The DOI matches its Crossref record; 96 of the 99 references it cites were found in a registry or an index.
L-asparaginase in the treatment of patients with acute lymphoblastic leukemia
Open accessAbstract
Acute lymphoblastic leukemia (ALL) is a hematologic malignancy that predominantly occurs in children between 2 and 10 years of age. L-asparaginase is an integral component of treatment for patients with ALL and since its introduction into pediatric treatment protocols in the 1960s, survival rates in children have progressively risen to nearly 90%. Outcomes for adolescent and young adult (AYA) patients, aged 15-39 years and diagnosed with ALL, have historically been less favorable. However, recent reports suggest substantially increased survival in AYA patients treated on pediatric-inspired protocols that include a greater cumulative dose of asparaginase. All currently available asparaginases share the same mechanism of action - the deamination and depletion of serum asparagine levels - yet each displays a markedly different pharmacokinetic profile. Pegylated asparaginase derived from the bacterium Escherichia coli is used as first-line therapy; however, up to 30% of patients develop a treatment-limiting hypersensitivity reaction. Patients who experience a hypersensitivity reaction to an E. coli-derived asparaginase can continue treatment with Erwinia chrysanthemi asparaginase. Erwinia asparaginase is immunologically distinct from E. coli-derived asparaginases and exhibits no cross-reactivity. Studies have shown that with adequate dosing, therapeutic levels of Erwinia asparaginase activity can be achieved, and patients switched to Erwinia asparaginase due to hypersensitivity can obtain outcomes similar to patients who do not experience a hypersensitivity reaction. Therapeutic drug monitoring may be required to ensure that therapeutic levels of asparaginase activity are maintained.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“L-asparaginase has been found to be effective in the treatment of ALL and is included in standard chemotherapy regimens for this disease (Table 1)(Egler et al., 2016).”
From Targeting Metabolism for Cancer Therapy (2017) · cites this paper as Egler et al., 2016
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Treatment of Acute Lymphoblastic Leukemia
Pui, C., & Evans, W. E. (2006) · New England Journal of Medicine · doi:10.1056/nejmra052603 · Cited by 2,012
Pui, C.-H., Robison, L. L., & Look, A. T. (2008) · The Lancet · doi:10.1016/s0140-6736(08)60457-2 · Cited by 1,564
Hunger, S. P., Lu, X., Devidas, M., Camitta, B. M., Gaynon, P. S., Winick, N. J., Reaman, G. H., & Carroll, W. L. (2012) · Journal of Clinical Oncology · doi:10.1200/jco.2011.37.8018 · Cited by 1,177
Silverman, L. B. (2001) · Blood · doi:10.1182/blood.v97.5.1211 · Cited by 869
Results of Treatment With Hyper-CVAD, a Dose-Intensive Regimen, in Adult Acute Lymphocytic Leukemia
Kantarjian, H. M., O'Brien, S. M., Smith, T. L., Cortes, J. E., Giles, F. J., Beran, M., Pierce, S. A., Huh, Y. O., Andreeff, M., Koller, C. A., et al. (2000) · Journal of Clinical Oncology · doi:10.1200/jco.2000.18.3.547 · Cited by 796
Armstrong, J. K., Hempel, G., Koling, S., Chan, L. S., Fisher, T., Meiselman, H. J., & Garratty, G. (2007) · Cancer · doi:10.1002/cncr.22739 · Cited by 699
Kantarjian, H. M., Thomas, D. A., O'Brien, S. M., Cortes, J. E., Giles, F. J., Jeha, S., Bueso-Ramos, C., Pierce, S. A., Shan, J., Koller, C. A., et al. (2004) · Cancer · doi:10.1002/cncr.20668 · Cited by 638
Boissel, N., Auclerc, M.-F., Lhéritier, V., Pérel, Y., Thomas, X., Leblanc, T. M., Rousselot, P. H., Cayuela, J., Gabert, J. A., Fegueux, N., et al. (2003) · Journal of Clinical Oncology · doi:10.1200/jco.2003.02.053 · Cited by 606
L‐asparaginase treatment in acute lymphoblastic leukemia: A focus on Erwinia asparaginase
Pieters, R., Hunger, S. P., Boos, J., Rizzari, C., Silverman, L., Baruchel, A., Goekbuget, N., Schrappe, M., & Pui, C. (2011) · Cancer · doi:10.1002/cncr.25489 · Cited by 569
Huguet, F., Leguay, T., Raffoux, E., Thomas, X., Beldjord, K., Delabesse, É., Chevallier, P., Buzyn, A., Delannoy, A., Chalandon, Y., et al. (2009) · Journal of Clinical Oncology · doi:10.1200/jco.2008.18.6916 · Cited by 566
Flagged first, then by citations
3 of the 99 references couldn’t be matched to a known paper.
