Effect of caffeine on bladder function in patients with overactive bladder symptoms
Open accessAbstract
OBJECTIVES: To evaluate the effect of caffeine at the dose of 4.5 mg/kg on bladder function in overactive bladder (OAB) adults. MATERIALS AND METHODS: Nine women and three men aged 21-40 years with OAB symptoms were included. Each subject drank 8 ml/kg of water with and without caffeine at two separate sessions. Cystometry and uroflowmetry were performed 30 minutes after each drink. The effects of caffeine on urodynamic parameters were compared. RESULTS: After caffeine ingestion, the mean volume at bladder filling phase decreased at first desire to void and normal desire to void (P<0.05), compared to the mean volume after taking water (control) drink. The mean volume at strong desire to void, urgency and maximum cystometric capacity also tended to decrease. No change in the detrusor pressure at filling phase was found. At voiding phase, the maximal flow rate, average flow rate and voided volume were increased (P<0.05). The urine flow time and time to maximal flow rate were not changed. CONCLUSION: Caffeine at 4.5 mg/kg caused diuresis and decreased the threshold of sensation at filling phase, with an increase in flow rate and voided volume. So, caffeine can promote early urgency and frequency of urination. Individuals with lower urinary tract symptom should avoid or be cautious in consuming caffeine containing foodstuffs.
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Caffeine intake of 4.5 mg/kg/day caused early urgency and frequency of urination in men and women with overactive bladder.
“caffeine intake of 4.5 mg/kg/day caused early urgency and frequency of urination in men and women with overactive bladder (159).”
From The Safety of Ingested Caffeine: A Comprehensive Review (2017) · cites this paper as [159]
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Purohit, R. S., & Blaivas, J. G. (2014) · Current clinical urology · doi:10.1007/978-1-4939-0008-4_11
Diagnosis and Management of Complex Pelvic Floor Disorders in Women
Gupta, P., Ehlert, M. J., & Bartley, J. M. (2015)
Refractory hyperactive bladder treated with sacral neuromodulator: case report and literature review
Navarro, J. J. A., Sánchez, R. D. L., Morales, O. A., Sosa, M. I. T., Reyes, F. L., & Vilchis, J. A. B. (2018) · International Journal of Reproduction Contraception Obstetrics and Gynecology · doi:10.18203/2320-1770.ijrcog20182910
Management of Overactive Bladder in the Young Man
Herforth, C. M., McLain, C. A., & Choe, C. H. (2019) · Current Bladder Dysfunction Reports · doi:10.1007/s11884-019-00528-5
Mindfulness, Meditation, and Yoga
Budd, K. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108650182.028
Work, Love, Play, and Joie de Vivre
Groningen, N. V., IsHak, W. W., Ganjian, S., Ong, M. K., & Slusser, W. M. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108650182.045
Acupuncture, Herbs, and Ayurvedic Medicine
Postolov, L., & Gilberg-Lenz, S. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108650182.031
Circadian Rhythm in the Digital Age
Ezzat-Velinov, M., & Guarneri, M. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108650182.035
Chaudhry, M., Gordon, A., Tadros, E., Sun, C., Tobia, G., & IsHak, W. W. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108650182.019
The Personalized Wellness Life Plan
IsHak, W. W., Bart, R., Gohar, Y., Lorea, N., Eskander, L., Chang, T., Cohen, S., Furman, K., Nayyar, P. P., & DeBonis, K. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108650182.050
Exercise, Dance, Tai Chi, Pilates, and Alexander Technique
Altug, Z. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108650182.025
Louy, C., Sweet, C., Pollock, G. A., de Zagon, C., Louy, Z., Weiss, J. M., & Maher, D. P. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108650182.017
Pharmaceuticals and Alternatives for Wellness
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Bucciarelli, A., Ellison, G. K., Sommer, E. K., & Spooner, H. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108650182.036
Screening and Assessment Methods for Wellness
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Wellness in Children and Adolescents
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Connection, Compassion, and Community
Hedrick, R., & Jones, K. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108650182.043
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- Authors
- Lohsiriwat, S., Hirunsai, M., & Chaiyaprasithi, B.
- Affiliations
- Siriraj Hospital (TH)
- Corresponding author
- Lohsiriwat, Supatra
- ORCID
- Hirunsai, Muthita
- Venue
- Urology Annals
- Published
- 2011
- Volume
- 3
- Issue
- 1
- Pages
- 14
- ISSN
- 0974-7796 (ISSN-L)
- PMC
- PMC3036994
- OpenAlex
- W2019744705
- Cited by
- 129
- References
- 20
- Citations by year
- 2026: 5 · 2025: 2 · 2024: 1 · 2023: 8 · 2022: 9 · 2021: 3 · 2020: 58 · 2019: 4 · 2018: 2 · 2017: 4 · 2016: 5 · 2015: 4 · 2014: 7 · 2013: 11 · 2012: 4
- FWCI
- 9.25
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc-sa
- Locations
- Urology Annals (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Urology › Urinary Bladder and Prostate Research
- Health Sciences › Medicine › Epidemiology › Urinary Tract Infections Management
- Health Sciences › Medicine › Pharmacology › Coffee research and impacts
- Keywords
- caffeine, overactive bladder, bladder function, urgency, diuresis, urodynamic parameters, cystometry, uroflowmetry, detrusor pressure, lower urinary tract symptoms
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