Malkova, A. (2012) · Biomolecules · doi:10.3390/biom2040483 · Cited by 41 · see citing works
One hundred years of somatic mutation theory of carcinogenesis: Is it time to switch?
Soto, A. M., & Sonnenschein, C. (2013) · BioEssays · doi:10.1002/bies.201300160 · Cited by 40 · see citing works
Habib, S. L. (2003) · Carcinogenesis · doi:10.1093/carcin/24.3.573 · Cited by 38 · see citing works
High level glucose increases mutagenesis in human lymphoblastoid cells
Zhang, Y., Zhou, J., Wang, T., & Cai, L. (2007) · International Journal of Biological Sciences · doi:10.7150/ijbs.3.375 · Cited by 38 · see citing works
Predicting values of lipids and white blood cell count for all-site cancer in type 2 diabetes
Yang, X., So, W., Ma, R. C. W., Ko, G. T. C., Kong, A. P. S., Wang, Q., Cockram, C. S., Chow, C. C., Chan, J. C. N., & Tong, P. C. Y. (2008) · Endocrine Related Cancer · doi:10.1677/erc-07-0266 · Cited by 37 · see citing works
Self-citationTelmisartan inhibits AGE-induced podocyte damage and detachment
Fukami, K., Yamagishi, S., Kaifu, K., Matsui, T., Kaida, Y., Ueda, S., Takeuchi, M., Asanuma, K., & Okuda, S. (2013) · Microvascular Research · doi:10.1016/j.mvr.2013.04.006 · Cited by 29 · see citing works
Kong, A. P. S., Yang, X., So, W., Luk, A. O. Y., Ronald, C. W., Ozaki, R., Cheung, K. K., Lee, H. M., Yu, L. W., Xu, G., et al. (2014) · BMC Medicine · doi:10.1186/1741-7015-12-76 · Cited by 26 · see citing works
Self-citationTakao, T., Horino, T., Kagawa, T., Matsumoto, R., Shimamura, Y., Ogata, K., Inoue, K., Taniguchi, Y., Taguchi, T., Morita, T., et al. (2010) · Journal of Nephrology · doi:10.5301/jn.2010.5785 · Cited by 26 · see citing works
Ye, C., Li, X., Wang, Y., Zhang, Y., Cai, M., Zhu, B., Mu, P., Xia, X., Zhao, Y. D., Weng, J., et al. (2011) · Laboratory Investigation · doi:10.1038/labinvest.2011.87 · Cited by 25 · see citing works
Genetic variants for type 2 diabetes and new-onset cancer in Chinese with type 2 diabetes
Ma, R. C. W., So, W. Y., Tam, C. H. T., Luk, A. O. Y., Ho, J. S. K., Wang, Y., Lam, V. K. L., Lee, H. M., Kong, A. P. S., Tong, P. C. Y., et al. (2014) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2013.12.016 · Cited by 18 · see citing works
Self-citationMutation, clonal fitness and field change in epithelial carcinogenesis
Frede, J., Adams, D. J., & Jones, P. H. (2014) · The Journal of Pathology · doi:10.1002/path.4409 · Cited by 13 · see citing works
Habib, S. L. (2009) · Journal of Molecular Signaling · doi:10.1186/1750-2187-4-8 · Cited by 9 · see citing works
Glucose consumption, newborn weight and nitrosomethylurea transplacental carcinogenesis in rats
Berstein, L. M., & Alexandrov, V. A. (1984) · Cancer Letters · doi:10.1016/s0304-3835(84)80042-7 · Cited by 5 · see citing works
Effects of glucose on cloning efficiency and mutagenesis of fetal rat cells
Donovan, P., Smith, G. T., Riggs, C. W., & Alexandrov, V. A. (2002) · Teratogenesis Carcinogenesis and Mutagenesis · doi:10.1002/tcm.10027 · Cited by 2 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Obesity, DNA Damage, and Development of Obesity-Related Diseases