Research works printed but not linked: 6
- [1]Gaynon P Schrappe M Cairo M Perkins S Childhood ALL Hematological Malignancies in Children, Adolescents and Young Adults 2012 Hackensack, NJ World Scientific Publishing Company 197 235
- [2]Howlader N Noone AM Krapcho M Garshell J Neyman N Altekruse SF National Cancer Institute. Section 28: Childhood cancer by site, incidence, survival, and mortality SEER Cancer Statistics Review, 1975-2011 2014 Bethesda, MD National Cancer Institute
- [7]Broome JD Evidence that the L-asparaginase of guinea pig serum is responsible for its antilymphoma effects. I. Properties of the L-asparaginase of guinea pig serum in relation to those of the antilymphoma substance J Exp Med 1963 118 99 120 14015821 PMC2137570
- [21]Clarkson B Krakoff I Burchenal J Karnofsky D Golbey R Dowling M Clinical results of treatment with E. coli L-asparaginase in adults with leukemia, lymphoma, and solid tumors Cancer 1970 25 279 305 4905154
- [55]Oettgen HF Stephenson PA Schwartz MK Leeper RD Tallai L Tan CC Toxicity of E. coli L-asparaginase in man Cancer 1970 25 253 78 4905153
- [71]Schwartz MK Lash ED Oettgen HF Tomato FA L-asparaginase activity in plasma and other biological fluids Cancer 1970 25 244 52 4905152
Cited by
Sorted by citations
Items 101–200 of 325
Tsai, C., Saito, T., Sarangdhar, M., Abu‐El‐Haija, M. A., Wen, L., Lee, B., Yu, M., Lipata, D., Manohar, M., Barakat, M. T., et al. (2023) · Science Translational Medicine · doi:10.1126/scitranslmed.abn2110 · Cited by 15
Sánchez‐Moguel, I., Costa-Silva, T. A., Pillaca‐Pullo, O. S., Flores-Santos, J. C., Freire, R. K. B., Carretero, G., Bueno, J. D. L., Camacho-Córdova, D. I., Santos, J. H. P. M., Sette, L. D., et al. (2023) · Process Biochemistry · doi:10.1016/j.procbio.2023.03.003 · Cited by 14
Endophytic Fungi as a Promising Source of Anticancer L-Asparaginase: A Review
Parashiva, J., Nuthan, B. R., Rakshith, D., & Satish, S. (2023) · Current Microbiology · doi:10.1007/s00284-023-03392-z · Cited by 14
Chulián, S., Stolz, B. J., Martínez-Rubio, Á., Goñi, C. B., Gutiérrez, J. F. R., Caballero‐Velázquez, T., Quintana, Á. M., Ramírez, M. R., Robleda, A. C., Soler, J. L. F., et al. (2023) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1011329 · Cited by 14
Oriuchi, N., Sugawara, S., & Shiga, T. (2020) · Biomedicines · doi:10.3390/biomedicines8090371 · Cited by 15
Cawley, J. R., Wright, Z. M., Meleo, K. A., Post, G. S., Clifford, C. A., Vickery, K. R., Vail, D. M., Bergman, P. J., & Thamm, D. H. (2020) · Journal of Veterinary Internal Medicine · doi:10.1111/jvim.15723 · Cited by 14
Mudaliar, S., Kumar, V., & Verma, P. (2025) · Process Safety and Environmental Protection · doi:10.1016/j.psep.2024.12.118 · Cited by 13
Gupta, D. G., Varma, N., Naseem, S., Sachdeva, M. U. S., Bose, P. L., Binota, J., Kumar, A., Gupta, M., Rana, P., Sonam, P., et al. (2021) · Turkish Journal of Hematology · doi:10.4274/tjh.galenos.2021.2021.0326 · Cited by 13
Lee, J. K., Rosales, J. L., & Lee, K. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1124164 · Cited by 13
