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Cited by 93Neurogenesis and neuroplasticity mechanismsStress Responses and CortisolNeuroinflammation and Neurodegeneration Mechanisms

Impact of glucocorticoid on neurogenesis

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Numakawa, Tadahiro, Odaka, Haruki, Adachi, Naoki·2017·Neural Regeneration Research
DOI 10.4103/1673-5374.211174PMC PMC5558474
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Abstract

Neurogenesis is currently an area of great interest in neuroscience. It is closely linked to brain diseases, including mental disorders and neurodevelopmental disease. Both embryonic and adult neurogeneses are influenced by glucocorticoids secreted from the adrenal glands in response to a variety of stressors. Moreover, proliferation/differentiation of the neural stem/progenitor cells (NSPCs) is affected by glucocorticoids through intracellular signaling pathways such as phosphoinositide 3-kinase (PI3K)/Akt, hedgehog, and Wnt. Our review presents recent evidence of the impact of glucocorticoids on NSPC behaviors and the underlying molecular mechanisms; this provides important information for understanding the pathological role of glucocorticoids on neurogenesis-associated brain diseases.

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  • Abnormal GR activation contributes to neuronal apoptosis and degeneration by reducing expression of BDNF and inhibiting cellular proliferation.

    “Abnormal GR activation contributes to neuronal apoptosis and degeneration by reducing the expression of BDNF and inhibiting cellular proliferation”

    From Serum/glucocorticoid regulated kinase 1 (SGK1) in neurological disorders: pain or gain (2024) · cites this paper as Odaka et al., 2017

    The ‘Glucocorticoid Effect on Neural Stem/Progenitor Cells’ section reports that increased glucocorticoids activate GR and reduce neural stem/progenitor-cell proliferation. It also reports reduced BDNF expression after stress or glucocorticoid exposure and GR-mediated repression of BDNF transcription. The paper does not establish that these effects cause neuronal apoptosis or degeneration. (LLM, conf=0.88)