Włodarczyk, M., & Nowicka, G. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20051146 · Cited by 246 · see citing works
Ramteke, P. L., Deb, A., Shepal, V., & Bhat, M. K. (2019) · Cancers · doi:10.3390/cancers11091402 · Cited by 156 · see citing works
Diabetes and cancer: A comprehensive review
Abudawood, M. (2019) · Journal of Research in Medical Sciences · doi:10.4103/jrms.jrms_242_19 · Cited by 140 · see citing works
Impact of obesity and overweight on DNA stability: Few facts and many hypotheses
Setayesh, T., Nersesyan, A., Mišík, M., Ferk, F., Langie, S., Andrade, V. M., Haslberger, A., & Knasmüller, S. (2018) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2018.07.001 · Cited by 98 · see citing works
Proteomics Analysis of Gastric Cancer Patients with Diabetes Mellitus
Osório, H., Silva, C., Ferreira, M., Gullo, I., Máximo, V., Barros, R., Mendonça, F. M., Oliveíra, C., & Carneiro, F. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10030407 · Cited by 83 · see citing works
Cell-free nucleic acid patterns in disease prediction and monitoring—hype or hope?
Crigna, A. T., Samec, M., Koklesová, L., Líšková, A., Giordano, F. A., Kubatka, P., & Golubnitschaja, O. (2020) · The EPMA Journal · doi:10.1007/s13167-020-00226-x · Cited by 79 · see citing works
Balkrishna, A., Kumar, A., Arya, V., Rohela, A., Verma, R., Nepovimová, E., Krejcar, O., Kumar, D., Thakur, N., & Kuča, K. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/3155962 · Cited by 85 · see citing works
Homayouni, F., Haidari, F., Hedayati, M., Zakerkish, M., & Angali, K. A. (2017) · Phytotherapy Research · doi:10.1002/ptr.5881 · Cited by 78 · see citing works
de Araújo, R. F. F., Martins, D. B. G., & Borba, M. A. C. S. M. (2016) · InTech eBooks · doi:10.5772/65366 · Cited by 73 · see citing works
Ferk, F., Kundi, M., Brath, H., Szekeres, T., Al-Serori, H., Mišík, M., Saiko, P., Marculescu, R., Wagner, K., & Knasmüller, S. (2017) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201700482 · Cited by 73 · see citing works
Knaś, M., Maciejczyk, M., Daniszewska, I., Klimiuk, A., Matczuk, J., Kołodziej, U., Waszkiel, D., Ładny, J. R., Żendzian‐Piotrowska, M., & Zalewska, A. (2016) · Journal of Diabetes Research · doi:10.1155/2016/4583742 · Cited by 69 · see citing works
Oxidative Stress, DNA Damage and DNA Repair in Female Patients with Diabetes Mellitus Type 2
Grindel, A., Guggenberger, B., Eichberger, L., Pöppelmeyer, C., Gschaider, M., Tosevska, A., Mare, G., Briskey, D. R., Brath, H., & Wagner, K. (2016) · PLoS ONE · doi:10.1371/journal.pone.0162082 · Cited by 66 · see citing works
Sun, D., Chen, S., Li, S., Wang, N., Zhang, S., Xu, L., Zhu, S., Li, H., Gu, Q., Xu, X., et al. (2022) · Redox Biology · doi:10.1016/j.redox.2022.102589 · Cited by 66 · see citing works
Shehata, M. G., Abu-Serie, M. M., El-Aziz, N. M. A., & Sohaimy, S. A. E. (2021) · Scientific Reports · doi:10.1038/s41598-021-85772-8 · Cited by 60 · see citing works
Haider, N., Lebastchi, J., Jayavelu, A. K., Batista, T. M., Pan, H., Dreyfuss, J. M., Carcamo‐Orive, I., Knowles, J. W., Mann, M., & Kahn, C. R. (2021) · Journal of Clinical Investigation · doi:10.1172/jci151818 · Cited by 58 · see citing works