Immunogenicity assessment of fungal l-asparaginases: an in silico approach
Belén, L. H., Lissabet, J. F. B., Rangel‐Yagui, C. D. O., Monteiro, G., Pessoa, A., & Farías, J. G. (2020) · SN Applied Sciences · doi:10.1007/s42452-020-2021-z · Cited by 12
Ebrahimipour, G., Yaghoubi-Avini, M., & Ghorbanmovahhed, M. (2020) · SciMedicine Journal · doi:10.28991/scimedj-2020-0202-1 · Cited by 12
Towards a dependable data set of structures for L -asparaginase research
Wlodawer, A., Dauter, Z., Lubkowski, J. T., Loch, J. I., Brzeziński, D., Gilski, M. J., & Jaskólski, M. (2024) · Acta Crystallographica Section D Structural Biology · doi:10.1107/s2059798324005461 · Cited by 12
Opportunistic complexes of E. coli L-asparaginases with citrate anions
Lubkowski, J. T., Chan, W., & Wlodawer, A. (2019) · Scientific Reports · doi:10.1038/s41598-019-46432-0 · Cited by 12
Naqvi, S. M. A., Islam, S. N., Kumar, A., Patil, C. R., Kumar, A., V, & Ahmad, A. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.130238 · Cited by 11
Sonowal, S., Pathak, K., Das, D., Buragohain, K., Gogoi, A., Borah, N., Das, A., & Nath, R. (2024) · Advanced Therapeutics · doi:10.1002/adtp.202400156 · Cited by 11
Christensen, S. R., Jensen, C. F., Heldrup, J., Taylor, Z. L., Ramsey, L. B., & Rosthøj, S. (2024) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-024-04713-0 · Cited by 11
Trimpont, M. V., Schalk, A. M., Hofkens, K., Peeters, E., T’Sas, S., Vandemeulebroecke, K., Su, Y., Loera, A. D., Garcia, A., Chen, H., et al. (2024) · Cancer Letters · doi:10.1016/j.canlet.2024.217404 · Cited by 11
Yakin, R., Syarif, S., & Tehuteru, E. S. (2017) · Indonesian Journal of Cancer · doi:10.33371/ijoc.v11i3.515 · Cited by 11
Fulcher, J., & Carrier, M. (2020) · Thrombosis Research · doi:10.1016/j.thromres.2020.02.015 · Cited by 11
Olawuni, B., & Bode, B. P. (2024) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00316.2024 · Cited by 10
Endophytes as a Source of High-Value, Bioactive Metabolites
Kapoor, N., Jamwal, V. L., & Gandhi, S. G. (2019) · Reference series in phytochemistry · doi:10.1007/978-3-319-90484-9_9 · Cited by 10
Patial, V., Kumar, S., Joshi, R., & Singh, D. P. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.128576 · Cited by 10
Variations in global prices of chemotherapy for childhood cancer: a descriptive analysis
Habashy, C., Yemeke, T. T., Bolous, N. S., Chen, Y., Ozawa, S., Bhakta, N. H., & Alexander, T. (2023) · EClinicalMedicine · doi:10.1016/j.eclinm.2023.102005 · Cited by 10
Treatment of Young Adults with Acute Lymphoblastic Leukemia
Kansagra, A. J., & Litzow, M. R. (2017) · Current Hematologic Malignancy Reports · doi:10.1007/s11899-017-0377-y · Cited by 10
Engineering l -asparaginase for spontaneous formation of calcium phosphate bioinspired microreactors
Louka, A., Matlahov, I., Giuntini, S., Cerofolini, L., Cavallo, A., Pillozzi, S., Ravera, E., Fragai, M., Arcangeli, A., Ramamoorthy, A., et al. (2018) · Physical Chemistry Chemical Physics · doi:10.1039/c8cp00419f · Cited by 10
