The DOI matches its Crossref record; 71 of the 71 references it cites were found in a registry or an index.
Harmful effects of nicotine
Open accessAbstract
With the advent of nicotine replacement therapy, the consumption of the nicotine is on the rise. Nicotine is considered to be a safer alternative of tobacco. The IARC monograph has not included nicotine as a carcinogen. However there are various studies which show otherwise. We undertook this review to specifically evaluate the effects of nicotine on the various organ systems. A computer aided search of the Medline and PubMed database was done using a combination of the keywords. All the animal and human studies investigating only the role of nicotine were included. Nicotine poses several health hazards. There is an increased risk of cardiovascular, respiratory, gastrointestinal disorders. There is decreased immune response and it also poses ill impacts on the reproductive health. It affects the cell proliferation, oxidative stress, apoptosis, DNA mutation by various mechanisms which leads to cancer. It also affects the tumor proliferation and metastasis and causes resistance to chemo and radio therapeutic agents. The use of nicotine needs regulation. The sale of nicotine should be under supervision of trained medical personnel.
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Cites
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Nicotine stimulates angiogenesis and promotes tumor growth and atherosclerosis
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Molecular and cellular aspects of nicotine abuse
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Nicotinic receptors in the brain: correlating physiology with function
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Cellular and synaptic mechanisms of nicotine addiction
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A prospective study of cigarette smoking and age-related macular degeneration in women
Seddon, J. M. (1996) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1996.03540140029022 · Cited by 435
Nicotine metabolite ratio as an index of cytochrome P450 2A6 metabolic activity*1
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Nicotine and its metabolites. Radioimmunoassays for nicotine and cotinine
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An updated overview of e-cigarette impact on human health
Marques, P., Piqueras, L., & Sanz, M.-J. (2021) · Respiratory Research · doi:10.1186/s12931-021-01737-5 · Cited by 470
Goldberg, L. R., & Gould, T. J. (2019) · European Journal of Neuroscience · doi:10.1111/ejn.14060 · Cited by 88
Dai, H., Benowitz, N. L., Achutan, C., Farazi, P. A., Degarege, A., & Khan, A. S. (2022) · JAMA Network Open · doi:10.1001/jamanetworkopen.2021.47891 · Cited by 74
Unique effects of nicotine across the lifespan
Ren, M., Lotfipour, S., & Leslie, F. (2022) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2022.173343 · Cited by 40
Aldali, J. A. (2026) · Healthcare · doi:10.3390/healthcare14030286 · Cited by 4
Metadata
- Authors
- Mishra, A., Chaturvedi, P., Datta, S., Sinukumar, S., Joshi, P., & Garg, A.
- Venue
- Indian Journal of Medical and Paediatric Oncology
- Publisher
- Georg Thieme Verlag KG
- Published
- 2015-01
- Volume
- 36
- Issue
- 01
- Pages
- 24-31
- ISSN
- 0971-5851 (ISSN-L)
- 0975-2129
- OpenAlex
- W2100907205
- Cited by
- 401
- References
- 71
- FWCI
- 8.18
- Type
- journal article
- Language
- en
- Open access
- diamond
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- Mishra, A., Chaturvedi, P., Datta, S., Sinukumar, S., Joshi, P., & Garg, A. (2015). Harmful effects of nicotine. Indian Journal of Medical and Paediatric Oncology. https://doi.org/10.4103/0971-5851.151771
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