Bhardwaj, P., & Brown, K. A. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.638918 · Cited by 54 · see citing works
Wang, Y., Liu, H., Hu, X., Wang, A., Wang, A., Kang, S., Zhang, L., Gu, W., Dou, J., Mu, Y., et al. (2023) · Chinese Medical Journal · doi:10.1097/cm9.0000000000002717 · Cited by 48 · see citing works
DNA repair deficiency and senescence in concussed professional athletes involved in contact sports
Schwab, N., Grenier, K., & Hazrati, L.-N. (2019) · Acta Neuropathologica Communications · doi:10.1186/s40478-019-0822-3 · Cited by 47 · see citing works
Vekić, J., Zeljković, A., Stefanović, A., Giglio, R. V., Ciaccio, M., & Rizzo, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222212409 · Cited by 46 · see citing works
Anthropometric and Dietary Factors as Predictors of DNA Damage in Obese Women
Włodarczyk, M., Jabłonowska-Lietz, B., Olejarz, W., & Nowicka, G. (2018) · Nutrients · doi:10.3390/nu10050578 · Cited by 39 · see citing works
Protective role of vitamin B6 (PLP) against DNA damage in Drosophila models of type 2 diabetes
Merigliano, C., Mascolo, E., Torre, M. L., Saggio, I., & Vernı̀, F. (2018) · Scientific Reports · doi:10.1038/s41598-018-29801-z · Cited by 41 · see citing works
Oxidative stress-mediated mouse liver lesions caused by Clonorchis sinensis infection
Maeng, S., Lee, H. W., Bashir, Q., Kim, T. I., Hong, S., Lee, T. J., Sohn, W., Na, B., Kim, T., & Pak, J. H. (2015) · International Journal for Parasitology · doi:10.1016/j.ijpara.2015.11.003 · Cited by 40 · see citing works
DNA: Damage and Repair Mechanisms in Humans
Ambekar, S. S. (2017) · Global Journal of Pharmacy & Pharmaceutical Sciences · doi:10.19080/gjpps.2017.03.555613 · Cited by 38 · see citing works
Abudawood, M., Tabassum, H., Almaarik, B. M., & Aljohi, A. O. (2019) · Saudi Journal of Biological Sciences · doi:10.1016/j.sjbs.2019.06.015 · Cited by 37 · see citing works
Ding, N., Maiuri, A. R., & O’Hagan, H. M. (2017) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2017.09.005 · Cited by 36 · see citing works
The Genetics of Diabetes: What We Can Learn from Drosophila
Liguori, F., Mascolo, E., & Vernı̀, F. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222011295 · Cited by 30 · see citing works
Mascolo, E., Amoroso, N., Saggio, I., Merigliano, C., & Vernı̀, F. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28990 · Cited by 29 · see citing works
Hepatic stress associated with pathologies characterized by disturbed glucose production
Gjorgjieva, M., Mithieux, G., & Rajas, F. (2019) · Cell Stress · doi:10.15698/cst2019.03.179 · Cited by 30 · see citing works
Salimi, M., Broumand, B., & Mozdarani, H. (2016) · Mutagenesis · doi:10.1093/mutage/gew029 · Cited by 28 · see citing works
Diabetes and Cancer: A Twisted Bond
Stan, M. C., & Paul, D. (2024) · Oncology Reviews · doi:10.3389/or.2024.1354549 · Cited by 26 · see citing works
Kong, A. P. S., Yang, X., So, W., Luk, A. O. Y., Ronald, C. W., Ozaki, R., Cheung, K. K., Lee, H. M., Yu, L. W., Xu, G., et al. (2014) · BMC Medicine · doi:10.1186/1741-7015-12-76 · Cited by 26 · see citing works