Khamespanah, E., Asad, S., Vanak, Z., & Mehrshad, M. (2024) · Microbial Ecology · doi:10.1007/s00248-024-02458-0 · Cited by 9
Human arginase I: a potential broad-spectrum anti-cancer agent
Anakha, J., Prasad, Y. R., Sharma, N., & Pande, A. H. (2023) · 3 Biotech · doi:10.1007/s13205-023-03590-3 · Cited by 9
Flores-Santos, J. C., Sánchez‐Moguel, I., Monteiro, G., Pessoa, A., & Vitolo, M. I. (2021) · Brazilian Journal of Microbiology · doi:10.1007/s42770-021-00534-y · Cited by 9
L-asparaginase from Dickeya chrysanthemi: expression, purification and cytotoxicity assessment
Saeed, H. M. S., Sheta, E., Shalaby, M. A., Abdel-Fattah, M., Hemida, A., Eldoksh, A., Ataya, F. S., Nematalla, H. A., Elkewedi, M., Labrou, N. E., et al. (2021) · Preparative Biochemistry & Biotechnology · doi:10.1080/10826068.2021.1983831 · Cited by 9
Kasonkanji, E., Kimani, S., Skiver, B. M., Ellis, G. K., Séguin, R., Kaimila, B., Tomoka, T., Mulenga, M., Montgomery, N. D., Fedoriw, Y. D., et al. (2022) · JCO Global Oncology · doi:10.1200/go.21.00388 · Cited by 9
Wang, Y., Ma, S., & Ruzzo, W. L. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/719294 · Cited by 9
Awwad, S., Alnasr, R. A., AlManjomi, F., Sultan, M. A., Howaidi, J., Almotairi, M., & AlFayyad, I. (2024) · Pediatric Hematology Oncology Journal · doi:10.1016/j.phoj.2024.03.001 · Cited by 8
Starobova, H., McCalmont, H., Shatunova, S., Tay, N., Smith, C. M., Robertson, A. A. B., Winkler, I. G., Lock, R. B., & Vetter, I. (2025) · HemaSphere · doi:10.1002/hem3.70092 · Cited by 8
Darnal, S., Raj, R., Chhimwal, J., Thakur, S., Padwad, Y. S., & Singh, D. P. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.128739 · Cited by 8
Sisay, T., Mobegi, V. A., Wachira, S. W., & Maina, N. W. (2024) · Electronic Journal of Biotechnology · doi:10.1016/j.ejbt.2024.05.002 · Cited by 8
Su, W., Stricherz, M., Martin, A., Belsey, J., Kemadjou, E. N., & DeAngelo, D. J. (2025) · American Journal of Hematology · doi:10.1002/ajh.27607 · Cited by 8
pH-Dependent Thermal Stability of Vibrio cholerae L-asparaginase
Radha, R., & Gummadi, S. N. (2019) · Protein and Peptide Letters · doi:10.2174/0929866526666190617092944 · Cited by 8
L-carnitine and Vitamin B Complex for PEG-L-asparaginase-Induced Hepatotoxicity
Arora, S. S., Klair, J. S., Bellizzi, A. M., & Tanaka, T. (2019) · ACG Case Reports Journal · doi:10.14309/crj.0000000000000194 · Cited by 8
Hu, Y., Chen, M., Song, Y., Liu, X., Gou, F., Zhang, J., & Huang, Y. (2019) · American Journal of Clinical Oncology · doi:10.1097/coc.0000000000000647 · Cited by 8
Pegylated Asparaginase‐Induced Liver Injury: A Case‐Based Review and Data From Pharmacovigilance
Vetro, C., Duminuco, A., Gozzo, L., Maugeri, C., Parisi, M. S., Brancati, S. B., Longo, L., Vitale, D. C., Romano, G. L., Ciuni, R., et al. (2022) · The Journal of Clinical Pharmacology · doi:10.1002/jcph.2052 · Cited by 8
Andjelkovic, M., Zinovjev, K., Ruiz-Pernía, J. J., & Tuñón, I. (2025) · ACS Catalysis · doi:10.1021/acscatal.4c07791 · Cited by 7