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  1. [1]Alonso SJ Arevalo R Afonso D Rodríguez M Effects of maternal stress during pregnancy on forced swimming test behavior of the offspring Physiol Behav 1991 50 511 517 1801003
  2. [2]Anacker C Cattaneo A Luoni A Musaelyan K Zunszain PA Milanesi E Rybka J Berry A Cirulli F Thuret S Price J Riva MA Gennarelli M Pariante CM Glucocorticoid-related molecular signaling pathways regulating hippocampal neurogenesis Neuropsychopharmacology 2013a 38 872 883 23303060 PMC3672002
  3. [4]Begni V Riva MA Cattaneo A Cellular and molecular mechanisms of the brain-derived neurotrophic factor in physiological and pathological conditions Clin Sci (Lond) 2017 131 123 138 28011898
  4. [5]Bengoa-Vergniory N Kypta RM Canonical and noncanonical Wnt signaling in neural stem/progenitor cells Cell Mol Life Sci 2015 72 4157 4172 26306936 PMC11113751
  5. [6]Beversdorf DQ Manning SE Hillier A Anderson SL Nordgren RE Walters SE Nagaraja HN Cooley WC Gaelic SE Bauman ML Timing of prenatal stressors and autism J Autism Dev Disord 2005 35 471 478 16134032
  6. [7]Bingham BC Rani CS Frazer A Strong R Morilak DA Exogenous prenatal corticosterone exposure mimics the effects of prenatal stress on adult brain stress response systems and fear extinction behavior Psychoneuroendocrinology 2013 38 2746 2757 23937971
  7. [8]Boldrini M Underwood MD Hen R Rosoklija GB Dwork AJ John Mann J Arango V Antidepressants increase neural progenitor cells in the human hippocampus Neuropsychopharmacology 2009 34 2376 2389 19606083 PMC2743790
  8. [9]Boldrini M Santiago AN Hen R Dwork AJ Rosoklija GB Tamir H Arango V John Mann J Hippocampal granule neuron number and dentate gyrus volume in antidepressant-treated and untreated major depression Neuropsychopharmacology 2013 38 1068 1077 23303074 PMC3629406
  9. [10]Boldrini M Hen R Underwood MD Rosoklija GB Dwork AJ Mann JJ Arango V Hippocampal angiogenesis and progenitor cell proliferation are increased with antidepressant use in major depression Biol Psychiatry 2012 72 562 571 22652019 PMC3438317
  10. [12]Bose R Moors M Tofighi R Cascante A Hermanson O Ceccatelli S Glucocorticoids induce long-lasting effects in neural stem cells resulting in senescence-related alterations Cell Death Dis 2010 1 e92 21368868 PMC3032322
  11. [13]Chen H Lombès M Le Menuet D Glucocorticoid receptor represses brain-derived neurotrophic factor expression in neuron-like cells Mol Brain 2017 10 12 28403881 PMC5389111
  12. [14]Crowther CA Doyle LW Haslam RR Hiller JE Harding JE Robinson JS ACTORDS Study Group Outcomes at 2 years of age after repeat doses of antenatal corticosteroids N Engl J Med 2007 357 1179 1189 17881750
  13. [15]De Kloet ER Vreugdenhil E Oitzl MS Joëls M Brain corticosteroid receptor balance in health and disease Endocr Rev 1998 19 269 301 9626555
  14. [16]Dwivedi Y Rizavi HS Pandey GN Antidepressants reverse corticosterone-mediated decrease in brain-derived neurotrophic factor expression: differential regulation of specific exons by antidepressants and corticosterone Neuroscience 2006 139 1017 1029 16500030 PMC1513636
  15. [17]Fitzsimons CP van Hooijdonk LW Schouten M Zalachoras I Brinks V Zheng T Schouten TG Saaltink DJ Dijkmans T Steindler DA Verhaagen J Verbeek FJ Lucassen PJ de Kloet ER Meijer OC Karst H Joels M Oitzl MS Vreugdenhil E Knockdown of the glucocorticoid receptor alters functional integration of newborn neurons in the adult hippocampus and impairs fear-motivated behavior Mol Psychiatry 2013 18 993 1005 22925833
  16. [18]French NP Hagan R Evans SF Mullan A Newnham JP Repeated antenatal corticosteroids: effects on cerebral palsy and childhood behavior Am J Obstet Gynecol 2004 190 588 595 15041985
  17. [19]Furay AR Bruestle AE Herman JP The role of the forebrain glucocorticoid receptor in acute and chronic stress Endocrinology 2008 149 5482 5490 18617609 PMC2584591
  18. [20]Gass P Kretz O Wolfer DP Berger S Tronche F Reichardt HM Kellendonk C Lipp HP Schmid W Schütz G Genetic disruption of mineralocorticoid receptor leads to impaired neurogenesis and granule cell degeneration in the hippocampus of adult mice EMBO Rep 2000 1 447 451 11258486 PMC1083761
  19. [21]González R Ruiz-León Y Gomendio M Roldan ER The effect of glucocorticoids on ERK-1/2 phosphorylation during maturation of lamb oocytes and their subsequent fertilization and cleavage ability in vitro Reprod Toxicol 2010 29 198 205 19892010