Self-citationHyperglycemia-driven signaling bridges between diabetes and cancer
Ghareghomi, S., Arghavani, P., Mahdavi, M., Khatibi, A., García‐Jiménez, C., & Moosavi‐Movahedi, A. A. (2024) · Biochemical Pharmacology · doi:10.1016/j.bcp.2024.116450 · Cited by 26 · see citing works
Taurine counteracts the neurotoxic effects of streptozotocin-induced diabetes in rats
Caletti, G., Herrmann, A. P., Pulcinelli, R. R., Reinhardt, L. S., Morás, A. M., Vianna, P., Chies, J. A. B., Moura, D. J., Barros, H. M. T., & Gomez, R. (2017) · Amino Acids · doi:10.1007/s00726-017-2495-1 · Cited by 25 · see citing works
The p66Shc Redox Protein and the Emerging Complications of Diabetes
Biondi, G., Marrano, N., Borrelli, A., Rella, M., D’Oria, R., Genchi, V. A., Caccioppoli, C., Cignarelli, A., Perrini, S., Laviola, L., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms25010108 · Cited by 25 · see citing works
Natalicchio, A., Marrano, N., Montagnani, M., Gallo, M., Faggiano, A., Zatelli, M., Argentiero, A., Re, M. D., D’Oronzo, S., Fogli, S., et al. (2024) · Journal of Endocrinological Investigation · doi:10.1007/s40618-024-02417-z · Cited by 25 · see citing works
Wang, W., He, Q., Yan, W., Sun, J., Chen, Z., Liu, Z., Lu, Z., Hou, J., Shao, Y., Zhou, X. C., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.22907 · Cited by 25 · see citing works
Wang, P., Lu, Y., Wang, J., Wang, L., Yu, H., Li, Y. F., Kong, A. P. S., Chan, J. C. N., & Lee, S. (2018) · Cellular Physiology and Biochemistry · doi:10.1159/000489812 · Cited by 24 · see citing works
Self-citationDİLSİZ, S. A., Bacanli, M. G., Anlar, H. G., Çal, T., Arı, N., Bucurgat, Ü. Ü., Başaran, A. A., & Başaran, N. (2018) · Food and Chemical Toxicology · doi:10.1016/j.fct.2018.11.038 · Cited by 23 · see citing works
Wójcik, M., Krawczyk, M., Zieleniak, A., Mac‐Marcjanek, K., & Woźniak, L. A. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-816918-6.00014-7 · Cited by 21 · see citing works
Diabetes and skin cancers: Risk factors, molecular mechanisms and impact on prognosis
Dobrică, E.-C., Banciu, L. M., Kipkorir, V., Tabari, M. A. K., Cox, M. J., Kutikuppala, L. V. S., & Găman, M. (2022) · World Journal of Clinical Cases · doi:10.12998/wjcc.v10.i31.11214 · Cited by 21 · see citing works
Yan, P., Wang, Y., Fu, T., Liu, Y., & Zhang, Z.-J. (2020) · Endocrine Journal · doi:10.1507/endocrj.ej20-0138 · Cited by 20 · see citing works
Zhang, R., Wang, P., Lu, Y., Lang, L., Wang, L., & Lee, S. C. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28455 · Cited by 18 · see citing works
Self-citationKumar, V., Zoltan, K., Sulaj, A., Blume, M., Kliemank, E., Tsilingiris, D., Groener, J., Brune, M., Shahzad, K., Isermann, B. H., et al. (2022) · EBioMedicine · doi:10.1016/j.ebiom.2023.104516 · Cited by 17 · see citing works
Shi, F., Xu, Y., Zhang, S., Fu, Z., Yu, Q., Zhang, S., Sun, M., Zhao, X. J., & Feng, X. (2022) · The FASEB Journal · doi:10.1096/fj.202200586r · Cited by 16 · see citing works