Iorio, M. C., Ganesh, N. U., Luise, M. D., Porcelli, A. M., Gasparre, G., & Kurelac, I. (2021) · Cancers · doi:10.3390/cancers13215447 · Cited by 7
Oriuchi, N., Endoh, H., & Kaira, K. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23169394 · Cited by 8
Small Molecule Catalysts with Therapeutic Potential
Ney, Y., Nasim, M. J., Kharma, A., Youssef, L. A., & Jacob, C. (2018) · Molecules · doi:10.3390/molecules23040765 · Cited by 8
Radha, R., & Gummadi, S. N. (2020) · Indian Chemical Engineer · doi:10.1080/00194506.2020.1758224 · Cited by 7
Silveira, T. D. C., Gomes, W. E., Tonon, G. C., Beatto, T. G., Spogis, N., Cunha, L. H. D., Lattaro, B. P., Borin, A., Mendes, R. K., Alvarenga, D. O., et al. (2021) · World Journal of Microbiology and Biotechnology · doi:10.1007/s11274-021-03094-3 · Cited by 7
Wei, Y., Iyer, S. V., Costa, A. S. H., Yang, Z., Kramer, M., Adelman, E. R., Klingbeil, O., Demerdash, O. E., Polyanskaya, S. A., Chang, K., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.12.22.424018 · Cited by 7
Mizrahi, N., Kugler, E., Hayman, L., Yeshurun, M., Grossman, A., Raanani, P., & Wolach, O. (2021) · Acta Haematologica · doi:10.1159/000519033 · Cited by 6
CASPER: A Phase I trial combining calaspargase pegol-mnkl and cobimetinib in pancreatic cancer
Lopez, C. D., Kardosh, A., Chen, E. Y.-S., Pegna, G. J., Guimarães, A. R., Foster, B. R., Brinkerhoff, B. T., Goodyear, S. M., Lim, J.-Y., Taber, E. N., et al. (2024) · Future Oncology · doi:10.1080/14796694.2024.2395235 · Cited by 6
Gilavand, F., Marzban, A., & Kavyanifard, A. (2019) · Research in Molecular Medicine · doi:10.18502/rmm.v6i3.4608 · Cited by 6
Baek, D. W., Kim, D. Y., Sohn, S. K., Koh, Y., Jung, S., Yhim, H., Choi, Y., & Moon, J. H. (2021) · The Korean Journal of Internal Medicine · doi:10.3904/kjim.2021.028 · Cited by 6
(2021) · Jordan Journal of Biological Sciences · doi:10.54319/jjbs/140304 · Cited by 6
L-asparaginase-mediated Therapy in L-asparagine Auxotrophic Cancers: A Review
Sindhu, R., & Manonmani, H. K. (2022) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/1871520622666220106103336 · Cited by 6
Hadi, W. A. M., Edwin, B. T., & Nair, A. J. (2021) · Journal of the Marine Biological Association of India · doi:10.6024/jmbai.2021.63.2.2195-06 · Cited by 6
Udayan, E., & Gnanadoss, J. J. (2023) · Biosciences Biotechnology Research Asia · doi:10.13005/bbra/3085 · Cited by 6
Schnuchel, A., Radcke, C., Theobald, L., & Doeding, S. (2023) · PLoS ONE · doi:10.1371/journal.pone.0285948 · Cited by 6
Zlotnikov, I. D., Ezhov, A. A., & Kudryashova, E. V. (2024) · Biophysica · doi:10.3390/biophysica4030024 · Cited by 6
Wu, J., Chen, C., Huang, S., Shen, S., Chen, J., & Zhang, S. (2020) · Technology in Cancer Research & Treatment · doi:10.1177/1533033820980113 · Cited by 6
Li, Z., Zhou, S. Y., Yang, X., Li, X., Yang, G. X., Chant, J., Snyder, M. P., & Wang, X. (2021) · Nutrition and Cancer · doi:10.1080/01635581.2021.2013904 · Cited by 6