  20. [22]Graignic-Philippe R Dayan J Chokron S Jacquet AY Tordjman S Effects of prenatal stress on fetal and child development: a critical literature review Neurosci Biobehav Rev 2014 43 137 162 24747487
  21. [23]Griffin GD Charron D Al-Daccak R Post-traumatic stress disorder: revisiting adrenergics, glucocorticoids, immune system effects and homeostasis Clin Transl Immunology 2014 3 e27 PMC4255796 25505957
  22. [24]Grizenko N Fortier ME Zadorozny C Thakur G Schmitz N Duval R Joober R Maternal stress during pregnancy, ADHD symptomatology in children and genotype: gene-environment interaction J Can Acad Child Adolesc Psychiatry 2012 21 9 15 22299010 PMC3269259
  23. [25]Han J Wang B Xiao Z Gao Y Zhao Y Zhang J Chen B Wang X Dai J Mammalian target of rapamycin (mTOR) is involved in the neuronal differentiation of neural progenitors induced by insulin Mol Cell Neurosci 2008 39 118 124 18620060
  24. [26]Herbert J Cortisol and depression: three questions for psychiatry Psychol Med 2013 43 449 469 22564216
  25. [27]Hill AS Sahay A Hen R Increasing adult hippocampal neurogenesis is sufficient to reduce anxiety and depression-like behaviors Neuropsychopharmacology 2015 40 2368 2378 25833129 PMC4538351
  26. [28]Holsboer F The corticosteroid receptor hypothesis of depression Neuropsychopharmacology 2000 23 477 501 11027914
  27. [29]Horsch K de Wet H Schuurmans MM Allie-Reid F Cato AC Cunningham J Burrin JM Hough FS Hulley PA Mitogen-activated protein kinase phosphatase 1/dual specificity phosphatase 1 mediates glucocorticoid inhibition of osteoblast proliferation Mol Endocrinol 2007 21 2929 2940 17761948 PMC2838148
  28. [30]Ising M Künzel HE Binder EB Nickel T Modell S Holsboer F The combined dexamethasone/CRH test as a potential surrogate marker in depression Prog Neuropsychopharmacol Biol Psychiatry 2005 29 1085 1093 15950349
  29. [31]Jha S Dong B Sakata K Enriched environment treatment reverses depression-like behavior and restores reduced hippocampal neurogenesis and protein levels of brain-derived neurotrophic factor in mice lacking its expression through promoter IV Transl Psychiatry 2011 1 e40 22832656 PMC3309483
  30. [32]Ka M Condorelli G Woodgett JR Km WY mTOR regulates brain morphogenesis by mediating GSK3 signaling Development 2014 141 4076 4086 25273085 PMC4302893
  31. [33]Kanagawa T Tomimatsu T Hayashi S Shioji M Fukuda H Shimoya K Murata Y The effects of repeated corticosteroid administration on the neurogenesis in the neonatal rat Am J Obstet Gynecol 2006 194 231 238 16389037
  32. [34]Katoh M Katoh M Cross-talk of WNT and FGF signaling pathways at GSK3beta to regulate beta-catenin and SNAIL signaling cascades Cancer Biol Ther 2006 5 1059 1064 16940750
  33. [35]Khashan AS Abel KM McNamee R Pedersen MG Webb RT Baker PN Kenny LC Mortensen PB Higher risk of offspring schizophrenia following antenatal maternal exposure to severe adverse life events Arch Gen Psychiatry 2008 65 146 152 18250252
  34. [37]Kisoh K Hayashi H Itoh T Asada M Arai M Yuan B Tanonaka K Takagi N Involvement of GSK-3β phosphorylation through PI3-K/Akt in cerebral ischemia-induced neurogenesis in rats Mol Neurobiol 2016 doi:10.1007/s12035-016-0290-8 PMC5684253 27866373 · DOI
  35. [38]Kiuchi T Lee H Mikami T Regular exercise cures depression-like behavior via VEGF-Flk-1 signaling in chronically stressed mice Neuroscience 2012 207 208 217 22306286
  36. [39]Kleiderman S Gutbier S Ugur Tufekci K Ortega F Sá JV Teixeira AP Brito C Glaab E Berninger B Alves PM Leist M Conversion of nonproliferating astrocytes into neurogenic neural stem cells: control by FGF2 and interferon-γ Stem Cells 2016 34 2861 2874 27603577
  37. [40]Kronenberg G Kirste I Inta D Chourbaji S Heuser I Endres M Gass P Reduced hippocampal neurogenesis in the GR(+/-) genetic mouse model of depression Eur Arch Psychiatry Clin Neurosci 2009 259 499 504 19644729 PMC2847168
  38. [41]Kumamaru E Numakawa T Adachi N Kunugi H Glucocorticoid suppresses BDNF-stimulated MAPK/ERK pathway via inhibiting interaction of Shp2 with TrkB FEBS Lett 2011 585 3224 3228 21946312
  39. [42]Kuo T Lew MJ Mayba O Harris CA Speed TP Wang JC Genome-wide analysis of glucocorticoid receptor-binding sites in myotubes identifies gene networks modulating insulin signaling Proc Natl Acad Sci U S A 2012 109 11160 11165 22733784 PMC3396543