Yasom, S., Khumsri, W., Boonsongserm, P., Kitkumthorn, N., Ruangvejvorachai, P., Sooksamran, A., Wanotayan, R., & Mutirangura, A. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.802024 · Cited by 15 · see citing works
DNA Damage and Repair in Eye Diseases
Sohn, J., Lee, S. E., & Shim, E.-Y. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043916 · Cited by 13 · see citing works
Self-citationDiabetes-associated dysregulated cytokines and cancer
Wu, Y., Dong, Y., Liu, Y., & Vadgama, J. V. (2016) · Integrative Cancer Science and Therapeutics · doi:10.15761/icst.1000173 · Cited by 13 · see citing works
Banerjee, S., Biswas, T. K., Chattopadhyay, K., Arzoo, S. H., & Chattopadhyay, B. (2020) · The Journal of Alternative and Complementary Medicine · doi:10.1089/acm.2020.0001 · Cited by 13 · see citing works
Ajiboye, B. O., Dada, S., Fatoba, H. O., Lawal, O. E., Oyeniran, O. H., Adetuyi, O. Y., Olatunde, A., Taher, M., Khotib, J., Darnis, D. S., et al. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115681 · Cited by 13 · see citing works
Genetic variants including markers from the exome chip and metabolite traits of type 2 diabetes
Jäger, S., Wahl, S., Kröger, J., Sharma, S., Hoffmann, P., Floegel, A., Pischon, T., Prehn, C. P., Adamski, J., Müller‐Nurasyid, M., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-06158-3 · Cited by 14 · see citing works
Mišík, M., Staudinger, M., Kundi, M., Worel, N., Nersesyan, A. K., Ferk, F., Dušinská, M., Azqueta, A., Möller, P., & Knasmüller, S. (2023) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2023.108458 · Cited by 13 · see citing works
Vitamin B6 and diabetes and its role in counteracting advanced glycation end products
Vernı̀, F. (2024) · Vitamins and hormones · doi:10.1016/bs.vh.2024.02.005 · Cited by 12 · see citing works
FTO is a major genetic link between breast cancer, obesity, and diabetes
Gholami, M. (2023) · Breast Cancer Research and Treatment · doi:10.1007/s10549-023-07188-4 · Cited by 12 · see citing works
The twin white herrings: Salt and sugar
Kalra, S., Gupta, L., Khandelwal, D., Dutta, D., Lal, P. R., & Gupta, Y. (2018) · Indian Journal of Endocrinology and Metabolism · doi:10.4103/ijem.ijem_117_18 · Cited by 12 · see citing works
Ruze, R., Xiong, Y., Li, J., Zhong, M., Xu, Q., Yan, Z.-B., Zhu, J., Cheng, Y., Hu, S., & Zhang, G. (2020) · World Journal of Gastroenterology · doi:10.3748/wjg.v26.i20.2599 · Cited by 8 · see citing works
The inhibitory influence of 3-β-hydroxybutyrate on calf thymus DNA glycation by glucose
Bohlooli, M., Miri, M., Khajeh, M., Ghamari, F., Khatibi, A., Ghaffari‐Moghaddam, M., Poormolaie, N., & Sheibani, N. (2016) · RSC Advances · doi:10.1039/c6ra17350k · Cited by 8 · see citing works
Xu, F., Jin, J., Guo, J., Xu, F., Chen, J., Liu, Q., Song, L., Zhang, Z., Zhou, L., Su, J., et al. (2024) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-023-05591-4 · Cited by 8 · see citing works
Li, Y., Shi, L., Wang, P., Wang, J., Shi, G., & Lee, S. C. (2021) · Oncology Reports · doi:10.3892/or.2021.8102 · Cited by 8 · see citing works
Self-citationGenotoxic markers in patients with diabetes mellitus (Literature review)
