Cited by 88Prenatal Substance Exposure EffectsEpigenetics and DNA MethylationNeurotransmitter Receptor Influence on Behavior

Multigenerational and transgenerational effects of paternal exposure to drugs of abuse on behavioral and neural function

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Goldberg, Lisa R., Gould, Thomas J.·2019·European Journal of Neuroscience

Abstract

Addictions are highly heritable disorders, with heritability estimates ranging from 39% to 72%. Multiple studies suggest a link between paternal drug abuse and addiction in their children. However, patterns of inheritance cannot be explained purely by Mendelian genetic mechanisms. Exposure to drugs of abuse results in epigenetic changes that may be passed on through the germline. This mechanism of epigenetic transgenerational inheritance may provide a link between paternal drug exposure and addiction susceptibility in the offspring. Recent studies have begun to investigate the effect of paternal drug exposure on behavioral and neurobiological phenotypes in offspring of drug‐exposed fathers in rodent models. This review aims to discuss behavioral and neural effects of paternal exposure to alcohol, cocaine, opioids, and nicotine. Although a special focus will be on addiction‐relevant behaviors, additional behavioral effects including cognition, anxiety, and depressive‐like behaviors will be discussed.

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Authors
Goldberg, L. R., & Gould, T. J.
Affiliations
Pennsylvania State University (US)
Corresponding author
Gould, Thomas J.
Venue
European Journal of Neuroscience
Publisher
Wiley
Published
2018-07-20
Volume
50
Issue
3
Pages
2453-2466
ISSN
  • 0953-816X (ISSN-L)
  • 1460-9568
OpenAlex
W2811133549
Cited by
88
References
151
Citations by year
2026: 6 · 2025: 6 · 2024: 12 · 2023: 9 · 2022: 15 · 2021: 13 · 2020: 13 · 2019: 13
FWCI
1.86
Type
journal article
Language
en
Open access
Locations
  • European Journal of Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute on Drug Abuse (U01DA041632)
Topics
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
paternal drug exposure, transgenerational epigenetic inheritance, alcohol, cocaine, opioids, nicotine, anxiety-like behavior, depression-like behavior, cognition, rodent models
MeSH terms
Adult, Brain, Child, Child Behavior Disorders, Humans, Male, Illicit Drugs, Child of Impaired Parents, Paternal Exposure, Substance-Related Disorders, Epigenesis, Genetic

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