  40. [43]Lehmann ML Brachman RA Martinowich K Schloesser RJ Herkenham M Glucocorticoids orchestrate divergent effects on mood through adult neurogenesis J Neurosci 2013 33 2961 2972 23407954 PMC3711562
  41. [44]Lenze EJ Mantella RC Shi P Goate AM Nowotny P Butters MA Andreescu C Thompson PA Rollman BL Elevated cortisol in older adults with generalized anxiety disorder is reduced by treatment: a placebo-controlled evaluation of escitalopram Am J Geriatr Psychiatry 2011 19 482 490 20808146 PMC3424606
  42. [46]Lordi B Patin V Protais P Mellier D Caston J Chronic stress in pregnant rats: effects on growth rate, learning, and memory capabilities of the offspring Int J Psychophysiol 2000 37 195 205 10832006
  43. [47]Madsen TM Treschow A Bengzon J Bolwig TG Lindvall O Tingström A Increased neurogenesis in a model of electroconvulsive therapy Biol Psychiatry 2000 47 1043 1049 10862803
  44. [48]Mitre-Aguilar IB Cabrera-Quintero AJ Zentella-Dehesa A Genomic and non-genomic effects of glucocorticoids: implications for breast cancer Int J Clin Exp Pathol 2015 8 1 10 25755688 PMC4348864
  45. [49]Moors M Bose R Johansson-Haque K Edoff K Okret S Ceccatelli S Dickkopf 1 mediates glucocorticoid-induced changes in human neural progenitor cell proliferation and differentiation Toxicol Sci 2012 125 488 495 22048647
  46. [50]Noorlander CW Visser GH Ramakers GM Nikkels PG de Graan PN Prenatal corticosteroid exposure affects hippocampal plasticity and reduces lifespan Dev Neurobiol 2008 68 237 246 18000831
  47. [51]Noorlander CW Tijsseling D Hessel EV de Vries WB Derks JB Visser GH de Graan PN Antenatal glucocorticoid treatment affects hippocampal development in mice PLoS One 2014 9 e85671 24465645 PMC3899077
  48. [52]Numakawa T Adachi N Richards M Chiba S Kunugi H Brain-derived neurotrophic factor and glucocorticoids: reciprocal influence on the central nervous system Neuroscience 2013 239 157 172 23069755
  49. [53]Numakawa T Kumamaru E Adachi N Yagasaki Y Izumi A Kunugi H Glucocorticoid receptor interaction with TrkB promotes BDNF-triggered PLC-gamma signaling for glutamate release via a glutamate transporter Proc Natl Acad Sci U S A 2009 106 647 652 19126684 PMC2626757
  50. [54]Odaka H Numakawa T Yoshimura A Nakajima S Adachi N Ooshima Y Inoue T Kunugi H Chronic glucocorticoid exposure suppressed the differentiation and survival of embryonic neural stem/progenitor cells: Possible involvement of ERK and PI3K/Akt signaling in the neuronal differentiation Neurosci Res 2016 113 28 36 27432545
  51. [55]Ohnaka K Tanabe M Kawate H Nawata H Takayanagi R Glucocorticoid suppresses the canonical Wnt signal in cultured human osteoblasts Biochem Biophys Res Commun 2005 329 177 181 15721290
  52. [56]Owashi T Otsubo T Oshima A Nakagome K Higuchi T Kamijima K Longitudinal neuroendocrine changes assessed by dexamethasone/CRH and growth hormone releasing hormone tests in psychotic depression Psychoneuroendocrinology 2008 33 152 161 18068306
  53. [57]Pan Y Bai CB Joyner AL Wang B Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation Mol Cell Biol 2006 26 3365 3377 16611981 PMC1447407
  54. [58]Raciti M Ong J Weis L Edoff K Battagli C Falk A Ceccatelli S Glucocorticoids alter neuronal differentiation of human neuroepithelial-like cells by inducing long-lasting changes in the reactive oxygen species balance Neuropharmacology 2016 107 422 431 26992751
  55. [59]Raglan GB Schmidt LA Schulkin J The role of glucocorticoids and corticotropin-releasing hormone regulation on anxiety symptoms and response to treatment Endocr Connect 2017 6 R1 R7 28119322 PMC5424777
  56. [60]Reynolds RM Glucocorticoid excess and the developmental origins of disease: two decades of testing the hypothesis – 2012 Curt Richter Award Winner Psychoneuroendocrinology 2013 38 1 11 22998948
  57. [61]Roozendaal B Phillips RG Power AE Brooke SM Sapolsky RM McGaugh JL Memory retrieval impairment induced by hippocampal CA3 lesions is blocked by adrenocortical suppression Nat Neurosci 2001 4 1169 1171 11713467
  58. [62]Salomon S Bejar C Schorer-Apelbaum D Weinstock M Corticosterone mediates some but not other behavioural changes induced by prenatal stress in rats J Neuroendocrinol 2011 23 118 128 21108672
  59. [64]Samuels IS Saitta SC Landreth GE MAP’ing CNS development and cognition: an ERKsome process Neuron 2009 61 160 167 19186160 PMC3663441