Eremina, N. V., Жанатаев, А. К., Lisitsyn, A. A., & Durnev, A. D. (2021) · Ecological genetics · doi:10.17816/ecogen65073 · Cited by 8 · see citing works
Implications of cancer stem cells in diabetes and pancreatic cancer
Mukherjee, A. G., Wanjari, U. R., Gopalakrishnan, A. V., Bradu, P., Sukumar, A., Patil, M., Renu, K., Dey, A., Vellingiri, B., George, A., et al. (2022) · Life Sciences · doi:10.1016/j.lfs.2022.121211 · Cited by 8 · see citing works
Weber, D., Thimm, J., Seiz, T., Kochlik, B., Raupbach, J., Bürkle, A., Grune, T., Grüber, M., & Moreno‐Villanueva, M. (2025) · Redox Biology · doi:10.1016/j.redox.2025.103764 · Cited by 6 · see citing works
Typ-2-Diabetes-mellitus und Krebsrisiko
Scherübl, H. (2021) · DMW - Deutsche Medizinische Wochenschrift · doi:10.1055/a-1529-4521 · Cited by 6 · see citing works
The Impact of the Association between Cancer and Diabetes Mellitus on Mortality
Kim, S.-S., & Kim, H. (2022) · Journal of Personalized Medicine · doi:10.3390/jpm12071099 · Cited by 6 · see citing works
Chemopreventive Potential of Oils Extracted from Seeds of Three Annona Species
Attanayake, P., Rupasinghe, D., Gamage, A., Madhujith, T., & Merah, O. (2024) · Seeds · doi:10.3390/seeds3010009 · Cited by 5 · see citing works
Zheng, Z., Xu, S., Zhu, J., Yang, Q., Ye, H., Li, M., Zhang, X., Liu, H., Cheng, Y., Zou, Y., et al. (2024) · Cancer Epidemiology · doi:10.1016/j.canep.2024.102725 · Cited by 5 · see citing works
Hattori, N., Ikeda, H., Watanabe, T., Satta, Y., Ehira, T., Suzuki, T., Kiyokawa, H., Nakahara, K., Takahashi, H., Matsunaga, K., et al. (2022) · JGH Open · doi:10.1002/jgh3.12805 · Cited by 5 · see citing works
The inverse association between DNA gaps and HbA1c levels in type 2 diabetes mellitus
Thongsroy, J., & Mutirangura, A. (2023) · Scientific Reports · doi:10.1038/s41598-023-46431-2 · Cited by 5 · see citing works
From diabetes to tumor growth: unravelling the impact of glucose-lowering therapies
Modica, R., Liccardi, A., Zamponi, V., Gagliardi, A., Nistor, A., Veroi, G., Arecco, A., Faggiano, A., & Colao, A. (2026) · Endocrine · doi:10.1007/s12020-026-04644-1 · Cited by 4 · see citing works
Oxidatively Damaged Nucleic Acid: Linking Diabetes and Cancer
Hong, X., Hu, Y., Yuan, Z., Fang, Z., Zhang, X., Yuan, Y., & Guo, C. (2022) · Antioxidants and Redox Signaling · doi:10.1089/ars.2022.0096 · Cited by 4 · see citing works
Typ-2-Diabetes mellitus und gastrointestinale Krebsvorsorge
Scherübl, H. (2022) · Zeitschrift für Gastroenterologie · doi:10.1055/a-1821-9108 · Cited by 4 · see citing works
Zhang, Y., Li, W.-Y., & Wan, Q. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1586309 · Cited by 3 · see citing works
Strukel, S., & Rai, V. (2025) · Biocell · doi:10.32604/biocell.2025.067207 · Cited by 3 · see citing works
Elbahrawy, A., Atalla, H., Mahmoud, A. A., Eliwa, A., Alsawak, A., Alboraie, M. A. A., Madian, A., Alashker, A., Mostafa, S., Alwassief, A., et al. (2023) · Frontiers in Virology · doi:10.3389/fviro.2023.1227317 · Cited by 3 · see citing works
Zhao, X., Shi, W., Liu, X., & Zhang, W. (2023) · Gynecological Endocrinology · doi:10.1080/09513590.2023.2283033 · Cited by 3 · see citing works