Long-circulating protein-polymer conjugates: Advancing beyond PEGylated proteins
Liang, S., Deng, X., & Liu, X. (2026) · Nano Research · doi:10.26599/nr.2026.94908529 · Cited by 5
Nguyen, T. N., Do, T. P., Nguyen, T. C., Trieu, H. P., Nguyen, T. G. A., & Thảo, Đ. T. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15051537 · Cited by 5
Harhala, M. A., Gembara, K., Rybicka, I., Kaźmierczak, Z. M., Miernikiewicz, P., Majewska, J., Budziar, W., Nasulewicz‐Goldeman, A., Nelson, D. C., Owczarek, B., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1075774 · Cited by 5
Lau, S. C. D., Loh, C., & Alias, H. (2021) · Frontiers in Pediatrics · doi:10.3389/fped.2021.660627 · Cited by 5
Guimarães, A. V. F., Frota, N., & Lourenzoni, M. R. (2021) · Journal of Molecular Graphics and Modelling · doi:10.1016/j.jmgm.2021.108007 · Cited by 5
Lin, T., Whigham, T. L., Fernando, I., Choi, M. R., Wang, Q., & Silverman, J. A. (2023) · Clinical and Translational Science · doi:10.1111/cts.13499 · Cited by 5
Mootoosamy, C., Kondyli, M., Serfaty, S. A., Tremblay, D.-É., Gagné, V., Ribère, M., Laverdière, C., Leclerc, J., Sinnett, D., Tran, T. H., et al. (2023) · Pharmacogenomics · doi:10.2217/pgs-2022-0164 · Cited by 4
Dobryakova, N. V., Zhdanov, D. D., Dumina, M. V., Александрова, С. С., Pokrovskaya, M. V., Genin, A., Shishparenok, A. N., Zhgun, A. A., & Kudryashova, E. V. (2023) · Catalysts · doi:10.3390/catal13050832 · Cited by 5
Nasrabadi, N. S., Vedad, A., Asadi, K., Poorbagher, M. R. M., Tabrizi, N. A., Dorooki, K., Sabouni, R. S., moghadam, M. B., Shafaei, N., Karimi, E., et al. (2024) · Biotechnology and Applied Biochemistry · doi:10.1002/bab.2564 · Cited by 5
The MET Family of Receptor Tyrosine Kinases Promotes a Shift to Pro-Tumor Metabolism
Davis, J. C., & Waltz, S. E. (2024) · Genes · doi:10.3390/genes15070953 · Cited by 5
BSA/ASN/Pol407 nanoparticles for acute lymphoblastic leukemia treatment
Tinoco, A., Sárria, M. P., Loureiro, A., Parpot, P., Espiña, B., Gomes, A. C., Cavaco-Paulo, A. M., & Ribeiro, A. (2018) · Biochemical Engineering Journal · doi:10.1016/j.bej.2018.10.006 · Cited by 5
Ko, M., Kim, M. G., Yoon, S., Kim, I., Suh, S. Y., Cho, Y., & Oh, J. M. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1122010 · Cited by 5
GPS2 confers l -asparaginase resistance in acute lymphoblastic leukemia cells through ATF4/ASNS axis
Chen, J., Luo, J., Liu, Y., Zhou, J., Cui, H., & Deng, L. (2025) · Carcinogenesis · doi:10.1093/carcin/bgaf035 · Cited by 4
PAX3-FOXO1 Drives Targetable Cell State–Dependent Metabolic Vulnerabilities in Rhabdomyosarcoma
Paras, K. I., Brunner, J. S., Boyer, J. A., Montero, A. M., Jackson, B. T., Chakraborty, S., Xie, A., Guillan, K. C., Siddiquee, A. H., Torres, L. P., et al. (2025) · Cancer Research · doi:10.1158/0008-5472.can-25-0315 · Cited by 4
Pilar Ovalle, B., Manuel Azócar, M., Carolina Nicklas, D., Milena Villarroel, C., & Morales, J. (2021) · Andes pediatrica · doi:10.32641/andespediatr.v92i2.2151 · Cited by 4
Symptomatic hyperammonemia secondary to recombinant Erwinia asparaginase
