Cited by 217Acute Myocardial Infarction ResearchCardiac Health and Mental HealthCardiac Ischemia and Reperfusion

L-Carnitine in the Secondary Prevention of Cardiovascular Disease: Systematic Review and Meta-analysis

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DiNicolantonio, James J., Lavie, Carl J., Fares, Hassan, Menezes, Arthur R., O'Keefe, James H.·2013·Mayo Clinic Proceedings

Abstract

Objective To evaluate the effects of L-carnitine compared with placebo or control on morbidity and mortality in the setting of acute myocardial infarction.Methods A systematic review and meta-analysis of 13 controlled trials (N=3629) was conducted to determine the effects of L-carnitine vs placebo or control on mortality, ventricular arrhythmias (VAs), angina, heart failure, and reinfarction. These trials were identified via searches of the Ovid MEDLINE, PubMed, and Excerpta Medica (Embase) databases between May 1, 2012, and August 31, 2012.Results Compared with placebo or control, L-carnitine was associated with a significant 27% reduction in all-cause mortality (odds ratio, 0.73; 95% CI, 0.54-0.99; P=.05; risk ratio [RR], 0.78; 95% CI, 0.60-1.00; P=.05), a highly significant 65% reduction in VAs (RR, 0.35; 95% CI, 0.21-0.58; P<.0001), and a significant 40% reduction in the development of angina (RR, 0.60; 95% CI, 0.50-0.72; P<.00001), with no reduction in the development of heart failure (RR, 0.85; 95% CI, 0.67-1.09; P=.21) or myocardial reinfarction (RR, 0.78; 95% CI, 0.41-1.48; P=.45).Conclusion Compared with placebo or control, L-carnitine is associated with a 27% reduction in all-cause mortality, a 65% reduction in VAs, and a 40% reduction in anginal symptoms in patients experiencing an acute myocardial infarction. Further study with large randomized controlled trials of this inexpensive and safe therapy in the modern era is warranted.

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Crossref · 10.1016/j.mayocp.2013.02.007

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  • A meta-analysis of 13 controlled trials (n=3,629) reported that low oral L-carnitine reduced all-cause mortality by 27% in acute myocardial infarction patients.

    “A meta-analysis of 13 controlled trials (n = 3,629 people) reported that low oral dosage of L-carnitine resulted in 27% reduction in all-cause mortality, a 65% reduction in ventricular arrhythmias, and a 40% reduction in angina symptoms in patients who had an acute myocardial infarction (37).”
  • In patients experiencing an acute myocardial infarction, l-carnitine is associated with a 40% reduction in anginal symptoms compared to controls.

    “A systematic review and meta-analysis of 13 controlled trials showed that l-carnitine is associated with a 27% reduction in all-cause mortality, a 65% reduction in ventricular arrhythmias and a 40% reduction in anginal symptoms in patients experiencing an acute myocardial infarction compared to controls [59].”

    From Trimethylamine N-oxide: the good, the bad and the unknown. (2016) · cites this paper as [59]

  • In patients experiencing an acute myocardial infarction, l-carnitine is associated with a 65% reduction in ventricular arrhythmias compared to controls.

    “A systematic review and meta-analysis of 13 controlled trials showed that l-carnitine is associated with a 27% reduction in all-cause mortality, a 65% reduction in ventricular arrhythmias and a 40% reduction in anginal symptoms in patients experiencing an acute myocardial infarction compared to controls [59].”

    From Trimethylamine N-oxide: the good, the bad and the unknown. (2016) · cites this paper as [59]

  • In patients experiencing an acute myocardial infarction, l-carnitine is associated with a 27% reduction in all-cause mortality compared to controls.

    “A systematic review and meta-analysis of 13 controlled trials showed that l-carnitine is associated with a 27% reduction in all-cause mortality, a 65% reduction in ventricular arrhythmias and a 40% reduction in anginal symptoms in patients experiencing an acute myocardial infarction compared to controls [59].”

    From Trimethylamine N-oxide: the good, the bad and the unknown. (2016) · cites this paper as [59]

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4 of the 37 references couldn’t be matched to a known paper.

Research works printed but not linked: 3

  1. Higgins JP, Green S, eds. Cochran Handbook for Systematic Re- view of Interventions: Assessing Risk of Bias in Included Studies. 5.0.0 ed. Hoboken, NJ: John Wiley & Sons Inc; 2008.
  2. Kobulia B, Chapichadze Z, Andriadze G, Machavariani P. Effects of carnitine on 6-month incidence of mortality and heart failure in patients with acute myocardial infarction. Ann Biomed Res Educ. 2002;2(3):240-243.
  3. Rebuzzi AG, Schiavoni G, Amico CM, Montenero AS, Meo F, Manzoli U. Beneficial effects of L-carnitine in the reduction of the necrotic area in acute myocardial infarction. Drugs Exp Clin Res. 1984;10:219-223.

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Authors
DiNicolantonio, J. J., Lavie, C. J., Fares, H., Menezes, A. R., & O'Keefe, J. H.
Affiliations
  • Pennington Biomedical Research Center (US)
  • The University of Queensland (AU)
Corresponding author
DiNicolantonio, James J.
Venue
Mayo Clinic Proceedings
Publisher
Elsevier BV
Published
2013-06
Volume
88
Issue
6
Pages
544-551
ISSN
0025-6196 (ISSN-L)
OpenAlex
W2171503971
Cited by
217
References
37
Citations by year
2026: 9 · 2025: 12 · 2024: 16 · 2023: 15 · 2022: 18 · 2021: 17 · 2020: 18 · 2019: 25 · 2018: 15 · 2017: 20 · 2016: 9 · 2015: 19 · 2014: 13 · 2013: 11
FWCI
2.96
Type
journal article
Language
en
Open access
Locations
  • Mayo Clinic Proceedings (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Acute Myocardial Infarction Research
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Cardiac Ischemia and Reperfusion
Keywords
L-carnitine, acute myocardial infarction, secondary prevention, all-cause mortality, ventricular arrhythmias, angina pectoris, reinfarction, heart failure, cardiovascular disease
MeSH terms
Angina Pectoris, Arrhythmias, Cardiac, Carnitine, Heart Failure, Humans, Myocardial Infarction, Vitamin B Complex, Odds Ratio, Treatment Outcome, Secondary Prevention

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