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Cited by 541

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Toxicological screening

Open access
S., Parasuraman·2011·Journal of Pharmacology and Pharmacotherapeutics
DOI 10.4103/0976-500x.81895
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Abstract

Toxicity testing of new compounds is essential for drug development process. The preclinical toxicity testing on various biological systems reveals the species-, organ- and dose- specific toxic effects of an investigational product. The toxicity of substances can be observed by (a) studying the accidental exposures to a substance (b) in vitro studies using cells/ cell lines (c) in vivo exposure on experimental animals. This review mainly focuses on the various experimental animal models and methods used for toxicity testing of substances. The pre-clinical toxicity testing helps to calculate "No Observed Adverse Effect Level" which is needed to initiate the clinical evaluation of investigational products.

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Metadata

Authors
S., P.
Venue
Journal of Pharmacology and Pharmacotherapeutics
Publisher
SAGE Publications
Published
2011-06
Volume
2
Issue
2
Pages
74-79
ISSN
  • 0976-500X (ISSN-L)
  • 0976-5018
DOI
10.4103/0976-500x.81895
OpenAlex
W4247050267
Cited by
541
References
0
FWCI
6.94
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Toxicological screening. https://app.cochat.ai/papers/10.4103/0976-500x.81895
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S., P. (2011). Toxicological screening. Journal of Pharmacology and Pharmacotherapeutics. https://doi.org/10.4103/0976-500x.81895

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.