In search of the tumour-suppressor functions of BRCA1 and BRCA2

A Strong Candidate for the Breast and Ovarian Cancer Susceptibility Gene BRCA1

Miki, Y., Swensen, J. J., Shattuck-Eidens, D. M., Futreal, P. A., Harshman, K., Tavtigian, S. V., Liu, Q., Cochran, C., Bennett, L. M., Ding, W., et al. (1994) · Science · doi:10.1126/science.7545954 · Cited by 6,069 · see citing works

A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage

Paull, T. T., Rogakou, E. P., Yamazaki, V., Kirchgessner, C. U., Gellert, M., & Bonner, W. M. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00610-2 · Cited by 2,098 · see citing works

Association of BRCA1 with Rad51 in Mitotic and Meiotic Cells

Scully, R., Chen, J., Plug, A., Xiao, Y., Weaver, D., Feunteun, J., Ashley, T., & Livingston, D. M. (1997) · Cell · doi:10.1016/s0092-8674(00)81847-4 · Cited by 1,459 · see citing works

Brca1 Controls Homology-Directed DNA Repair

Moynahan, M. E., Chiu, J. W., Koller, B. H., & Jasin, M. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80202-6 · Cited by 1,245 · see citing works

Gatekeepers and caretakers

Kinzler, K. W., & Vogelstein, B. (1997) · Nature · doi:10.1038/386761a0 · Cited by 1,240 · see citing works

BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures.

Wang, Y., Cortez, D., Yazdi, P., Neff, N., Elledge, S. J., & Qin, J. (2000) · Genes & Development · doi:10.1101/gad.14.8.927 · Cited by 1,221 · see citing works

RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination

Lorick, K. L., Jensen, J. P., Fang, S., Ong, A. M., Hatakeyama, S., & Weissman, A. M. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.20.11364 · Cited by 1,151 · see citing works

Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2

Sharan, S. K., Morimatsu, M., Albrecht, U., Lim, D., Regel, E., Dinh, C. Q., Sands, A., Gregor Eichele, C., Hasty, P., & Bradley, A. (1997) · Nature · doi:10.1038/386804a0 · Cited by 1,071 · see citing works

Requirement of ATM-Dependent Phosphorylation of Brca1 in the DNA Damage Response to Double-Strand Breaks

Cortez, D., Wang, Y., Qin, J., & Elledge, S. J. (1999) · Science · doi:10.1126/science.286.5442.1162 · Cited by 1,020 · see citing works

<i>ATR</i> disruption leads to chromosomal fragmentation and early embryonic lethality

Brown, E. J., & Baltimore, D. (2000) · Genes &amp; Development · doi:10.1101/gad.14.4.397 · Cited by 951 · see citing works

Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage

Scully, R., Chen, J., Ochs, R. L., Keegan, K., Hoekstra, M., Feunteun, J., & Livingston, D. M. (1997) · Cell · doi:10.1016/s0092-8674(00)80503-6 · Cited by 900 · see citing works

Rad51‐deficient vertebrate cells accumulate chromosomal breaks prior to cell death

Sonoda, E., Sasaki, M., Buerstedde, J., Bezzubova, O., Shinohara, A., Ogawa, H., Takata, M., Yamaguchi-Iwai, Y., & Takeda, S. (1998) · EMBO Journal · doi:10.1093/emboj/17.2.598 · Cited by 860 · see citing works

Identification of a RING protein that can interact in vivo with the BRCA1 gene product

Wu, L. C., Wang, Z. W., Tsan, J. T., Spillman, M. A., Phung, A., Xu, X. L., Yang, M.-C. W., Hwang, L.-Y., Bowcock, A. M., & Baer, R. J. (1996) · Nature Genetics · doi:10.1038/ng1296-430 · Cited by 743 · see citing works

The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse.

