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Cellular and synaptic mechanisms of nicotine addiction

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Mansvelder, Huibert D., McGehee, Daniel S.·2002·Journal of Neurobiology
DOI 10.1002/neu.10148
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Abstract

The tragic health effects of nicotine addiction highlight the importance of investigating the cellular mechanisms of this complex behavioral phenomenon. The chain of cause and effect of nicotine addiction starts with the interaction of this tobacco alkaloid with nicotinic acetylcholine receptors (nAChRs). This interaction leads to activation of reward centers in the CNS, including the mesoaccumbens DA system, which ultimately leads to behavioral reinforcement and addiction. Recent findings from a number of laboratories have provided new insights into the biologic processes that contribute to nicotine self‐administration. Examination of the nAChR subtypes expressed within the reward centers has identified potential roles for these receptors in normal physiology, as well as the effects of nicotine exposure. The high nicotine sensitivity of some nAChR subtypes leads to rapid activation followed in many cases by rapid desensitization. Assessing the relative importance of these molecular phenomena in the behavioral effects of nicotine presents an exciting challenge for future research efforts. © 2002 Wiley Periodicals, Inc. J Neurobiol 53: 606–617, 2002

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Metadata

Authors
Mansvelder, H. D., & McGehee, D. S.
Venue
Journal of Neurobiology
Publisher
Wiley
Published
2002-11-15
Volume
53
Issue
4
Pages
606-617
ISSN
  • 0022-3034 (ISSN-L)
  • 1097-4695
DOI
10.1002/neu.10148
OpenAlex
W2131366415
Cited by
440
References
23
FWCI
6.91
Type
journal article
Language
en
Open access
hybrid
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)

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Mansvelder, H. D., & McGehee, D. S. (2002). Cellular and synaptic mechanisms of nicotine addiction. Journal of Neurobiology. https://doi.org/10.1002/neu.10148

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