Martin, C. E., Kohorst, M. A., Ferdjallah, A., Kalmes, J. L., Johnson, H. M., Galardy, P. J., Khan, S. P., & Kuhn, A. K. (2023) · Pediatric Blood & Cancer · doi:10.1002/pbc.30208 · Cited by 4
Wahab, M. R. A., Palaniyandi, T., Wyson, J. D. B., Sivaji, A., & Thamada, S. (2023) · Avicenna Journal of Medical Biotechnology · doi:10.18502/ajmb.v16i1.14170 · Cited by 4
Lee, J. K., Kamran, H., & Lee, K. (2024) · Cell Death Discovery · doi:10.1038/s41420-024-02142-9 · Cited by 4
Chatterjee, A., Khan, R., Mukherjee, T., Sahoo, P. P., Tiwari, L. N., Singh, B. N., Kumari, R., Kumari, A., Rai, A., & Ray, S. (2024) · Archives of Microbiology · doi:10.1007/s00203-024-04179-x · Cited by 5
Dhankhar, R., Kawatra, A., Gupta, V., Mohanty, A., & Gulati, P. (2022) · 3 Biotech · doi:10.1007/s13205-022-03292-2 · Cited by 4
L-Asparaginase-Induced Hepatotoxicity Treated Successfully With L-Carnitine and Vitamin B Infusion
Lee, C., Leventhal, T. M., & Anugwom, C. M. (2021) · Cureus · doi:10.7759/cureus.16917 · Cited by 4
Perforated jejunitis in a child with acute lymphoblastic leukemia treated with pegaspargase
Tang, E. R., Chapman, T., Finn, L. S., & Leger, K. J. (2018) · Radiology Case Reports · doi:10.1016/j.radcr.2018.02.017 · Cited by 4
Therapeutic Targeting of Glutamine Metabolism in Colorectal Cancer
Ratre, Y. K., Verma, H. K., Mehta, A., Soni, V. K., Sonkar, S. C., Shukla, D., Ekka, A., Prajapati, S. K., Mahilkar, S., & Vishvakarma, N. K. (2021) · Springer eBooks · doi:10.1007/978-3-030-64668-4_15 · Cited by 4
3-year survival rate in acute lymphoblastic leukemia: comparison of ALL-2006 and ALL-2013 Protocols
Meirizkia, A., Ayu, D. R., Indra, R. M., & Sari, D. P. (2021) · Paediatrica Indonesiana · doi:10.14238/pi61.3.2021.155-64 · Cited by 4
Diseases & Disorders | Therapies Targeting Glutamine Addiction in Cancer
Attarwala, N., Zhang, C., & Le, A. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819460-7.00079-7 · Cited by 4
Marine-derived L-asparaginase: unlocking marine power in anti-tumor therapeutics
Gopalakrishnan, R., Kamala, K., Gunasekaran, R., Ramachandran, P., Ganapathy, D. M., & Sivaperumal, P. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1710780 · Cited by 3
The yin and yang of bacterial Asn in tumor biology
Lobel, L. (2026) · Cell Host & Microbe · doi:10.1016/j.chom.2025.12.011 · Cited by 3
Microbial endophytes: an untapped resource with antitumor and anti-microbial properties
Kaur, P., & Kaur, G. (2020) · The Applied Biology & Chemistry Journal · doi:10.52679/tabcj.2020.0003 · Cited by 2
Toxicity Analysis of Recombinant L-asparaginase I and II in Zebrafish
Suresh, S. A., Ethiraj, S., & Narayanan, R. (2020) · Indian Journal of Microbiology · doi:10.1007/s12088-020-00890-7 · Cited by 3
Lassaletta, Á., Gutiérrez, F., & the PEGASO study investigators (2022) · Cancer Reports · doi:10.1002/cnr2.1729 · Cited by 3
Strzelczyk, P., Zhang, D., Wlodawer, A., & Lubkowski, J. T. (2022) · FEBS Letters · doi:10.1002/1873-3468.14526 · Cited by 3