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Initiation of genetic recombination and recombination-dependent replication

Kowalczykowski, S. C. (2000) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(00)01569-3 · Cited by 674 · see citing works

Stable Interaction between the Products of the BRCA1 and BRCA2 Tumor Suppressor Genes in Mitotic and Meiotic Cells

Chen, J., Silver, D. P., Walpita, D., Cantor, S. B., Gazdar, A. F., Tomlinson, G. E., Couch, F. J., Weber, B. L., Ashley, T., Livingston, D. M., et al. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80276-2 · Cited by 635 · see citing works

Involvement of Brca2 in DNA Repair

Patel, K. J., Yu, V. P. C. C., Lee, H., Corcoran, A. E., Thistlethwaite, F. C., Evans, M. J., Colledge, W. H., Friedman, L. S., Ponder, B. A. J., & Venkitaraman, A. R. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80035-0 · Cited by 631 · see citing works

An entire functional mammary gland may comprise the progeny from a single cell

Kordon, E. C., & Smith, G. H. (1998) · Development · doi:10.1242/dev.125.10.1921 · Cited by 553 · see citing works

BRCA1 Is Associated with a Human SWI/SNF-Related Complex

Bochar, D. A., Wang, L., Beniya, H., Kinev, A. V., Xue, Y., Lane, W. S., Wang, W., Kashanchi, F., & Shiekhattar, R. (2000) · Cell · doi:10.1016/s0092-8674(00)00030-1 · Cited by 546 · see citing works

hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response

Lee, J., Collins, K. M., Brown, A. L., Lee, C. H., & Chung, J. H. (2000) · Nature · doi:10.1038/35004614 · Cited by 529 · see citing works

Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress

Tibbetts, R. S., Cortez, D., Brumbaugh, K. M., Scully, R., Livingston, D., Elledge, S. J., & Abraham, R. T. (2000) · Genes &amp; Development · doi:10.1101/gad.851000 · Cited by 512 · see citing works

Evidence for a transcriptional activation function of BRCA1 C-terminal region

Monteiro, Á. N. A., August, A., & Hanafusa, H. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.24.13595 · Cited by 447 · see citing works

Transcriptional activation by BRCA1

Chapman, M. S., & Verma, I. M. (1996) · Nature · doi:10.1038/382678a0 · Cited by 437 · see citing works

Genetic Analysis of BRCA1 Function in a Defined Tumor Cell Line

Scully, R., Ganesan, S., Vlasakova, K., Chen, J., Socolovsky, M., & Livingston, D. M. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80238-5 · Cited by 359 · see citing works

Insights into the functions of BRCA1 and BRCA2

Welcsh, P. L., Owens, K. N., & King, M. (2000) · Trends in Genetics · doi:10.1016/s0168-9525(99)01930-7 · Cited by 335 · see citing works

Intergenic transcription and transinduction of the human β-globin locusPreprint

Ashe, H. L., Monks, J., Wijgerde, M., Fraser, P., & Proudfoot, N. J. (1997) · Genes & Development · doi:10.1101/gad.11.19.2494 · Cited by 332 · see citing works

The Atr and Atm protein kinases associate with different sites along meiotically pairing chromosomes.Preprint

Keegan, K. S., Holtzman, D. A., Plug, A. W., Christenson, E., Brainerd, E. E., Flaggs, G., Bentley, N. J., Taylor, E. M., Meyn, M. S., Moss, S. B., et al. (1996) · Genes & Development · doi:10.1101/gad.10.19.2423 · Cited by 283 · see citing works

ATM: A mediator of multiple responses to genotoxic stress

Rotman, G., & Shiloh, Y. (1999) · Oncogene · doi:10.1038/sj.onc.1203124 · Cited by 272 · see citing works

Second cancers following pediatric Hodgkin's disease.