Attia, S. M., Albekairi, N. A., Alshamrani, A. A., Ahmad, S. F., Almutairi, F., Attia, M. S. M., Ansari, M. A., Bakheet, S. A., Harisa, G. I., & Nadeem, A. (2024) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2024.503765 · Cited by 3 · see citing works
Diabetes-associated oxidative damage to DNA base in colon cells
Wang, P., Liu, Q., & Lee, S. (2019) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmz010 · Cited by 3 · see citing works
Self-citationKroeger, A. A., & Karton, A. (2018) · Journal of Computational Chemistry · doi:10.1002/jcc.25595 · Cited by 2 · see citing works
Obezitenin Genotoksik Etkileri
GÖNEY, G. (2020) · Turkish Journal of Diabetes and Obesity · doi:10.25048/tudod.767219 · Cited by 2 · see citing works
Pros and cons of live kidney donation in prediabetics: A critical review and way forward
Khalil, M. A. M., Sadagah, N. M., Tan, J. C., Syed, F. O., Chong, V. H., & Al-Qurashi, S. H. (2024) · World Journal of Transplantation · doi:10.5500/wjt.v14.i1.89822 · Cited by 2 · see citing works
High prevalence of dermatophytosis of the feet in acral melanoma of the foot
Waki, Y., Nobeyama, Y., Nakagawa, H., & Asahina, A. (2024) · The Journal of Dermatology · doi:10.1111/1346-8138.17256 · Cited by 2 · see citing works
Diabetic ulcer with cutaneous squamous cell carcinoma: A case report
Luo, Y. P., Li, C., Wang, Y., Xiang, S.-M., & Zhao, C. (2024) · World Journal of Clinical Oncology · doi:10.5306/wjco.v15.i12.1514 · Cited by 2 · see citing works
Promising pioneer study on identification of lung cancer cells using DNA-based Schottky diodes
Hussaini, A. A., Çekin, A., Hamarat, Z. G., Erdal, M. O., Gunel, N. S., & Yıldırım, M. (2025) · Sensors and Actuators A Physical · doi:10.1016/j.sna.2025.116407 · Cited by 2 · see citing works
Middle-distance running and DNA damage in diabetics
Lippi, G., Tarperi, C., Danese, E., Montagnana, M., Festa, L., Benati, M., Salvagno, G. L., Bonaguri, C., Bacchi, E., Donà, S., et al. (2018) · Journal of Laboratory and Precision Medicine · doi:10.21037/jlpm.2018.02.02 · Cited by 2 · see citing works
Cytogenotoxic potential of Terminalia actinophylla (Mart.) bark in Allium cepa L.
de Sousa, F. M. S., Araújo, J. R. D. S., Couto, L. M. F. M. C. B., Sousa, R. M. S., de Oliveira, M. D. D. A., Júnior, J. S. D. C., Martins, F. A., & de Almeida, P. M. (2020) · Research Society and Development · doi:10.33448/rsd-v9i9.7322 · Cited by 1 · see citing works
Taş, S., Sarandöl, E., Tekin, C. N., Tosunoğlu, A., Vatan, Ö., Huriyet, H., Bozyigit, C., Çinkılıç, N., Çavaş, T., & Dirican, M. (2022) · Journal of Applied Biological Sciences · doi:10.71336/jabs.1053 · Cited by 1 · see citing works
Early glycaemic exposure and cancer risk in people with newly diagnosed type 2 diabetes
Zhang, X., Yang, A., Wu, H., Lau, E. S. H., Shi, M., Fan, B., Chow, E., Kong, A. P. S., Chan, J. T. S., Ronald, C. W., et al. (2026) · Diabetologia · doi:10.1007/s00125-026-06758-7 · Cited by 1 · see citing works
Self-citationTea, the “Ambrosia” Beverage: Biochemical, Cellular, Molecular, and Clinical Evidences