  60. [66]Santarelli L Saxe M Gross C Surget A Battaglia F Dulawa S Weisstaub N Lee J Duman R Arancio O Belzung C Hen R Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants Science 2003 301 805 809 12907793
  61. [67]Sawamoto A Okuyama S Yamamoto K Amakura Y Yoshimura M Nakajima M Furukawa Y 3,5,6,7,8,3′,4′-heptamethoxyflavone, a citrus flavonoid, ameliorates corticosterone-induced depression-like behavior and restores brain-derived neurotrophic factor expression, neurogenesis, and neuroplasticity in the hippocampus Molecules 2016 21 541 27120588 PMC6273269
  62. [68]Schaaf MJ Hoetelmans RW de Kloet ER Vreugdenhil E Corticosterone regulates expression of BDNF and trkB but not NT-3 and trkC mRNA in the rat hippocampus J Neurosci Res 1997 48 334 341 9169859
  63. [69]Schloesser RJ Manji HK Martinowich K Suppression of adult neurogenesis leads to an increased hypothalamo-pituitary-adrenal axis response Neuroreport 2009 20 553 557 19322118 PMC2693911
  64. [70]Schneider ML Moore CF Kraemer GW Roberts AD DeJesus OT The impact of prenatal stress, fetal alcohol exposure, or both on development: perspectives from a primate model Psychoneuroendocrinology 2002 27 285 298 11750784
  65. [71]Schoenfeld TJ Cameron HA Adult neurogenesis and mental illness Neuropsychopharmacology 2015 40 113 128 25178407 PMC4262910
  66. [72]Smith E Frenkel B Glucocorticoids inhibit the transcriptional activity of LEF/TCF in differentiating osteoblasts in a glycogen synthase kinase-3beta-dependent and -independent manner J Biol Chem 2005 280 2388 2394 15537647
  67. [73]Smith MA Makino S Kvetnansky R Post RM Stress and glucocorticoids affect the expression of brain-derived neurotrophic factor and neurotrophin-3 mRNAs in the hippocampus J Neurosci 1995 3 Pt 1 1768 1777 7891134 PMC6578156
  68. [74]Stutchfield PR Whitaker R Gliddon AE Hobson L Kotecha S Doull IJ Behavioural, educational and respiratory outcomes of antenatal betamethasone for term caesarean section (ASTECS trial) Arch Dis Child Fetal Neonatal Ed 2013 98 F195 200 23424017 PMC3623033
  69. [75]Sundberg M Savola S Hienola A Korhonen L Lindholm D Glucocorticoid hormones decrease proliferation of embryonic neural stem cells through ubiquitin-mediated degradation of cyclin D1 J Neurosci 2006 26 5402 5410 16707792 PMC6675314
  70. [77]Surget A Tanti A Leonardo ED Laugeray A Rainer Q Touma C Palme R Griebel G Ibarguen-Vargas Y Hen R Belzung C Antidepressants recruit new neurons to improve stress response regulation Mol Psychiatry 2011 16 1177 1188 21537331 PMC3223314
  71. [78]Tang MM Lin WJ Pan YQ Guan XT Li YC Hippocampal neurogenesis dysfunction linked to depressive-like behaviors in a neuroinflammation induced model of depression Physiol Behav 2016 161 166 173 27106565
  72. [79]Van den Bergh BR Marcoen A High antenatal maternal anxiety is related to ADHD symptoms, externalizing problems, and anxiety in 8- and 9-year-olds Child Dev 2004 75 1085 1097 15260866
  73. [81]van Os J Selten JP Prenatal exposure to maternal stress and subsequent schizophrenia. The May 1940 invasion of The Netherlands Br J Psychiatry 1998 172 324 326 9715334
  74. [82]Wang B Li Y Evidence for the direct involvement of {beta}TrCP in Gli3 protein processing Proc Natl Acad Sci U S A 2006 103 33 38 16371461 PMC1325010
  75. [83]Wang L Zhou K Fu Z Yu D Huang H Zang X Mo X Brain development and Akt signaling: the crossroads of signaling pathway and neurodevelopmental diseases J Mol Neurosci 2017 61 379 384 28025777 PMC5344939
  76. [84]Wilcoxon JS Redei EE Maternal glucocorticoid deficit affects hypothalamic-pituitary-adrenal function and behavior of rat offspring Horm Behav 2007 51 321 327 17275820 PMC1865577
  77. [85]Wong ML Kling MA Munson PJ Listwak S Licinio J Prolo P Karp B McCutcheon IE Geracioti TD Jr DeBellis MD Rice KC Goldstein DS Veldhuis JD Chrousos GP Oldfield EH McCann SM Gold PW Pronounced and sustained central hypernoradrenergic function in major depression with melancholic features: relation to hypercortisolism and corticotropin-releasing hormone Proc Natl Acad Sci U S A 2000 97 325 330 10618417 PMC26662
  78. [86]Yun S Reynolds RP Masiulis I Eisch AJ Re-evaluating the link between neuropsychiatric disorders and dysregulated adult neurogenesis Nat Med 2016 22 1239 1247 27783068 PMC5791154
  79. [87]Zou W Yang S Zhang T Sun H Wang Y Xue H Zhou D Hypoxia enhances glucocorticoid-induced apoptosis and cell cycle arrest via the PI3K/Akt signaling pathway in osteoblastic cells J Bone Miner Metab 2015 33 615 624 25230819