Wolden, S. L., Lamborn, K. R., Cleary, S. F., et al. (1998) · Journal of Clinical Oncology · doi:10.1200/jco.1998.16.2.536 · Cited by 272 · see citing works

Transcriptional activation functions in BRCA2

Milner, J., Ponder, B. A. J., Hughes‐Davies, L., Seltmann, M., & Kouzarides, T. (1997) · Nature · doi:10.1038/386772a0 · Cited by 211 · see citing works

BRCA1 deficient embryonic stem cells display a decreased homologous recombination frequency and an increased frequency of non-homologous recombination that is corrected by expression of a Brca1 transgene

Snouwaert, J. N., Gowen, L. C., Latour, A. M., Mohn, A. R., Xiao, A., DiBiase, L., & Koller, B. H. (1999) · Oncogene · doi:10.1038/sj.onc.1203334 · Cited by 197 · see citing works

BRCA1 and BRCA2 are necessary for the transcription-coupled repair of the oxidative 8-oxoguanine lesion in human cells.

Page, F. L., Randrianarison-Huetz, V., Marot, D., Cabannes, J., Perricaudet, M., Feunteun, J., & Sarasin, A. R. (2000) · PubMed · Cited by 190 · see citing works

Role of the tumor suppressor gene Brca1 in genetic stability and mammary gland tumor formation

Deng, C., & Scott, F. (2000) · Oncogene · doi:10.1038/sj.onc.1203269 · Cited by 158 · see citing works

Malignant Breast Tumors Among Atomic Bomb Survivors, Hiroshima and Nagasaki, 1950–1974

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Diverse and dynamic functions of the Sir silencing complex

Guarente, L. (1999) · Nature Genetics · doi:10.1038/15458 · Cited by 154 · see citing works

The Role of Estrogen in Mammary Carcinogenesisa

Fishman, J., Osborne, M. P., & TELANG, N. T. (1995) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1995.tb12113.x · Cited by 140 · see citing works

Analysis of DNA replication forks encountering a pyrimidine dimer in the template to the leading strand 1 1Edited by M. Yaniv

Cordeiro‐Stone, M., Makhov, A. M., Zaritskaya, L., & Griffith, J. D. (1999) · Journal of Molecular Biology · doi:10.1006/jmbi.1999.2847 · Cited by 102 · see citing works

Nuclear organization and gene expression: homologous pairing and long-range interactions

Henikoff, S. (1997) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(97)80012-9 · Cited by 90 · see citing works

DNA polymerase stalling, sister chromatid recombination and the BRCA genes

Scully, R., Puget, N., & Vlasáková, K. (2000) · Oncogene · doi:10.1038/sj.onc.1203971 · Cited by 68 · see citing works

The Functions of Breast Cancer Susceptibility Gene 1 (BRCA1) Product and Its Associated Proteins

Irminger‐Finger, I., Siegel, B., & Leung, W.-C. (1999) · Biological Chemistry · doi:10.1515/bc.1999.019 · Cited by 53 · see citing works

Recombination of parent and daughter strand DNA after UV-irradiation in mammalian cells

Fornace, A. J. (1983) · Nature · doi:10.1038/304552a0 · Cited by 34 · see citing works

Genome maintenance mechanisms for preventing cancer

Hoeijmakers, J. H. J. (2001) · Nature · doi:10.1038/35077232 · Cited by 3,939 · see citing works

Cell cycle checkpoint signaling through the ATM and ATR kinases

Abraham, R. T. (2001) · Genes &amp; Development · doi:10.1101/gad.914401 · Cited by 1,966 · see citing works

Cancer Susceptibility and the Functions of BRCA1 and BRCA2

Venkitaraman, A. R. (2002) · Cell · doi:10.1016/s0092-8674(02)00615-3 · Cited by 1,713 · see citing works

Chk1 and Chk2 kinases in checkpoint control and cancer

Bartek, J., & Lukas, J. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00110-7 · Cited by 1,513 · see citing works

BRCA1 and BRCA2: 1994 and beyond

Narod, S. A., & Foulkes, W. D. (2004) · Nature Reviews Cancer · doi:10.1038/nrc1431 · Cited by 967 · see citing works

Showing your ID: intrinsic disorder as an ID for recognition, regulation and cell signaling