Ramlagan, P., Narrain, D., Fawdar, S., & Bahorun, T. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-815270-6.00001-3 · Cited by 1 · see citing works
Diabetes Mellitus is Associated with High Grade and High Stage in Urinary Bladder Cancer
Horsanalı, M. O., Özer, K., Görgel, S. N., & Özbek, E. (2016) · SM Journal of Urology · doi:10.36876/smju.1020 · Cited by 1 · see citing works
Thomas, P. B., Çavuşoğlu, E. E., & Kaluç, N. (2021) · Biologia · doi:10.1007/s11756-021-00912-9 · Cited by 1 · see citing works
Krebsrisiko bei Prädiabetes und Typ-2-Diabetes mellitus
Scherübl, H. (2022) · Diabetologie und Stoffwechsel · doi:10.1055/a-1837-2035 · Cited by 1 · see citing works
Scholten, M., & Halling, A. (2023) · PLoS ONE · doi:10.1371/journal.pone.0292853 · Cited by 1 · see citing works
Ayat, P., Sawassnajjar, D., Alkaissi, H. R., Gill, H., Otey, J., AlFaraj, M., & McFarlane, S. I. (2024) · Cureus · doi:10.7759/cureus.63061 · Cited by 1 · see citing works
The diabetes mellitus and oncopathоlogy
Zhuravlyova, L., & Сокольникова, Н. В. (2021) · Medicine of Ukraine · doi:10.37987/1997-9894.2021.2(248).229022 · Cited by 1 · see citing works
Farahani-Zangaraki, M., Taheri, A., & Etebari, M. (2021) · Human & Experimental Toxicology · doi:10.1177/09603271211036124 · Cited by 1 · see citing works
Methods and Techniques in Molecular Toxicology of Nanomaterials
Wang, Y., Li, C., & Chen, C. (2016) · doi:10.1002/9783527689125.ch10
Puvvula, J. (2018) · DigitalCommons@UNMC
Shah, N. R. (2019) · Surrey Research Insight Open Access (The University of Surrey) · doi:10.15126/thesis.00850963
The Role of DNA Damage-induced Cellular Senescence in the Pathophysiology of mTBI
Schwab, N. (2019) · TSpace (University of Toronto)
Dep Of Chemistry, U. N. S. (2019) · Proceeding of Chemistry Conferences · doi:10.20961/pcc.v3i0.27520
Typ-2-Diabetes mellitus und gastrointestinale Krebsvorsorge
Scherübl, H. (2022) · Diabetes aktuell · doi:10.1055/a-1923-1686
- Authors
- Lee, S. C., & Chan, J. C.
- Affiliations
- Shanxi University (CN)
- Corresponding author
- Lee, Shao Chin
- Venue
- Chinese Medical Journal
- Published
- 2015-06-05
- Volume
- 128
- Issue
- 11
- Pages
- 1543-1548
- ISSN
- 0366-6999 (ISSN-L)
- PMC
- PMC4733759
- OpenAlex
- W1500301819
- Cited by
- 106
- References
- 61
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 13 · 2023: 12 · 2022: 12 · 2021: 14 · 2020: 7 · 2019: 13 · 2018: 9 · 2017: 7 · 2016: 8 · 2015: 1 · 2014: 1
- FWCI
- 0.81
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc-nd
- Locations
- Chinese Medical Journal (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
- Keywords
- DNA damage, diabetes mellitus, cancer, type 2 diabetes, carcinogenesis, oxidative stress, reactive oxygen species, antioxidant capacity, DNA strand breaks, DNA base modification, hyperglycemia, advanced glycation end products, free fatty acids, palmitic acid, mutagenesis, cancer risk
- MeSH terms
- Animals, Diabetes Mellitus, Type 2, DNA Damage, Humans, Neoplasms, Reactive Oxygen Species, Oxidative Stress
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