Hikmat, A. A. F., Andarsini, M. R., Setyoboedi, B., Larasati, M. C. S., Cahyadi, A., & Ugrasena, I. D. G. (2023) · Pharmacognosy Journal · doi:10.5530/pj.2022.14.190 · Cited by 3
Kassab, M. M. S. (2023) · Egyptian Academic Journal of Biological Sciences. G, Microbiology · doi:10.21608/eajbsg.2023.283740 · Cited by 3
Ali, A. M., Adam, H., Hailu, D., Howe, R., Abula, T., & Coenen, M. J. H. (2023) · The Application of Clinical Genetics · doi:10.2147/tacg.s404695 · Cited by 3
Tan, Y. Q., Loh, C., & Makpol, S. (2023) · Malaysian Journal of Medical Sciences · doi:10.21315/mjms2023.30.5.4 · Cited by 3
Targeting Asparagine Metabolism in Well-Differentiated/Dedifferentiated Liposarcoma
Klingbeil, K. D., Wilde, B. R., Graham, D. S., Lofftus, S. Y., McCaw, T. R., Matulionis, N., Dry, S., Crompton, J. G., Eilber, F. C., Graeber, T. G., et al. (2024) · Cancers · doi:10.3390/cancers16173031 · Cited by 3
McCarty, K. L., Smith, C. C., Zhang, S., Gao, A., Patel, B., Cox, J., Winick, N. J., & Slone, T. L. (2025) · Pediatric Blood & Cancer · doi:10.1002/pbc.31640 · Cited by 3
Endophytes as a Source of High-Value, Bioactive Metabolites
Kapoor, N., Jamwal, V. L., & Gandhi, S. G. (2018) · Reference series in phytochemistry · doi:10.1007/978-3-319-76900-4_9-1 · Cited by 3
Monoclonal Antibody-Based Treatment and Other New Agents for B-Lineage Acute Lymphoblastic Leukemia
Molina, J. C., & Shah, N. N. (2022) · Springer eBooks · doi:10.1007/978-3-030-85147-7_13 · Cited by 3
Setiawan, R., & Larasati, D. R. (2019) · Biosaintifika Journal of Biology & Biology Education · doi:10.15294/biosaintifika.v11i2.17435 · Cited by 3
Ghorbanmovahhed, M., Ebrahimipour, G., & Marzban, A. (2019) · Iranian Journal of Medical Microbiology · doi:10.30699/ijmm.13.5.374 · Cited by 3
Metadata
- Authors
- Egler, R. A., Ahuja, S. P., & Matloub, Y.
- Affiliations
- Rainbow Babies & Children's Hospital (US)
- Corresponding author
- Egler, Rachel A.
- ORCID
- Ahuja, Sanjay P.
- Venue
- Journal of Pharmacology and Pharmacotherapeutics
- Publisher
- SAGE Publications
- Published
- 2016-06
- Volume
- 7
- Issue
- 2
- Pages
- 62-71
- ISSN
- 0976-500X (ISSN-L)
- 0976-5018
- PMC
- PMC4936081
- OpenAlex
- W2471256249
- Cited by
- 334
- References
- 99
- Citations by year
- 2026: 24 · 2025: 28 · 2024: 42 · 2023: 50 · 2022: 36 · 2021: 55 · 2020: 37 · 2019: 26 · 2018: 17 · 2017: 17 · 2016: 1
- FWCI
- 20.16
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Pharmacology and Pharmacotherapeutics (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Acute Lymphoblastic Leukemia research
- Health Sciences › Medicine › Pharmacology (medical) › Drug-Induced Adverse Reactions
- Health Sciences › Medicine › Hematology › Chronic Lymphocytic Leukemia Research
- Keywords
- L-asparaginase, acute lymphoblastic leukemia, childhood acute lymphoblastic leukemia, adolescent and young adult leukemia, pegylated asparaginase, hypersensitivity, cross-reactivity, pharmacokinetics, therapeutic drug monitoring, survival outcomes
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