Uversky, V. N., Oldfield, C. J., & Dunker, A. K. (2005) · Journal of Molecular Recognition · doi:10.1002/jmr.747 · Cited by 847 · see citing works

Insights into DNA recombination from the structure of a RAD51–BRCA2 complex

Pellegrini, L., Yu, D. S., Lo, T., Anand, S., Lee, M., Blundell, T. L., & Venkitaraman, A. R. (2002) · Nature · doi:10.1038/nature01230 · Cited by 704 · see citing works

BRCT Repeats As Phosphopeptide-Binding Modules Involved in Protein Targeting

Manke, I. A., Lowery, D. M., Nguyen, A., & Yaffe, M. B. (2003) · Science · doi:10.1126/science.1088877 · Cited by 651 · see citing works

BRCA1 and BRCA2 and the genetics of breast and ovarian cancer

Welcsh, P. L. (2001) · Human Molecular Genetics · doi:10.1093/hmg/10.7.705 · Cited by 648 · see citing works

A mutational signature reveals alterations underlying deficient homologous recombination repair in breast cancer

Polak, P., Kim, J., Braunstein, L. Z., Karlic, R., Haradhavala, N. J., Tiao, G., Rosebrock, D., Livitz, D., Kübler, K., Mouw, K. W., et al. (2017) · Nature Genetics · doi:10.1038/ng.3934 · Cited by 531 · see citing works

Recombinational DNA repair and human disease

Thompson, L. H., & Schild, D. (2002) · Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis · doi:10.1016/s0027-5107(02)00224-5 · Cited by 417 · see citing works

DNA Damage-Induced Cell Cycle Checkpoint Control Requires CtIP, a Phosphorylation-Dependent Binding Partner of BRCA1 C-Terminal Domains

Yu, X., & Chen, J. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.21.9478-9486.2004 · Cited by 410 · see citing works

BACH1 is critical for homologous recombination and appears to be the Fanconi anemia gene product FANCJ

Litman, R., Peng, M., Jin, Z., Zhang, F., Zhang, J., Powell, S., Andreassen, P. R., & Cantor, S. B. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.08.004 · Cited by 396 · see citing works

Human Fanconi anemia monoubiquitination pathway promotes homologous DNA repair

Nakanishi, K., Yang, Y.-G., Pierce, A. J., Taniguchi, T., Digweed, M., D'Andrea, A. D., Wang, Z.-Q., & Jasin, M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407796102 · Cited by 384 · see citing works

DNA double strand break repair and chromosomal translocation: Lessons from animal models

Ferguson, D. O., & Alt, F. W. (2001) · Oncogene · doi:10.1038/sj.onc.1204767 · Cited by 333 · see citing works

Chk2 Phosphorylation of BRCA1 Regulates DNA Double-Strand Break Repair

Zhang, J., Willers, H., Feng, Z., Ghosh, J. C., Kim, S., Weaver, D. T., Chung, J. H., Powell, S. N., & Xia, F. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.2.708-718.2004 · Cited by 323 · see citing works

Multifactorial contributions to an acute DNA damage response by BRCA1/BARD1-containing complexes

Greenberg, R. A., Sobhian, B., Pathania, S., Cantor, S. B., Nakatani, Y., & Livingston, D. M. (2006) · Genes &amp; Development · doi:10.1101/gad.1381306 · Cited by 308 · see citing works

ATM: Genome stability, neuronal development, and cancer cross paths

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Senescence, aging, and malignant transformation mediated by p53 in mice lacking the Brca1 full-length isoform

Cao, L., Li, W., Kim, S., Brodie, S. G., & Deng, C.-X. (2003) · Genes &amp; Development · doi:10.1101/gad.1050003 · Cited by 293 · see citing works

A Role for Proapoptotic BID in the DNA-Damage Response

Zinkel, S. S., Hurov, K. E., Ong, C., Abtahi, F. M., Gross, A., & Korsmeyer, S. J. (2005) · Cell · doi:10.1016/j.cell.2005.06.022 · Cited by 239 · see citing works