Cited by

Sorted by citations

Authors
Numakawa, T., Odaka, H., & Adachi, N.
Affiliations
  • National Center of Neurology and Psychiatry (JP)
  • Waseda University (JP)
  • Kwansei Gakuin University (JP)
Corresponding author
Numakawa, Tadahiro
ORCID
Venue
Neural Regeneration Research
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2017
Volume
12
Issue
7
Pages
1028
ISSN
1673-5374 (ISSN-L)
DOI
10.4103/1673-5374.211174
PMC
PMC5558474
OpenAlex
W2738706733
Cited by
93
References
8
Citations by year
2026: 8 · 2025: 12 · 2024: 11 · 2023: 8 · 2022: 14 · 2021: 21 · 2020: 12 · 2019: 5 · 2018: 2
FWCI
0.79
Type
journal article
Language
en
Open access
Licence
cc-by-nc-sa
Locations
  • Neural Regeneration Research (publishedVersion, cc-by-nc-sa)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-sa)
  • PubMed Central (publishedVersion, cc-by-nc-sa)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Japan Society for the Promotion of Science (17J04183)
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords
glucocorticoids, neurogenesis, neural stem/progenitor cells, adult neurogenesis, embryonic neurogenesis, stress response, PI3K/Akt signaling, Hedgehog signaling, Wnt signaling, brain disorders, mental illness, neurodevelopmental disorders

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