CCDC98 is a BRCA1-BRCT domain-binding protein involved in the DNA damage response

Kim, H., Huang, J., & Chen, J. (2007) · Nature Structural &amp; Molecular Biology · doi:10.1038/nsmb1277 · Cited by 212 · see citing works

Structure of the BRCT Repeats of BRCA1 Bound to a BACH1 Phosphopeptide

Shiozaki, E. N., Gu, L., Yan, N., & Shi, Y. (2004) · Molecular Cell · doi:10.1016/s1097-2765(04)00238-2 · Cited by 174 · see citing works

CCDC98 targets BRCA1 to DNA damage sites

Liu, Z., Wu, J., & Yu, X. (2007) · Nature Structural &amp; Molecular Biology · doi:10.1038/nsmb1279 · Cited by 148 · see citing works

Hereditary Breast Cancer and the BRCA1-Associated FANCJ/BACH1/BRIP1

Cantor, S. B., & Guillemette, S. (2011) · Future Oncology · doi:10.2217/fon.10.191 · Cited by 106 · see citing works

Evidence for DNA Damage as a Biological Link Between Diabetes and Cancer

Lee, S. C., & Chan, J. C. (2015) · Chinese Medical Journal · doi:10.4103/0366-6999.157693 · Cited by 106 · see citing works

AGuIX nanoparticles enhance ionizing radiation-induced ferroptosis on tumor cells by targeting the NRF2-GPX4 signaling pathway

Sun, H., Cai, H., Xu, C., Zhai, H., Lux, F., Xie, Y., Feng, L., Du, L., Liu, Y., Sun, X., et al. (2022) · Journal of Nanobiotechnology · doi:10.1186/s12951-022-01654-9 · Cited by 86 · see citing works

BACH1 is a DNA repair protein supporting BRCA1 damage response

Peng, M., Litman, R., Jin, Z., Fong, G., & Cantor, S. B. (2006) · Oncogene · doi:10.1038/sj.onc.1209257 · Cited by 88 · see citing works

H2AX post-translational modifications in the ionizing radiation response and homologous recombination

Xie, A., Odate, S., Chandramouly, G., & Scully, R. A. (2010) · Cell Cycle · doi:10.4161/cc.9.17.12884 · Cited by 59 · see citing works

The mutational landscape of human somatic and germline cells

Moore, L., Cagan, A., Coorens, T. H. H., Neville, M. D. C., Sanghvi, R., Sanders, M. A., Oliver, T. R. W., Leongamornlert, D. A., Ellis, P., Noorani, A., et al. (2022) · Yearbook of pediatric endocrinology · doi:10.1101/2020.11.25.398172 · Cited by 55 · see citing works

Differences between germline and somatic mutation rates in humans and mice

Milholland, B., Dong, X., Zhang, L., Hao, X., Suh, Y., & Vijg, J. (2017) · Nature Communications · doi:10.1038/ncomms15183 · Cited by 423 · see citing works

Germline mutations in the Von Hippel-Lindau disease (VHL) gene in families from North America, Europe, and Japan

Zbar, B., Kishida, T., Chen, F., Schmidt, L. S., Maher, E. R., Richards, F. M., Crossey, P. A., Webster, A. R., Affara, N. A., Ferguson-Smith, M. A., et al. (1996) · Human Mutation · doi:10.1002/(sici)1098-1004(1996)8:4 · Cited by 503 · see citing works

28. Identification of TP53 germline variants in pediatric patients undergoing tumor testing

Luo, M., MacFarland, S. P., Zelley, K., et al. (2022) · Cancer Genetics · doi:10.1016/j.cancergen.2021.05.042

Simultaneous Adrenocortical Carcinoma and Neuroblastoma in an Infant With a Novel Germline p53 Mutation

Courtney, R., & Ranganathan, S. (2014) · Journal of Pediatric Hematology/Oncology · doi:10.1097/mph.0000000000000281 · Cited by 10 · see citing works